Article
Immunology
Yu Kato, Nathaniel Bloom, Peifang Sun, Corey A. Balinsky, Qi Qiu, Ying Cheng, Vihasi Jani, Megan A. Schilling, Carl W. Goforth, Dawn L. Weir, Irene Ramos, Stuart C. Sealfon, Andrew G. Letizia, Shane Crotty
Summary: This study investigated the impact of mild symptomatic and asymptomatic SARS-CoV-2 infection on antibody and memory B cell responses. The results showed that among young adults, asymptomatic infection induced antibody and memory B cell responses comparable to mild symptomatic infection.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Microbiology
Entao Li, Shen Wang, Wenwen He, Jun He, Luogeng Liu, Xiaotuan Zhang, Songtao Yang, Feihu Yan, Yuwei Gao, Bin Liu, Xianzhu Xia
Summary: This study investigates the clinical characteristics, cytokine responses, and antibody levels in asymptomatic carriers and symptomatic patients with COVID-19. The results show that symptomatic patients have higher levels of cytokines, while asymptomatic carriers have higher levels of specific antibodies. Comparable levels of neutralizing antibodies were detected in both groups.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Alhaji H. Janneh, Mohamed Faisal Kassir, Connor J. Dwyer, Paramita Chakraborty, Jason S. Pierce, Patrick A. Flume, Hong Li, Satish N. Nadig, Shikhar Mehrotra, Besim Ogretmen
Summary: Changes in sphingolipids are closely related to the development of COVID-19, with reduced levels of sphingosine potentially serving as a sensitive biomarker for the early identification of symptomatic and asymptomatic COVID-19 patients.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Allison N. Grossberg, Lilia A. Koza, Aurelie Ledreux, Chad Prusmack, Hari Krishnan Krishnamurthy, Vasanth Jayaraman, Ann-Charlotte Granholm, Daniel A. Linseman
Summary: This study presents results from a multiplex serology test for assessing COVID-19 antibody responses, showing distinct dynamics of IgG, IgM, and IgA responses in patients with different disease severity. It suggests that antibody responses to SARS-CoV-2 may serve as important biomarkers for assessing the risk of viral transmission.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Serena Marchi, Simonetta Viviani, Edmond J. Remarque, Antonella Ruello, Emilio Bombardieri, Valentina Bollati, Gregorio P. Milani, Alessandro Manenti, Giulia Lapini, Annunziata Rebuffat, Emanuele Montomoli, Claudia M. Trombetta
Summary: The study showed that hospitalized COVID-19 patients produce a strong antibody response to SARS-CoV-2 with high correlation between different viral antigens and antibody classes. The antibody peak is reached around 3 weeks from hospital admission followed by a sharp decrease. There was no difference in antibody levels between patients who recovered or had a fatal outcome, and few asymptomatic subjects developed detectable levels of antibodies.
Article
Biochemistry & Molecular Biology
Xiang-Na Zhao, Yue You, Xiao-Ming Cui, Hui-Xia Gao, Guo-Lin Wang, Sheng-Bo Zhang, Lin Yao, Li-Jun Duan, Ka-Li Zhu, Yu-Ling Wang, Li Li, Jian-Hua Lu, Hai-Bin Wang, Jing-Fang Fan, Huan-Wei Zheng, Er-Hei Dai, Lu-Yi Tian, Mai-Juan Ma
Summary: By comparing the immune responses of asymptomatic and moderate patients, it was found that asymptomatic patients have specific immune characteristics in NK cells and effector T cells, with stronger TCR clonal expansion compared to moderate patients. Moderate patients exhibit varied magnitude and temporal dynamics of ISG expression across multiple cell populations but lower compared to patients with severe disease.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Immunology
Alessandra Soares-Schanoski, Natalie Sauerwald, Carl W. Goforth, Sivakumar Periasamy, Dawn L. Weir, Stephen Lizewski, Rhonda Lizewski, Yongchao Ge, Natalia A. Kuzmina, Venugopalan D. Nair, Sindhu Vangeti, Nada Marjanovic, Antonio Cappuccio, Wan Sze Cheng, Sagie Mofsowitz, Clare M. Miller, Xuechen B. Yu, Mary-Catherine George, Elena Zaslavsky, Alexander Bukreyev, Olga G. Troyanskaya, Stuart C. Sealfon, Andrew G. Letizia, Irene Ramos
Summary: Research has shown that asymptomatic and mild symptomatic COVID-19 infections in young adults have similar viral loads and specific antibody responses, but there are differences in inflammatory protein profiles. Some analytes in asymptomatic infections are associated with tissue repair and may contribute to symptom control.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Pyoeng Gyun Choe, Kye-Hyung Kim, Chang Kyung Kang, Hyeon Jeong Suh, EunKyo Kang, Sun Young Lee, Nam Joong Kim, Jongyoun Yi, Wan Beom Park, Myoung-Don Oh
Summary: A study investigated antibody responses of 58 individuals 8 months after infection with severe acute respiratory syndrome coronavirus 2, showing high seropositivity rates for 3 out of 4 immunoassays used.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Virology
Chad Pickering, Bo Zhou, Gege Xu, Rachel Rice, Prasanna Ramachandran, Hector Huang, Tho D. Pham, Jeffrey M. Schapiro, Xin Cong, Saborni Chakraborty, Karlie Edwards, Srinivasa T. Reddy, Faheem Guirgis, Taia T. Wang, Daniel Serie, Klaus Lindpaintner
Summary: Glycosylation, the most common form of protein post-translational modification, is critical for protein structure and function. By analyzing the differential glycoisoform distributions of serum glycopeptides in COVID-19 patients using advanced techniques, significant differences were found between symptomatic and asymptomatic patients, as well as between symptomatic patients and healthy controls or patients with bacterial sepsis. Machine learning techniques were used to predict symptomatic COVID-19 infection based on glycoprotein profiles. These findings suggest the potential value of glycoproteomic biomarkers in understanding and managing severe infectious conditions.
