Review
Chemistry, Analytical
Tianyou Chen, Song Yin, Jing Wu
Summary: Both nanomaterials and microfluidics have experienced unprecedented development in recent years, offering new opportunities and methods. Combining nanomaterials with microfluidics can improve methods and enhance synthesis efficiency. The focus is on categorizing different microfluidic methods and NM synthesis to enhance efficiency in biochemical analysis.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Review
Materials Science, Multidisciplinary
Daniel B. Miracle, Mu Li, Zhaohan Zhang, Rohan Mishra, Katharine M. Flores
Summary: This review evaluates recent progress in CHT evaluations for structural materials, highlighting the application of high-throughput computations and new synthesis methods. It also points out challenges in measurement and production, and proposes a strategy to enhance efficiency by conducting two layers of evaluations.
ANNUAL REVIEW OF MATERIALS RESEARCH, VOL 51, 2021
(2021)
Article
Engineering, Environmental
Kanakaraj Aruchamy, Kalpana Dharmalingam, Chang Woo Lee, Dibyendu Mondal, Nataraj Sanna Kotrappanavar
Summary: In recent years, there has been a growing interest in developing cost-effective, simple, and environmentally friendly methods using abundant biomass resources to address water contamination issues and store renewable energy. This study successfully converted toxic weed Parthenium hysterophorous into porous activated carbon with excellent electrochemical performance and organic pollutant removal capabilities. The functional carbon materials showed promising potential for sustainable water purification in continuous flow systems.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Satoko Yamaoka, Carla M. Weisend, Vaille A. Swenson, Hideki Ebihara
Summary: A highly accessible and robust BRBV minigenome system was developed for high-throughput antiviral drug screening. DHODH inhibitors showed effectiveness against BRBV and other orthomyxoviruses. The system provides a powerful platform for the development of antivirals against emerging orthomyxoviruses.
ANTIVIRAL RESEARCH
(2022)
Article
Biophysics
Asha P. Johnson, Chinnu Sabu, N. Kumara Swamy, Annstephy Anto, H. V. Gangadharappa, K. Pramod
Summary: Graphene nanoribbons (GNRs) are considered a promising platform for biomedical applications due to their unique properties. By altering the edge functionalities and geometry, their properties can be significantly reformed and controlled. GNRs are extensively explored in the field of biosensing.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Engineering, Environmental
Hiep Van Nguyen, Hau Van Nguyen, Vu Minh Phan, Bum Jun Park, Tae Seok Seo
Summary: A high-throughput platform for synthesizing gold nanoparticles has been reported, which consists of a centrifugal microfluidic device and a portable automatic workstation. The platform can perform multiple reactions and produce different types of gold nanoparticles in one run without human interference.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Chemistry, Physical
Shahzadi Noreen, Muhammad Bilal Tahir, Abid Hussain, T. Nawaz, Jalil Ur Rehman, A. Dahshan, Meshal Alzaid, Hussein Alrobei
Summary: The article introduces the unique properties and wide applications of 2D monoelemental materials Borophene and Bismuthene, discussing the attention they have attracted in various scientific fields and potential research directions.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2022)
Article
Microbiology
Luiza Chaves de Miranda Leonhardt Losada, Ruan Campos Monteiro, Jamile Ambrosio de Carvalho, Ferry Hagen, Matthew C. Fisher, Bram Spruijtenburg, Jacques F. Meis, Theun de Groot, Sarah Santos Goncalves, Ricardo Negroni, Rui Kano, Alexandro Bonifaz, Zoilo Pires de Camargo, Anderson Messias Rodrigues
Summary: This study developed a panel of highly polymorphic SSR markers suitable for genotyping Sporothrix species. PCR amplification revealed 240 alleles in 180 Sporothrix isolates, supporting the effectiveness of SSR markers in uncovering cryptic genetic diversity. The analysis of SSR diversity provided insights into the origins and transmission dynamics of cat-transmitted sporotrichosis.
