Article
Cell Biology
Leslie Duplaquet, Yixiang Li, Matthew A. Booker, Yingtian Xie, Sarah Naomi Olsen, Radhika A. Patel, Deli Hong, Charlie Hatton, Thomas Denize, Emily Walton, Yasmin N. Laimon, Rong Li, Yijia Jiang, Roderick T. Bronson, Jackson Southard, Shuqiang Li, Sabina Signoretti, Xintao Qiu, Paloma Cejas, Scott A. Armstrong, Henry W. Long, Michael Y. Tolstorukov, Michael C. Haffner, Matthew G. Oser
Summary: This study investigates the impact of KDM6A/UTX gene inactivation on the plasticity switch between ASCL1 and NEUROD1 subtypes in small cell lung cancer (SCLC) using a genetically engineered mouse model. The results demonstrate that KDM6A inactivation induces the transition from ASCL1 to NEUROD1 subtype, providing insights into the heterogeneity and plasticity of SCLC subtypes.
NATURE CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Teng-fei Chen, Hui-fei Hao, Yan Zhang, Xiao-yu Chen, Hua-si Zhao, Rui Yang, Ping Li, Ling-xiao Qiu, Yong-hua Sang, Chun Xu, Shao-xia Liu
Summary: This study examined the expression and biological function of HBO1 in non-small cell lung cancer (NSCLC). The results showed that HBO1 transcripts were elevated in NSCLC, and HBO1 overexpression promoted NSCLC cell growth and migration. On the other hand, silencing or knockout of HBO1 significantly inhibited cell viability and migration. Furthermore, HBO1 silencing or knockout also led to decreased expression of specific oncogenic genes.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Chemistry, Medicinal
Hye-Young Min, Ho-Young Lee
Summary: Non-small cell lung cancer (NSCLC) accounts for a majority of lung cancer cases and is typically treated with a combination of therapies, such as radiotherapy, chemotherapy, targeted therapy, and immunotherapy. However, chemoresistance remains a significant obstacle in the management of NSCLC, necessitating a better understanding of the underlying mechanisms to develop effective treatment strategies.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Oncology
Hiba Abou Daya, Sana Kouba, Hakim Ouled-Haddou, Nazim Benzerdjeb, Marie-Sophie Telliez, Charles Dayen, Henri Sevestre, Loic Garcon, Frederic Hague, Halima Ouadid-Ahidouch
Summary: Resistance to platinum drugs in the treatment of non-small cell lung cancer is closely related to the enrichment of cancer stem cell populations. The Orai3 channel has been identified as a predictive marker for metastasis and survival, playing a role in inducing CSC populations and affecting the efficacy of chemotherapy.
Article
Biotechnology & Applied Microbiology
Shizhen Zheng, Chao Wang, Hao Yan, Yuejun Du
Summary: The circular RNA HC0074027 plays a crucial role in regulating chemoresistance in non-small cell lung cancer, suggesting its potential as a therapeutic target in NSCLC treatment.
Article
Biochemistry & Molecular Biology
Arin Nam, Atish Mohanty, Supriyo Bhattacharya, Sourabh Kotnala, Srisairam Achuthan, Kishore Hari, Saumya Srivastava, Linlin Guo, Anusha Nathan, Rishov Chatterjee, Maneesh Jain, Mohd W. Nasser, Surinder Kumar Batra, Govindan Rangarajan, Erminia Massarelli, Herbert Levine, Mohit Kumar Jolly, Prakash Kulkarni, Ravi Salgia
Summary: This study developed a mathematical approach based on game theory to model the response of non-small cell lung cancer cells to cisplatin treatment. The findings suggest that dynamic interactions and group behavior play a role in drug resistance, with tolerant cells displaying a 'persister-like' behavior and educating sensitive cells to evade chemotherapy. Furthermore, intermittent chemotherapy may be a better treatment strategy to reduce the emergence of tolerant cells in lung cancer.
