Article
Immunology
Jeremy A. W. Gold, Emma E. Seagle, Joelle Nadle, Devra M. Barter, Christopher A. Czaja, Helen Johnston, Monica M. Farley, Stepy Thomas, Lee H. Harrison, Jill Fischer, Brittany Pattee, Rajal K. Mody, Erin C. Phipps, Sarah Shrum Davis, Brenda L. Tesini, Alexia Y. Zhang, Tiffanie M. Markus, William Schaffner, Shawn R. Lockhart, Snigdha Vallabhaneni, Brendan R. Jackson, Meghan Lyman
Summary: The study found that a considerable proportion of patients with candidemia were initially treated with fluconazole, which may not be appropriate for cases involving non-albicans or fluconazole-resistant species. Therefore, it is important to evaluate the reasons for nonadherence to treatment guidelines and provide clinician education.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Anna Dudakova, Claudia Blei, Uwe Gross, Marco H. Schulze
Summary: This study analyzes the impact of bedside antifungal stewardship (AFS) on clinical management and prognosis of patients with candidemia at a university hospital in Germany. The results show that bedside AFS significantly improves adherence to recommendations for antifungal treatment and follow-up in patients with Candida fungemia. However, improving the prognosis of patients with candidemia remains a huge challenge.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Infectious Diseases
Rashi Verma, Dibyabhaba Pradhan, Ziaul Hasan, Harpreet Singh, Arun Kumar Jain, Luqman Ahmad Khan
Summary: This study presents the distribution and antifungal resistance patterns of Candida species among the Indian population, which could assist in forming treatment recommendations for the region and beyond in the future.
Article
Microbiology
Yong Jun Kwon, Eun Jeong Won, Seok Hoon Jeong, Kyeong Seob Shin, Jeong Hwan Shin, Young Ree Kim, Hyun Soo Kim, Young Ah Kim, Young Uh, Taek Soo Kim, Jae Hyeon Park, Jaehyeon Lee, Min Ji Choi, Seung A. Byun, Soo Hyun Kim, Jong Hee Shin
Summary: Mortality and predictors of mortality differ between ICUAC and non-ICUAC patients, mainly mediated by different Candida species.
Review
Infectious Diseases
Anna Maria Tortorano, Anna Prigitano, Gianluca Morroni, Lucia Brescini, Francesco Barchiesi
Summary: Candidemia and invasive candidiasis are common and have high mortality rates, with treatment needing to consider various factors. Antifungal resistance is relatively rare, but new resistant strains have emerged. Treatment options should be tailored based on individual cases and durations.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Infectious Diseases
Toshiki Kajihara, Koji Yahara, Minoru Nagi, Norikazu Kitamura, Aki Hirabayashi, Yumiko Hosaka, Masahiro Abe, Yoshitsugu Miyazaki, Motoyuki Sugai
Summary: This study shows that the proportion of Candida species in Japan remained stable from 2010-2019. However, certain species, such as C. glabrata, C. tropicalis, and C. krusei, exhibited higher resistance to azoles and micafungin. The increasing incidence of candidemia and the emergence of drug-resistant Candida species highlight the need for long-term surveillance studies.
Article
Infectious Diseases
Amir Arastehfar, Samira Yazdanpanah, Mina Bakhtiari, Wenjie Fang, Weihua Pan, Shahram Mahmoudi, Keyvan Pakshir, Farnaz Daneshnia, Teun Boekhout, Macit Ilkit, David S. Perlin, Kamiar Zomorodian, Farid Zand
Summary: This prospective study investigated candidemia in three major healthcare centers in southern Iran and found that over 60% of patients received fluconazole treatment without consideration of species identification or antifungal susceptibility testing. Candida albicans was the most prevalent species, with low antifungal resistance, but notable therapeutic failure against fluconazole in non-albicans Candida species. The results suggest a need for species-specific treatment strategies and antifungal susceptibility testing to improve candidemia management in Iran.
