Article
Medicine, General & Internal
Eloisa Sofia Tanzarella, Joel Vargas, Marco Menghini, Stefania Postorino, Francesca Pozzana, Maria Sole Vallecoccia, Francesco Lorenzo De Matteis, Federico Franchi, Amato Infante, Luigi Larosa, Maria Antonietta Mazzei, Salvatore Lucio Cutuli, Domenico Luca Grieco, Alessandra Bisanti, Simone Carelli, Gianmarco Lombardi, Edoardo Piervincenzi, Gabriele Pintaudi, Tommaso Pirronti, Mario Tumbarello, Massimo Antonelli, Gennaro De Pascale
Summary: Antibiotics overuse in COVID-19 patients remains a problem. A predictive scoring model was developed to diagnose bacterial pneumonia in ICU-admitted COVID-19 patients. The study identified seven variables as predictors of bacterial pneumonia and a composite risk score was established. This predictive score, known as C19-PNEUMOSCORE, may be an effective tool for early identification of severe COVID-19 patients with pulmonary bacterial co-infection at ICU admission.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Banan M. Aiesh, Maisa A. Nazzal, Aroub I. Abdelhaq, Shatha A. Abutaha, Sa'ed H. Zyoud, Ali Sabateen
Summary: Antimicrobial misuse is a global issue, and the resistance to such drugs is a major challenge in healthcare. This study evaluated the impact of antibiotic stewardship programs (ASPs) on antibiotic consumption, costs, and antimicrobial sensitivity. The results showed that ASPs can effectively reduce antibiotic consumption, costs, and improve sensitivity to certain antimicrobials.
SCIENTIFIC REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Sophie Coenen, Jara R. de la Court, David T. P. Buis, Lilian J. Meijboom, Rogier P. Schade, Caroline E. Visser, Reinier van Hest, Marianne Kuijvenhoven, Jan M. Prins, Suzan F. M. Nijman, Elske Sieswerda, Kim C. E. Sigaloff
Summary: This study found a low frequency of respiratory community-acquired bacterial co-infection in patients with COVID-19, supporting recommendations for restrictive use of antibacterial drugs in these patients.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2021)
Review
Immunology
Ibrahim Omer, Noorah Abuthiyab, Nura Al Zaid, Raghad Alkanani, Reema Abualnaja, Ghadeer Khan
Summary: This systematic review aimed to evaluate the potential appropriateness of Procalcitonin as an antimicrobial stewardship tool in COVID-19 patients. Despite variations in Procalcitonin cut-off values, the majority of studies indicated the appropriateness of using Procalcitonin as an antimicrobial stewardship tool in COVID-19 patients.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Asa Alsioe, Salmir Nasic, Lars Ljungstroem, Gunnar Jacobsson
Summary: The study showed a negative correlation between body mass index and outcomes of severe bacterial infections, with increasing BMI associated with decreasing case fatality rates.
Article
Immunology
Owen R. Albin, Louis Saravolatz, Joshua Petrie, Oryan Henig, Keith S. Kaye
Summary: Performing respiratory cultures for fever/leukocytosis in mechanically ventilated patients without clear evidence of pneumonia may result in increased antibiotic use.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Oana Sandulescu, Anca Streinu-Cercel, Maria Magdalena Motoi, Adrian Streinu-Cercel, Liliana Lucia Preotescu
Summary: The implementation of multiplex polymerase chain reaction for syndromic testing in clinical practice has allowed for early diagnosis and targeted treatment. However, diagnostic stewardship is necessary to prevent the risks of misdiagnosis. We present two cases illustrating the importance of proper diagnostic stewardship for patient management and antimicrobial usage.
Article
Immunology
Cara L. Nys, Kristen Fischer, Jason Funaro, Christopher J. Shoff, Rebecca G. Theophanous, Catherine A. Staton, Jennifer Mando-Vandrick, Rachel Toler, Jenny Shroba, Nicholas A. Turner, Beiyu Liu, Hui-Jie Lee, Rebekah W. Moehring, Rebekah H. Wrenn
Summary: This multifaceted antimicrobial stewardship (AS) intervention involving the use of guidelines, education, and provider-specific feedback increased guideline-concordant antibiotic choices for treat-and-release patients in the emergency department (ED).
