Article
Cell Biology
Weixiong Yang, Chang-Han Chen, Minghan Jia, Xiangbin Xing, Lu Gao, Hsin-Ting Tsai, Zhanfei Zhang, Zhenguo Liu, Bo Zeng, Sai-Ching Jim Yeung, Mong-Hong Lee, Chao Cheng
Summary: The study revealed significant differences in the microbiota composition between patients with ESCC and those with PN esophagus, with the former showing reduced microbial diversity and decreased abundances of specific taxa. Functional analysis indicated altered nitrate reductase and nitrite reductase functions in the microbiota of ESCC patients. These findings suggest that specific microbes and microbiota may influence the development of ESCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Stefano Bibbo, Serena Porcari, Livio Enrico Del Vecchio, Andrea Severino, Benjamin H. Mullish, Gianluca Ianiro, Antonio Gasbarrini, Giovanni Cammarota
Summary: The gut microbiome plays a crucial role in cancer development and treatment. Modulating the gut microbiome has shown to enhance the response to immune checkpoint inhibitors, especially in the treatment of renal cancer.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Review
Immunology
Jian-wei Yang, Shun Wan, Kun-peng Li, Si-Yu Chen, Li Yang
Summary: Mounting evidence suggests that both gut and urinary microbiota play significant roles in the development and treatment of renal cell carcinoma (RCC). Dysbiosis and potential mechanisms have been identified for gut microbiota involvement in RCC, while the presence of urinary microbiota challenges the traditional belief of urine sterility and its potential role in RCC development has been implicated as well. Additionally, the composition of gut microbiota may serve as a predictive marker for the efficacy of immune checkpoint inhibitors, and modulating microbiota may enhance the therapeutic effects of drugs for RCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Yang Chen, Junjie Ma, Yunze Dong, Ziyu Yang, Na Zhao, Qian Liu, Wei Zhai, Junhua Zheng
Summary: This study analyzed the differences in gut microbiota between individuals with clear cell renal cell carcinoma (ccRCC) and healthy individuals. The results showed that specific gut microbiota were positively associated with ccRCC and promoted its proliferation, migration, and invasion via the TGF-signaling pathway. These findings suggest that gut microbiota could serve as a potential non-invasive tool for predicting ccRCC risk and as a target for cancer therapy.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Oncology
Marina Ninkov, Crystal L. Schmerk, Manoosh Moradizadeh, Seema N. Parvathy, Rene Figueredo, Jeremy P. Burton, Michael S. Silverman, Ricardo Fernandes, Saman Maleki Vareki, S. M. Mansour Haeryfar
Summary: This study assessed the impact of fecal microbiota transplantation (FMT) on innate-like, antimicrobial T lymphocytes in metastatic renal cell carcinoma (mRCC) patients. The results showed that FMT improved the function of mucosa-associated invariant T (MAIT) cells, which could benefit patients in subsequent microbial challenges in the face of cancer-elicited immunosuppression.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Review
Immunology
Huimin Bai, Jing Yang, Shu Meng, Chengcheng Liu
Summary: The microbial species in the oral cavity play a role in the development and progression of cancer through stimulating chronic inflammation, affecting cell proliferation, and influencing cell migration. Understanding the molecular mechanisms by which oral microbiota regulates cell migration is important in furthering our knowledge of carcinogenesis and cancer metastasis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Editorial Material
Oncology
Elizabeth P. Henske, Liang Cheng, A. Ari Hakimi, Toni K. Choueiri, David A. Braun
Summary: Chromophobe renal cell carcinoma (ChRCC) is the second most common variant of non-clear cell renal cell carcinoma. ChRCC differs from clear cell RCC (ccRCC) in terms of genetics, genomics, metabolism, cell of origin, and response to targeted and immune therapies. The pathogenesis of ChRCC is not well understood, but current evidence suggests two potential mechanisms: mTORC1 hyperactivation through PTEN pathway mutations and mitochondrial dysfunction leading to oxidative stress.
Article
Microbiology
Bo-Yu Yang, Fang-Zhou Zhao, Xuan-Hao Li, Mei-Shan Zhao, Jing-Cheng Lv, Ming-Jun Shi, Jun Li, Zhi-Yuan Zhou, Jing-Jing Wang, Jian Song
Summary: This study investigated the association between gut microbiota and clear cell renal cell carcinoma (ccRCC). The structure of gut microbiota was found to be significantly different between ccRCC patients and healthy controls, with Desulfovibrionaceae and certain Lactobacillus species enriched in ccRCC patients. In addition, a decrease in taurine level and an upregulation of macrophage-related genes were observed in ccRCC patients. These findings may serve as risk predictors for ccRCC.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Food Science & Technology
Xianming Yang, Jinyong Zhu, Chaoyang Hu, Wen Yang, Zhongming Zheng
Summary: In this study, the researchers investigated the dynamic characteristics and response patterns of transcriptomes and gut microbiomes in the gastropod Bellamya aeruginosa in response to toxic cyanobacterial exposure. They found that toxic cyanobacteria induced changes in the hepatopancreatic transcriptome, with differentially expressed genes related to antioxidation, immunity, and metabolism. In the early phase of exposure, the immune system played a key role in resistance to toxins, while oxidative stress and metabolism of exogenous substances dominated in the later phase. The gut microbiota also changed in response to toxic cyanobacteria, with increased diversity and altered microbiota function. These findings contribute to a comprehensive understanding of the response mechanisms of gastropods and gut microbiota to toxic cyanobacterial stress.
