Article
Materials Science, Multidisciplinary
Avinash Sharma, Kanika Dulta, Rupak Nagraik, Kamal Dua, Sachin K. Singh, Dinesh K. Chellappan, Deepak Kumar, Dong-Soo Shin
Summary: Cancer is a deadly disease that affects people worldwide, with late-stage diagnosis being a major challenge. Developing early and sensitive cancer diagnostics is crucial, and aptasensors have shown promise as a potentially important tool.
Review
Chemistry, Analytical
Somayeh Vandghanooni, Zohreh Sanaat, Raheleh Farahzadi, Morteza Eskandani, Hossein Omidian, Yadollah Omidi
Summary: Early diagnosis of cancer is crucial, and aptamer-based biosensors have been developed as reliable tools for detecting various cancer markers, increasing the chances of successful treatment.
MICROCHEMICAL JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Ethan Hau Yin Lam, Fengqing Yu, Sabrina Zhu, Zongjie Wang
Summary: In the past decade, personalized medicine has made significant progress in addressing patient-specific disease complexities and developing individualized treatment strategies. The emergence of 3D bioprinting has provided novel opportunities for personalized medicine, although current bioprinted constructs have limitations in achieving anatomically realistic organs with mature biological functions. This review discusses the principles and realizations of bioprinting, focusing on techniques such as extrusion printing and digital light processing (DLP). It also explores the applications of bioprinted constructs in regenerative medicine and drug discovery. Despite the challenges, bioprinting shows promise as an empowering technology to overcome critical obstacles in personalized medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Analytical
Gabriela Palavicini
Summary: Technology has enabled the integration of artificial intelligence into medicine, allowing for the identification of health issues, improvement of overall health, and prevention of diseases through intelligent devices. The use of sensor-based monitoring and disease diagnosis has brought about a shift towards prevention rather than solely focusing on healing in medical practices.
Review
Chemistry, Analytical
Yuqiao Liu, Junmin Li, Shenghao Xiao, Yanhui Liu, Mingxia Bai, Lixiu Gong, Jiaqian Zhao, Dajing Chen
Summary: Precision medicine is essential for optimizing drug dosage and minimizing toxicity. Wearable sensors offer real-time and continuous drug monitoring, enabling personalized medicine and reducing healthcare costs.
Article
Chemistry, Analytical
Perrine Lasserre, Banushan Balansethupathy, Vincent J. Vezza, Adrian Butterworth, Alexander Macdonald, Ewen O. Blair, Liam McAteer, Stuart Hannah, Andrew C. Ward, Paul A. Hoskisson, Alistair Longmuir, Steven Setford, Eoghan C. W. Farmer, Michael E. Murphy, Harriet Flynn, Damion K. Corrigan
Summary: Diagnostic practices for SARS-CoV-2 involve qPCR-based nucleic acid amplification or antigen-based tests. qPCR has high sensitivity but is time-consuming and requires expensive equipment and expertise. LFAs are low-cost and near real-time, but have lower sensitivity and are mostly qualitative. This study presents an antigen-based electrochemical aptamer sensor that can quickly detect SARS-CoV-2 in a simple measurement format.
ANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Environmental
Paulo A. Raymundo-Pereira, Nathalia O. Gomes, Sergio A. S. Machado, Osvaldo N. Oliveira Jr
Summary: This paper reports on wearable glove-embedded sensors for non-invasive and selective determination of therapeutic drugs and biomarkers in sweat samples. The sensors showed high sensitivity and selectivity, as well as robustness against multiple flexion cycles.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Rannissa Puspita Jayanti, Nguyen Phuoc Long, Nguyen Ky Phat, Yong-Soon Cho, Jae-Gook Shin
Summary: To control the growing number of drug-resistant TB cases, innovative approaches like precision dosing and TDM play a crucial role in adjusting drug doses for improved treatment outcomes. These tools are particularly important for patients with complex comorbidities and high risk of treatment failure.
Article
Chemistry, Multidisciplinary
Nathalia O. O. Gomes, Paulo A. A. Raymundo-Pereira
Summary: Paracetamol is recommended by WHO as the main non-opioid analgesic for mild pain, but high levels of its use can cause hepatotoxicity and nephrotoxicity. This study developed a sensor on a polyester substrate to detect paracetamol levels in human saliva, showing interference-free results. The sensor can be used as a disposable device to quickly detect paracetamol in untreated raw saliva, enabling personalized therapy by tracking the active substance and preventing overdoses and side effects.