Article
Microbiology
Tsidiso G. Maphanga, Serisha D. Naicker, Stanford Kwenda, Jose F. Munoz, Erika van Schalkwyk, Jeannette Wadula, Trusha Nana, Arshad Ismail, Jennifer Coetzee, Chetna Govind, Phillip S. Mtshali, Ruth S. Mpembe, Nelesh P. Govender
Summary: A study on Candida auris isolates from South African hospitals revealed a high prevalence of multidrug resistance, particularly to azoles. Even phenotypically susceptible isolates showed mutations in resistance genes, indicating a complex pattern of antifungal resistance in this fungal pathogen.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Arturo Luna-Tapia, Josie E. Parker, Steven L. Kelly, Glen E. Palmer
Summary: The study compared the tendencies of C-5 sterol desaturases from different fungal pathogens to produce toxic diol upon S14DM inhibition and contribute to antifungal efficacy. It found that species-specific properties of C-5 sterol desaturase may be an important determinant of intrinsic azole sensitivity.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Shiori Kitaya, Hajime Kanamori, Yukio Katori, Koichi Tokuda
Summary: This secondary analysis of a retrospective cohort study aimed to assess the differences in hospital-acquired persistent candidemia (HA-PC) based on different Candida species, antifungal resistance (AFR), and clearance status. The study found that the non-albicans Candida and resistant strain groups had higher mortality rates, indicating the need for more meticulous therapeutic management approach.
Review
Infectious Diseases
Vasiliki Soulountsi, Theodoros Schizodimos, Serafeim Chrysovalantis Kotoulas
Summary: In recent decades, invasive candidiasis (IC) has become a significant cause of morbidity, mortality, and economic burden in the intensive care unit (ICU). The epidemiology of IC remains a difficult and unsolved puzzle for the literature. IC burden estimation is challenging due to various definitions and limitations in case-finding methodologies. Candidemia and intra-abdominal candidiasis (IAC) are the predominant types of IC in the ICU, with an increasing incidence of candidemia, particularly in elderly or immunosuppressed patients, and a shift towards non-albicans species worldwide.
Article
Microbiology
Eun Jeong Won, Min Ji Choi, Seok Hoon Jeong, Dokyun Kim, Kyeong Seob Shin, Jeong Hwan Shin, Young Ree Kim, Hyun Soo Kim, Young Ah Kim, Young Uh, Namhee Ryoo, Jeong Su Park, Kyoung Un Park, Seung A. Byun, Ga Yeong Lee, Soo Hyun Kim, Jong Hee Shin
Summary: This study incorporated nationwide Candida antifungal surveillance into the Korea Global Antimicrobial Resistance Surveillance System. The results showed a high proportion of Candida species among blood pathogens, with a majority originating in hospitals and occurring in intensive care unit patients. Furthermore, non-susceptibility and resistance to commonly used antifungal drugs were identified in certain Candida isolates.
Article
Infectious Diseases
Yong Kwan Lim, Oh Joo Kweon, Hye Ryoun Kim, Tae-Hyoung Kim, Mi-Kyung Lee
Summary: This study evaluated the neutralization performance of various automated blood culture systems for antifungal agents against commonly isolated Candida species. The results showed that peak concentrations of specific antifungal agents can influence the performance of blood culture detection systems, potentially leading to prolonged time to detection for candidemia.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2022)
Article
Microbiology
Asad Hamad, Yiyuan Chen, Mohsin A. Khan, Shirin Jamshidi, Naima Saeed, Melanie Clifford, Charlotte Hind, J. Mark Sutton, Khondaker Miraz Rahman
Summary: In this study, a new class of antifungal agents, the Schiff bases of sulphonamides, showed activity against various Candida species, including multidrug-resistant strains causing Candidemia. These novel compounds have drug-like properties and potential for optimization with medicinal chemistry techniques to develop more potent analogs for pre-clinical evaluation.
Article
Infectious Diseases
Alessandra Leal Silva Chaves, Luciana Trilles, Gabriela Machado Alves, Maria Helena Galdino Figueiredo-Carvalho, Fabio Brito-Santos, Rowena Alves Coelho, Ianick S. Martins, Rodrigo Almeida-Paes
Summary: This study evaluated the clinical and microbiological aspects of six patients with bloodstream infections caused by the Meyerozyma guilliermondii species complex in Brazil, highlighting reduced antifungal susceptibility and variable production of virulence-related enzymes. Neutropenic patients with BSI caused by this emerging species complex had a poor prognosis.