Article
Biochemistry & Molecular Biology
Dorin Novacescu, Talida Georgiana Cut, Alin Adrian Cumpanas, Felix Bratosin, Raluca Amalia Ceausu, Marius Raica
Summary: Despite advancements in RCC detection and molecular pathology, mortality rates are increasing and better clinical management tools are needed. The study found TD expression in RCC tissue and healthy renal parenchyma, with possible prognostic relevance. Further molecular analysis is required to fully understand the biological significance of this newly documented TD expression in RCC.
Article
Oncology
Junpeng Wang, Xin Li, Xiaoqiang Wu, Zhiwei Wang, Chan Zhang, Guanghui Cao, Kangdong Liu, Tianzhong Yan
Summary: The study found decreased species diversity and significant differences in bacterial composition between RCC and normal tissues. Certain taxa such as Chloroplast and Streptophyta showed high accuracy in distinguishing RCC tissues. Additionally, altered pathways in RCC tissues could provide insights into potential microbial functions.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Baihua Zhang, Qin Xiao, Huahai Chen, Tao Zhou, Yeshi Yin
Summary: Esophageal microbiota plays a crucial role in the development of esophageal squamous cell carcinoma (ESCC). The bacterial community undergoes significant changes during ESCC development, with certain pathogenic bacteria potentially contributing to carcinogenesis and progression. The study found differences in bacterial composition between tumor and nontumor tissues, with variations observed at different tumor stages. Certain bacteria were associated with nitrotoluene degradation in nontumor tissues, while others were related to base excision repair in tumor tissues.
Review
Chemistry, Multidisciplinary
Xiongmin Mao, Guanyi Wang, Zijian Wang, Chen Duan, Xiaoliang Wu, Hua Xu
Summary: This review comprehensively summarizes the recent advances in lipid nanoparticles (LNPs) for the precision diagnosis and treatment of renal cell carcinoma (RCC). It introduces the chemical compositions of LNPs and modification strategies for enhanced tumor targeting. The authors also discuss the ongoing and foreseeable biomedical applications of LNPs.
ADVANCED MATERIALS
(2023)
Article
Oncology
Meng Meng, Tianjun Lan, Duanqing Tian, Zeman Qin, Yu Li, Jinsong Li, Haotian Cao
Summary: This study investigated the role of chromatin accessibility in clear cell renal cell carcinoma (ccRCC) and identified five prognostic chromatin accessibility biomarkers as well as two potential function modules. A prognostic model based on gene expression data was established, and distinct immune cell infiltration patterns were observed between different risk groups. The study indicated that mast cell resting is associated with the prognosis of ccRCC and could be a target of immunotherapy, providing a new direction for treatment.
FRONTIERS IN ONCOLOGY
(2021)
Review
Endocrinology & Metabolism
Haiyan Zhu, Xin Wang, Shihao Lu, Kongbo Ou
Summary: Clear cell renal cell carcinoma (ccRCC) is a malignancy characterized by metabolic reprogramming, which provides potential targets for therapeutic interventions. This review summarizes recent discoveries of metabolic alterations in ccRCC, including changes in glucose, lipid, and amino acid metabolism. It also discusses the development of metabolic drugs targeting these pathways and proposes future trends in drug development. Overall, this review highlights the potential for developing new treatments for ccRCC based on metabolic alterations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Virology
Zhong Zheng, Zhixian Yao, Ke Wu, Junhua Zheng
JOURNAL OF MEDICAL VIROLOGY
(2020)
Review
Virology
Zhong Zheng, Zhixian Yao, Ke Wu, Junhua Zheng
JOURNAL OF MEDICAL VIROLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Zhong Zheng, Xinyi Zheng, Yiwen Zhu, Zhixian Yao, Weiguang Zhao, Youjia Zhu, Feng Sun, Xingyu Mu, Yong Wang, Wanqing He, Zhihong Liu, Ke Wu, Junhua Zheng
Summary: The study revealed that levels of IL-6 and MDSCs were positively correlated in MIBC tissues, promoting cancer cell proliferation and immune suppression. MDSCs, stimulated by IL-6, were found to inhibit T lymphocyte proliferation, while IL-6 upregulated the MAPK signaling pathway in MDSCs, contributing to MIBC progression.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Cell Biology
Zhixian Yao, Zhong Zheng, Xinyi Zheng, Hantao Wu, Weiguang Zhao, Xingyu Mu, Feng Sun, Ke Wu, Junhua Zheng
Summary: This study investigated the metabolic aspects of clear cell RCC and found a positive correlation between high metabolic scores and patient prognosis and treatment response.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
