Article
Oncology
Gundula Rendl, Gregor Schweighofer-Zwink, Stefan Sorko, Hans-Juergen Gallowitsch, Wolfgang Hitzl, Diana Reisinger, Christian Pirich
Summary: In patients with progressive metastatic radioiodine-refractory differentiated thyroid cancer, tyrosine kinase inhibitor (TKI) therapy with lenvatinib improves progression-free survival. The use of metabolic response criteria derived from F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging can help to identify those patients who benefit from treatment.
Review
Oncology
Federica Matteucci, Giovanni Paganelli, Giovanni Martinelli, Claudio Cerchione
Summary: Recent advances in the diagnosis and treatment of multiple myeloma have emphasized the importance of imaging methods, particularly PET/CT, in providing accurate information for disease localization, prognosis, and therapy response evaluation. While 18F-FDG tracer is commonly used and has high sensitivity, limitations such as physiological uptake in the bone marrow and brain have prompted research on other PET tracers for improved accuracy in multiple myeloma management.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Hyunjong Lee, Seung Hyup Hyun, Young Seok Cho, Seung Hwan Moon, Joon Young Choi, Kihyun Kim, Kyung-Han Lee
Summary: In this study, features were extracted from FDG PET/CT images of multiple myeloma patients using an artificial intelligence autoencoder algorithm. The clustering analysis grouped the patients into three clusters and identified high metabolic tumor volume, unsupervised cluster C, and supervised cluster C as independent predictors of worse progression-free survival. Therefore, artificial intelligence algorithm-based cluster analysis of FDG PET/CT images could be useful for risk stratification in multiple myeloma.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yueqi Wang, Qiuping Fan, Minggang Su
Summary: A 42-year-old woman presented with numbness and weakness in the lower limbs, and was diagnosed with multiple myeloma after examination, requiring further treatment.
CLINICAL NUCLEAR MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jin Qi, Elizabeth Kurian, Orhan K. oez
Summary: Hibernomas are rare benign tumors originating from fetal brown adipose tissue. They can occur in various parts of the body, with thigh, shoulder, back, and neck being the most common locations, and are rarely found in the abdominal cavity, retroperitoneum, breast, bones, scrotum, and perirectum. We present a case of a 58-year-old woman with a mediastinal mass, who was incidentally found to have an FDG-avid fat-containing lesion in the omentum abutting the stomach.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
Jeffrey P. Leal, Steven P. Rowe, Vered Stearns, Roisin M. Connolly, Christos Vaklavas, Minetta C. Liu, Anna Maria Storniolo, Richard L. Wahl, Martin G. Pomper, Lilja B. Solnes
Summary: This study developed an image-processing workflow that combines traditional image processing with AI technology to identify and quantify tissue in whole-body [F-18]FDG PET/CT studies. The results showed that the CNN-based workflow can specifically identify breast cancer tissue.
FRONTIERS IN ONCOLOGY
(2022)
Article
Neurosciences
Yanxiao Li, Yee Ling Ng, Manish D. Paranjpe, Qi Ge, Fengyun Gu, Panlong Li, Shaozhen Yan, Jie Lu, Xiuying Wang, Yun Zhou
Summary: This study aimed to improve the statistical power in detecting changes in brain glucose metabolism, amyloid, and tau deposition in Alzheimer's disease studies by using a reference tissue-based quantification approach. The results showed that the tracer-specific reference tissue improved the detection of PET SUVR changes, which is beneficial for early diagnosis, disease progression monitoring, and therapeutic response in Alzheimer's disease.
HUMAN BRAIN MAPPING
(2022)
Article
Biochemistry & Molecular Biology
Maria Morales-Lozano, Paula Rodriguez-Otero, Lidia Sancho, Jorge M. Nunez-Cordoba, Elena Prieto, Maria Marcos-Jubilar, Juan J. Rosales, Ana Alfonso, Edgar F. Guillen, Jesus San-Miguel, Maria J. Garcia-Velloso
Summary: This study compares the diagnostic accuracy and prognostic value of FDG and MET in multiple myeloma patients. The study finds that MET has higher sensitivity than FDG in detecting myeloma lesions. Additionally, the TMTV and TLMU of MET PET/CT have prognostic value in the evaluation of patients with multiple myeloma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christos Sachpekidis, Olof Enqvist, Johannes Ulen, Annette Kopp-Schneider, Leyun Pan, Anna Jauch, Marina Hajiyianni, Lukas John, Niels Weinhold, Sandra Sauer, Hartmut Goldschmidt, Lars Edenbrandt, Antonia Dimitrakopoulou-Strauss
Summary: This study aims to validate a novel three-dimensional deep learning-based tool on PET/CT images for automated assessment of the intensity of bone marrow metabolism in multiple myeloma patients. The results showed that the proposed method is feasible and correlates with clinically relevant parameters in the disease, offering a potentially reliable tool for PET/CT interpretation in multiple myeloma.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Caroline Stokke, Jakob Nordberg Norgaard, Hilde Feiring Phillips, Alexander Sherwani, Syed Nuruddin, James Connelly, Fredrik Schjesvold, Mona-Elisabeth Revheim
Summary: This study compared the performance of [F-18]fluciclovine PET and [F-18]FDG PET in newly diagnosed MM patients, and found that [F-18]fluciclovine PET showed more positive results, higher lesion SUVmax values, and ratios during the diagnostic process.