Article
Pathology
Xizhen Xu, Guoping Wang, Yaqi Duan, Zitian Huo
Summary: High expression of INSM1 in SCLC is correlated with poor prognosis, lymph node metastasis, and later TNM stages. INSM1 plays a role in tumor progression and chemoresistance through down-regulating AMPK signal pathway. Metformin shows potential in reversing INSM1-induced chemoresistance.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Oncology
Yueqin Sun, Weitao Shen, Shulu Hu, Qiong Lyu, Qiongyao Wang, Ting Wei, Weiliang Zhu, Jian Zhang
Summary: This study found that METTL3 is a marker for poor prognosis in small cell lung cancer (SCLC) and is highly expressed in chemoresistant SCLC cells. METTL3 promotes SCLC chemoresistance by positively regulating mitophagy. METTL3 induces m6A methylation of DCP2 and causes the degradation of DCP2, which promotes mitochondrial autophagy through the Pink1-Parkin pathway, leading to chemotherapy resistance. Additionally, a novel METTL3 inhibitor, STM2457, can reverse SCLC chemoresistance.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Sarah Sayed Hassanein, Sherif Abdelaziz Ibrahim, Ahmed Lotfy Abdel-Mawgood
Summary: Lung cancer is a complex disease associated with gene mutations, particularly KRAS and EGFR. miRNAs play a key role in regulating EGFR crosstalk, affecting sensitivity to EGFR-TKI treatment, and can be used as diagnostic, prognostic, and therapeutic targets in NSCLC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Clara Bourreau, Lucas Treps, Sebastien Faure, Delphine Fradin, Nicolas Clere
Summary: Although new targeted therapies have improved the treatment and prognosis of non-small cell lung cancer, they often fail due to primary or acquired resistances. Chemoresistance is a complex process involving various factors. Two approaches that could improve treatment response are developing predictive tools and understanding the influence of the tumor microenvironment. Personalized medicine requires identifying relevant experimental models and biomarkers to combat chemoresistance.
PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Medicine, General & Internal
Hollis Viray, Deepa Rangachari, Daniel B. Costa
Summary: The study reported initial data of trastuzumab deruxtecan in the treatment of lung cancers with ERBB2 mutations, including patients who had previously received ineffective ERBB2 tyrosine kinase inhibitors.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Cell Biology
Jing Zhou, Yang Lin, Xiuhua Kang, Zhicheng Liu, Juntao Zou, Fei Xu
Summary: This study reveals the role of FBXL7 in NSCLC and its upstream and downstream mechanisms. FBXL7 is downregulated in NSCLC and degrades PFKFB4, inhibiting glucose metabolism and malignant phenotypes. The EZH2/FBXL7/PFKFB4 axis plays a regulatory role in glucose metabolism and tumor growth of NSCLC.
CELL DEATH & DISEASE
(2023)
Review
Oncology
Rui Xu, Xin Luo, Xuan Ye, Huan Li, Hongyue Liu, Qiong Du, Qing Zhai
Summary: Resistance to treatment in non-small cell lung cancer (NSCLC) is often driven by hypoxia, which can induce molecular metabolic adaptations leading to chemotherapy resistance. Molecular mediators like SIRT1/PGC-1 alpha/PPAR-gamma play a role in regulating mitochondrial function in response to hypoxia, affecting chemoresistance in NSCLC. Targeting hypoxia-related metabolic adaptations may be a promising therapeutic strategy to overcome drug resistance in NSCLC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Qi Yang, Pei Xu, Qingtao Liu, Fengqing Hu, Xiao Xie, Lianyong Jiang, Rui Bi, Lei Wang, Fangbao Ding, Haibo Xiao
Summary: This study found that DDX1 is overexpressed in non-small cell lung cancer (NSCLC). Depleting DDX1 increased the sensitivity of NSCLC cells to the chemotherapy drug cisplatin, increased cell apoptosis, and inhibited cell migration and invasion. Furthermore, DDX1 bound to ADAR1 and increased ADAR1 protein expression. The results suggest that DDX1 plays an important role in the development and progression of NSCLC and may serve as a therapeutic target in NSCLC patients.
