ΔNp63 silencing, DNA methylation shifts, and epithelial-mesenchymal transition resulted from TAp63 genome editing in squamous cell carcinoma

Isoform-Specific Roles of Mutant p63 in Human Diseases

(2021) Christian Osterburg et al.   Cancers

Global detection of DNA repair outcomes induced by CRISPR–Cas9

(2021) Mengzhu Liu et al.   NUCLEIC ACIDS RESEARCH

Familial cleft tongue caused by a unique translation initiation codon variant in TP63

(2021) Julia Schmidt et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

TP63 links chromatin remodeling and enhancer reprogramming to epidermal differentiation and squamous cell carcinoma development

(2020) Mei Yi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Guidelines and definitions for research on epithelial–mesenchymal transition

(2020) Jing Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TP63, SOX2, and KLF5 Establish a Core Regulatory Circuitry That Controls Epigenetic and Transcription Patterns in Esophageal Squamous Cell Carcinoma Cell Lines

(2020) Yan-Yi Jiang et al.   GASTROENTEROLOGY

Genome-Wide Analysis of Off-Target CRISPR/Cas9 Activity in Single-Cell-Derived Human Hematopoietic Stem and Progenitor Cell Clones

(2020) Richard H. Smith et al.   Genes

C-terminal α Domain of p63 Binds to p300 to Coactivate β-Catenin

(2019) Iyoko Katoh et al.   NEOPLASIA

p63 establishes epithelial enhancers at critical craniofacial development genes

(2019) Enrique Lin-Shiao et al.   Science Advances

Epigenomic profiling discovers trans-lineage SOX2 partnerships driving tumor heterogeneity in lung squamous cell carcinoma

(2019) Takashi Sato et al.   CANCER RESEARCH

ΔNp63α is a super enhancer-enriched master factor controlling the basal-to-luminal differentiation transcriptional program and gene regulatory networks in nasopharyngeal carcinoma

(2019) Jing Cai et al.   CARCINOGENESIS

Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species

(2018) Dafni Anastasiadi et al.   Epigenetics & Chromatin

Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression

(2018) Yuan Jiang et al.   Nature Communications

Heterochromatin delays CRISPR-Cas9 mutagenesis but does not influence the outcome of mutagenic DNA repair

(2018) Eirini M. Kallimasioti-Pazi et al.   PLOS BIOLOGY

Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis

(2016) Lorenzo Rinaldi et al.   Cell Stem Cell

Gene regulatory mechanisms orchestrated by p63 in epithelial development and related disorders

(2015) Evelyn N. Kouwenhoven et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Transcription factor p63 bookmarks and regulates dynamic enhancers during epidermal differentiation

(2015) E. N. Kouwenhoven et al.   EMBO REPORTS

RNA-seq Studies Reveal New Insights into p63 and the Transcriptomic Landscape of the Mouse Skin

(2015) Jason M. Rizzo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Maintenance of Epigenetic States by p53: The Guardian of the Epigenome

(2015) Arnold J. Levine et al.   Oncotarget

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

(2013) Yanfang Fu et al.   NATURE BIOTECHNOLOGY

Multiple Roles of p53-Related Pathways in Somatic Cell Reprogramming and Stem Cell Differentiation

(2012) L. Yi et al.   CANCER RESEARCH

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer

(2012) P. Tucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p63, a Story of Mice and Men

(2011) Hans Vanbokhoven et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

DNA Methylation of the First Exon Is Tightly Linked to Transcriptional Silencing

(2011) Fabienne Brenet et al.   PLoS One

ΔNp63 knockdown mice: A mouse model for AEC syndrome

(2009) Maranke I. Koster et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Loss of  Np63  Promotes Invasion of Urothelial Carcinomas via N-Cadherin/Src Homology and Collagen/Extracellular Signal-Regulated Kinase Pathway

(2009) H. Fukushima et al.   CANCER RESEARCH

TAp63 Prevents Premature Aging by Promoting Adult Stem Cell Maintenance

(2009) Xiaohua Su et al.   Cell Stem Cell

NCAM-induced focal adhesion assembly: a functional switch upon loss of E-cadherin

(2008) Francois Lehembre et al.   EMBO JOURNAL