Article
Chemistry, Physical
M. Barshutina, N. Doroshina, A. Baizhumanov, E. Nikelshparg, A. Fedotova, A. Popov, A. Semyanov, D. Yakubovsky, G. Tselikov, O. Luneva, I. Kirilyuk, G. Maksimov, V. Volkov, A. Arsenin, N. Brazhe, S. Novikov
Summary: Oxidative stress can lead to various pathological changes in cell and biological liquid properties, including cardiovascular and metabolic diseases. This study presents an effective, scalable, and inexpensive technique for manufacturing biomimetic SERS sensors to detect biomembrane oxidation. The technique utilizes rose petals as templates to create SERS substrates with a cavity structure, allowing for the capture and immobilization of blood cells. By covering the silicone replicas of rose petals with a thin Au film (100 nm) and spherical Au nanoparticles, SERS effect can be achieved in the microcavities, enabling the study of individual erythrocytes and early detection of membrane oxidation for diagnosis of blood and metabolic diseases.
APPLIED SURFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Maria Carvalho, Marcia M. Medeiros, Ines Morais, Catarina S. Lopes, Ana Balau, Nuno C. Santos, Filomena A. Carvalho, Ana Paula Arez
Summary: Malaria is a major global public health problem that contributes to poverty and inequality. Pyruvate kinase deficiency, which leads to an increased concentration of 2,3-diphosphoglycerate (2,3-DPG), has been associated with resistance to malaria. This study investigates the effects of 2,3-DPG on the morphology, biomechanical properties, and membrane of red blood cells infected with Plasmodium falciparum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biophysics
Bing -De Zheng, Mei-tian Xiao
Summary: Nano-RBMs is a disguised therapeutic platform that can resist recognition by the immune system and prolong the circulation time of the treatment agent in the blood, achieving ideal phototherapy effects.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biochemical Research Methods
Yuncheng Man, Debnath Maji, Ran An, Sanjay P. Ahuja, Jane A. Little, Michael A. Suster, Pedram Mohseni, Umut A. Gurkan
Summary: This study introduces a novel microfluidic testing method, MIRCA, for standardized assessment of RBC-mediated microvascular occlusion. The technology shows promise in diseases like SCD and hereditary spherocytosis, correlating electrical impedance measurement with high-resolution imaging and clinical treatment outcomes. Impedance measurement obviates the need for high-resolution imaging, making it portable and suitable for point-of-care use in the future.
Article
Biochemistry & Molecular Biology
Gregory Barshtein, Alexander Gural, Dan Arbell, Refael Barkan, Leonid Livshits, Ivana Pajic-Lijakovic, Saul Yedgar
Summary: Reduced deformability of red blood cells (RBCs) is associated with various circulatory disorders and anemias, and is linked to metabolic and structural alterations. This study identified 14 proteins that are positively correlated with RBC deformability, suggesting that the level of one or a few of these proteins can be used to assess cell deformability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Sizhe Xie, Hairui Wang, Nannan Li, Yulong Liu, Jianfeng Wu, Yongnan Xu, Jianwei Xie
Summary: A facile, rapid, and sensitive surface enhanced Raman spectroscopy (SERS) method for the analysis of cyanide in blood samples has been developed, which could be a powerful tool for the diagnosis of cyanide poisoning in clinical and forensic applications.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Lining Huang, Ibrahim Jasim, Omar Alkorjia, Cansu Agca, Anna Oksman, Yuksel Agca, Daniel E. Goldberg, James D. Benson, Mahmoud Almasri
Summary: The paper investigates a microfluidic device for real-time measurement of cell membrane permeability, specifically targeting the quality assessment of individual red blood cells (RBCs). The device utilizes unique features to manipulate and mix RBCs with different media, allowing for accurate estimation of water permeability at the individual cell level. The study presents experimental results confirming the relationship between voltage and diameter in standards and demonstrates the linear relationship between voltage and volume in rat RBCs. The findings also align with previously published data for human RBCs, demonstrating the potential application of the device in measuring water permeability.
