Article
Nanoscience & Nanotechnology
Kai Guo, Heran Wang, Shijie Li, Hui Zhang, Song Li, Huixuan Zhu, Zhenda Yang, Liming Zhang, Peng Chang, Xiongfei Zheng
Summary: The synthesized norbornene-functionalized neutral soluble collagen exhibits excellent cell-friendly properties and can be quickly cross-linked to form cell-laden hydrogels via a photo-click reaction. It can be mixed with other polymers to create hybrid bio-inks that respond to multiple stimuli, showing flexibility and excellent biocompatibility in temperature-, ion-, and photo-based bioprinting. This collagen is a promising candidate for tissue engineering, regenerative medicine, and personalized therapeutics due to its unique properties.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Organic
Jimin Guo, Jianjian Zha, Tao Zhang, Chang-Hua Ding, Qitao Tan, Bin Xu
Summary: Unsymmetrical disulfides can be prepared effectively through thiol exchange with symmetrical disulfides using a simple PdCl2/DMSO catalytic system. The method demonstrates excellent functional group tolerance, a broad substrate scope, and operational simplicity. This reaction is particularly valuable for late-stage functionalization of bioactive scaffolds such as peptides and pharmaceuticals.
Article
Chemistry, Organic
Amit Chakraborty, Fernando Albericio, Beatriz G. de la Torre
Summary: Chemoselective disulfide formation is achieved through thiol-disulfide interchange approach using sec-isoamyl mercaptan (SIT) as an alkyl sulfenyl-protecting group. SIT acts as a masking group during synthesis and directs disulfide formation in the presence of a free thiol. This novel approach is demonstrated by synthesizing several peptides of biological interest.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Polymer Science
Taylor Wright, Ziyue Zhang, Carl A. Michal, Savvas G. Hatzikiriakos, Michael O. Wolf
Summary: The study demonstrates the photo-oxidation of thiol functionalities into disulfide cross-links using a telluride catalyst and photo-generated singlet oxygen, resulting in degradable elastic materials. The kinetics of the process are influenced by the telluride concentration for cross-linking rate and the rate of telluride oxidation for cross-linking onset.
Article
Chemistry, Physical
Ying Chen, Feng Hu, Yanan Hao, Yonghan Wang, Yaoyi Xie, Hui Wang, Lijie Yin, Deshuang Yu, Hongchao Yang, Jun Ma, Dan Kai, Linlin Li, Shengjie Peng
Summary: The study successfully designed a novel thiol-capped silver electrocatalyst for efficient CO2 reduction to CO. Thiols play an important role in the electrochemical CO2 reduction process.
Article
Food Science & Technology
Andreia F. R. Silva, Mariana Monteiro, Rute Nunes, Ana Baiao, Susana S. Braga, Bruno Sarmento, Manuel A. Coimbra, Artur M. S. Silva, Susana M. Cardoso
Summary: This study evaluated the impact of two delivery systems on the stability, antioxidant activity, bio-accessibility, and bioavailability of trans-resveratrol integrated into a bread matrix. The results showed that bread itself can effectively deliver trans-resveratrol without the need for additional delivery systems.
Article
Materials Science, Multidisciplinary
Ladislav Cvrcek, Jan Krcil, Jana Musilkova, Veronika Musilkova, Lucie Bacakova, Vaclav Nehasil, Frantisek Denk, Zdenek Cejka
Summary: In this study, a PEEK material with a gradient surface topography and suitable chemical composition was prepared by 3D printing and coating with a nanostructured TiNb layer. The surface properties and biological activity were analyzed, and the results showed that the nanostructured TiNb layer significantly improved the biological activity of PEEK.
