期刊
NATURAL PRODUCT RESEARCH
卷 31, 期 5, 页码 555-561出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2016.1207074
关键词
Moorea producens; cytotoxicity; malyngamide; floridamide
资金
- National Institute of Health [GM 63554, CA 52955]
A bioassay-guided investigation (cancer cell cytotoxicity) of a Moorea producens collection from Key West, Florida, led to the discovery of two new bioactive natural products [(+)-malyngamide Y and a cyclic depsipeptide, (+)-floridamide]. Their planar structures were deduced through extensive analysis of 1D and 2D NMR spectroscopic data and supported by HRFAB mass spectrometry. The new cyclic depsipeptide contains four amino acids units, including N- methyl phenylalanine, proline, valine and alanine, beside the unique unit, 2,2-dimethyl-3hydroxy- octanoic acid. In addition to the discovery of these two new compounds, two previously reported metabolites were also isolated and identified from this cyanobacterial collection; (-)-C-12 lyngbic acid and the antibacterial agent (-)-malyngolide.
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