Article
Immunology
Peng Wu, Fengfeng Liu, Zhaorui Chang, Yun Lin, Minrui Ren, Canjun Zheng, Yu Li, Zhibin Peng, Yin Qin, Jianxing Yu, Mengjie Geng, Xiaokun Yang, Hongting Zhao, Zhili Li, Sheng Zhou, Lu Ran, Benjamin J. Cowling, Shengjie Lai, Qiulan Chen, Liping Wang, Tim K. Tsang, Zhongjie Li
Summary: The study found that symptomatic cases are more likely to transmit the virus compared to asymptomatic cases, while asymptomatic and presymptomatic transmissions also play an important role in spreading the infection. Therefore, early case detection and effective test-and-trace measures are crucial in reducing transmission.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Medicine, Research & Experimental
Brianna M. Doratt, Suhas Sureshchandra, Heather True, Monica Rincon, Nicole E. Marshall, Ilhem Messaoudi
Summary: Even in the absence of vertical transmission or symptoms in the neonate, mild/asymptomatic maternal COVID-19 alters the transcriptional and functional state of fetal immune cells in circulation and in the placenta.
Article
Infectious Diseases
Manaf Al-Qahtani, Salman AlAli, AbdulKarim AbdulRahman, Adel Salman Alsayyad, Sameer Otoom, Stephen L. Atkin
Summary: The study found that asymptomatic COVID-19 patients were more prevalent than symptomatic patients and may act as an infection reservoir; there was no significant difference in viral clearance time between symptomatic and asymptomatic patients in virus retesting; asymptomatic patients who tested positive had a faster viral clearance time than those who were asymptomatic upon arrival.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Virology
Emin Ediz Tutuncu, Didem Ozgur, Murat Karamese
Summary: The study found that saliva specimens can be considered as a reliable and less resource-intensive alternative to nasopharyngeal specimens for screening asymptomatic SARS-CoV-2 infections.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Medicine, Research & Experimental
Anna Lucia Tornesello, Chiara Botti, Alberto Micillo, Francesco Labonia, Sergio Arpino, Maria Antonietta Isgro, Serena Meola, Luigi Russo, Ernesta Cavalcanti, Silvia Sale, Carmine Nicastro, Luigi Atripaldi, Noemy Starita, Andrea Cerasuolo, Ulf Reimer, Pavlo Holenya, Luigi Buonaguro, Franco M. M. Buonaguro, Maria Lina Tornesello
Summary: This study evaluated the IgG response to linear peptides in SARS-CoV-2 infected patients, aiming to identify immunological indicators of COVID-19 clinical outcome. The results showed that antibody production in SARS-CoV-2 infected patients is age-dependent and related to the severity of the disease. Additionally, antibodies against other coronaviruses were detected in all patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Erick C. Castelli, Mateus de Castro, Michel S. Naslavsky, Marilia O. Scliar, Nayane S. B. Silva, Heloisa S. Andrade, Andreia S. Souza, Raphaela N. Pereira, Camila F. B. Castro, Celso T. Mendes-Junior, Diogo Meyer, Kelly Nunes, Larissa R. B. Matos, Monize V. R. Silva, Jaqueline Y. T. Wang, Joyce Esposito, Vivian R. Coria, Raul H. Bortolin, Mario H. Hirata, Jhosiene Y. Magawa, Edecio Cunha-Neto, Veronica Coelho, Keity S. Santos, Maria Lucia C. Marin, Jorge Kalil, Miguel Mitne-Neto, Rui M. B. Maciel, Maria Rita Passos-Bueno, Mayana Zatz
Summary: Research has found differences in immune response and genetics between COVID-19 patients and asymptomatic infected individuals, potentially related to HLA-DRB1 and HLA-A alleles in the MHC region. Additionally, variants in MICA and MICB genes have been associated with symptomatic infections.
FRONTIERS IN IMMUNOLOGY
(2021)