MATERIALS & DESIGN
(2022)
Article
Chemistry, Physical
Mariam Hohagen, Patrick Guggenberger, Endre Kiss, Hanspeter Kaehlig, Doris Marko, Giorgia Del Favero, Freddy Kleitz
Summary: In this study, different TANNylation methods were used to modify mesoporous silica nanoparticles (MSNs) and investigate the impact of this modification on the performance/biocompatibility of these nanocarriers. The activity profiling of intestinal cells showed that the type of chemical linker used for the binding of tannic acid plays a crucial role in driving the biological response. The results highlight the importance of the surface functionality of nanocarriers in influencing cellular behavior.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Shuyin Duan, Meihua Zhang, Junxia Li, Jiaqi Tian, Haoyu Yin, Xietong Wang, Lin Zhang
Summary: The extensive application of nanomaterials has increased the risk of silica nanoparticle exposure, and this study focused on evaluating the biological effect of SiNP on reproduction. FITC-SiNP was found to be internalized by trophoblast cells in vitro and in pregnant mice, leading to trophoblast dysfunction and apoptosis, as well as uterine inflammatory infiltration. Dysregulation of 75 genes, including ACOT2, SCD1, and CPT1A, was observed after SiNP exposure, indicating a link to the biosynthesis of unsaturated fatty acids and subsequent metabolic disorder in the uterus.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Sofia Tachtalidou, Panagiotis Arapitsas, Marie-Jose Penouilh, Franck Denat, Philippe Schmitt-Kopplin, Regis D. Gougeon, Maria Nikolantonaki
Summary: Bisulfite (HSO3-) is the main form of sulfur dioxide in wine under acidic pH, and its reaction with thiols and flavanols has been found to play a key role in wine preservation against oxidation. This study investigated the kinetics and stability of sulfonation reactions of thiols and flavanols under simulated wine aging conditions. The results showed that the presence of iron and oxygen promoted the sulfonation reactions, and the sulfonation derivatives were more prevalent in aged wines. These findings provide new insights for the precise use of sulfur dioxide in winemaking.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Materials Science, Ceramics
Zhiyan Xu, Emily Keller, Ana M. Beltran, Kai Zheng, Aldo R. Boccaccini
Summary: In this study, a post-impregnation approach was successfully used to incorporate metallic ions into dendritic mesoporous silica nanoparticles, resulting in SiO2-CaO and SiO2-CaO-CeO2 particles. The synthesized particles exhibited high bioactivity and drug loading efficiency, making them suitable for bone regeneration applications.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2023)
Article
Agricultural Engineering
Wei Zhang, Jiandong Shen, Pei Gao, Qixing Jiang, Wenshui Xia
Summary: This study presents a green and simple method to produce spherical lignin nanoparticles (LNPs) using betaine:lactic acid deep eutectic solvent (DES) and water. The LNPs exhibited improved thermal stability, enhanced antioxidant activity, and lower minimum inhibitory concentration against Staphylococcus aureus. Additionally, they showed potential as a stabilizer in Pickering emulsions. The study lays a critical foundation for expanding the further utilization of lignin.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Chemistry, Analytical
Oluwasesan Adegoke, Svetlana Zolotovskaya, Amin Abdolvand, Niamh Nic Daeid
Summary: A novel rapid and selective colorimetric detection method for nitrite using a chemically modified gold nanoparticle-cerium oxide nanoparticle-graphene oxide hybrid nanozyme was reported. The method showed quantitative detection of nitrite with high selectivity in water samples, demonstrating potential for practical applications in environmental monitoring.