ANALYTICA CHIMICA ACTA
(2023)
Article
Cell Biology
Heon-Su Kim, Jung-Soo Suh, Yoon-Kwan Jang, Sang-Hyun Ahn, Gyu-Ho Choi, Jin-Young Yang, Gah-Hyun Lim, Youngmi Jung, Jie Jiang, Jie Sun, Myungeun Suk, Yingxiao Wang, Tae-Jin Kim
Summary: This study reveals the relationship between Piezo1-mediated Ca2+ influx and cellular behavior using innovative biosensors and imaging analysis. The results demonstrate that Piezo1 induces extracellular Ca2+ influx, which requires the support of caveolin, cholesterol, and the cytoskeleton. Increased cytoplasmic Ca2+ levels enhance the activity of PKA, ERK, Rac1, and ROCK, promoting cancer cell survival and migration. Furthermore, Piezo1-mediated Ca2+ influx upregulates membrane ruffling, a characteristic feature of cancer cell metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Evelina I. Nikelshparg, Ekaterina S. Prikhozhdenko, Roman A. Verkhovskii, Vsevolod S. Atkin, Vitaly A. Khanadeev, Boris N. Khlebtsov, Daniil N. Bratashov
Summary: A new type of flat substrate utilizing stabilized aggregates of gold nanostars and a polymer layer has been used for visualizing structures and studying biochemical processes within living cells via surface-enhanced Raman scattering (SERS). The long tips of the gold nanostars can penetrate the cell membrane to receive the SERS signal from biomolecules inside the cell, aiding in the study of biomolecular distribution in different cell compartments.
Article
Biotechnology & Applied Microbiology
Pengkai Wu, Xing Jiang, Shuai Yin, Ying Yang, Tianqing Liu, Kaikai Wang
Summary: The study demonstrated the successful preparation of biomimetic reconstituted RBC membrane using a disassembly-reassembly strategy, showing the superiority of rRBC NPs compared to other forms in terms of toxicity, stability, pharmacokinetics, and pharmacodynamics. This green technology has great potential to overcome the deficiency of functionalization in cell membrane-coated nanoparticles.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Physiology
Giacomo Marchi, Claudia Bozzini, Lorenzo Bertolone, Francesco Dima, Fabiana Busti, Annalisa Castagna, Chiara Stranieri, Anna Maria Fratta Pasini, Simonetta Friso, Giuseppe Lippi, Domenico Girelli, Alice Vianello
Summary: Peripheral blood smear is still a valuable tool for diagnosing blood cell abnormalities despite advances in automated and molecular techniques. The morphological abnormalities of red blood cells in COVID-19 patients may be associated with immune-inflammatory stress hematopoiesis and have a certain correlation with mortality rate.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Brian S. Ferguson, Leslie E. Neidert, Matthew J. Rogatzki, Keith R. Lohse, L. Bruce Gladden, Heidi A. Kluess
Summary: The study found no significant difference in the release of ATP from RBCs of different densities under hypoxic and normoxic conditions, and the release of ATP was linearly correlated with the release of Hb.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Physiology
Jane Dobkin, Ling Wu, Nilam S. Mangalmurti
Summary: The human immune system has evolved in response to pathogens, with malaria being one of the deadliest. Red blood cells, which are the target of malaria, have immunomodulatory properties that remain understudied in relation to critical illness. Understanding the evolutionary adaptations of red blood cells to malaria may provide insight into the host response to critical illness and guide future precision medicine approaches.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Immunology
Maria Andrea Hernandez-Castaneda, Marilyne Lavergne, Pierina Casanova, Bryan Nydegger, Carla Merten, Bibin Yesodha Subramanian, Patricia Matthey, Nils Lannes, Pierre-Yves Mantel, Michael Walch
Summary: Malaria is a serious health problem in developing countries, and Plasmodium parasites deplete cholesterol in red blood cells making their membranes vulnerable, but it is the exposure of phosphatidylserine that triggers resistance to eukaryotic pore-forming proteins in parasitized cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Xubin Hao, Hui Zhang, Rui Liu, Junyi Che, Dagan Zhang, Jun Liang, Lingyun Sun
Summary: In this study, red blood cell membrane-coated and Cyclosporin A-loaded PLGA nanoparticles (CsA-RNPs) were designed for SLE treatment. CsA-RNPs exhibited typical core-shell structures, narrow size distribution, and negative surface charge. Moreover, CsA-RNPs showed excellent biocompatibility due to the decoration of cell membrane.
MATERIALS TODAY ADVANCES
(2022)
Article
Chemistry, Multidisciplinary
Yanjun Yang, Chunyuan Song, Jingjing Zhang, Jie Chao, Hoang Mai Luong, Yiping Zhao, Lianhui Wang
Summary: This article introduces a surface-enhanced Raman scattering (SERS) sensor based on a functionalized multiple-armed tetrahedral DNA nanostructure, which is capable of detecting multiple nucleic acid and protein biomarkers related to lung cancer and has enhanced sensitivity. The sensor achieves enhanced Raman signals through DNA self-assembled gold nanoparticle clusters in multiplex detections.
