期刊
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
卷 35, 期 -, 页码 314-321出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jgar.2023.10.019
关键词
Fluconazole tolerance; Fluconazole synergistic lethal targets; Fluconazole synergistic lethal adjuvants; Invasive fungal disease; Candida albicans
This review discusses the high incidence of FLC tolerance in Candida species and the importance of successfully clearing FLC tolerance in treating candidiasis. It further defines and characterizes FLC tolerance in C. albicans.
Objectives: Fluconazole (FLC) tolerant phenotypes in Candida species contribute to persistent candidemia and the emergence of FLC resistance. Therefore, making FLC fungicidal and eliminating FLC tolerance are important for treating invasive fungal diseases (IFDs) caused by Candida species. However, the mecha-nisms of FLC tolerance in Candida species remain to be fully explored.Methods: This review discusses the high incidence of FLC tolerance in Candida species and the impor-tance of successfully clearing FLC tolerance in treating candidiasis. We further define and characterize FLC tolerance in C. albicans.Results: This review identifies global factors affecting FLC tolerance and suggest that FLC tolerance is a strategy of C. albicans response to FLC damage whose mechanism differs from FLC resistance.Conclusions: This review highlights the significance of the cell membrane and cell wall integrity in FLC tolerance, guiding approaches to combat IFDs caused by Candida species..(c) 2023 The Author(s). Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
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