Review
Cardiac & Cardiovascular Systems
Alessio Gasperetti, Cynthia A. James, Marina Cerrone, Mario Delmar, Hugh Calkins, Firat Duru
Summary: Physical exercise can influence the progression and arrhythmia risk of arrhythmogenic right ventricular cardiomyopathy (ARVC), guidelines currently recommend individuals with ARVC to avoid competitive or high-intensity endurance exercise, as exercise-induced physiological changes may mimic classic features of ARVC.
EUROPEAN HEART JOURNAL
(2021)
Article
Medicine, General & Internal
Valentina A. Rossi, David Niederseer, Justyna M. Sokolska, Boldizsar Kovacs, Sarah Costa, Alessio Gasperetti, Corinna Brunckhorst, Deniz Akdis, Felix C. Tanner, Firat Duru, Christian M. Schmied, Ardan M. Saguner
Summary: This study proposed a new diagnostic score based on atrial dimensions and other readily available parameters to differentiate between ARVC and athlete's heart, showing good diagnostic accuracy comparable to the 2010 Task Force Criteria (TFC). ARVC patients had larger right atrium dimensions and higher RAVI/LAVI ratio compared to athletes, highlighting the usefulness of atrial dimensions in distinguishing between the two conditions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Chiara Cappelletto, Caterina Gregorio, Giulia Barbati, Simona Romani, Antonio De Luca, Marco Merlo, Luisa Mestroni, Davide Stolfo, Gianfranco Sinagra
Summary: The study found that in ARVC patients with long-term follow-up, only beta-blockers administered at >50% target dose were associated with lower risk of SCD/recurrent MVA.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kerstin Boengler, Susanne Rohrbach, Norbert Weissmann, Rainer Schulz
Summary: This article focuses on the importance of connexin 43 (Cx43) for the developing heart, discussing its expression and localization in diseased right ventricle (RV) conditions such as tetralogy of Fallot and pulmonary hypertension. Other connexin molecules involved in RV pathophysiology are also introduced, along with therapeutic strategies aiming to improve RV function in pulmonary hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Emilio A. Mendiola, Denielli da Silva Goncalves Bos, Dana M. Leichter, Alexander Vang, Peng Zhang, Owen P. Leary, Richard J. Gilbert, Reza Avazmohammadi, Gaurav Choudhary
Summary: This study investigated the effect of architectural remodeling on right ventricular (RV) adaptation in pulmonary hypertension (PH) using two rodent models. The results showed that in rats with mild RV maladaptation, there was a decrease in fiber orientation helical range in the RV free wall, preserved global circumferential strain, and less reduction in RV-pulmonary arterial coupling. These findings suggest that adaptive RV architectural remodeling could improve RV function in PH.
CIRCULATION-HEART FAILURE
(2023)
Article
Critical Care Medicine
Michael J. Lanspa, Meghan M. Cirulis, Brandon M. Wiley, Troy D. Olsen, Emily L. Wilson, Sarah J. Beesley, Samuel M. Brown, Eliotte L. Hirshberg, Colin K. Grissom
Summary: This study found that right ventricular dysfunction is common in septic patients and is associated with over threefold higher 28-day mortality. LV systolic dysfunction, on the other hand, was not found to be significantly associated with increased mortality.