MOLECULAR IMAGING AND BIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nicolas Aide, Pauline Fauchille, Elodie Coquan, Gwenael Ferron, Pierre Combe, Jerome Meunier, Jerome Alexandre, Dominique Berton, Alexandra Leary, Gaetan De Rauglaudre, Nathalie Bonichon, Eric Pujade Lauraine, Florence Joly
Summary: The ancillary study evaluated F-18-FDG PET parameter changes after one cycle of treatment in patients receiving neoadjuvant anti-angiogenic nintedanib combined with chemotherapy. The study showed that EORTC or PERCIST criteria are useful tools in predicting survival and second-look surgery outcome. However, MATV and TLG were not found to be useful in predicting survival in ovarian cancer patients.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Bastien Jamet, Caroline Bodet-Milin, Philippe Moreau, Francoise Kraeber-Bodere, Cyrille Touzeau
Summary: T-cell-redirecting bispecific antibodies are now the standard of care for triple-class refractory myeloma patients. A 61-year-old woman with relapsed myeloma underwent 2-[F-18]FDG PET/CT imaging to assess the metabolic response to talquetamab, a GPRC5DxCD3 bispecific antibody. At day 28, the patient showed very good partial response based on monoclonal component assessment, but early bone flare-up was observed through 2-[F-18]FDG PET/CT imaging. By day 84, complete response was confirmed through bone marrow aspirate, M-component assessment, and 2-[F-18]FDG PET/CT, supporting the early flare-up hypothesis.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
R. Gallicchio, A. Nardelli, G. Calice, A. Guarini, G. Guglielmi, G. Storto
Summary: This study evaluated the prognostic significance of combined use of FDG and FLT PET/CT in MM patients, showing that PET/CT can predict patient prognosis and that FDG+; FLT- patients have better EFS compared to other groups.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sung Ryul Shim, Seong-Jang Kim
Summary: This study evaluated the diagnostic accuracies of F-18-FDG PET or PET/CT for Merkel cell carcinoma (MCC) through a systematic review and meta-analysis. The results showed that F-18-FDG PET/CT had excellent performance in diagnosing MCC and could be useful for exclusion and confirmation of the disease. Further large multicenter studies are needed to validate its diagnostic accuracy.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Toshiki Terao, Youichi Machida, Kenji Hirata, Ayumi Kuzume, Rikako Tabata, Takafumi Tsushima, Daisuke Miura, Kentaro Narita, Masami Takeuchi, Ukihide Tateishi, Kosei Matsue
Summary: The study found that high MH-SUVmax predicted poor prognosis in patients with multiple myeloma, especially in those with high-risk cytogenetic abnormalities.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Oncology
Xiaofan Pu, Chaolei Zhang, Guoping Ding, Hongpeng Gu, Yang Lv, Tao Shen, Tianshu Pang, Liping Cao, Shengnan Jia
Summary: This study demonstrated the potential utility of the sEV-miRNA d-signature in the diagnosis of PDAC via machine learning methods. A novel sEV biomarker, miR-664a-3p, was identified for the diagnosis of PDAC. It can also potentially promote angiogenesis and metastasis, provide insight into PDAC pathogenesis, and reveal novel regulators of this disease.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Jiaping Wang, Zhijuan Xu, Yanli Lai, Yanli Zhang, Ping Zhang, Qitian Mu, Shujun Yang, Yongcheng Sun, Lixia Sheng, Guifang Ouyang
Summary: This study demonstrates the significance of PD-1 in EBV-infected lymphoma cells. Silencing PD-1 enhances the tumor targeting effect of EBV-specific killer T cells on B lymphocytes and attenuates the immune escape effect.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Qiliang Peng, Jialong Tao, Yingjie Xu, Yi Shen, Yong Wang, Yang Jiao, Yiheng Mao, Yaqun Zhu, Yulong Liu, Ye Tian
Summary: This study investigates the potential role of lipid metabolism-associated genes (LMAGs) in neoadjuvant chemoradiotherapy (nCRT) and immunotherapy for rectal cancer. The results suggest that the SREBF2 gene is a highly predictive factor for nCRT in rectal cancer and is associated with favorable prognosis. SREBF2 is also closely associated with immune cell infiltration and immunotherapy-related genes.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Shiquan Li, Nan Zhang, Yongping Yang, Tongjun Liu
Summary: This study investigated the potential molecular mechanism of SPDEF in immune evasion of colorectal cancer (CRC) and found that it suppresses immune evasion by activating CCL28 through the modulation of M2 polarization of macrophages. These findings provide a new research direction and potential therapeutic target for immunotherapy in CRC.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Manas Sehgal, Soundharya Ramu, Joel Markus Vaz, Yogheshwer Raja Ganapathy, Srinath Muralidharan, Sankalpa Venkatraghavan, Mohit Kumar Jolly