Article
Chemistry, Physical
Junchao Chen, Fang Wang, Yujie Wen, Weiping Tang, Luming Peng
Summary: Recent advances in applying O-17 solid-state NMR spectroscopy have provided valuable information on the surface structure, active sites, and reaction mechanisms of catalytic oxides. This article provides a brief introduction to O-17 solid-state NMR spectroscopy and discusses recent methodological developments related to its applications. Furthermore, it reviews the applications of O-17 NMR in elucidating the structure of oxide catalysts and related mechanisms, with a specific focus on recent research on oxide nanomaterials and zeolites. Finally, it offers opinions on remaining challenges and future directions in this emerging field.
Article
Environmental Sciences
Donald Wlodkowic, Marcus Jansen
Summary: The article discusses the development trends and technological prospects of high-throughput bioanalytical methods in ecotoxicology, emphasizing the importance of automated data acquisition, while also exploring the existing challenges of ecotoxicity testing strategies.
Review
Chemistry, Analytical
Yongxin Li, Zewei Luo, Chuyan Zhang, Rui Sun, Chen Zhou, Chengjun Sun
Summary: Nucleic acids serve as genetic information carriers and powerful building blocks for signal amplification. Entropy-driven circuit (EDC) is considered a milestone in DNA circuits, featuring advantages of rapidness, simplicity, robustness, and modularity.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yijie Liu, Xuexuan Li, Yuliang Zhang, Lin Ge, Yingchun Guan, Zhen Zhang
Summary: This study presents a novel approach, the ultra-large scale stitchless atomic force microscopy (ULSS-AFM), which combines a compliant nano-manipulator (CNM) to enable high-throughput characterization of an area of up to 1 x 1 mm(2). Experimental results demonstrate the effectiveness of the ULSS-AFM in different scanning ranges, modes, resolutions, and frequencies. Compared to conventional AFMs, this approach allows for the characterization of ultra-large scale samples without stitching or bow errors, expanding the scanning area of traditional AFMs by two orders of magnitude and opening up important avenues for cross-scale scientific research and industrial applications in nano- and microscale.
Review
Biochemistry & Molecular Biology
Qian Yu, Wenhui Shi, Shun Li, Hong Liu, Jianming Zhang
Summary: Cancer is a deadly disease that has prompted researchers to explore effective therapeutic strategies. In recent decades, nanomaterials with unique physical and chemical properties have been used for the treatment of various cancers. Piezoelectric nanomaterials, which can convert ultrasound vibration energy into electrical energy, have attracted increasing attention in biomedical research, leading to the emerging technique of ultrasound-driven tumor therapy. Piezoelectric materials are expected to provide a better solution for efficient and safe cancer treatment, as well as patient pain relief.
Article
Engineering, Environmental
Qi Lei, Lanyu Li, Honghao Chen, Xiaonan Wang
Summary: This article discusses the application of the SMART approach in the development of carbon capture technologies, combining high-throughput calculation and data-driven modeling to achieve advanced capabilities in simulating and optimizing carbon capture processes. The authors also propose a framework for material discovery and emphasize the synergies among deep learning models, pretrained models, and comprehensive data sets.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Yasaman-Sadat Borghei, Saman Hosseinkhani, Mohammad Reza Ganjali
Summary: This review focuses on the basic physicochemical properties of plasmonic nanoparticles and their applications in biomedical and tissue engineering. It aims to provide a comprehensive and authoritative overview to the scientific community. The review introduces the fundamental characteristics of nanomaterials and illustrates their applications in the field through selected case studies.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Michael J. Burgum, Martin J. D. Clift, Stephen J. Evans, Nicole Hondow, Afshin Tarat, Gareth J. Jenkins, Shareen H. Doak
Summary: The study found that FLG induced cytotoxicity in TT1 cells in monoculture experiments, while in co-culture experiments, FLG induced genotoxicity without cytotoxic effects. Pre-exposure of co-cultures to N-acetylcysteine (NAC) showed that genotoxicity observed in the co-culture experiment was driven by oxidative stress and revealed secondary mechanisms of DNA damage.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Amna Ali, Aliyah Zaman, Elshaimaa Sayed, David Evans, Stuart Morgan, Chris Samwell, John Hall, Muhammad Sohail Arshad, Neenu Singh, Omar Qutachi, Ming-Wei Chang, Zeeshan Ahmad
Summary: EHDA technologies, such as electrospraying, have been utilized in pharmaceutical and drug delivery fields to manipulate particulate structures and meet specific application needs, showing great potential for sensitive biologics and molecules. Various parameters and modifications during the process can greatly influence the resulting particles and their applications.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Chemistry, Analytical
Monique E. Johnson, Joe Bennett, Antonio R. Montoro Bustos, Shannon K. Hanna, Andrei Kolmakov, Nicholas Sharp, Elijah J. Petersen, Patricia E. Lapasset, Christopher M. Sims, Karen E. Murphy, Bryant C. Nelson
Summary: The study combined dynamic SIMS and spICP-MS techniques to determine the biodistribution and quantity of gold nanoparticles ingested by Caenorhabditis elegans. The complementary data from SIMS image depth profiling and spICP-MS provided a complete view of the uptake, translocation, and size distribution of ingested NPs within Caenorhabditis elegans.
