Development of Long Asymmetric siRNA Structure for Target Gene Silencing and Immune Stimulation in Mammalian Cells

Activation of Innate Immunity by Therapeutic Nucleic Acids

(2021) Ali Bishani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Single-stranded phosphorothioated regions enhance cellular internalization of cholesterol-conjugated siRNA but not silencing efficacy

(2020) Socheata Ly et al.   Molecular Therapy-Nucleic Acids

Editorial focus: understanding off-target effects as the key to successful RNAi therapy

(2019) Rafal Bartoszewski et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Trial Watch: Toll-like receptor agonists in cancer immunotherapy

(2018) Melody Smith et al.   OncoImmunology

RNA Interference-Induced Innate Immunity, Off-Target Effect, or Immune Adjuvant?

(2017) Zhongji Meng et al.   Frontiers in Immunology

Development of Cell-Penetrating Asymmetric Interfering RNA Targeting Connective Tissue Growth Factor

(2016) Jihye Hwang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Effect of siRNA with an Asymmetric RNA/dTdT Overhang on RNA Interference Activity

(2015) June Hyun Park et al.   Nucleic Acid Therapeutics

Effect of the guide strand 3′-end structure on the gene-silencing potency of asymmetric siRNA

(2014) Sun Woo Hong et al.   BIOCHEMICAL JOURNAL

Identification of RNA Sequence Motifs Stimulating Sequence-Specific TLR8-Dependent Immune Responses

(2014) A. Forsbach et al.   JOURNAL OF IMMUNOLOGY

Extracellular MicroRNAs Activate Nociceptor Neurons to Elicit Pain via TLR7 and TRPA1

(2014) Chul-Kyu Park et al.   NEURON

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivo

(2013) Q. Zhang et al.   BLOOD

TLR7 Triggering with Polyuridylic Acid Promotes Cross-Presentation in CD8 + Conventional Dendritic Cells by Enhancing Antigen Preservation and MHC Class I Antigen Permanence on the Dendritic Cell Surface

(2013) M. I. Crespo et al.   JOURNAL OF IMMUNOLOGY

Development of Therapeutic-Grade Small Interfering RNAs by Chemical Engineering

(2012) Jesper B. Bramsen et al.   Frontiers in Genetics

Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists

(2010) D. Rajagopal et al.   BLOOD

The RNA-induced Silencing Complex: A Versatile Gene-silencing Machine

(2009) Ashley J. Pratt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Asymmetric Shorter-duplex siRNA Structures Trigger Efficient Gene Silencing With Reduced Nonspecific Effects

(2009) Chan Il Chang et al.   MOLECULAR THERAPY

Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes

(2009) Yanli Wang et al.   NATURE

In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

(2009) Marcin Kortylewski et al.   NATURE BIOTECHNOLOGY

Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection

(2008) Masayuki Sano et al.   NUCLEIC ACIDS RESEARCH