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Andrew J. Fratoni, Abigail K. Kois, Jessica L. Colmerauer, Kristin E. Linder, David P. Nicolau, Joseph L. Kuti
Summary: The implementation of a pharmacist-managed procalcitonin monitoring program did not significantly decrease antibiotic use or health care resource utilization in hospitalized COVID-19 patients.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
J. Van Laethem, S. Wuyts, S. Van Laere, J. Koulalis, M. Colman, M. Moretti, L. Seyler, E. De Waele, D. Pierard, P. Lacor, S. D. Allard
Summary: This study retrospectively analyzed antibiotic consumption in COVID-19 patients in a Belgian university hospital and identified drivers associated with antibiotic prescribing, such as fever on admission and lower SpO(2)/FiO(2) ratio. Specific patient characteristics, like underlying pulmonary disease, and hospital stay duration were also linked to antibiotic prescription. The findings aim to guide antimicrobial stewardship programs in optimizing interventions in COVID-19 wards.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Immunology
Kristin L. Moffitt, Mari M. Nakamura, Cameron C. Young, Margaret M. Newhams, Natasha B. Halasa, J. Nelson Reed, Julie C. Fitzgerald, Philip C. Spinella, Vijaya L. Soma, Tracie C. Walker, Laura L. Loftis, Aline B. Maddux, Michele Kong, Courtney M. Rowan, Charlotte Hobbs, Jennifer E. Schuster, Becky J. Riggs, Gwenn E. McLaughlin, Kelly N. Michelson, Mark W. Hall, Christopher J. Babbitt, Natalie Z. Cvijanovich, Matt S. Zinter, Mia Maamari, Adam J. Schwarz, Aalok R. Singh, Heidi R. Flori, Shira J. Gertz, Mary A. Staat, John S. Giuliano Jr, Saul R. Hymes, Katharine N. Clouser, John McGuire, Christopher L. Carroll, Neal J. Thomas, Emily R. Levy, Adrienne G. Randolph
Summary: The majority of US children admitted to intensive care for COVID-19 received empiric antibiotics, but bacterial coinfection was infrequent and more common in patients with underlying nonasthma lung disease.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Immunology
Keith S. Kaye, Vikas Gupta, Aruni Mulgirigama, Ashish Joshi, Nicole E. Scangarella-Oman, Kalvin Yu, Gang Ye, Fanny S. Mitrani-Gold
Summary: The study found a high prevalence of antimicrobial resistance among E. coli isolated from outpatient urine samples in the United States, with an increasing trend in multidrug-resistant phenotypes over the study period. There was significant regional variation in antimicrobial resistance rates.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Irina Rajakumar, Rami Jaber, Raafi Ali, Elissa Rennert-May, Deana Sabuda
Summary: This study aimed to compare the recurrence rates of hospital-acquired CDI patients receiving standard duration of therapy (SDT) and extended duration of therapy (EDT). The results showed no significant difference in recurrence rates or new-onset VRE between the SDT and EDT groups in patients receiving concurrent antibiotics.
AMERICAN JOURNAL OF INFECTION CONTROL
(2023)
Review
Infectious Diseases
Jense Wils, Veroniek Saegeman, Annette Schuermans
Summary: MRVP results can reduce inappropriate antibiotic use, guide appropriate antiviral therapy, and have added value in infection control measures. Factors that contribute to reduction in antibiotic therapy include active antimicrobial stewardship, low likelihood of bacterial infection, and quick turnaround time.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Virology
Yin Zhang, Ying Huang, Yuanhong Xu
Summary: The study assessed the incidence and management of co-infections in hospitalized SFTS patients and found various types of co-infections, with a high incidence of fungal infections. It suggested evaluating the risk of fungal infection in older patients. Patients in the co-infection group required more intensive treatments and had longer hospital stays compared to the non-infection group.
JOURNAL OF MEDICAL VIROLOGY
(2022)