Article
Microbiology
Pierre L. Bonnet, Solene Le Gal, Claire Hoffmann, Florent Morio, Fouleymata Diabira, Athena de Quelen, Guillaume Curral, Steven Negri, Virginie Cogulet, Jean-Francois Huon, Matthieu Gregoire, Nicolas Papon, Patrice Le Pape, Jean-Philippe Bouchara, Gilles Nevez
Summary: This study analyzed the diversity of the P. jirovecii gsc1 gene and the potential impact of Echinocandins on P. jirovecii. The results showed that the diversity of the P. jirovecii gsc1 gene was identical in both patient groups, indicating no selection pressure of Echinocandins on P. jirovecii microorganisms.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Immunology
Laurence Millon, Denis Caillot, Ana Berceanu, Stephane Bretagne, Fanny Lanternier, Florent Morio, Valerie Letscher-Bru, Frederic Dalle, Blandine Denis, Alexandre Alanio, David Boutoille, Marie-Elisabeth Bougnoux, Francoise Botterel, Taieb Chouaki, Amandine Charbonnier, Florence Ader, Damien Dupont, Anne-Pauline Bellanger, Steffi Rocchi, Emeline Scherer, Houssein Gbaguidi-Haore, Raoul Herbrecht
Summary: This study confirms the satisfactory performance of serum Mucorales quantitative polymerase chain reaction (qPCR) for the diagnosis of mucormycosis and argues for the addition of this new tool in clinical settings and consensus definitions to improve the management of mucormycosis.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Romain Lecuyer, Nahema Issa, Benoit Tessoulin, Rose-Anne Lavergne, Florent Morio, Frederic Gabriel, Emmanuel Canet, Celine Bressollette-Bodin, Aurelie Guillouzouic, David Boutoille, Francois Raffi, Raphael Lecomte, Paul Le Turnier, Colin Deschanvres, Fabrice Camou, Benjamin Jean Gaborit
Summary: Respiratory cytomegalovirus (CMV) coinfection at diagnosis of Pneumocystis jirovecii pneumonia (PcP) is independently associated with increased 90-day mortality, specifically in HIV-negative patients. This suggests that CMV coinfection may have an adverse impact on the prognosis of PcP patients.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Dermatology
Debora Castelo-Branco, Shawn R. Lockhart, Yee-Chun Chen, Daniel Assis Santos, Ferry Hagen, Nichola Jane Hawkins, Rose-Anne Lavergne, Jacques Meis, Patrice Le Pape, Marcos Fabio Gadelha Rocha, Jose Julio Costa Sidrim, Maiken Arendrup, Florent Morio
Summary: Even pathogenic yeasts can be widely present in the environment, potentially developing resistance to drugs through environmental pathways. Studies show that pathogenic yeasts may cross borders between plants, animals, and humans, and environmental reservoirs may lead to resistance in Candida or other yeasts for humans.
Article
Critical Care Medicine
Jean-Pierre Gangneux, Eric Dannaoui, Arnaud Fekkar, Charles-Edouard Luyt, Francoise Botterel, Nicolas De Prost, Jean-Marc Tadie, Florian Reizine, Sandrine Houze, Jean-Francois Timsit, Xavier Iriart, Beatrice Riu-Poulenc, Boualem Sendid, Saad Nseir, Florence Persat, Florent Wallet, Patrice Le Pape, Emmanuel Canet, Ana Novara, Melek Manai, Estelle Cateau, Arnaud W. Thille, Sophie Brun, Yves Cohen, Alexandre Alanio, Bruno Megarbane, Muriel Cornet, Nicolas Terzi, Lionel Lamhaut, Estelle Sabourin, Guillaume Desoubeaux, Stephan Ehrmann, Christophe Hennequin, Guillaume Voiriot, Gilles Nevez, Cecile Aubron, Valerie Letscher-Bru, Ferhat Meziani, Marion Blaize, Julien Mayaux, Antoine Monsel, Frederique Boquel, Florence Robert-Gangneux, Yves Le Tulzo, Philippe Seguin, Helene Guegan, Brice Autier, Matthieu Lesouhaitier, Romain Pelletier, Sorya Belaz, Christine Bonnal, Antoine Berry, Jordan Leroy, Nadine Francois, Jean-Christophe Richard, Sylvie Paulus, Laurent Argaud, Damien Dupont, Jean Menotti, Florent Morio, Marie Soulie, Carole Schwebel, Cecile Garnaud, Juliette Guitard, Solene Le Gal, Dorothee Quinio, Jeff Morcet, Bruno Laviolle, Jean-Ralph Zahar, Marie-Elisabeth Bougnoux
Summary: This study demonstrates a high prevalence of invasive pulmonary aspergillosis and candidemia in mechanically ventilated patients with severe COVID-19, and a high mortality associated with pr/pb CAPA. These findings highlight the importance of active surveillance for fungal pathogens in patients with severe COVID-19.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Microbiology
Rose-Anne Lavergne, Marjorie Albassier, Jean-Benoit Hardouin, Carlos Alvarez-Moreno, Fabrice Pagniez, Florent Morio, Patrice Le Pape, Isabelle Ourliac-Garnier
Summary: This study investigated the composition of sterols in azole-resistant Aspergillus fumigatus and found that the composition was qualitatively equivalent under basal conditions, regardless of alterations in the target of azole drugs. Exposure to azole drugs also led to a reduction in ergosterol composition. These findings are important for a better understanding of the mechanisms of action and resistance of azole drugs in fungi.