Article
Chemistry, Physical
Xiaoming Yuan, Xinhui Yang, Zhiwei Huang, Liqiang Zhang, Xinxin Peng, Haitao Chen, Jun He
Summary: Reducing gap distance to the nanometer range provides a promising platform for exploring light-matter interactions at the nanoscale. The designed nanocavity using BPT and WSe2 as a barrier and Ag nanowire and Au film as a cavity enables local electric field enhancement and strong polarization-dependent Raman scattering. It also exhibits enhanced trion emission intensity and a new low energy emission peak below 173 K, making it an excellent platform to study emission phenomena in transition-metal dichalcogenide and related heterostructures.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Pharmacology & Pharmacy
Chun Yuen Jerry Wong, Hani Al-Salami, Crispin R. Dass
Summary: In this study, a nanoparticulate drug delivery system was developed to protect insulin in the GI tract. The addition of cryoprotectants improved stability, encapsulation efficiency, and reduced premature release of insulin. The entrapped insulin maintained bioactivity in enzymatic medium.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Biochemical Research Methods
John D. O'Connor, Ian M. Overton, Stephen J. McMahon
Summary: This study presents a comprehensive benchmarking framework for radio sensitivity (RS) signatures, evaluating multiple published signatures and comparing them to control signatures. The results show that both published and cellular process signatures have limited radiation-specific information. Therefore, improved modeling strategies are needed to predict intrinsic RS accurately.
BRIEFINGS IN BIOINFORMATICS
(2022)
Review
Oncology
Hisanori Fukunaga, Akinari Yokoya, Kevin M. Prise
Summary: Translation: Effects of radiation on spermatogenesis and transgenerational effects are reviewed in this article. The review explores novel radiobiological approaches for male fertility preservation during radiotherapy. The genotoxicity of radiation on germ cells and its potential transgenerational effects are discussed. The clinical importance of preserving male fertility during radiation treatment is also addressed. Further research in this field is needed to better understand the potential role of transgenerational effects.
Article
Oncology
Shannon J. Thompson, Aoife Rooney, Kevin M. Prise, Stephen J. McMahon
Summary: This study evaluates the performance of different Monte Carlo nanoscale physics models using a dataset on strand breaking in a single DNA strand. The models had similar energy distributions but made significantly different predictions for other endpoints. Multi-endpoint analysis is necessary to fully validate these models.
Article
Engineering, Biomedical
C. A. McAnespie, M. J. Streeter, M. Rankin, P. Chaudhary, S. J. McMahon, K. M. Prise, G. Sarri
Summary: A femtosecond-scale photon source based on inverse Compton scattering of laser-plasma accelerated electron beams is proposed to study the fundamental physical processes involved in radical production during irradiation in living tissue. This source can provide ultra-short and high-flux MeV-scale photon beams, offering the potential for time-resolved radiobiological experiments and advancements in radio-therapeutic techniques.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Biology
B. Villagomez-Bernabe, S. W. Chan, J. A. Coulter, A. M. Roseman, F. J. Currell
Summary: This study investigates the interplay between ionization tracks and nucleocapsid RNA structural biology, using fast ion-beam inactivation of SARS-CoV as an example. The findings suggest that ion beams can be used to predict dose-inactivation curves for virions and contribute to determining RNA tertiary/quaternary structures. The study concludes that the two problems are mutually informative and highlights the importance of ion-beam technology in elucidating RNA structures.
RADIATION RESEARCH
(2022)
Article
Oncology
Dmitri Alexandrov, Nickolay Korabel, Frederick Currell, Sergei Fedotov
Summary: Nanoparticles play a crucial role in cancer treatment and drug delivery. This study obtained the cluster density of nanoparticles using Smoluchowski's coagulation equation and compared it with experimental data. The results show that the exact cluster density provides a better description of nanoparticle distribution inside cells.
