Article
Cardiac & Cardiovascular Systems
Shengjie Wu, Lan Su, Pugazhendhi Vijayaraman, Rujie Zheng, Mengxing Cai, Lei Xu, Ruiyu Shi, Zhouqing Huang, Zachary Whinnett, Weijian Huang
Summary: Left bundle branch pacing (LBBP) appears to be a promising method for delivering cardiac resynchronization therapy (CRT), showing similar improvements in symptoms and left ventricular function compared with His bundle pacing (HBP) but more significant than biventricular pacing (BVP).
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Yuping Fu, Peng Liu, Lingyan Jin, Yingqi Li, Yudi Zhang, Xinghua Qin, Qiangsun Zheng
Summary: Cardiac resynchronization therapy (CRT) is considered as the first-line treatment for heart failure patients with conduction disorders. Conventional biventricular pacing (BVP) has limitations, and left bundle branch pacing (LBBP) has emerged as a promising alternative. LBBP has shown superior outcomes compared to BVP in terms of CRT delivery, QRS complex width, left ventricular ejection fraction improvement, and functional class.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Rafal Gardas, Krzysztof S. Golba, Tomasz Soral, Jolanta Biernat, Piotr Kulesza, Mateusz Sajdok, Kamil Zub
Summary: Pacing-induced cardiomyopathy is a common complication of right ventricular pacing. Upgrading to cardiac resynchronization therapy is recommended, and this study suggests that His bundle pacing can be a valid alternative to biventricular pacing, leading to better clinical outcomes and left ventricle reverse remodeling.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Physiology
Marina Strocchi, Nadeev Wijesuriya, Mark K. Elliott, Karli Gillette, Aurel Neic, Vishal Mehta, Edward J. Vigmond, Gernot Plank, Christopher A. Rinaldi, Steven A. Niederer
Summary: Biventricular endocardial pacing and left bundle pacing are new delivery methods for cardiac resynchronization therapy. Leadless pacing can be used to avoid risks associated with traditional lead systems. This study investigated the impact of RV-LV delay, RV lead location, and left bundle capture on the efficacy of leadless pacing.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yao Wang, Haojie Zhu, Xiaofeng Hou, Zhao Wang, Fengwei Zou, Zhiyong Qian, Yongyue Wei, Xiang Wang, Longyao Zhang, Xiaofei Li, Zhimin Liu, Siyuan Xue, Chaotong Qin, Jiaxin Zeng, Hui Li, Hongping Wu, Hong Ma, Kenneth A. Ellenbogen, Michael R. Gold, Xiaohan Fan, Jiangang Zou
Summary: Left bundle branch pacing (LBBP) shows greater improvement in left ventricular ejection fraction (LVEF) compared to biventricular pacing (BiVP) in heart failure patients with nonischemic cardiomyopathy and left bundle branch block (LBBB).
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Eugene S. J. Tan, Rodney Soh, Elaine Boey, Jie-Ying Lee, Jhobeleen de Leon, Siew-Pang Chan, Hiong-Hiong Gan, Swee-Chong Seow, Pipin Kojodjojo
Summary: This study investigated the differences in feasibility, device performance, and clinical outcomes between left bundle branch and His-bundle pacing.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Juan Hua, Chenxi Wang, Qiling Kong, Yichu Zhang, Qijun Wang, Ziyi Xiong, Jinzhu Hu, Juxiang Li, Qi Chen, Kui Hong
Summary: The network meta-analysis showed that compared to biventricular pacing (BVP), left bundle branch area pacing (LBBAP) and His bundle pacing (HBP) resulted in greater improvement in left ventricular ejection fraction (LVEF) and narrower QRS duration for cardiac resynchronization therapy (CRT). Additionally, LBBAP had lower pacing thresholds and similar clinical outcomes compared to HBP. These findings suggest that LBBAP may offer advantages over HBP for CRT.
