Article
Endocrinology & Metabolism
Anastasia Gant Kanegusuku, Katherine A. Araque, Hung Nguyen, Bin Wei, Saman Hosseini, Steven J. Soldin
Summary: The study evaluated the impact of abnormal concentrations of specific binding proteins (BPs) on immunoassay (IA) measurements of thyroid hormones. Results showed significant differences between IA and LC-MS/MS measurements of T3, FT3, and cortisol when TBG or CBG concentrations were low or high, indicating potential inaccuracies in diagnosis and treatment due to the influence of BP concentrations.
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Chemistry, Medicinal
Dorina Cibotaru, Marie N. Celestin, Michael P. Kane, Florin M. Musteata
Summary: The study aimed to develop new methods for measuring the free concentration, total concentration, and plasma binding capacity of compounds in samples, which were validated by analyzing clinical and known concentration samples. The methods using labeled compound addition were found to be the fastest and most reproducible. Microextraction-based methods showed higher sensitivity and accuracy for clinical samples compared to ultrafiltration-based methods. Overall, the new approach provides more information from samples and has great potential for personalized drug dosage and therapy for individual patients.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Jiang-Nan Wu, Faustino R. Perez-Lopez, Ting Peng, Feng Xie, Ming-Qing Li
Summary: This hospital-based cohort study aimed to assess the association between free triiodothyronine (FT3) and total triiodothyronine (TT3) levels in early pregnancy and the risk of gestational diabetes mellitus (GDM), as well as determine appropriate TT3 thresholds for GDM screening. A total of 27,184 pregnant women underwent a universal thyroid function test before 24 weeks of gestation, and 3,073 GDM cases were diagnosed using an oral glucose tolerance test. Logistic regression analysis revealed a nonlinear association between maternal high FT3 and TT3 levels in early pregnancy and the subsequent risk of GDM. The study findings provide insights for early detection and potential prevention of GDM.
ENDOCRINE PRACTICE
(2023)
Article
Medical Laboratory Technology
Christy Salameh, Anis Al Achkar, Joelle El Boustany, Ghassan Sleilaty, Marie-Helene Gannage-Yared
Summary: This study aimed to establish reference intervals for thyroid function tests in the Lebanese population, finding significant differences compared to manufacturer recommendations, especially in TSH, FT4, TT3, and FT3. Higher TT3 and FT3 levels were observed in men compared to women, with FT4 and FT3 decreasing with age.
ANNALS OF CLINICAL BIOCHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Valerie Anne Galton, Arturo Hernandez
Summary: This article explores the importance of thyroid hormone metabolism and its role in maintaining hormone balance, emphasizing that thyroid hormone metabolism is not solely for degradation and elimination but plays a crucial role in regulating various organs and tissues.
Review
Endocrinology & Metabolism
Nilkanta Chakrabarti, Pradip K. Sarkar, Arun K. Ray, Joseph V. Martin
Summary: This article provides a comprehensive review of the contributions and studies in the field of nongenomic actions of thyroid hormones in the adult mammalian brain, focusing on the work of Mary B. Dratman and other researchers. The research findings suggest that thyroid hormones and their derivatives have direct actions at synaptic regions, which may contribute to the physiological and pathophysiological roles of thyroid hormone in psychobehavioral control. However, further studies are needed to understand the exact mode of nongenomic actions of thyroid hormones in the adult mammalian brain.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Carmen Sydlik, Ilja Dubinski, Susanne Bechtold, Heinrich Schmidt
Summary: Thyroid-stimulating hormone is commonly used to evaluate thyroid function, but relying solely on this hormone may be misleading. This study found that the free triiodothyronine/free-thyroxine ratio is significantly lower in children with congenital hypothyroidism, primarily due to higher levels of free thyroxine.
ENDOCRINE CONNECTIONS
(2022)
Article
Endocrinology & Metabolism
Carmen Sydlik, Ilja Dubinski, Susanne Bechtold, Heinrich Schmidt
Summary: This study compared the thyroid function parameters of children with congenital hypothyroidism and healthy children, finding significantly lower free triiodothyronine/free thyroxine ratios in the former group.
ENDOCRINE CONNECTIONS
(2022)
Article
Medicine, General & Internal
Yuji Shimizu, Shin-Ya Kawashiri, Yuko Noguchi, Seiko Nakamichi, Yasuhiro Nagata, Naomi Hayashida, Takahiro Maeda
Summary: The study showed a complex association between FT3/FT4 and CKD and SCH, with FT3/FT4 positively associated with SCH but negatively associated with CKD, suggesting that higher activity of peripheral thyroxin deiodination might be beneficial in preventing CKD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Agriculture, Dairy & Animal Science
Maria Chmurska-Gasowska, Natalia Sowinska, Sylwia Palka, Michal Kmiecik, Joanna Lenarczyk-Knapik, Lukasz Migdal
Summary: Thyroid hormones are crucial for metabolism, energy balance, and reproduction. By comparing thyroid hormone analysis in the urine and feces of domestic rabbits with serum analyses, it was found that free triiodothyronine can be accurately and reliably measured in the urine and feces.
Article
Endocrinology & Metabolism
Beibei Zhu, Yan Han, Fen Deng, Kun Huang, Shuangqin Yan, Jiahu Hao, Peng Zhu, Fangbiao Tao
Summary: This study found significant and stable associations between T3 and T3/fT4 with glucose metabolism indicators during pregnancy, indicating their potential as predictors of gestational diabetes mellitus risk. Both T3 and T3/fT4 improved the performance of the GDM predictive model.
ENDOCRINE CONNECTIONS
(2021)
Review
Endocrinology & Metabolism
Federico Salas-Lucia, Antonio C. Bianco
Summary: The study indicates that serum T3 levels can accurately predict tissue T3 content and T3 signaling in most tissues, which is of great importance for managing patients with hypothyroidism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Elisa Merchan-Ramirez, Guillermo Sanchez-Delgado, Cristina Arrizabalaga-Arriazu, Borja Martinez-Tellez, Andrea Mendez-Gutierrez, Manuel Munoz-Torres, Jose M. Llamas-Elvira, Jonatan R. Ruiz
Summary: The study found that cold exposure led to an increase in FT4 levels and a decrease in TSH levels, but had no effect on FT3 serum concentration. There were no associations between TSH and THs levels at thermoneutral or cold-induced conditions and BAT volume, F-18-FDG uptake, and mean radiodensity in young healthy euthyroid adults.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Biochemical Research Methods
Rongmei Huang, Yi Hong, Yike Wu, Weifeng Li, Wenlan Liu
Summary: We developed a new LC-MS/MS method for simultaneous determination of serum testosterone and free testosterone levels. The method is simple to perform and can be applied in clinical practice, providing important information for diagnosis, treatment, and monitoring of androgen-related diseases.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Medical Laboratory Technology
Heleen I. Jansen, Antonius E. van Herwaarden, Henk J. Huijgen, Marc G. Vervloet, Jacquelien J. Hillebrand, Anita Boelen, Annemieke C. Heijboer
Summary: The study aimed to investigate the accuracy of testosterone, cortisol, and FT4 measurements in samples of HDp and to gain more insight into interfering factors. The results revealed that the average bias from LC-MS/MS was higher in HDp samples for testosterone, cortisol, and FT4 immunoassays compared to HC samples. FT4 IA results were falsely decreased in HDp samples, while cortisol and testosterone concentrations in females were predominantly falsely increased. These findings indicate that several IAs for testosterone, cortisol, and FT4 are less reliable in the altered serum matrix of HDp samples.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
