Evolution of fatty acid taste in drosophilids

Comparative studies of related but ecologically distinct species can reveal how the nervous system evolves to drive behaviors that are particularly suited to certain environments. Drosophila melanogaster is a generalist that feeds and oviposits on most overripe fruits. A sibling species, D. sechellia, is an obligate specialist of Morinda citrifolia (noni) fruit, which is rich in fatty acids (FAs). To understand evolution of noni taste preference, we characterized behavioral and cellular responses to noni-associated FAs in three related drosophilids. We find that mixtures of sugar and noni FAs evoke strong aversion in the generalist species but not in D. sechellia. Surveys of taste sensory responses reveal noni FA-and species-specific differences in at least two mechanisms-bitter neuron activation and sweet neuron inhibition-that correlate with shifts in noni preference. Chemoreceptor mutant analysis in D. melanogaster predicts that multiple genetic changes account for evolution of gustatory preference in D. sechellia.

Automated summary

Comparative studies of ecologically distinct species can provide insights into the evolution of the nervous system to drive behaviors adapted to specific environments. This study investigated the taste preference of different drosophilids towards noni fruit fatty acids, and revealed species-specific differences in taste sensory responses that correlate with noni preference. Mutant analysis further predicted multiple genetic changes responsible for the evolution of gustatory preference in D. sechellia.