Article
Cardiac & Cardiovascular Systems
Catherine G. Ireland, Rachel L. Damico, Todd M. Kolb, Stephen C. Mathai, Monica Mukherjee, Stefan L. Zimmerman, Ami A. Shah, Fredrick M. Wigley, Brian A. Houston, Paul M. Hassoun, David A. Kass, Ryan J. Tedford, Steven Hsu
Summary: The study found that measuring RV contractile reserve during exercise by changes in RV Ees and dilation can better predict occult RV dysfunction, with RV ejection fraction during exercise proving to be a robust surrogate. This parameter was found to predict clinical outcomes more effectively than resting measures of RV function.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Carolina M. S. Messina, Eloara V. M. Ferreira, Inderjit Singh, Angelo X. C. Fonseca, Roberta P. Ramos, Luiz E. Nery, David M. Systrom, Rudolf K. F. Oliveira, Jaquelina S. Ota-Arakaki
Summary: The study revealed that peak RV stroke work index and Delta PA compliance significantly influence pVO2 in patients with idiopathic pulmonary arterial hypertension, highlighting the crucial role of hemodynamic coupling to exercise capacity in IPAH.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Lucas H. Wilson, Shahryar M Chowdhury, Lanier B. Jackson
Summary: A study found that there is QRS complex fragmentation in patients with Fontan anatomy. This fragmentation is associated with invasive hemodynamic markers of ventricular performance, but not with CPET performance. On the other hand, QRS prolongation may be a better predictor of exercise function following Fontan.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Julia Cadrin-Tourigny, Laurens P. Bosman, Anna Nozza, Weijia Wang, Rafik Tadros, Aditya Bhonsale, Mimount Bourfiss, Annik Fortier, Oyvind H. Lie, Ardan M. Saguner, Anneli Svensson, Antoine Andorin, Crystal Tichnell, Brittney Murray, Katja Zeppenfeld, Maarten P. van den Berg, Folkert W. Asselbergs, Arthur A. M. Wilde, Andrew D. Krahn, Mario Talajic, Lena Rivard, Stephen Chelko, Stefan L. Zimmerman, Ihab R. Kamel, Jane E. Crosson, Daniel P. Judge, Sing-Chien Yap, Jeroen F. van der Heijden, Harikrishna Tandri, Jan D. H. Jongbloed, Marie-Claude Guertin, J. Peter van Tintelen, Pyotr G. Platonov, Firat Duru, Kristina H. Haugaa, Paul Khairy, Richard N. W. Hauer, Hugh Calkins, Anneline S. J. M. te Riele, Cynthia A. James
Summary: We developed a prediction model for incident VA/SCD in ARVC patients using readily available clinical parameters, which accurately distinguished patients with and without events and showed superior clinical benefit compared to current ICD placement algorithms.
EUROPEAN HEART JOURNAL
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Masanori Hirota, Takanori Suezawa, Yasuyuki Kobayashi, Takuya Kawabata, Yosuke Kuroko, Yasuhiro Kotani, Hiroshi Ito, Shingo Kasahara
Summary: Primary cardiac tumors can occur in any location of the right and left cardiac chambers, and complete excision is generally recommended to minimize functional deterioration post-surgery. This case report discusses details of preserving right ventricular volume and tricuspid valve function during surgery for an endocardial hemangioma on the free wall of the right ventricle.
ANNALS OF THORACIC SURGERY
(2021)
Article
Medicine, General & Internal
Federica Ilardi, Mario Crisci, Cecilia Calabrese, Anna Scognamiglio, Fortunato Arenga, Rachele Manzo, Domenica F. Mariniello, Valentino Allocca, Anna Annunziata, Antonello D'Andrea, Raffaele Merenda, Vittorio Monda, Giovanni Esposito, Giuseppe Fiorentino
Summary: The aim of this study was to investigate subclinical cardiac dysfunction in recovered COVID-19 patients with a history of pulmonary embolism (PE). The study included 44 patients without known cardiopulmonary disease and divided them into two groups based on PE diagnosis. The results showed a significant reduction in right-ventricle global longitudinal strain (RV-GLS) and RV free wall longitudinal strain (RV-FWLS) in PE+ patients compared to PE- patients. RV-FWLS < 21% was independently associated with COVID-related PE.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Paloma Jorda, Laurens P. Bosman, Alessio Gasperetti, Andrea Mazzanti, Jean-Baptiste Gourraud, Brianna Davies, Tanja Charlotte Frederiksen, Zoraida Moreno Weidmann, Andrea Di Marco, Jason D. Roberts, Ciorsti MacIntyre, Colette Seifer, Antoine Deliniere, Wael Alqarawi, Deni Kukavica, Damien Minois, Alessandro Trancuccio, Marine Arnaud, Mattia Targetti, Annamaria Martino, Giada Oliviero, Daniel C. Pipilas, Corrado Carbucicchio, Paolo Compagnucci, Antonio Dello Russo, Iacopo Olivotto, Leonardo Calo, Steven A. Lubitz, Michael J. Cutler, Philippe Chevalier, Elena Arbelo, Silvia Giuliana Priori, Jeffrey S. Healey, Hugh Calkins, Michela Casella, Henrik Kjaerulf Jensen, Claudio Tondo, Rafik Tadros, Cynthia A. James, Andrew D. Krahn, Julia Cadrin-Tourigny
