期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 12, 期 5, 页码 1253-1262出版社
ELSEVIER
DOI: 10.1016/j.nano.2016.01.005
关键词
Biosensors; Magnetic nanoparticles; Magnetic resonance; Nanodiagnostics; Nanomedical devices; Nanoengineering
资金
- Spanish Ministry of Economy and Competitiveness
- FEDER [FIS-PI14-1600]
- Regional Ministry of Health [PI2013-375, PI2013-0559]
- Regional Ministry of Economy, Science and Innovation [P10-CTS-6928, P11-CTS-8161]
- PAIDI Program from the Andalusian Government [CTS-677]
- European Commission [327151]
Since pioneering work in the early 60s on the development of enzyme electrodes the field of sensors has evolved to different sophisticated technological platforms. Still, for biomedical applications, there are key requirements to meet in order to get fast, low-cost, real-time data acquisition, multiplexed and automatic biosensors. Nano-based sensors are one of the most promising healthcare applications of nanotechnology, and prone to be one of the first to become a reality. From all nanosensors strategies developed, Magnetic Relaxation Switches (MRSw) assays combine several features which are attractive for nanomedical applications such as safe biocompatibility of magnetic nanoparticles, increased sensitivity/specificity measurements, possibility to detect analytes in opaque samples (unresponsive to light-based interferences) and the use of homogeneous setting assay. This review aims at presenting the ongoing progress of MRSw technology and its most important applications in clinical medicine. (C) 2016 Elsevier Inc. All rights reserved.
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