Summary: This study investigates the relationship between gene expression patterns and phenotypic plasticity and heterogeneity in colorectal cancer (CRC). The results demonstrate the interconnectedness between different Consensus Molecular Subtypes (CMS) of CRC and specific phenotypes such as epithelial and mesenchymal characteristics. Additionally, the study reveals correlations between metabolic pathways and phenotypic scores, as well as between PD-L1 activity and mesenchymal phenotype. Single-cell RNA sequencing analysis further confirms the heterogeneity of different CMS subtypes. These findings have important implications for understanding CRC heterogeneity and developing targeted therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yutong Zou, Siyao Guo, Yan Liao, Weidong Chen, Ziyun Chen, Junkai Chen, Lili Wen, Xianbiao Xie
Summary: This study found that ceramide metabolism is associated with the progression and clinical outcome of osteosarcoma by analyzing data from osteosarcoma patients. The gene ST3GAL1 plays an important role in osteosarcoma, regulating the tumor immune microenvironment and affecting T cell function. It may become a new target for the treatment of osteosarcoma.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Chuanhui Chen, Mengzhi Wan, Xiong Peng, Qing Zhang, Yu Liu
Summary: This study examines the function and mechanism of the ceRNA network centered around GPR37 in LUAD. The findings show that high expression of GPR37 in LUAD tissue samples is associated with poor prognosis, and it may regulate the expression of downstream target genes by competitively binding to lncRNA DLEU1 and miR-4458.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Junping Li, Hong Hu, Jinping He, Yuling Hu, Manting Liu, Bihui Cao, Dongni Chen, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Wen Long, Hui Lian, Deji Chen, Likun Chen, Lili Yang, Zhenfeng Zhang
Summary: Sequential administration of CDC7 inhibitor XL413 after carboplatin enhances the chemotherapeutic effect of carboplatin on ovarian cancer cells, possibly by inhibiting homologous recombination repair activity and increasing the accumulation of chemotherapy-induced DNA damage.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Madison Catalanotto, Joel Markus Vaz, Camille Abshire, Reneau Youngblood, Min Chu, Herbert Levine, Mohit Kumar Jolly, Ana -Maria Dragoi
Summary: The study demonstrates that loss of FLASH in cancer cells leads to a hybrid E/M phenotype with high epithelial scores, suggesting FLASH acts as a repressor of the epithelial phenotype. Additionally, FLASH expression is inversely correlated with the epithelial score and subsets of mesenchymal markers are distinctly up-regulated in FLASH, NPAT, or SLBP-depleted cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Xiaorui Wang, Na Li, Minying Zheng, Yongjun Yu, Shiwu Zhang
Summary: Adipocytes are derived from pluripotent mesenchymal stem cells and histone modifications play a key role in their differentiation. Recent studies have shown that cancer stem cells can differentiate into adipocytes, reducing the malignancy of cancer cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Hana Q. Sadida, Alanoud Abdulla, Sara Al Marzooqi, Sheema Hashem, Muzafar A. Macha, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat
Summary: Cancer heterogeneity and drug resistance are major obstacles to effective cancer treatment, and epigenetic modifications play a pivotal role in these processes. This review explores essential epigenetic modifications, including DNA methylation, histone modifications, and chromatin remodeling, and discusses their complex contributions to cancer biology. However, the interplay of epigenetic and genetic changes in cancer cells presents unique challenges that must be addressed to fully exploit the potential of epigenetic modifications.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Pedro De Marchi, Leticia Ferro Leal, Luciane Sussuchi da Silva, Rodrigo de Oliveira Cavagna, Flavio Augusto Ferreira da Silva, Vinicius Duval da Silva, Eduardo C. A. da Silva, Augusto O. Saito, Vladmir C. Cordeiro de Lima, Rui Manuel Reis
Summary: The TIS and IFN-gamma signatures are predictive biomarkers for identifying NSCLC patients who could potentially benefit from immune checkpoint inhibitor therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Giovanni Marchi, Anna Rajavuori, Mai T. N. Nguyen, Kaisa Huhtinen, Sinikka Oksa, Sakari Hietanen, Sampsa Hautaniemi, Johanna Hynninen, Jaana Oikkonen
Summary: The study shows that ctDNA can adequately represent high-grade serous ovarian carcinoma (HGSC), and the mutations observed at relapse suggest personalized therapy options.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yuncang Yuan, Jiawei Fan, Dandan Liang, Shijie Wang, Xu Luo, Yongjie Zhu, Nan Liu, Tingxiu Xiang, Xudong Zhao
Summary: This study demonstrates that csGRP78-directed CAR-T cells can selectively kill pancreatic cancer cells, and the combination with chemotherapy enhances cytotoxicity.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Niyati Piplani, Tanusri Roy, Neha Saxena, Shamik Sen
Summary: The glycocalyx, a protective barrier surrounding cells, has been found to play a role in cancer cell proliferation, survival, and metastasis. However, its function in maintaining DNA/nuclear integrity during migration through dense matrices has not been explored. This study shows that the bulkiness of the glycocalyx is inversely associated with nuclear stresses, and highlights its mechanical role in shielding migration-associated stresses.
TRANSLATIONAL ONCOLOGY
(2024)