Summary: This study validated a 5-year risk prediction model for ARVC patients, demonstrating its superior performance in guiding ICD implantation decisions compared to other published guidelines and consensus statements. The findings support the use of this model for shared decision making in the primary prevention of SCD in ARVC patients.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Alessio Gasperetti, Rita Sicuso, Antonio Dello Russo, Giulio Zucchelli, Ardan Muammer Saguner, Pasquale Notarstefano, Ezio Soldati, Maria Grazia Bongiorni, Domenico Giovanni Della Rocca, Sanghamitra Mohanty, Corrado Carbucicchio, Firat Duru, Luigi Di Biase, Andrea Natale, Claudio Tondo, Michela Casella
Summary: RFCA is an effective treatment for PVCs, with AI guidance showing better arrhythmic outcomes at 6 months follow-up for RVOT idiopathic PVCs.
Article
Cardiac & Cardiovascular Systems
Tomio Tran, Akshay Muralidhar, Kendall Hunter, Cullen Buchanan, Greg Coe, Michinari Hieda, Christine Tompkins, Matthew Zipse, Melanie J. Spotts, Stephanie G. Laing, Kristina Fosmark, Jordan Hoffman, Amrut V. Ambardekar, Eugene E. Wolfel, Justin Lawley, Benjamin Levine, Wendy M. Kohrt, Jay Pal, William K. Cornwell
Summary: The study showed that patients with CF-LVAD have limited right ventricular contractile reserve during exercise, marked elevations in pulmonary, left-sided filling, and right-sided filling pressures, and severe ventilatory inefficiency.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Sport Sciences
Giulia Quinto, Daniel Neunhaeuserer, Andrea Gasperetti, Francesca Battista, Giulia Foccardi, Veronica Baioccato, Stefano Gobbo, Marco Bergamin, Andrea Ermolao
Summary: This study compared the effects of submaximal Harvard Step Test (HST) with incremental Maximal Exercise Test (MET) on inducing and detecting arrhythmias in younger athletes. It found that MET induced more arrhythmias than HST, regardless of the test phase. Higher test intensity and longer exercise duration in MET might contribute to its higher arrhythmogenicity.
RESEARCH IN SPORTS MEDICINE
(2023)
Article
Sport Sciences
Silvia Giagio, Stefano Salvioli, Tiziano Innocenti, Giulia Gava, Marco Vecchiato, Paolo Pillastrini, Andrea Turolla
Summary: This study developed a screening tool for pelvic floor dysfunction in female athletes and established a set of symptoms and items to guide specialist care. The tool is valuable for assessing female athletes and identifying and managing PFD at an early stage. Despite an increase in awareness, barriers to identifying PFD still exist.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Endocrinology & Metabolism
Marco Vecchiato, Giulia Quinto, Daniel Neunhaeuserer, Francesca Battista, Silvia Bettini, Andrea Gasperetti, Roberto Vettor, Luca Busetto, Andrea Ermolao
Summary: Obesity is associated with a higher risk of cardiac arrhythmias. Sleeve gastrectomy (SG) may increase the risk of exercise-induced arrhythmias in the early post-surgical phase, but it does not seem to increase the occurrence of arrhythmias in the long-term.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Review
Medicine, General & Internal
Marco Vecchiato, Emanuele Zanardo, Francesca Battista, Giulia Quinto, Chiara Bergia, Stefano Palermi, Federica Duregon, Andrea Ermolao, Daniel Neunhaeuserer
Summary: This study investigated the effect of different exercise training modalities and intensities on irisin concentration in patients with type 2 diabetes. The results showed that high-intensity exercise training was more effective in increasing irisin secretion. Based on limited evidence, high-intensity training is suggested as a valid exercise training to increase circulating irisin in patients with type 2 diabetes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Paolo Palatini, Lucio Mos, Francesca Saladini, Olga Vriz, Claudio Fania, Andrea Ermolao, Francesca Battista, Marcello Rattazzi
Summary: The aim of this study was to investigate the reproducibility of white-coat hypertension (WCH) and its predictive capacity for hypertension needing antihypertensive treatment (HT) in young to middle-age subjects. The results showed that WCH has limited reproducibility, and the risk of future hypertension increased when diagnosed with two sets of blood pressure measurements instead of one.
