Article
Immunology
Yaoyao Xue, Lang Pan, Spiros Vlahopoulos, Ke Wang, Xu Zheng, Zsolt Radak, Attila Bacsi, Lloyd Tanner, Allan R. Brasier, Xueqing Ba, Istvan Boldogh
Summary: Interferons can activate the expression of IFN stimulated genes, increasing the resistance of cells to virus infections. The DNA repair protein OGG1 plays a crucial role in modulating IFN expression by binding to 8-oxoguanine and altering the binding of transcription factors to the genome.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
I. Patlan, M. P. Jeffrey, D. Lewis, J. Green-Johnson, S. Dogra
Summary: This study compared the effects of exercise in cold-dry and normal conditions on salivary cytokine levels and airway response in young healthy males. The results showed that IL-8 levels increased in normal conditions but not in cold-dry conditions, while the opposite trend was observed for IL-1RA.
Article
Pharmacology & Pharmacy
Wanfu Lin, Shu Li, Yongbin Meng, Guokai Huang, Shufang Liang, Juan Du, Qun Liu, Binbin Cheng
Summary: This study found that ursodeoxycholic acid (UDCA) can inhibit hypoxic hepatocellular carcinoma (HCC) cell-induced angiogenesis by suppressing HIF-1 alpha/VEGF/IL-8-mediated intercellular signaling.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Shuai Song, Yahui Zhang, Xinchun Duan, Chunquan Liu, Yanlin Du, Xiaoran Wang, Yi Luo, Yong Cui
Summary: In this study, the influence of hypoxia-treated tumor-associated macrophages (TAMs) on the malignant phenotypes of esophageal cancer (EC) cells was examined. It was found that hypoxic macrophages contributed to the proliferation, cell cycle progression, and metastasis of EC cells. Additionally, hypoxia treatment accelerated the transformation of macrophages into M2 polarization. The upregulation of interleukin-8 (IL-8) secretion by macrophages after hypoxia treatment was found to be mediated by hypoxia-inducible factor-1 alpha (HIF-1 alpha). IL-8 secreted by hypoxic macrophages further facilitated EC cell proliferation, cell cycle progression, and metastasis by elevating programmed death 1 ligand (PD-L1) expression. The study suggests that the HIF-1 alpha/IL-8 axis in hypoxic macrophages could enhance EC advancement through upregulating PD-L1 expression, providing a novel potential target for EC treatment.
CANCER GENE THERAPY
(2023)
Article
Pharmacology & Pharmacy
A. E. GODA, T. SAKAI
Summary: In this study, the researchers investigated the effects of SB225002 in SW480 human colorectal adenocarcinoma cells and found that it has antimitotic activity and induces cell death. Mechanistically, SB225002 activates the CHK1 checkpoint and JNK signaling, and mediates cytotoxicity by increasing intracellular ROS.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Respiratory System
Yanyu Li, Guomei Su, Yu Zhong, Zhilin Xiong, Tong Huang, Jingyun Quan, Jiewen Huang, Xiaoxia Wen, Chaole Luo, Weilin Zheng, Jinfeng Chen, Junfen Cheng, Weimin Yao, Tianwen Lai
Summary: The study found that HB-EGF-induced IL-8 promotes proliferation and migration of lung fibroblasts, with the effects attenuated after neutralizing IL-8, suggesting that HB-EGF may be involved in the pathology of airway fibrosis by inducing the release of IL-8 from airway epithelium.
BMC PULMONARY MEDICINE
(2021)
Article
Medicine, Research & Experimental
Tayyab Rehman, Philip H. Karp, Ping Tan, Brian J. Goodell, Alejandro A. Pezzulo, Andrew L. Thurman, Ian M. Thornell, Samantha L. Durfey, Michael E. Duffey, David A. Stoltz, Edward F. McKone, Pradeep K. Singh, Michael J. Welsh
Summary: Inflammation plays a key role in regulating HCO3- secretion in CF airways, affecting the pH of ASL. The study shows that inflammation leads to an increase in ASL pH, and CFTR modulators can further alkalize ASL. These findings suggest that airway inflammation is an important determinant of the response to CFTR modulators in CF airways.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, General & Internal
Ting-Yu Lin, Po-Jui Chang, Chun-Yu Lo, Yu-Lun Lo, Chih-Teng Yu, Shu-Min Lin, Chih-His Scott Kuo, Horng-Chyuan Lin
Summary: This study demonstrates that the interaction between fibrocytes from asthmatic patients and ASMCs increases IL-8 and IL-33 production and promotes AKT/mTOR signaling in ASMCs. IL-8 production in the co-culture from asthmatic patients is less affected by corticosteroid than that in the co-culture from normal subjects. These findings reveal a novel role of fibrocytes and ASMCs in the pathogenesis of asthma.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Endalew Getnet Tsega
Summary: This study used computational fluid dynamics to investigate the respiratory airflow dynamics in response to walking and running for oral breathing. The results showed that running had higher turbulence, velocity, and pressure changes compared to walking. The airway model exhibited higher flow mixing during running and more skewed flows at airway curvatures during inspiration.