Review
Microbiology
Ziqian Huang, Xin Yu, Qingli Yang, Ying Zhao, Wei Wu
Summary: Staphylococcus aureus is a common pathogen causing epidemics and food poisoning, and the authentication of which is crucial for both pathologic diagnosis and food hygiene supervision. Various biosensor methods, including optical and electrochemical aptasensors, have been established for the identification of S. aureus. The future challenges lie in the feasibility of S. aureus detection and the trend of combining aptasensors with nanomaterials.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Environmental Sciences
Swathi Satish, Aayush Dey, Maithri Tharmavaram, Nitasha Khatri, Deepak Rawtani
Summary: The long-term effects of pharmaceutical residues on wildlife are still not fully understood, but quick and reliable methods for their detection are needed. Aptasensors, based on biological recognition, are highly specific and have the potential to be used for the detection of pharmaceutical residues in wildlife.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Chemistry, Analytical
Kamila Malecka, Edyta Mikula, Elena E. Ferapontova
Summary: The improvement in outcomes for various types of cancer in recent years is attributed to early tumor detection and widespread use of screening tests, with non-invasive, fast, and accurate diagnostic devices playing a crucial role. Biosensors utilizing aptamers in cancer diagnosis offer advantages such as in-vitro aptamer production, cost-effective chemical synthesis, and thermal stability, while electrochemical biosensing approaches provide sensitive, accurate, and affordable sensing methods. This review evaluates the design strategies and analytical performance of electrochemical aptamer-based biosensors for cancer diagnosis, highlighting their future prospects in cancer diagnostics.
Review
Biochemical Research Methods
Florence Anne Castelli, Giulio Rosati, Christian Moguet, Celia Fuentes, Jose Marrugo-Ramirez, Thibaud Lefebvre, Herve Volland, Arben Merkoci, Stephanie Simon, Francois Fenaille, Christophe Junot
Summary: Metabolomics involves detecting, quantifying, and analyzing small molecules in biological samples on a large scale. While it has shown relevance for patient stratification in research projects and clinical studies, challenges related to standardization, metabolite identification, and data processing hinder its implementation in clinical practice, especially in personalized medicine. Streamlining complex molecular signatures and improving interoperability of data are crucial for the future integration of metabolomics into healthcare.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Review
Cell Biology
Jia-Mei Dong, Rui-Qi Wang, Ning-Ning Yuan, Jia-Hao Guo, Xin-Yang Yu, Ang-Hui Peng, Jia-Yi Cai, Lei Xue, Zhi-Ling Zhou, Yi-Hao Sun, Ying-Yin Chen
Summary: Hepatocellular carcinoma (HCC), accounting for 90% of all primary liver cancers, is a major malignancy globally. Aptasensors, known for their high sensitivity, excellent selectivity, and low production costs, have attracted attention for the diagnosis and surveillance of HCC. Optical aptasensors, offering advantages of a wide range of targets, rapid response, and simple instrumentation, show great potential in early diagnosis and prognosis monitoring of HCC. This review summarizes recent progress in various types of optical aptasensors for biomarkers in HCC, evaluates their strengths and limitations, and discusses the challenges and future perspectives for their use in HCC diagnosis and surveillance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Microbiology
Lightson Ngashangva, Santanu Chattopadhyay
Summary: The gastrointestinal microbiota plays a crucial role in maintaining human health, and dysbiosis is associated with various diseases. Therefore, monitoring the composition and interactions of the gut microbiota is important for health information and disease predisposition. Early detection of pathogens and quantifying beneficial microbial strains is essential in preventing dysbiosis. However, routine monitoring of gut microbiota health is currently limited by conventional methods.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Walhan Alshaer, Hamdi Nsairat, Zainab Lafi, Omar M. Hourani, Abdulfattah Al-Kadash, Ezaldeen Esawi, Alaaldin M. Alkilany
Summary: Nanomedicine is a growing field and liposomal formulations are a major platform in this field. Quality by design (QbD) is a powerful approach that can be applied to develop liposomal-based nano-pharmaceuticals, ensuring efficient and safe therapeutics. This review discusses the current practices of employing QbD in this area.
Article
Pharmacology & Pharmacy
Mais M. Saleh, Raghad M. Abuhamdan, Walhan Alshaer, Marzouq Amarin, Hiba Abdelnabi, Maram Abdaljaleel, Kholoud Friehat, Salah Aljamal, Samer M. Najjar, Saja H. Hamed
Summary: Long-term exposure to solar radiation can cause skin damage, which can be prevented by topically applying alpha-tocopherol phosphate (alpha-TP). This study aimed to develop various formulations of alpha-TP and investigate their effects on membrane diffusion and human skin permeation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Medicine, Research & Experimental
Mohamed El-Tanani, Hamdi Nsairat, Alaa A. Aljabali, Angel Serrano-Aroca, Vijay Mishra, Yachana Mishra, Gowhar A. Naikoo, Walhan Alshaer, Murtaza M. Tambuwala
Summary: The mammalian target of rapamycin (mTOR), a signalling system, is necessary for various cell proliferation activities. It recognizes PI3KAKT stress signals as a serine-threonine kinase. The abnormal regulation of mTOR pathway has been proven to be crucial in cancer growth and advancement. This review primarily discusses the normal functions of mTOR as well as its abnormal roles in cancer development.
Review
Medicine, General & Internal
Mohammad A. I. Al-Hatamleh, Mai A. Abusalah, Ma'mon M. Hatmal, Walhan Alshaer, Suhana Ahmad, Manali H. Mohd-Zahid, Engku Nur Syafirah E. A. Rahman, Chan Y. Yean, Iskandar Z. Alias, Vuk Uskokovic, Rohimah Mohamud
Summary: Unlike previous pandemics, the outbreak of COVID-19 spread rapidly worldwide and was met with different control measures. The lack of understanding of the fundamental nature of the outbreak continues to challenge healthcare practitioners and scientists. This review discusses the challenges in managing COVID-19 and emphasizes the need for better understanding of this pandemic.
JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES
(2023)
Review
Chemistry, Applied
Hamdi Nsairat, Zainab Lafi, Mazen Al-Sulaibi, Lobna Gharaibeh, Walhan Alshaer
Summary: Nanotechnology has significant potential in enhancing the properties and applications of phyto-bioactive compounds (PBCs) in the field of nutraceuticals and food. By encapsulating PBCs into suitable nanocarriers, their solubility and stability can be improved, thus increasing their bioavailability and targeted delivery.
Article
Pharmacology & Pharmacy
Fedaa Adaileh, Walhan Alshaer, Hamdi Nsairat, Dana A. Alqudah, Suha Wehaibi, Fadwa Daoud, Rula Al-Buqain, Shrouq Alsotari, Abeer Al Bawab, Fadwa Odeh
Summary: In this study, a nanocarrier for curcumin was successfully developed, which exhibited enhanced physiochemical characteristics. The results demonstrated that the nanocarrier improved cellular uptake and therapeutic efficacy of curcumin, and showed good thermal and colloidal stability. It also exhibited excellent wound healing and anti-inflammatory potential.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hamdi Nsairat, Mazen Al-Sulaibi, Walhan Alshaer
Summary: This study developed self-assembled nanostructures of Edelfosine (EDL) and Fulvestrant (FUL) with high encapsulation efficiency and stability in aqueous suspension. The selected nanostructures were characterized and evaluated for their cytotoxicity and cellular uptake against breast cancer cell lines. The results showed that the nanostructures exhibited improved antitumor activity and could be a promising platform for delivering both drugs.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hamdi Nsairat, Abed Alqader Ibrahim, Areej M. Jaber, Sharif Abdelghany, Randa Atwan, Naeem Shalan, Hiba Abdelnabi, Fadwa Odeh, Mohamed El-Tanani, Walhan Alshaer
Summary: This review aims to provide a perspective and a clear understanding of the main factors regulating the colloidal and bilayer stability of liposomes, with a focus on the role of cholesterol and its potential alternatives. Furthermore, strategies for achieving more stable in vitro and in vivo liposomes with improved drug release and encapsulation efficiencies are analyzed.
JOURNAL OF LIPOSOME RESEARCH
(2023)
Article
Medicine, Research & Experimental
Mohamed El-Tanani, Angela Platt-Higgins, Hamdi Nsairat, Ismail I. Matalka, Khaled Abdul-Aziz Ahmed, Shu-Dong Zhang, Walhan Alshaer, Abdalla Awidi, Kyle B. Matchett, Alaa A. Aljabali, Vijay Mishra, Angel Serrano-Aroca, Murtaza M. Tambuwala, Philip S. Rudland
Summary: This research finds that the expression of Ran is associated with survival, metastasis, and relapse in breast cancer patients, suggesting it as a unique biomarker for prognosis and diagnosis.
Correction
Medicine, Research & Experimental
Mohamed El-Tanani, Angela Platt-Higgins, Hamdi Nsairat, Ismail I. Matalka, Khaled Abdul-Aziz Ahmed, Shu-Dong Zhang, Walhan Alshaer, Abdalla Awidi, Kyle B. Matchett, Alaa A. Aljabali, Vijay Mishra, Angel Serrano-Aroca, Murtaza M. Tambuwala, Philip S. Rudland
Article
Multidisciplinary Sciences
Zainab Lafi, Walhan Alshaer, Lobna Gharaibeh, Dana A. Alqudah, Baidaa Alquaissi, Banan Bashaireh, Abed Alqader Ibrahim
Summary: Disulfiram and hydralazine have been found to have anti-cancer effects and have been repositioned as adjuvants in cancer therapy. This study evaluated the triple combination of doxorubicin, hydrazine, and disulfiram against wild-type and doxorubicin-resistant MCF-7 breast cancer cells. The results showed that the triple combination reduced drug resistance and enhanced chemosensitivity to doxorubicin in the cancer cells.
Article
Biochemical Research Methods
Hamdi Nsairat, Walhan Alshaer, Zainab Lafi, Somaya Ahmad, Alaa Al-Sanabrah, Mohamed El-Tanani
Summary: This study developed and validated an HPLC technique for the determination of fulvestrant and disulfiram in liposomes. The method showed specificity, linearity, precision, and accuracy, making it suitable for simultaneous determination of the two drugs. The study also found high encapsulation efficiencies, indicating improved anticancer potential.