Article
Cell Biology
Justin W. Magrath, Hong-Jun Kang, Alifiani Hartono, Madelyn Espinosa-Cotton, Romel Somwar, Marc Ladanyi, Nai-Kong Cheung, Sean B. Lee
Summary: This study found that elevated levels of stemness markers are associated with worse survival and metastasis in DSRCT patients. Additionally, they developed the first in vitro DSRCT CSC model, which showed resistance to chemotherapy. These findings provide important tools for further investigation of the DSRCT subpopulation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Xiaofan Pu, Chaolei Zhang, Guoping Ding, Hongpeng Gu, Yang Lv, Tao Shen, Tianshu Pang, Liping Cao, Shengnan Jia
Summary: This study demonstrated the potential utility of the sEV-miRNA d-signature in the diagnosis of PDAC via machine learning methods. A novel sEV biomarker, miR-664a-3p, was identified for the diagnosis of PDAC. It can also potentially promote angiogenesis and metastasis, provide insight into PDAC pathogenesis, and reveal novel regulators of this disease.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Jiaping Wang, Zhijuan Xu, Yanli Lai, Yanli Zhang, Ping Zhang, Qitian Mu, Shujun Yang, Yongcheng Sun, Lixia Sheng, Guifang Ouyang
Summary: This study demonstrates the significance of PD-1 in EBV-infected lymphoma cells. Silencing PD-1 enhances the tumor targeting effect of EBV-specific killer T cells on B lymphocytes and attenuates the immune escape effect.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Qiliang Peng, Jialong Tao, Yingjie Xu, Yi Shen, Yong Wang, Yang Jiao, Yiheng Mao, Yaqun Zhu, Yulong Liu, Ye Tian
Summary: This study investigates the potential role of lipid metabolism-associated genes (LMAGs) in neoadjuvant chemoradiotherapy (nCRT) and immunotherapy for rectal cancer. The results suggest that the SREBF2 gene is a highly predictive factor for nCRT in rectal cancer and is associated with favorable prognosis. SREBF2 is also closely associated with immune cell infiltration and immunotherapy-related genes.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Shiquan Li, Nan Zhang, Yongping Yang, Tongjun Liu
Summary: This study investigated the potential molecular mechanism of SPDEF in immune evasion of colorectal cancer (CRC) and found that it suppresses immune evasion by activating CCL28 through the modulation of M2 polarization of macrophages. These findings provide a new research direction and potential therapeutic target for immunotherapy in CRC.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Manas Sehgal, Soundharya Ramu, Joel Markus Vaz, Yogheshwer Raja Ganapathy, Srinath Muralidharan, Sankalpa Venkatraghavan, Mohit Kumar Jolly
Summary: This study investigates the relationship between gene expression patterns and phenotypic plasticity and heterogeneity in colorectal cancer (CRC). The results demonstrate the interconnectedness between different Consensus Molecular Subtypes (CMS) of CRC and specific phenotypes such as epithelial and mesenchymal characteristics. Additionally, the study reveals correlations between metabolic pathways and phenotypic scores, as well as between PD-L1 activity and mesenchymal phenotype. Single-cell RNA sequencing analysis further confirms the heterogeneity of different CMS subtypes. These findings have important implications for understanding CRC heterogeneity and developing targeted therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yutong Zou, Siyao Guo, Yan Liao, Weidong Chen, Ziyun Chen, Junkai Chen, Lili Wen, Xianbiao Xie
Summary: This study found that ceramide metabolism is associated with the progression and clinical outcome of osteosarcoma by analyzing data from osteosarcoma patients. The gene ST3GAL1 plays an important role in osteosarcoma, regulating the tumor immune microenvironment and affecting T cell function. It may become a new target for the treatment of osteosarcoma.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Chuanhui Chen, Mengzhi Wan, Xiong Peng, Qing Zhang, Yu Liu
