Calcium-sensing receptor activator cinacalcet for treatment of cyclic nucleotide-mediated secretory diarrheas

A Potent Inhibitor of the Cystic Fibrosis Transmembrane Conductance Regulator Blocks Disease and Morbidity Due to Toxigenic Vibrio cholerae

(2022) Fabian Rivera-Chávez et al.   Toxins

Lubiprostone is a Non-Selective Activator of cAMP-Gated Ion Channels and Chloride Channel Protein 2 (Clc-2) Has a Minor Role in its Prosecretory Effect in Intestinal Epithelial Cells

(2022) Apurva A. Oak et al.   MOLECULAR PHARMACOLOGY

A Phase 2a randomized, single-center, double-blind, placebo-controlled study to evaluate the safety and preliminary efficacy of oral iOWH032 against cholera diarrhea in a controlled human infection model

(2021) Rahsan Erdem et al.   PLoS Neglected Tropical Diseases

Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel

(2020) Anna K. Koster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of price and convenience in use of oral rehydration salts to treat child diarrhea: A cluster randomized trial in Uganda

(2019) Zachary Wagner et al.   PLOS MEDICINE

Slowed gastric emptying and improved oral glucose tolerance produced by a nanomolar-potency inhibitor of calcium-activated chloride channel TMEM16A

(2019) Onur Cil et al.   FASEB JOURNAL

Cholera toxin promotes pathogen acquisition of host-derived nutrients

(2019) Fabian Rivera-Chávez et al.   NATURE

Development and Pathophysiology of Oral Rehydration Therapy for the Treatment for Diarrhea

(2019) Henry J. Binder   DIGESTIVE DISEASES AND SCIENCES

Vitamin D and Calcimimetics in Cardiovascular Disease

(2018) Kenneth Lim et al.   SEMINARS IN NEPHROLOGY

Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Christopher Troeger et al.   LANCET INFECTIOUS DISEASES

Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins

(2017) Onur Cil et al.   FASEB JOURNAL

Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation

(2017) Onur Cil et al.   Translational Research

Sodium glucose cotransporter SGLT1 as a therapeutic target in diabetes mellitus

(2016) Panai Song et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Calcium-sensing receptor: A new target for therapy of diarrhea

(2016) Sam Xianjun Cheng   WORLD JOURNAL OF GASTROENTEROLOGY

Congenital secretory diarrhoea caused by activating germline mutations inGUCY2C

(2015) Thomas Müller et al.   GUT

Secretory diarrhoea: mechanisms and emerging therapies

(2015) Jay R. Thiagarajah et al.   Nature Reviews Gastroenterology & Hepatology

Revisiting CFTR inhibition: a comparative study of CFTRinh-172 and GlyH-101 inhibitors

(2014) N Melis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Chenodeoxycholic acid stimulates Cl− secretion via cAMP signaling and increases cystic fibrosis transmembrane conductance regulator phosphorylation in T84 cells

(2013) Mei Ao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cinacalcet hydrochloride for the treatment of hyperparathyroidism

(2013) Nicolas Verheyen et al.   EXPERT OPINION ON PHARMACOTHERAPY

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL