Review
Oncology
Yi Wang, Kai Conrad Cecil Johnson, Margaret E. Gatti-Mays, Zihai Li
Summary: Immune checkpoint inhibitors have revolutionized oncology, but only a small percentage of patients benefit from them. Understanding the role of myeloid cells in the tumor microenvironment is crucial for differentiating treatment response from non-response. Recent advancements have provided insights into the heterogeneity and function of myeloid cells, and strategies targeting these cells are being explored in preclinical and clinical settings.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Cell Biology
Seiji Mabuchi, Tomoyuki Sasano, Naoko Komura
Summary: Myeloid-derived suppressor cells (MDSCs) play a crucial role in ovarian cancer, with increased frequencies associated with poor prognosis. Depletion of MDSCs can significantly inhibit tumor growth and enhance the efficacy of existing anticancer therapies.
Review
Oncology
Simon T. Barry, Dmitry I. Gabrilovich, Owen J. Sansom, Andrew D. Campbell, Jennifer P. Morton
Summary: Myeloid cells in the tumour microenvironment have a significant impact on tumour progression, making them a key target for clinical therapies. However, large-scale clinical trials targeting these cells have had limited success. Understanding the specific functions and roles of different myeloid cell subpopulations within the tumour microenvironment could improve the design of successful clinical trials for myeloid-targeting therapies.
NATURE REVIEWS CANCER
(2023)
Review
Cell Biology
Jianying Li, Chelsea Bolyard, Gang Xin, Zihai Li
Summary: Targeting the metabolic profiles of tumor-infiltrating myeloid cells is crucial for overcoming immunotherapy resistance in cancer, as metabolic modulation can shift these cells from pro-tumor to anti-tumor phenotypes. Regulating specific metabolic pathways in myeloid cells within the tumor microenvironment holds therapeutic value in enhancing and improving outcomes with cancer immunotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Miriam Colombo, Laura Marongiu, Francesca Mingozzi, Roberta Marzi, Clara Cigni, Fabio Alessandro Facchini, Rany Rotem, Mihai Valache, Giulia Stucchi, Giuseppe Rocca, Laura Gornati, Maria Antonietta Rizzuto, Lucia Salvioni, Ivan Zanoni, Alessandro Gori, Davide Prosper, Francesca Granucci
Summary: Calcineurin inhibitors can prevent transplant rejection but also hinder graft tolerance. Inhibiting calcineurin only in dendritic cells instead of T cells can prevent T cell responses while allowing for tolerance development. A new generation of selective immune suppressive agents based on nanoparticles shows promise for better control of transplant acceptance.
Article
Chemistry, Multidisciplinary
Veronica Duran, Elena Grabski, Constantin Hozsa, Jennifer Becker, Hanzey Yasar, Joao T. Monteiro, Bibiana Costa, Nicole Koller, Yvonne Lueder, Bettina Wiegmann, Gudrun Brandes, Volkhard Kaever, Claus-Michael Lehr, Bernd Lepenies, Robert Tampe, Reinhold Foerster, Berislav Bosnjak, Marcus Furch, Theresa Graalmann, Ulrich Kalinke
Summary: The antibiotic treatment of tuberculosis is complex and lengthy, and can lead to poor patient compliance and the selection of multi-drug resistant bacteria. Encapsulating levofloxacin in lipid nanocarriers functionalized with fucosyl residues has shown to target MMR-positive cells more efficiently, improving the delivery and efficacy of the antibiotic in clearing the pathogen. Carbohydrate-functionalized nanocarriers present a promising tool for enhancing TB treatment by targeted antibiotic delivery.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Patrick Connerty, Ernest Moles, Charles E. de Bock, Nisitha Jayatilleke, Jenny L. Smith, Soheil Meshinchi, Chelsea Mayoh, Maria Kavallaris, Richard B. Lock
Summary: The study developed a new lipid nanoparticle loaded with siRNA for silencing oncogenic lncRNA LINC01257, demonstrating its potential feasibility in the treatment of AML.