Article
Mycology
Sander Boden, Florent Morio, Miaomiao Zhou, Bert Gerrits van den Ende, Ferry Hagen
Summary: In this study, we report the de novo genome assembly of a clinical type-strain of D. catenulata and compare it to an environmental strain using Illumina sequencing.
Article
Microbiology
Stephane Bretagne, Karine Sitbon, Marie Desnos-Ollivier, Dea Garcia-Hermoso, Valerie Letscher-Bru, Sophie Cassaing, Laurence Millon, Florent Morio, Jean-Pierre Gangneux, Lilia Hasseine, Loic Favennec, Estelle Cateau, Eric Bailly, Maxime Moniot, Julie Bonhomme, Nicole Desbois-Nogard, Taieb Chouaki, Andre Paugam, Bernard Bouteille, Marc Pihet, Frederic Dalle, Odile Eloy, Milene Sasso, Magalie Demar, Patricia Mariani-Kurkdjian, Vincent Robert, Olivier Lortholary, Francoise Dromer
Summary: The epidemiology of invasive fungal diseases (IFDs) is difficult to determine due to diagnostic challenges. This study emphasizes the importance of active surveillance by mycologists and clinicians to understand global incidence and main IFDs. The findings show an increase in yeast fungemia and a higher prevalence of IFDs in older individuals. Despite advancements in diagnostic tools and antifungal drugs, global survival rates for IFDs have not improved.
Article
Respiratory System
Antoine Moui, Stephanie Dirou, Christine Sagan, Renan Liberge, Claire Defrance, Pierre-Paul Arrigoni, Olivier Morla, Christine Kandel-Aznar, Laurent Cellerin, Arnaud Cavailles, Emmanuel Eschapasse, Florent Morio, Pierre-Antoine Gourraud, Thomas Goronflot, Adrien Tissot, Francois-Xavier Blanc
Summary: Our study highlights the additional value of BAL qualitative description in ILD. We suggest incorporating the immune alveolitis profile for the diagnosis and management of ILD, especially in immunocompromised patients, since it guides towards specific diagnoses.
BMC PULMONARY MEDICINE
(2022)
Article
Microbiology
Laurene Tardieu, Gillian Divard, Olivier Lortholary, Anne Scemla, Eric Rondeau, Isabelle Accoceberry, Remi Agbonon, Alexandre Alanio, Adela Angoulvant, Laetitia Albano, Philippe Attias, Anne Pauline Bellanger, Dominique Bertrand, Julie Bonhomme, Francoise Botterel, Nicolas Bouvier, Matthias Buchler, Taieb Chouaki, Thomas Crepin, Marie-Fleur Durieux, Guillaume Desoubeaux, Gary Doppelt, Loic Favennec, Arnaud Fekkar, Ophelie Fourdinier, Marie Frimat, Jean-Pierre Gangneux, Claire Garandeau, Lilia Hasseine, Christophe Hennequin, Xavier Iriart, Nassim Kamar, Hannah Kaminski, Raphael Kormann, Laurence Lachaud, Christophe Legendre, Moglie Le Quintrec Donnette, Jordan Leroy, Charlene Levi, Marie Machouart, David Marx, Jean Menotti, Valerie Moal, Florent Morio, Natacha Mrozek, Muriel Nicolas, Philippe Poirier, Marie-Noelle Peraldi, Benjamin Poussot, Stephane Ranque, Jean-Philippe Rerolle, Boualem Sendid, Renaud Snanoudj, Jerome Tourret, Marc Vasse, Cecile Vigneau, Odile Villard, Laurent Mesnard, Fanny Lanternier, Cedric Rafat
Summary: This study analyzed the clinical characteristics of cryptococcosis in kidney transplant recipients in France. The incidence of cryptococcal meningitis (CM) was relatively high, and the prognosis was poor. Hyponatremia and neurological symptoms were associated with CM.
