期刊
NATURAL PRODUCT REPORTS
卷 33, 期 10, 页码 1146-1165出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6np00004e
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资金
- Pew Scholars Program, University of California Cancer Research Coordinating Committee funds
- Hellman Fellows Fund
Antimycin-type depsipeptides are a family of natural products with great structural diversity and outstanding biological activities. These compounds have typically been isolated from actinomycetes and are generated from hybrid nonribosomal peptide synthetase (NRPS)-polyketide synthase (PKS) assembly lines. This review covers the literature on the four classes of antimycin-type depsipeptides, which differ by macrolactone ring size, and it discusses the discovery, biosynthesis, chemical synthesis, and biological activities of this family of compounds.
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