Article
Biochemistry & Molecular Biology
Frederikke Hyldahl, Elisabeth Hem-Jensen, Ulrik L. Rahbek, Katerina Tritsaris, Steen Dissing
Summary: The study found that external pulsed electric fields can activate microglia cells and affect capillary function. By applying transcranial pulsed electromagnetic fields identical to those produced by neurons, the synthesis of mRNA for VEGF, IL-8, IL-6 and the proglucagon gene as well as the PC1/3 enzyme can be enhanced. Additionally, the combined effects of transcranial pulsed electromagnetic fields and purinergic transmitters can enhance microglia secretion. Applying these electric fields can effectively treat refractory depressions and show promise for treating neurodegenerative brain diseases.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Microbiology
Yun Hui Choi, Jing Lai, Myeong-A Kim, Aeryun Kim, Jinmoon Kim, Hanfu Su, Linhu Ge, Jeong-Heon Cha
Summary: This study investigated the role of CagL polymorphisms in the pathogenesis of Helicobacter pylori. The results showed that K74 CagL has less ability to induce IL-8 secretion compared to G27 or 26695 CagL. Further research is needed to explore how the different capabilities of IL-8 induction between intraspecies-CagL are associated with the large differences of the incidence of gastric cancer between East Asian and Western countries.
JOURNAL OF MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nadeem Akhter, Ajit Wilson, Reeby Thomas, Fatema Al-Rashed, Shihab Kochumon, Areej Al-Roub, Hossein Arefanian, Ashraf Al-Madhoun, Fahd Al-Mulla, Rasheed Ahmad, Sardar Sindhu
Summary: IL-8/MCP-1 expression in adipose tissue is elevated in obesity. The synergistic effect of ROS/TNF-alpha can drive the expression of chemokines in monocytic cells, potentially through inducing ER stress, HIF1A stabilization, and signaling via NF-kappa B/ERK-1,2. NAC may have a therapeutic significance in inhibiting oxidative stress-driven IL-8/MCP-1 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Respiratory System
Li Che, Chao Yu, Guangshu Chen, Jiaxin Lin, Zhefan Xie, Tingting Xia, Wenzhi Luo, Xingdong Cai, Shengming Liu
Summary: The research found that RELM beta can promote the expression of inflammatory cytokines IL-8 and IL-1 beta in airway epithelial cells of COPD patients, and this effect is mediated by the p38 MAPK signaling pathway. Therefore, RELM beta may be a potential target for the treatment of COPD.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Jae Woo Lee, Mi Na Kim, Eun Gyul Kim, Ji Su Leem, Seung Min Baek, Min Jung Kim, Kyung Won Kim, Myung Hyun Sohn
Summary: Viral respiratory infections can cause lung diseases with inflammation. CHI3L1 protein may be involved in regulating inflammatory responses through the MAPK pathways in airway epithelial cells following viral infections.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Marzena Tylicka, Tomasz Guszczyn, Michal Maksimowicz, Joanna Kaminska, Ewa Matuszczak, Maria Karpinska, Olga Martyna Koper-Lenkiewicz
Summary: The study evaluated the concentration of inflammatory cytokines, CRP, and DAMPs in response to bone fracture and subsequent surgery in children, finding that the CRKF procedure caused less damage and inflammatory response compared to the fracture itself.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Otorhinolaryngology
Hyun Jin Min, Joon Soon Park, Kyung Soo Kim, Miran Kang, Ju Hee Seo, Joo-Heon Yoon, Chang-Hoon Kim, Hyung-Ju Cho