Review
Sport Sciences
Agostino Rossoni, Marco Vecchiato, Erica Brugin, Eliana Tranchita, Paolo Emilio Adami, Manuela Bartesaghi, Elena Cavarretta, Stefano Palermi
Summary: Recently, eSports has emerged as a popular form of new media, thanks to the widespread availability of games and online technologies. Despite ongoing discussions about its definition, eSports athletes undergo rigorous training, compete in tournaments, and must follow rules set by governing bodies, just like traditional athletes. However, like any competitive discipline, eSports players are susceptible to injuries related to their sedentary lifestyle, improper posture, prolonged screen time, and repetitive movements. This paper highlights the importance of conducting pre-participation evaluations and implementing effective injury prevention strategies for professional eSports athletes.
Article
Medicine, General & Internal
Paolo Palatini, Lucio Mos, Francesca Saladini, Olga Vriz, Claudio Fania, Andrea Ermolao, Francesca Battista, Mattia Canevari, Marcello Rattazzi
Summary: The aim of this study was to evaluate the association between alcohol and smoking and cardiovascular and renal events, and to investigate the impact of moderate and heavy alcohol consumption on this association. The findings showed that smoking had a detrimental effect on cardiovascular and renal events in alcohol drinkers, but not in abstainers. There was a synergistic effect between smoking and alcohol use, and this was seen in both moderate and heavy alcohol consumers.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Marco Vecchiato, Sara Faggian, Giulia Quinto, Francesca Battista, Mirto Foletto, Angelo Di Vincenzo, Silvia Bettini, Andrea Gasperetti, Luca Busetto, Andrea Ermolao, Daniel Neunhaeuserer
Summary: This study analyzed the impact of sleeve gastrectomy (SG) on walking economy in subjects with severe obesity. It found that after the surgery, patients experienced weight loss, decreased energy expenditure during walking, and improved walking economy, which facilitated daily routines and increased physical activity.
Article
Pediatrics
Marco Vecchiato, Andrea Ermolao, Emanuele Zanardo, Francesca Battista, Giacomo Ruvoletto, Stefano Palermi, Giulia Quinto, Gino Degano, Andrea Gasperetti, Massimo A. Padalino, Giovanni Di Salvo, Daniel Neunhaeuserer
Summary: This study investigates the overshoot of respiratory exchange ratio (RER) after exercise in young patients with congenital heart disease (CHD) and compares it with healthy controls. The results show that CHD patients have a lower magnitude of RER overshoot, indicating reduced cardiorespiratory fitness. Therefore, RER overshoot should be included as part of routine exercise testing in CHD patients to improve prognostic risk stratification accuracy.
