Knockout tales: the versatile roles of histone H3.3 in development and disease

A knockout‐first model of H3f3a gene targeting leads to developmental lethality

(2023) Kelly Bush et al.   GENESIS

Postmitotic accumulation of histone variant H3.3 in new cortical neurons establishes neuronal chromatin, transcriptome, and identity

(2022) Owen H. Funk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone variants at a glance

(2021) Paul B. Talbert et al.   JOURNAL OF CELL SCIENCE

The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma

(2021) Irena Bočkaj et al.   PLoS Genetics

Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling

(2020) Kuang-Yui Chen et al.   Communications Biology

Histone H3.3 beyond cancer: Germline mutations in Histone 3 Family 3A and 3B cause a previously unidentified neurodegenerative disorder in 46 patients

(2020) Laura Bryant et al.   Science Advances

Phosphorylation of histone H3.3 at serine 31 promotes p300 activity and enhancer acetylation

(2019) Sara Martire et al.   NATURE GENETICS

Non-neutral evolution of H3.3-encoding genes occurs without alterations in protein sequence

(2019) Brejnev M. Muhire et al.   Scientific Reports

Histone Modifications: Insights into Their Influence on Gene Expression

(2018) Bruce Stillman   CELL

Accumulation of histone variant H3.3 with age is associated with profound changes in the histone methylation landscape

(2017) Andrey Tvardovskiy et al.   NUCLEIC ACIDS RESEARCH

Histone variant H3F3A promotes lung cancer cell migration through intronic regulation

(2016) Seong-Min Park et al.   Nature Communications

The interplay of histone modifications - writers that read

(2015) T. Zhang et al.   EMBO REPORTS

Histone H3.3 maintains genome integrity during mammalian development

(2015) Chuan-Wei Jang et al.   GENES & DEVELOPMENT

Contribution of the Two Genes Encoding Histone Variant H3.3 to Viability and Fertility in Mice

(2015) Michelle C. W. Tang et al.   PLoS Genetics

Histone H3.3 regulates dynamic chromatin states during spermatogenesis

(2014) B. T. K. Yuen et al.   DEVELOPMENT

Hira-Mediated H3.3 Incorporation Is Required for DNA Replication and Ribosomal RNA Transcription in the Mouse Zygote

(2014) Chih-Jen Lin et al.   DEVELOPMENTAL CELL

ATRX Dysfunction Induces Replication Defects in Primary Mouse Cells

(2014) David Clynes et al.   PLoS One

Histone H3.3 Mutations: A Variant Path to Cancer

(2013) Benjamin T.K. Yuen et al.   CANCER CELL

Identification of Long-Lived Proteins Reveals Exceptional Stability of Essential Cellular Structures

(2013) Brandon H. Toyama et al.   CELL

Hira-Dependent Histone H3.3 Deposition Facilitates PRC2 Recruitment at Developmental Loci in ES Cells

(2013) Laura A. Banaszynski et al.   CELL

Conditional allelic replacement applied to genes encoding the histone variant H3.3 in the mouse

(2013) Michelle C.W. Tang et al.   GENESIS

Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone

(2013) Sam Behjati et al.   NATURE GENETICS

Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma

(2013) P. W. Lewis et al.   SCIENCE

Endogenous mammalian histone H3.3 exhibits chromatin-related functions during development

(2013) Kelly M Bush et al.   Epigenetics & Chromatin

Compromised genomic integrity impedes muscle growth after Atrx inactivation

(2012) Michael S. Huh et al.   JOURNAL OF CLINICAL INVESTIGATION

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

(2012) Gang Wu et al.   NATURE GENETICS

A Developmental Requirement for HIRA-Dependent H3.3 Deposition Revealed at Gastrulation in Xenopus

(2012) Emmanuelle Szenker et al.   Cell Reports

The double face of the histone variant H3.3

(2011) Emmanuelle Szenker et al.   CELL RESEARCH

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

(2010) Aaron D. Goldberg et al.   CELL

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

(2010) P. W. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global turnover of histone post-translational modifications and variants in human cells

(2010) Barry M Zee et al.   Epigenetics & Chromatin

Transcriptional and Developmental Functions of the H3.3 Histone Variant in Drosophila

(2009) Akiko Sakai et al.   CURRENT BIOLOGY