Summary: This study aimed to evaluate the possibility of using the serum high-mobility group box 1 protein level as a biologic marker in obstructive sleep apnea patients. The results showed a significant correlation between this protein level and the lowest arterial oxygen concentration, suggesting its potential involvement in the pathogenesis of obstructive sleep apnea. Further research is needed to explore the potential role and value of this protein.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Suk Won Chang, Jae Sung Nam, Jong-Gyun Ha, Na Won Kim, Wasan F. Almarzouq, Chang-Hoon Kim, Joo-Heon Yoon, Hyung-Ju Cho
Summary: The serum galactomannan test showed limited accuracy in diagnosing confirmed AIAS based on the meta-analysis. Results indicate that reliance solely on the serum galactomannan test for initial AIAS diagnosis may be insufficient, and further studies are needed for a more accurate assessment of its diagnostic value in AIAS patients.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Hyo Jin Chung, Hyun Seon Lim, Kyuin Lee, Hyun Seung Choi, Junhui Jeong, Hyang Ae Shin, Chang-Hoon Kim, Jung Hyun Chang
Summary: This study aimed to evaluate the prevalence of clinically diagnosed olfactory dysfunction in South Korea and its associations with neurodegenerative disorders. The results showed that olfactory dysfunction is underdiagnosed in South Korea, but it is clinically important considering the possibility of being a presymptom of neurodegenerative disorders. The study suggests that in clinical practice, the association between olfactory dysfunction and neurodegenerative disorders and possibly other systemic conditions should be considered.
ENT-EAR NOSE & THROAT JOURNAL
(2023)
Article
Otorhinolaryngology
Jae-Sung Nam, Yun-Ho Roh, Jungghi Kim, Suk-Won Chang, Jong-Gyun Ha, Jeong-Jin Park, Wasan Almazouq Fahad, Joo-Heon Yoon, Chang-Hoon Kim, Hyung-Ju Cho
Summary: In a national population-based study, significant associations were found between DM and CRS with nasal polyps, but not between DM and CRS without nasal polyps. Among patients with CRS, olfactory dysfunction lasting for more than three months was significantly more common in the DM group compared to the non-DM group.
CLINICAL OTOLARYNGOLOGY
(2022)
Article
Surgery
Sang Chul Park, Jae-Sung Nam, Kyu-In Lee, Young-Woo Lee, Jeong-Jin Park, Jong-Gyun Ha, Hyung-Ju Cho, Joo-Heon Yoon, Chang-Hoon Kim
Summary: This study compares the effectiveness of ADM in primary and revision dorsal augmentation rhinoplasties. The results indicate that dorsal augmentation surgery is associated with changes in the degree of augmentation and patients' and surgeons' satisfaction with aesthetic and functional results.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Review
Otorhinolaryngology
Min-Seok Rha, Chang-Hoon Kim, Joo-Heon Yoon, Hyung-Ju Cho
Summary: This meta-analysis reveals a significant association between HPV infection and recurrence of SNIP, suggesting the pathological role of HPV in SNIP. These findings suggest that HPV infection should be considered in the management of SNIP.
Article
Otorhinolaryngology
Min-Seok Rha, Hyung-Ju Cho, Joo-Heon Yoon, Seok Jun Moon, Chang-Hoon Kim
Summary: This study found that GD is significantly associated with OD, especially in patients with PTOD. Age ≥55 years and PTOD are factors associated with a higher frequency of GD among patients with OD.
Article
Otorhinolaryngology
Min-Seok Rha, Hyung-Ju Cho, Joo-Heon Yoon, Chang-Hoon Kim
Summary: This study found a significant association between the use of electronic cigarettes (ECs) and the prevalence of chronic rhinosinusitis (CRS) and allergic rhinitis (AR) in adults.