ANALYTICA CHIMICA ACTA
(2021)
Article
Nanoscience & Nanotechnology
Melanie Kah, Linda J. Johnston, Rai S. Kookana, Wendy Bruce, Andrea Haase, Vera Ritz, Jordan Dinglasan, Shareen Doak, Hemda Garelick, Vladimir Gubala
Summary: Nanopesticides are advancing in research and development and appearing on the market, prompting the need for a comprehensive framework and guidance for human health risk assessments. The study suggests adapting existing pesticide frameworks, identifying relevant nanopesticide entities and their concentrations, and addressing additional data requirements based on the nature of the nanopesticides. The tiered approach proposed in the framework aims to support regulators and industry in making informed decisions on nanopesticide submissions.
NATURE NANOTECHNOLOGY
(2021)
Article
Chemistry, Medicinal
Mariko Shikata, Tatsushi Toyooka, Yukako Komaki, Yuko Ibuki
Summary: The study found that NNK globally acetylated histone H3, impacting gamma-H2AX generation. Activation of the nicotinic acetylcholine receptor alpha 7nAChR by NNK activated the PI3K/Akt pathway, leading to Ac-H3. The enhanced Ac-H3 contributed to increased gamma-H2AX, implying that NNK-induced DNA damage is influenced by the alpha 7nAChR-mediated signal transduction pathway.
CHEMICAL RESEARCH IN TOXICOLOGY
(2021)
Article
Chemistry, Physical
Christopher M. Sims, Jeffrey A. Fagan
Summary: This research quantitatively determined the effects of surfactant chemistry and polymer chain length on the extraction of specific single-wall carbon nanotube (SWCNT) species in an aqueous two-polymer phase extraction (ATPE) separation. The results showed that alkyl surfactant tail length strongly affects the amount of surfactant necessary for extraction in ATPE. Substitution of different bile salts results in different surfactant packings on the SWCNTs, significantly affecting the concentrations required for extraction.
Article
Chemistry, Multidisciplinary
Shareen H. Doak, Martin J. D. Clift, Anna Costa, Christiaan Delmaar, Ilse Gosens, Sabina Halappanavar, Sean Kelly, Willie J. G. M. Pejinenburg, Barbara Rothen-Rutishauser, Roel P. F. Schins, Vicki Stone, Lang Tran, Martina G. Vijver, Ulla Vogel, Wendel Wohlleben, Flemming R. Cassee
Summary: The European Green Deal aims to build a more sustainable, climate neutral, and circular economy by 2050. To achieve this, the European Commission has released the Chemicals Strategy for Sustainability, which sets targets for innovation in addressing challenges posed by hazardous chemicals and animal testing. The PATROLS project has developed innovative tools to support the safe and sustainable development of new nano-enabled products.
Article
Chemistry, Multidisciplinary
Amirsadra Ahmadi, Moses Sokunbi, Trisha Patel, Ming-Wei Chang, Zeeshan Ahmad, Neenu Singh
Summary: This study statistically analyzed the factors influencing the biocompatibility and toxicity of Mesoporous Silica Nanoparticles (MSNs) in the past five years, including physicochemical properties, experimental conditions, and other experimental parameters.
