4.6 Article

Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires

期刊

NANOTECHNOLOGY
卷 28, 期 3, 页码 -

出版社

IOP PUBLISHING LTD
DOI: 10.1088/1361-6528/28/3/03LT01

关键词

RF-mediated thermotherapy; magnetic core-shell nanowire; RF radiation; cancer

资金

  1. Masdar Institute New Faculty Start-up Funds
  2. National Research Foundation of Korea [2014M3A7B4052193, 2015R1A2A1A15053002]
  3. National Research Foundation of Korea [2014M3A7B4052193] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

向作者/读者索取更多资源

We present a novel method of radio frequency (RF)-mediated thermotherapy in tumors by remotely heating nickel (Ni)-gold (Au) core-shell nanowires (CSNWs). Ectopic pancreatic tumors were developed in nude mice to evaluate the thermotherapeutic effects on tumor progression. Tumor ablation was produced by RF-mediated thermotherapy via activation of the paramagnetic properties of the Ni-Au CSNWs. Histopathology demonstrated that heat generated by RF irradiation caused significant cellular death with pyknotic nuclei and nuclear fragmentation dispersed throughout the tumors. These preliminary results suggest that thermotherapy ablation induced via RF activation of nanowires provides a potential alternative therapy for cancer treatment.

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