CANCER NANOTECHNOLOGY
(2022)
Review
Engineering, Biomedical
Frank Verhaegen, Karl T. Butterworth, Anthony J. Chalmers, Rob P. Coppes, Dirk de Ruysscher, Sophie Dobiasch, John D. Fenwick, Patrick Granton, Stefan H. J. Heijmans, Mark A. Hill, Constantinos Koumenis, Kirsten Lauber, Brian Marples, Katia Parodi, Lucas C. G. G. Persoon, Nick Staut, Anna Subiel, Rianne D. W. Vaes, Stefan van Hoof, Ioannis L. Verginadis, Jan J. Wilkens, Kaye J. Williams, George D. Wilson, Ludwig J. Dubois
Summary: This paper provides an overview of precision preclinical x-ray radiation studies in animal models. It focuses on cancer and normal tissue response to radiation, but also addresses other disease models. The advancements in imaging, irradiation, dosimetry, and monitoring are discussed, along with future developments. The paper also explores clinical translation and reverse translation.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Engineering, Biomedical
Shannon J. Thompson, Kevin M. Prise, Stephen J. McMahon
Summary: Laser-accelerated protons offer an alternative delivery mechanism for proton therapy. This study investigates the possibility of inter-track interactions between successive protons within a pulse delivered at ultra-high dose-rates. The results suggest that such interactions would not play a role in any potential changes in biological response between laser-accelerated and conventional proton therapy.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Engineering, Biomedical
Yusuke Matsuya, Stephen J. McMahon, Karl T. Butterworth, Yoshie Yachi, Ryo Saga, Tatsuhiko Sato, Kevin M. Prise
Summary: This study aimed to understand the mechanisms of intercellular communication under hypoxic conditions by modeling the cell-killing effects. The developed IMK model successfully predicted the dose-response curves for survival and lethal lesions, and demonstrated that the probability of releasing cell-killing signals depends on oxygen. The study also suggests that residual DNA double-strand breaks correlate with logarithmic survival fraction for in- and out-of-field cells, and the oxygen enhancement ratio determined using uniform-field exposure can predict the radiosensitivity of cells to intensity-modulated beams.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Oncology
Kathryn H. H. Brown, Jacob Illyuk, Mihaela Ghita, Gerard M. M. Walls, Conor K. K. McGarry, Karl T. T. Butterworth
Summary: Radiomics image analysis has the potential to uncover disease characteristics for predictive signatures and personalized radiotherapy treatment. Variabilities in observer and software delineations reduce the reliability of radiomics features. This study investigates the impact of these variabilities on CBCT scan results.
Article
Biochemistry & Molecular Biology
Aideen C. Roddy, Caitriona E. McInerney, Tom Flannery, Estelle G. Healy, James P. Stewart, Veronica J. Spence, Jamie Walsh, Manuel Salto-Tellez, Darragh G. McArt, Kevin M. Prise
Summary: Glioblastoma is a common and aggressive brain tumor, and therapy resistance may stem from glioma-stem cells. Transcriptome profiling revealed that angiogenesis and immune-related processes dominate the recurrence of glioblastoma. By using connectivity mapping analysis, FDA-approved repurposing drugs including rosiglitazone, nizatidine, pantoprazole, and tolmetin were identified as potential treatments against glioma-stem cells and glioblastoma recurrence. This translational bioinformatics pipeline offers a promising approach for identifying target compounds to overcome therapy resistance in cancers like glioblastoma.
Article
Biochemistry & Molecular Biology
Brianna N. Kerr, Daniel Duffy, Caitriona E. McInerney, Ashton Hutchinson, Inaya Dabaja, Rana Bazzi, Stephane Roux, Kevin M. Prise, Karl T. Butterworth
Summary: This study aimed to evaluate the radiosensitizing and immunomodulatory properties of differentially PEGylated GNPs in GBM cells. The results showed that PEGylation improved the radiobiological efficacy, with double-strand break induction being identified as a mechanism. PEGylated GNPs also enhanced the immunogenicity of radiotherapy, correlating with upregulation of inflammatory cytokines. These findings suggest that ID11 and ID12 could be potential candidates for RT-drug combination in future GBM preclinical investigations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Caitriona E. McInerney, Joanna A. Lynn, Alan R. Gilmore, Tom Flannery, Kevin M. Prise
Summary: The study characterized IDH1 expression and associated genes and pathways in adult gliomas, identifying 90 genes overexpressed in different signaling pathways related to IDH1. Potential prognostic and diagnostic biomarkers were discovered, showing correlations with IDH1 expression, and highlighting metabolic vulnerabilities and therapeutic targets for future clinical trials._IDS with mechanistic links were involved in neuronal development, cell proliferation, tumor suppression, and anaplerosis.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)