Review
Otorhinolaryngology
Min-Seok Rha, Yeonsu Jeong, Jungghi Kim, Chang-Hoon Kim, Joo-Heon Yoon, Hyung-Ju Cho
Summary: This systematic review and meta-analysis investigated the association between obstructive sleep apnea (OSA) and erythrocytosis. The study found that patients with OSA had significantly higher hematocrit values compared to controls, especially in severe cases. However, the increase was modest and not clinically significant.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Min-Seok Rha, Yeonsu Jeong, Chang-Hoon Kim, Joo-Heon Yoon, Hyung-Ju Cho
Summary: This study found that the presence of mixed apnea (MA) events in patients with obstructive sleep apnea (OSA) leads to different clinical characteristics and surgical outcomes. The mixed group had a lower surgical success rate and smaller postoperative improvements in sleep apnea indices compared to the pure group. Logistic regression analysis confirmed that the presence of MA is an independent predictor of poor surgical outcomes in OSA patients.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Cell Biology
Ju-Ri Sim, Dong Hoon Shin, Pil-Gu Park, So-Hyeon Park, Joon-Yong Bae, Youngchae Lee, Dha-Yei Kang, Ye Jin Kim, Sowon Aum, Shin Hye Noh, Su Jin Hwang, Hye-Ran Cha, Cheong Bi Kim, Si Hwan Ko, Sunghoon Park, Dongkyu Jeon, Sungwoo Cho, Gee Eun Lee, Jeonghun Kim, Young-hye Moon, Jae-Ouk Kim, Jae-Sung Nam, Chang-Hoon Kim, Sungmin Moon, Youn Wook Chung, Man-Seong Park, Ji-Hwan Ryu, Wan Namkung, Jae Myun Lee, Min Goo Lee
Summary: This study demonstrates the importance of ANO6/TMEM16F-mediated cell surface exposure of phosphatidylserine in SARS-CoV-2 entry and the effectiveness of ANO6-selective inhibitors against SARS-CoV-2 infections. A6-001, a potent ANO6 inhibitor, shows promising results in inhibiting SARS-CoV-2 infection and viral replication.
Article
Otorhinolaryngology
Min-Seok Rha, Yeonsu Jeong, Khalid A. Alyahya, Joo-Heon Yoon, Chang-Hoon Kim, Hyung-Ju Cho
Summary: This study investigated the clinical features and surgical outcomes of patients with hypopnea- and apnea-predominant obstructive sleep apnea (OSA). The results showed that patients with apnea-predominant OSA had more severe disease but comparable surgical outcomes compared to those with hypopnea-predominant OSA. Additionally, multilevel upper airway surgery may induce the transition from apnea to hypopnea in patients with apnea-predominant OSA.
CLINICAL OTOLARYNGOLOGY
(2023)
Article
Medicine, General & Internal
Geun Cheol Shin, Ju Wan Kang, Ju Ha Park, Han Cheol Lee, Kyung-Su Kim
Summary: This study aimed to investigate changes in subjective outcomes within 6 months after septoturbinoplasty. Retrospective analysis of medical records of patients who underwent septoturbinoplasty at Gangnam Severance Hospital was conducted. Significant decreases in SNOT-22 and obstruction scores were observed at 1 month after surgery, but no significant changes were found at 3 and 6 months after surgery. A larger difference between preoperative and 1-month postoperative SNOT-22 scores was significantly associated with an improvement in symptoms at 3 or 6 months after surgery.
YONSEI MEDICAL JOURNAL
(2023)
Article
Allergy
Hyung-Ju Cho, Youn Wook Chung, Sungmin Moon, Ju Hee Seo, Miran Kang, Jae Sung Nam, Sang-Nam Lee, Chang-Hoon Kim, Augustine M. K. Choi, Joo-Heon Yoon
Summary: In this study, the effect of allergic inflammation on nasal epithelial cell transcriptomes at the single-cell level was investigated using scRNAseq. The results showed that IL-4 led to a decrease in multiciliated cells and loss of deuterosomal cells. Furthermore, cell-specific markers that may be important for studying respiratory inflammatory diseases were identified.
Article
Otorhinolaryngology
Tae-Seong Eo, Ho Young Lee, Hyung-Ju Cho, Joo-Heon Yoon, Min-Seok Rha, Chang-Hoon Kim
Summary: This study investigated the clinical characteristics and associated factors of parosmia and phantosmia in patients with subjective smell disturbance. The results showed that younger age and female sex were related to both parosmia and phantosmia. Patients with COVID-19 had younger ages and higher TDI scores. Patients with parosmia or phantosmia had higher TDI scores and experienced more disruption in daily life. Younger age and higher TDI score were identified as independent factors associated with both parosmia and phantosmia.