Article
Chemistry, Analytical
Yanjun Yang, Jackelyn Murray, James Haverstick, Ralph A. Tripp, Yiping Zhao
Summary: The researchers developed a rapid coronavirus detection method using a functionalized silver nanotriangle array localized surface plasmon resonance sensor. The sensor shows high sensitivity and specificity in detecting SARS-CoV-2 infection, and the detection time is less than 20 minutes.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Physics, Applied
Nima Karimitari, Bin Ai, Yiping Zhao
Summary: A detailed analysis was conducted on the Born-Kuhn model for two coupled oscillators and compared to the chiral optical properties of the corner-stacked plasmonic nanorods (CSPNs). The study found that the Born-Kuhn model, based on normalized coupling constant and damping constant, could accurately predict the chiral optical response of CSPNs.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2022)
Review
Chemistry, Multidisciplinary
Bin Ai, Yujing Sun, Yiping Zhao
Summary: This review provides an overview of plasmonic hydrogen sensors (PHS) based on nanostructures. PHS offer high sensitivity, fast response speed, miniaturization, and high-degree of integration. The review discusses the working principle, sensing properties, and the effects of resonance mode, configuration, material, and structure on the sensing performances. It also summarizes the advantages and disadvantages of different types of plasmonic nanostructures and proposes potential development directions. The aim of this review is to clarify current strategies for PHS and provide a comprehensive understanding of their working principle to inspire innovative designs and execution of advanced hydrogen sensors.
Article
Nanoscience & Nanotechnology
Yanfeng Wang, Shen Ao, Fei Yang, Zhengjun Zhang, Yiping Zhao
Summary: By independently tuning the structure parameters of the nanorods in nanohole arrays, a mode splitting phenomenon can be introduced, which improves the performance of plasmonic sensors.
ACS APPLIED NANO MATERIALS
(2022)
Article
Spectroscopy
Lauren Hanna, Edgar Movsesian, Miguel Orozco, Anthony R. Bernot, Mona Asadinamin, Learnmore Shenje, Susanne Ullrich, Yiping Zhao, Nicholas Marshall, Jason A. Weeks, Michael B. Thomas, Joseph A. Teprovich, Patrick A. Ward
Summary: This study investigates the electronic and excited state effects of porphyrin functionalization by synthesizing and characterizing four meso-substituted porphyrins. The results reveal the significant influence of different para substituents (-hydroxy, -carboxy, and -nitro) on the spectral features, electrochemical behavior, and fluorescence behavior of the porphyrins.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Polymer Science
Nicholas Filla, Yiping Zhao, Xianqiao Wang
Summary: This article proposes innovative methods to address the issues in stochastic modeling of fibrous materials, such as estimating 3D fiber orientation distributions, achieving desired fiber tortuosity distributions, and dealing with fiber-fiber penetration. The methods introduced provide a mapping from 2D to 3D fiber orientation data and a means to select parameters for random walks to generate desired fiber tortuosity. These methods enhance the empirical consistency and tractability of stochastic modeling of fibrous materials.
Article
Biophysics
Nicholas Filla, Yiping Zhao, Xianqiao Wang
Summary: In this paper, a phenomenological, bilinear, force-strain model is derived to accurately reproduce the fibrin fiber force-strain curve. The model assumes that the initial linear response is due to entropic extension of polypeptide chains, and the final linear response is due to enthalpic extension of protofibrils. The model provides strong support to a previously proposed deformation mechanism and offers a rigorous tool for analyzing fibrin fiber force-strain data and simulating fibrin fibers in tension.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2023)
Article
Biophysics
Yanjun Yang, Beibei Xu, Jackelyn Murray, James Haverstick, Xianyan Chen, Ralph A. Tripp, Yiping Zhao
Summary: This study presents a label-free diagnostic platform combining surface-enhanced Raman scattering (SERS) and machine learning for rapid and accurate detection of respiratory viruses. The combination of SERS, machine learning algorithms, and regression enables classification, quantification, and estimation of unknown virus concentrations. This technology has potential applications in medical diagnosis and therapeutic intervention.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Physics, Applied
Andrei Galiautdinov, Yiping Zhao
Summary: During the operation of a core-shell nanoparticle based localized surface plasmon resonance (LSPR) sensor, target molecules penetrate into the shell layer, resulting in nonuniform distribution of molecules or reactants. This phenomenon is observed in composition graded plasmonic particles, which exhibit different LSPR characteristics compared to uniform core-shell particles. A perturbation theory is developed to predict the LSPR properties of composition graded plasmonic particles, considering the effects of composition gradient caused by metal hydride, dielectric, and effective medium. The results demonstrate the tunability of LSPR peak location and amplitude by different configurations of the composition gradient. These findings are crucial for understanding the sensing performance of composition graded plasmonic particles and can be applied to other composition graded structures.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2023)
Article
Nanoscience & Nanotechnology
Mona Asadinamin, Aleksandar Zivkovic, Susanne Ullrich, Henning Meyer, Yiping Zhao
Summary: The study provides insights into the charge dynamics of a CuO thin film using transient absorption spectroscopy, revealing the role of different excitation energies in the photocatalytic process. This information is crucial for designing and optimizing materials for renewable energy applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Hoang Mai Luong, Tu Anh Ngo, Minh Thien Pham, Yiping Zhao, George Keefe Larsen, Thuc-Quyen Nguyen, Tho Duc Nguyen
Summary: Magnetism in curved nano-geometries has led to the exploration of a hexagonally-packed array of magnetic nano-caps as a sensing element for the spark-free magnetic-circular-dichroism (MCD) H-2 sensor. The MCD H-2 sensor outperforms current optical sensors and meets the performance targets set by the US Department of Energy. The sensor exhibits fast response time, high selectivity, and low limit of detection.