Article
Endocrinology & Metabolism
Giulia Quinto, Silvia Bettini, Daniel Neunhaeuserer, Francesca Battista, Gabriella Milan, Andrea Gasperetti, Marco Vecchiato, Roberto Vettor, Andrea Ermolao, Luca Busetto
Summary: The aim of this study was to assess the modifications in EOSS and EOSS-CRF before and after bariatric surgery (BS). The study found that after BS, there was a significant reduction in the number of patients classified as severely obese. Using EOSS, the percentage of patients without functional impairment increased from 61% before surgery to 69% after BS. Using EOSS-CRF, the percentage of patients considered without functional impairment increased from 9.7% before BS to 50% after BS. This study suggests that objective measurements of CRF can provide additional value in assessing the severity of obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Sport Sciences
Juergen M. Steinacker, Willem van Mechelen, Wilhelm Bloch, Mats Boerjesson, Maurizio Casasco, Bernd Wolfarth, Carolin Knoke, Theodora Papadopoulou, Janine Wendt, Hashel Al Tunaiji, Dietrich Andresen, Olena Andrieieva, Norbert Bachl, Victoriya Badtieva, Friedhelm J. Beucher, Cheri A. Blauwet, Jose-Antonio Casajus Mallen, Ju-Ho Chang, German Clenin, Naama Constantini, Demitri Constantinou, Luigi Di Luigi, Lukas Declercq, Stephane Doutreleau, Svitlana Drozdovska, Martine Duclos, Andrea Ermolao, Thomas Fischbach, Anastasia N. Fischer, Chiara Fossati, Jeorge Franchella, Mark Fulcher, Jan C. Galle, Christian Gerloff, Evelina Georgiades, Boris Gojanovic, Marcela Gonzalez Gross, Andy Grote, Martin Halle, Hans Hauner, Matthew Payton Herring, Mikio Hiura, Kerstin Holze, Gerhard Huber, David Hughes, Mark R. Hutchinson, Anca Ionescu, Dina Christina Janse van Rensburg, Anna Jegier, Natasha Jones, Kirsten Kappert-Gonther, Monika Kellerer, Yutaka Kimura, Agrita Kiopa, Bernd Kladny, Gerhard Koch, Elin Kolle, Greg Kolt, Yiannis Koutedakis, Stephan Kress, Susi Kriemler, Jens Kroeger, Christian Kuhn, Roman Laszlo, Ralph Lehnert, Francois J. Lhuissier, Kerstin Luedtke, Shigeru Makita, Pedro Manonelles Marqueta, Winfried Maerz, Kirill Micallef-Stafrace, Mike Miller, Melita Moore, Erich Mueller, Danie Neunhaeuserer, I. Renay Onur, Vahur Oeoepik, Malgorzata Perl, Anastassios Philippou, Hans-Georg Predel, Sebastien Racinais, Algirdas Raslanas, Ruediger Reer, Klaus Reinhardt, Claus Reinsberger, Sandra Rozenstoka, Robert Sallis, Luis B. Sardinha, Martin Scherer, Jasper Schipperijn, Romain Seil, Benedict Tan, Arno Schmidt-Trucksaess, Nils Schumacher, Bernhard Schwaab, Ansgar Schwirtz, Masato Suzuki, Jeroen Swart, Ralph Tiesler, Ulf Tippelt, Eleanor Tillet, Jane Thornton, Bulent Ulkar, Eve Unt, Evert Verhagen, Thomas Weikert, Roberto Vettor, Sheng Zeng, Richard Budgett, Lars Engebretsen, Ugur Erdener, Fabio Pigozzi, Yannis P. Pitsiladis
Summary: Non-communicable diseases, such as coronary heart disease and diabetes, are increasing worldwide due to a lack of physical activity. This leads to negative health outcomes and economic burdens. To address this issue, the 'Hamburg Declaration' was signed, aiming to promote physical activity and improve individual and community health.
BMJ OPEN SPORT & EXERCISE MEDICINE
(2023)
Article
Medicine, General & Internal
Francesca Battista, Daniel Neunhaeuserer, Anna Centanini, Andrea Gasperetti, Giulia Quinto, Marco Vecchiato, Elia Bianchi, Anna Chiara Frigo, Silvia Bettini, Roberto Vettor, Luca Busetto, Andrea Ermolao
Summary: Cardiorespiratory fitness (CRF) is significantly related to morbidity and mortality in patients with obesity. This study shows that age and BMI are independent determinants of CRF in obese patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Psychology, Clinical
Margherita Bertuccelli, Maria Rubega, Francesca Cantele, Claudia Favero, Andrea Ermolao, Emanuela Formaggio, Stefano Masiero
Summary: This study aimed to investigate the cognitive processes involved in body image disorders in adolescents with idiopathic scoliosis. The results showed attentional biases towards disease-relevant body parts and a tendency for body dissatisfaction in scoliosis patients.
EUROPEAN JOURNAL OF INVESTIGATION IN HEALTH PSYCHOLOGY AND EDUCATION
(2023)