CLINICAL CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ying Gu, Yanming Li, Ying Zhu, Xiuyu Lin, Tian Tian, Qigao Zhang, Jianbin Gong, Lei Wang, Jianhua Li
Summary: The study concludes that left bundle branch pacing (LBBP) is a feasible and effective treatment for heart failure patients with left ventricular ejection fraction (LVEF) <50% and left bundle branch block (LBBB). LBBP improves left ventricular structure and function with a low and stable pacing threshold.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Juan Carlos Diaz, William H. Sauer, Mauricio Duque, Bruce A. Koplan, Eric D. Braunstein, Jorge Eduardo Marin, Julian Aristizabal, Cesar Daniel Nino, Oriana Bastidas, Juan Manuel Martinez, Carolina Hoyos, Carlos D. Matos, Nestor Lopez-Cabanillas, Nathaniel A. Steiger, Sunil Kapur, Thomas M. Tadros, David T. Martin, Paul C. Zei, Usha B. Tedrow, Jorge E. Romero
Summary: This study compares the outcomes of LBBAP and BiVp as initial implant strategies for CRT. The results show that LBBAP as an initial CRT strategy can reduce the risk of hospitalization due to heart failure compared to BiVp, and improvements in procedural and fluoroscopy times, QRS duration, and left ventricular ejection fraction were observed.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Michael Vinther, Niels Risum, Jesper Hastrup Svendsen, Rasmus Mogelvang, Berit Thornvig Philbert
Summary: This study compared His-CRT and BiV-CRT in patients with symptomatic heart failure and LBBB, finding similar clinical and physical improvements in both groups at the 6-month follow-up, with His-CRT requiring higher pacing thresholds.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Oscar Cano, Javier Navarrete-Navarro, Pablo Jover, Joaquin Osca, Maite Izquierdo, Josep Navarro, Hebert D. Ayala, Luis Martinez-Dolz
Summary: Cardiac resynchronization therapy (CRT) is a major treatment for heart failure patients, but a significant portion of patients do not respond to this therapy. Recent advancements in physiological pacing techniques, such as His bundle pacing (HBP) and left bundle branch area pacing (LBBAP), have shown promise in increasing the percentage of CRT responders. These pacing techniques aim to restore normal electrical activation of the ventricles, providing better outcomes compared to conventional right ventricular pacing.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Cardiac & Cardiovascular Systems
Jiyi Liu, Fengzhi Sun, Zefeng Wang, Jiao Sun, Xue Jiang, Weilong Zhao, Zhipeng Zhang, Lu Liu, Shulong Zhang
Summary: In patients with heart failure eligible for cardiac resynchronization therapy (CRT), left bundle branch area pacing (LBBAP) showed significant improvements in QRS duration, left ventricular ejection fraction, left ventricular end-diastolic dimension, New York Heart Association class, and CRT response compared to biventricular pacing (BVP). The current evidence from non-randomized studies suggests that LBBAP is a promising method for CRT, offering more remarkable improvements in symptoms and cardiac function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Wen Zhuo, Xiaojie Zhong, Hualong Liu, Jianhua Yu, Qi Chen, Jinzhu Hu, Qinmei Xiong, Kui Hong
Summary: Comparing the pacing parameters and clinical outcomes between His bundle pacing (HBP) and left bundle branch pacing (LBBP), it was found that LBBP had higher implant success rates, lower capture thresholds, larger sensed R wave amplitudes, and greater reduction in QRS duration compared to HBP.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Physiology
Marina Strocchi, Karli Gillette, Aurel Neic, Mark K. Elliott, Nadeev Wijesuriya, Vishal Mehta, Edward J. Vigmond, Gernot Plank, Christopher A. Rinaldi, Steven A. Niederer
Summary: This study compared the electrical synchrony of conventional CRT, HBP, and LBP in RBBB patients and found that HBP significantly improved activation times for RBBB patients, while CRT and LBP were ineffective. Furthermore, the response to LBP improved when LBP was combined with anodal capture of the RV septum myocardium.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Rehan Mahmud, Eduardo Back Sternick, Damian Sanchez-Quintana, Yolanda Macias, Shakeel Muhammad Jamal, Beth Bailey, Ayush Mohan, Matthew T. Lee, Jenna E. Lee, Marcos Celio de Almeida, Robert H. Anderson
Summary: This study found that histologically specialised pathways connecting the branching component of the atrioventricular conduction axis with the crest of the muscular ventricular septum exist in about three-fourths of the histological datasets. By observing 34 patients undergoing His bundle pacing, it was found that the QRS complex closely resembled known conduction through fasciculo-ventricular pathways in 32 patients, with only two patients not showing a delta wave at any pacing voltages. Therefore, the conclusion was drawn that His bundle pacing can reveal fasciculo-ventricular pathways concealed during sinus rhythm.
