期刊
MOVEMENT DISORDERS
卷 32, 期 1, 页码 80-88出版社
WILEY
DOI: 10.1002/mds.26837
关键词
deep brain stimulation; Parkinson's disease; beta oscillations; low frequency; subthalamic nucleus
资金
- Michael J. Fox Foundation for Parkinson's Research
- Robert and Ruth Halperin Foundation
- Helen M. Cahill Award for Research in Parkinson's disease
Background: The objective of this study was to investigate the hypothesis that attenuation of subthalamic nucleus (STN) alpha-/beta-band oscillations is causal to improvement in bradykinesia. Methods: STN local field potentials from a sensing neurostimulator (Activa VR PC1S; Medtronic, Inc.) and kinematics from wearable sensors were recorded simultaneously during 60-and 140-Hz deep brain stimulation (DBS) in 9 freely moving PD subjects (15 STNs) performing repetitive wrist flexion-extension. Kinematics were recorded during 20-Hz DBS in a subgroup. Results: Both 60-and 140-Hz DBS improved the angular velocity and frequency of movement (P=0.002 and P=0.029, respectively, for 60 Hz; P < 0.001 and P < 0.001, respectively, for 140 Hz), but 60-Hz DBS did not attenuate beta-band power (13-30 Hz). In fact, 60-Hz DBS amplified alpha/low-beta (11-15 Hz, P=0.007) and attenuated high-beta power (19-27 Hz, P < 0.001), whereas 140-Hz DBS broadly attenuated beta power (15-30 Hz, P < 0.001). Only 60-Hz DBS improved the regularity of angular range (P=0.046) and 20-Hz DBS did not worsen bradykinesia. There was no correlation between beta-power modulation and bradykinesia. Conclusions: These novel results obtained from freely moving PD subjects demonstrated that both 140and 60-Hz DBS improved bradykinesia and attenuated high beta oscillations; however, 60-Hz DBS amplified a subband of alpha/low-beta oscillations, and DBS at a beta-band frequency did not worsen bradykinesia. Based on recent literature, we suggest that both 140and 60-Hz DBS decouple the cortico-STN hyperdirect pathway, whereas 60-Hz DBS increases (C) VC 2016 International Parkinson and Movement Disorder Society
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据