Review
Immunology
Alberto Mantovani, Federica Marchesi, Sebastien Jaillon, Cecilia Garlanda, Paola Allavena
Summary: Myeloid cells in tumor tissues, including tumor-associated macrophages and tumor-associated neutrophils, play crucial roles in tumor growth and invasion. In recent years, successful therapeutic approaches have been developed and tested in preclinical cancer models, with some strategies reaching clinical trials.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Oncology
Lilian van Vlerken-Ysla, Yulia Y. Tyurina, Valerian E. Kagan, Dmitry I. Gabrilovich
Summary: This review discusses the classification of myeloid cells using single-cell omics technologies in the tumor microenvironment (TME). It suggests that the biology of myeloid cells is primarily determined by a limited number of functional states, including classical and pathological activation states. The article also explores the relationship between lipid peroxidation of myeloid cells and their activation state in the TME, highlighting its potential as a therapeutic target.
Review
Biochemistry & Molecular Biology
Yuan Zhang, Juhura G. G. Almazi, Hui Xin Ong, Matt D. D. Johansen, Scott Ledger, Daniela Traini, Philip M. M. Hansbro, Anthony D. D. Kelleher, Chantelle L. L. Ahlenstiel
Summary: This review article introduces the potential and application of RNA-interference-based gene therapy in antiviral treatment of COVID-19 disease, with a focus on the role and challenges of nanoparticles as carriers in siRNA delivery, as well as the application of inhalation devices and animal models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Germana Grassi, Stefania Notari, Simona Gili, Veronica Bordoni, Rita Casetti, Eleonora Cimini, Eleonora Tartaglia, Davide Mariotti, Chiara Agrati, Alessandra Sacchi
Summary: SARS-CoV-2 is the causative agent of COVID-19, which can lead to severe respiratory distress syndrome. The immune response in COVID-19 patients is impaired, and there is a massive expansion of MDSCs. The early expansion of MDSCs can predict the fatal outcome of the infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Gloria Delfanti, Filippo Cortesi, Alessandra Perini, Gaia Antonini, Laura Azzimonti, Claudia de Lalla, Claudio Garavaglia, Mario L. Squadrito, Maya Fedeli, Michela Consonni, Silvia Sesana, Francesca Re, Haifa Shen, Paolo Dellabona, Giulia Casorati
Summary: Adoptive immunotherapy using T cells engineered with tumor-specific TCRs holds promise for cancer treatment. In this study, researchers harnessed iNKT cells with a second TCR specific for a tumor-associated peptide to generate bispecific effectors for CD1d- and MHC-restricted antigens. The TCR-engineered iNKT cells demonstrated high efficacy in restraining tumor progression and achieved robust cancer control by simultaneously modulating intratumoral suppressive myeloid populations and killing malignant cells. These findings support the potential use of tumor-redirected TCR-iNKT cells and local alpha-GalCer boosting as a therapy for cancer patients.
SCIENCE IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Inaya Hayek, Valentin Schatz, Christian Bogdan, Jonathan Jantsch, Anja Luehrmann
Summary: The tissue microenvironment, including factors like oxygen concentration, plays a crucial role in host-pathogen interactions. Hypoxia and hypoxia-inducible factors (HIF) have been identified as important factors affecting both pathogens and hosts, influencing inflammatory and antimicrobial activities in myeloid cells, bacterial responses to low oxygen conditions, and the metabolism of immune cells. Additionally, the consequences of hypoxia and HIF alpha activation on various invading pathogens like Pseudomonas aeruginosa, Mycobacterium tuberculosis, Coxiella burnetii, Salmonella enterica, and Staphylococcus aureus, including how these pathogens sense and respond to hypoxic environments, are discussed.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Annarita D'Urso, Francesca Oltolina, Chiara Borsotti, Maria Prat, Donato Colangelo, Antonia Follenzi
Summary: New therapeutic strategies are needed in cancer therapy, and re-educating tumor-associated macrophages (TAMs) in the tumor microenvironment through nanotechnology could be a potential approach for cancer immunotherapy. Researchers have found that polydopamine-coupled magnetite nanoparticles can inhibit PERK expression in TAMs and re-polarize them from M2 to M1, which has anti-inflammatory and anti-tumor properties.
Review
Cell Biology
Jia-Nan Cheng, Yi-Xiao Yuan, Bo Zhu, Qingzhu Jia
Summary: MDSCs play a crucial role in regulating immune responses, promoting tumor progression, and predicting therapeutic outcomes. Targeting MDSCs could potentially improve treatment efficacy in cancer therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)