Article
Chemistry, Multidisciplinary
Yilong Ju, Oara Neumann, Mary Bajomo, Yiping Zhao, Peter Nordlander, Naomi J. Halas, Ankit Patel
Summary: This article presents a machine learning algorithm that can identify chemicals by matching their SERS spectra to a standard Raman spectral library. The algorithm uses a facial recognition-like approach for spectral recognition and quantifies the degree of similarity to a Raman spectrum using a metric called Characteristic Peak Similarity (CaPSim). The analysis shows that CaPSim outperforms existing spectral matching algorithms in terms of accuracy. This machine learning-based approach could greatly facilitate the spectroscopic identification of molecules in fieldable SERS applications.
Article
Chemistry, Multidisciplinary
Shahab Razavi, Yiping Zhao
Summary: This study demonstrates that a hybridized plasmonic mode in a compound nanohole structure can be described as a quasi-dipole oscillator. By introducing two nanorods into a nanohole, these two quasi-dipoles can couple and hybridize, resulting in additional transmission peaks. The intensities and separations of these peaks can be controlled by adjusting the incident polarization and modifying the nanorod length. This concept can be extended to predict the behavior of more complex compound configurations, allowing for precise engineering of transmission peaks.
Article
Chemistry, Multidisciplinary
Yiping Zhao
Summary: This paper presents a comprehensive theoretical framework for understanding surface-enhanced Raman scattering (SERS) measurements, focusing on the principles of electromagnetic enhancement. The study investigates different types of SERS substrates and their interactions with molecules, providing explanations for various phenomena observed in SERS measurements. The findings offer valuable guidance for optimizing SERS substrate design and improving the accuracy of SERS detection.
Article
Nanoscience & Nanotechnology
Daniela Rubanova, Svitlana Skoroplyas, Alena Libanska, Eva Randarova, Josef Bryja, Michaela Chorvatova, Tomas Etrych, Lukas Kubala
Summary: This study explored the use of nanocarriers to deliver dexamethasone for treating rheumatoid arthritis. The results showed that this method increased the accumulation of dexamethasone in the arthritic area, had a dose-dependent healing effect, and reduced the accumulation of the RA mediator RANKL. This study provides a feasible strategy for improving rheumatoid arthritis therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Article
Nanoscience & Nanotechnology
Thanpisit Lomphithak, Apiwit Sae-Fung, Simone Sprio, Anna Tampieri, Siriporn Jitkaew, Bengt Fadeel
Summary: In this study, iron-doped hydroxyapatite (FeHA) was evaluated as a potential nanomedicine approach for treating PDAC. The results showed that FeHA, in combination with a sublethal dose of the GPX4 inhibitor RSL3, could trigger ferroptosis in KRAS mutant PANC-1 cells while sparing normal human cells. The induction of ferroptosis by FeHA plus RSL3 was found to be dependent on the metalloreductase STEAP3 in PDAC cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Review
Nanoscience & Nanotechnology
Marco Felipe Salas-Orozco, Ana Cecilia Lorenzo-Leal, Idania de Alba Montero, Nuria Patino Marin, Miguel Angel Casillas Santana, Horacio Bach
Summary: The emergence of antibiotic-resistant bacteria in severe infections is a growing concern, particularly in hospital environments. Metal-based nanomaterials have shown potential as an alternative to combat these bacteria, but there is a risk of bacterial resistance and environmental accumulation.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