Summary: This study examines the function and mechanism of the ceRNA network centered around GPR37 in LUAD. The findings show that high expression of GPR37 in LUAD tissue samples is associated with poor prognosis, and it may regulate the expression of downstream target genes by competitively binding to lncRNA DLEU1 and miR-4458.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Junping Li, Hong Hu, Jinping He, Yuling Hu, Manting Liu, Bihui Cao, Dongni Chen, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Wen Long, Hui Lian, Deji Chen, Likun Chen, Lili Yang, Zhenfeng Zhang
Summary: Sequential administration of CDC7 inhibitor XL413 after carboplatin enhances the chemotherapeutic effect of carboplatin on ovarian cancer cells, possibly by inhibiting homologous recombination repair activity and increasing the accumulation of chemotherapy-induced DNA damage.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Madison Catalanotto, Joel Markus Vaz, Camille Abshire, Reneau Youngblood, Min Chu, Herbert Levine, Mohit Kumar Jolly, Ana -Maria Dragoi
Summary: The study demonstrates that loss of FLASH in cancer cells leads to a hybrid E/M phenotype with high epithelial scores, suggesting FLASH acts as a repressor of the epithelial phenotype. Additionally, FLASH expression is inversely correlated with the epithelial score and subsets of mesenchymal markers are distinctly up-regulated in FLASH, NPAT, or SLBP-depleted cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Xiaorui Wang, Na Li, Minying Zheng, Yongjun Yu, Shiwu Zhang
Summary: Adipocytes are derived from pluripotent mesenchymal stem cells and histone modifications play a key role in their differentiation. Recent studies have shown that cancer stem cells can differentiate into adipocytes, reducing the malignancy of cancer cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Hana Q. Sadida, Alanoud Abdulla, Sara Al Marzooqi, Sheema Hashem, Muzafar A. Macha, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat
Summary: Cancer heterogeneity and drug resistance are major obstacles to effective cancer treatment, and epigenetic modifications play a pivotal role in these processes. This review explores essential epigenetic modifications, including DNA methylation, histone modifications, and chromatin remodeling, and discusses their complex contributions to cancer biology. However, the interplay of epigenetic and genetic changes in cancer cells presents unique challenges that must be addressed to fully exploit the potential of epigenetic modifications.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Pedro De Marchi, Leticia Ferro Leal, Luciane Sussuchi da Silva, Rodrigo de Oliveira Cavagna, Flavio Augusto Ferreira da Silva, Vinicius Duval da Silva, Eduardo C. A. da Silva, Augusto O. Saito, Vladmir C. Cordeiro de Lima, Rui Manuel Reis
Summary: The TIS and IFN-gamma signatures are predictive biomarkers for identifying NSCLC patients who could potentially benefit from immune checkpoint inhibitor therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Giovanni Marchi, Anna Rajavuori, Mai T. N. Nguyen, Kaisa Huhtinen, Sinikka Oksa, Sakari Hietanen, Sampsa Hautaniemi, Johanna Hynninen, Jaana Oikkonen
Summary: The study shows that ctDNA can adequately represent high-grade serous ovarian carcinoma (HGSC), and the mutations observed at relapse suggest personalized therapy options.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yuncang Yuan, Jiawei Fan, Dandan Liang, Shijie Wang, Xu Luo, Yongjie Zhu, Nan Liu, Tingxiu Xiang, Xudong Zhao
Summary: This study demonstrates that csGRP78-directed CAR-T cells can selectively kill pancreatic cancer cells, and the combination with chemotherapy enhances cytotoxicity.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Niyati Piplani, Tanusri Roy, Neha Saxena, Shamik Sen
Summary: The glycocalyx, a protective barrier surrounding cells, has been found to play a role in cancer cell proliferation, survival, and metastasis. However, its function in maintaining DNA/nuclear integrity during migration through dense matrices has not been explored. This study shows that the bulkiness of the glycocalyx is inversely associated with nuclear stresses, and highlights its mechanical role in shielding migration-associated stresses.
TRANSLATIONAL ONCOLOGY
(2024)