Article
Infectious Diseases
Celine Nourrisson, Maxime Moniot, Rose-Anne Lavergne, Estelle Robert, Virginie Bonnin, Ferry Hagen, Frederic Grenouillet, Claudia Cafarchia, Geraldine Butler, Sophie Cassaing, Marcela Sabou, Patrice Le Pape, Philippe Poirier, Florent Morio
Summary: This study aimed to investigate the relationship between drug resistance and genetic diversity, and found a high infection rate of D. catenulata with drug resistance. The results showed that there were differences in the susceptibility of the strains to antifungal drugs, and there may be genetic mutations leading to drug resistance. In addition, the study revealed the correlation between genetic diversity and drug resistance of the strains, indicating the possible clonal transmission of resistant isolates.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Infectious Diseases
Damien Blez, Didier Bronnimann, Blandine Rammaert, Valerie Zeller, Laurence Delhaes, Laurent Hustache, Frederic Grenouillet, Nicolas Traversier, Julie Bonhomme, Taieb Chouaki, Thomas Perpoint, Florence Persat, Marie Elisabeth Bougnoux, Sophie Bayle, Luc Quaesaet, Gilles Nevez, David Boutoille, Florent Morio, Laurence Pougnet, Viviane Queyrel-Moranne, Beate Heym, Romain Guillemain, Eric Dannaoui, Antoine Roux, Dea Garcia-Hermoso, Fanny Lanternier
Summary: This study describes 15 cases of localized osteoarticular Scedosporiosis (LOS) from the nationwide French Scedosporiosis Observational Study. LOS mainly presents as arthritis, osteitis, and thoracic wall infection, with non-specific clinical manifestations. The analysis shows that these patients have a good prognosis, as long as they receive a prolonged course of antifungal therapy and adequate surgical management.
Article
Parasitology
Damien Costa, Romy Razakandrainibe, Louise Basmaciyan, Jerome Raibaut, Pascal Delaunay, Florent Morio, Gilles Gargala, Venceslas Villier, Abdelmounaim Mouhajir, Bernard Levy, Catherine Rieder, Sebastien Larreche, Sophie Lesthelle, Noemie Coron, Estelle Menu, Magalie Demar, Vincent Pommier de Santi, Veronique Blanc, Stephane Valot, Frederic Dalle, Loic Favennec
Summary: Cryptosporidium is a known foodborne pathogen and its outbreaks in France are more common than previously reported. During the period from 2017 to 2020, there were 11 outbreaks of cryptosporidiosis in France, most of which were caused by water contamination. However, foodborne outbreaks, which are more difficult to detect, were likely underreported.
FOOD AND WATERBORNE PARASITOLOGY
(2022)
Article
Parasitology
Sophie Hartuis, Rose-Anne Lavergne, Celine Nourrisson, Jaco Verweij, Guillaume Desoubeaux, Florian Lussac-Sorton, Jean-Philippe Lemoine, Estelle Cateau, Fakhri Jeddi, Philippe Poirier, Patrice Le Pape, Florent Morio
Summary: This study evaluated the performance of the CE-IVD marked Novodiag(R) stool parasites assay (NVD), which is capable of rapid and high-quality detection of 26 distinct types of parasites in stool samples. The NVD showed higher sensitivity than the routine procedure for most parasites tested, with some exceptions. False-positive results were observed for certain parasites using the NVD. Compared to the routine procedure, the NVD provided faster diagnosis, with results available on the day of sample receipt.
Article
Parasitology
Nicolas Argy, Celine Nourrisson, Ahmed Aboubacar, Philippe Poirier, Stephane Valot, Adrien Laude, Guillaume Desoubeaux, Christelle Pomares, Marie Machouart, Yohann Le Govic, Frederic Dalle, Francoise Botterel, Nathalie Bourgeois, Estelle Cateau, Marion Leterrier, Patrice Le Pape, Florent Morio, Sandrine Houze
Summary: Commercial multiplex PCR assay panels show high sensitivity and specificity for parasitological diagnosis, serving as a complement to traditional microscopic examination methods. However, the PCR procedure and analytical performance for each specific protist may vary depending on the multiplex PCR assay, which should be considered when implementing a PCR-based diagnostic approach.