Review
Cardiac & Cardiovascular Systems
Angela W. C. Lee, Caroline Mendonca Costa, Marina Strocchi, Christopher A. Rinaldi, Steven A. Niederer
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2018)
Article
Biophysics
Marina Strocchi, Matthias A. F. Gsell, Christoph M. Augustin, Orod Razeghi, Caroline H. Roney, Anton J. Prassl, Edward J. Vigmond, Jonathan M. Behar, Justin S. Gould, Christopher A. Rinaldi, Martin J. Bishop, Gernot Plank, Steven A. Niederer
JOURNAL OF BIOMECHANICS
(2020)
Article
Cardiac & Cardiovascular Systems
Marina Strocchi, Angela W. C. Lee, Aurel Neic, Julien Bouyssier, Karli Gillette, Gernot Plank, Mark K. Elliott, Justin Gould, Jonathan M. Behar, Baldeep Sidhu, Vishal Mehta, Martin J. Bishop, Edward J. Vigmond, Christopher A. Rinaldi, Steven A. Niederer
Article
Multidisciplinary Sciences
Marina Strocchi, Christoph M. Augustin, Matthias A. F. Gsell, Elias Karabelas, Aurel Neic, Karli Gillette, Orod Razeghi, Anton J. Prassl, Edward J. Vigmond, Jonathan M. Behar, Justin Gould, Baldeep Sidhu, Christopher A. Rinaldi, Martin J. Bishop, Gernot Plank, Steven A. Niederer
Article
Biology
Sofia Monaci, Marina Strocchi, Cristobal Rodero, Karli Gillette, John Whitaker, Ronak Rajani, Christopher A. Rinaldi, Mark O'Neill, Gernot Plank, Andrew King, Martin J. Bishop
COMPUTERS IN BIOLOGY AND MEDICINE
(2020)
Article
Biochemical Research Methods
Cristobal Rodero, Marina Strocchi, Maciej Marciniak, Stefano Longobardi, John Whitaker, Mark D. O'Neill, Karli Gillette, Christoph Augustin, Gernot Plank, Edward J. Vigmond, Pablo Lamata, Steven A. Niederer
Summary: This study investigates the impact of changes in cardiac anatomy on cardiac function, revealing that even shape components explaining a large amount of electromechanical function variance only explain a small amount of anatomical variance. This highlights the importance of high-fidelity anatomical models in cardiac simulations and demonstrates that subtle changes in cardiac anatomy can have a significant impact on function.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Biology
Angela W. C. Lee, Orod Razeghi, Jose Alonso Solis-Lemus, Marina Strocchi, Baldeep Sidhu, Justin Gould, Jonathan M. Behar, Mark Elliott, Vishal Mehta, Gernot Plank, Christopher A. Rinaldi, Steven A. Niederer
Summary: CRT in dyssynchronous heart failure patients is ineffective in 20-30% of cases. Non-invasive electrical and mechanical indices can predict optimal epicardial lead location, potentially reducing time, costs and risks to patients.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Biology
Cristobal Rodero, Marina Strocchi, Angela W. C. Lee, Christopher A. Rinaldi, Edward J. Vigmond, Gernot Plank, Pablo Lamata, Steven A. Niederer
Summary: Lead position plays a crucial role in the response to CRT in patients with HF, and MPP improves potential outcomes. By evaluating different pacing configurations, it was found that a single optimal lead design can achieve near-optimal results for most patients.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Engineering, Biomedical
Elias Karabelas, Stefano Longobardi, Jana Fuchsberger, Orod Razeghi, Cristobal Rodero, Marina Strocchi, Ronak Rajani, Gundolf Haase, Gernot Plank, Steven Niederer
Summary: Computational Fluid Dynamics (CFD) is used for designing artificial valves and planning procedures, but assessing overall cardiovascular function or predicting long-term outcomes requires comprehensive models. We created a validated patient-specific CFD model and used surrogate models for sensitivity analysis, finding preload to be the main driver of flow in the heart.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Cardiac & Cardiovascular Systems
Marina Strocchi, Karli Gillette, Aurel Neic, Mark K. Elliott, Nadeev Wijesuriya, Vishal Mehta, Edward J. Vigmond, Gernot Plank, Christopher A. Rinaldi, Steven A. Niederer
Summary: This study compared the electrical synchrony induced by different conduction system pacing (CSP) methods in patients. The results showed that severe left ventricular His-Purkinje conduction disease attenuated the benefits of CSP, but improvements were achieved with HOT-CRT and LOT-CRT. Patients with slower myocardium conduction velocity benefited more from CSP. Additionally, septal scar had no effect on CSP, while lateral wall scar made CSP ineffective.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Biology
Argyrios Petras, Matthias A. F. Gsell, Christoph M. Augustin, Jairo Rodriguez-Padilla, Alexander Jung, Marina Strocchi, Frits W. Prinzen, Steven A. Niederer, Gernot Plank, Edward J. Vigmond
Summary: Mechanoelectric feedback (MEF) in the heart operates through various mechanisms to regulate cardiac function, including the stretch activated channels (SACs) and tension dependence. SACs do not significantly affect mechanical response, while tension and shortening velocity have a bigger impact on stroke volume. MEF reduces heterogeneity in stretch and could potentially mitigate activation problems.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)