期刊
NATURAL PRODUCT RESEARCH
卷 31, 期 4, 页码 445-452出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2016.1188094
关键词
Glycyrrhiza pallidiflora; flavonoids; pterocarpans; isoflavonoids; cytotoxic activity
资金
- Russian Science Foundation [14-13-00822]
- Russian Ministry of Education and Science 'Organisation of scientific research 151' [17.1891.2014/K]
Twenty-one phenolic compounds (1-21) including dihydrocinnamic acid, isoflavonoids, flavonoids, coumestans, pterocarpans, chalcones, isoflavan and isoflaven, were isolated from the roots of Glycyrrhiza pallidiflora Maxim. Phloretinic acid (1), chrysin (6), 9-methoxycoumestan (8), isoglycyrol (9), 6-O-acetylanonin (19) and 6-O-acetylwistin (21) were isolated from G. pallidiflora for the first time. Isoflavonoid acetylglycosides 19, 21 might be artefacts that could be produced during the EtOAc fractionation process of whole extract. Compounds 2-4, 10, 11, 19 and 21 were evaluated for their cytotoxic activity with respect to model cancer cell lines (CEM-13, MT4, U-937) using the conventional MTT assays. Isoflavonoid calycosin (4) showed the best potency against human T-cell leukaemia cells MT-4 (CTD50, 2.9 mu M). Pterocarpans medicarpin (10) and homopterocarpin (11) exhibit anticancer activity in micromolar range with selectivity on the human monocyte cells U-937. The isoflavan (3R)-vestitol (16) was highly selective on the lymphoblastoid leukaemia cells CEM-13 and was more active than the drug doxorubicin [GRAPHICS] .
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