期刊
NANOSCALE
卷 8, 期 3, 页码 1374-1382出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nr06041a
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资金
- NSFC [51372173, 51002107, 21173159, 51025207]
- NSFZJ [LR16B010002]
- Research Climb Plan of ZJED [pd2013383]
- State Key Laboratory of High Performance Ceramics and Superfine Microstructure [SKL201409SIC]
Developing multifunctional near-infrared (NIR) light-driven photothermal agents is in high demand for efficient cancer therapy. Herein, PEGylated Cu3BiS3 hollow nanospheres (HNSs) with an average diameter of 80 nm were synthesized through a facile ethylene glycol-mediated solvothermal route. The obtained PEGylated Cu3BiS3 HNSs exhibited strong NIR optical absorption with a large molar extinction coefficient of 4.1 x 10(9) cm(-1) M-1 at 980 nm. Under the irradiation of a 980 nm laser with a safe power density of 0.72 W cm(-2), Cu3BiS3 HNSs produced significant photothermal heating with a photothermal transduction efficiency of 27.5%. The Cu3BiS3 HNSs also showed a good antitumoral drug doxorubicin (DOX) loading capacity and pH-and NIR-responsive DOX release behaviors. At a low dosage of 10 mg mL(-1), HeLa cells could be efficiently killed through a synergistic effect of chemo-and photothermo-therapy respectively based on the DOX release and the photothermal effect of Cu3BiS3 HNSs. In addition, Cu3BiS3 HNSs displayed a good X-ray computed tomography (CT) imaging capability. Furthermore, Cu3BiS3 HNSs could be used for efficient in vivo photothermochemotherapy and X-ray CT imaging of mice bearing melanoma skin cancer. This multifunctional theranostic nanomaterial shows potential promise for cancer therapy.
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