Article
Chemistry, Multidisciplinary
Kirsty Meldrum, Joana A. Moura, Shareen H. Doak, Martin J. D. Clift
Summary: This study used fluid flow conditions to simulate the lung environment and investigate the effects of particle exposure on cells in an in vitro model. The results showed that exposure under fluid flow conditions can influence cell viability, membrane integrity, and inflammatory responses, depending on the type and concentration of particles.
Article
Chemistry, Physical
Han Li, Christopher M. Sims, Rui Kang, Frank Biedermann, Jeffrey A. Fagan, Benjamin S. Flavel
Summary: In this study, highly purified (>80%) left- and right-handed (6,5) single-wall carbon nanotubes (SWCNTs) were separated using aqueous two-phase extraction (ATPE), with limited experimental steps. The optimized surfactant conditions were determined, and analytical ultracentrifugation (AUC) and near-infrared photoluminescence (PL) measurements were used to examine the required conditions for surfactant wrapping and partition coefficient change (PCCCs). This study provides valuable insights into the underlying mechanisms behind surfactant-assisted SWCNT separations and promotes the future use of SWCNT enantiomers in fundamental studies and applications.
Article
Genetics & Heredity
Shareen H. Doak, Cristina Andreoli, Michael J. Burgum, Qasim Chaudhry, Eric A. J. Bleeker, Cecilia Bossa, Josefa Domenech, Damjana Drobne, Valerie Fessard, Nina Jeliazkova, Eleonora Longhin, Elise Runden-Pran, Maciej Stepnik, Naouale El Yamani, Julia Catalan, Maria Dusinska
Summary: Genotoxicity testing for nanomaterials is challenging and requires adaptation of standard testing approaches. New approach methodologies (NAMs) are being developed to provide relevant information on genotoxic action. The implementation and utilization of NAMs for nanomaterial genotoxicity assessment in a regulatory context need clarification and increased engagement between scientists and regulators.
Article
Chemistry, Medicinal
Kazutaka Hirakawa, Naoki Kishimoto, Yoshinobu Nishimura, Yuko Ibuki, Masaaki Fuki, Shigetoshi Okazaki
Summary: The photoexcited state of the trimer is almost the same as that of the monomer, and these phosphorus(V)porphyrins demonstrate a similar protein-photodamaging activity. The difference in association between the photosensitizer molecules and cells is the key factor of phototoxicity by these phosphorus(V)porphyrins.
CHEMICAL RESEARCH IN TOXICOLOGY
(2023)
Article
Genetics & Heredity
Leanne M. Stannard, Ann Doherty, Katherine E. Chapman, Shareen H. Doak, Gareth J. Jenkins
Summary: Cadmium chloride (CdCl2) has multiple effects on cells, including DNA damage, cell cycle abnormalities, and changes in cell shape. The main mechanisms behind these effects involve the generation of reactive oxygen species (ROS), oxidative DNA damage, and activation of p53.
Proceedings Paper
Engineering, Electrical & Electronic
Tae Joon Cho, Vincent Hackley, Vytas Reipa, Alessandro Tona, Christopher Sims, Natalia Farkas
Summary: We report on the synthesis and characterization of a stability-enhanced suspension of gold-polyethyleneimine conjugates (Au-PEIs). The nanoparticles showed excellent colloidal stability in aqueous environments and demonstrated significant cytotoxicity, making them a potential universal nanoscale positive control material for nanotoxicity studies.
2022 IEEE 22ND INTERNATIONAL CONFERENCE ON NANOTECHNOLOGY (NANO)
(2022)
Article
Nanoscience & Nanotechnology
Kirsty Meldrum, Stephen J. Evans, Ulla Vogel, Lang Tran, Shareen H. Doak, Martin J. D. Clift
Summary: Exposure to engineered nanomaterials can pose health risks, and this study aimed to determine the level of hazard using in vitro lung cell cultures. The results showed that DQ(12) caused pro-inflammatory responses, while TiO2 and BaSO4 did not. These findings highlight the importance of considering the appropriateness of positive controls, cell culture model, exposure time, and type when determining the response to specific ENMs.