Article
Cell Biology
Michal A. Stanczak, Natalia Rodrigues Mantuano, Nicole Kirchhammer, David E. Sanin, Francis Jacob, Ricardo Coelho, Arun V. Everest-Dass, Jinyu Wang, Marcel P. Trefny, Gianni Monaco, Anne Barenwaldt, Melissa A. Gray, Adam Petrone, Abhishek S. Kashyap, Katharina Glatz, Benjamin Kasenda, Karl Normington, James Broderick, Li Peng, Oliver M. T. Pearce, Erika L. Pearce, Carolyn R. Bertozzi, Alfred Zippelius, Heinz Laubli
Summary: This study demonstrates the correlation between tumor sialylation and immune states as well as survival, and proposes therapeutic desialylation as an approach to enhance antitumor immunity. The study also reveals the impact of desialylation on tumor-associated macrophages and the efficacy of immune checkpoint blockade.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Emma Scott, Emily Archer Goode, Rebecca Garnham, Kirsty Hodgson, Margarita Orozco-Moreno, Helen Turner, Karen Livermore, Kyla Putri Nangkana, Fiona M. Frame, Abel Bermudez, Fernando Jose Garcia Marques, Urszula L. McClurg, Laura Wilson, Huw Thomas, Adriana Buskin, Anastasia Hepburn, Adam Duxfield, Kayla Bastian, Hayley Pye, Hector M. Arredondo, Gerald Hysenaj, Susan Heavey, Urszula Stopka-Farooqui, Aiman Haider, Alex Freeman, Saurabh Singh, Edward W. Johnston, Shonit Punwani, Bridget Knight, Paul McCullagh, John McGrath, Malcolm Crundwell, Lorna Harries, Rakesh Heer, Norman J. Maitland, Hayley Whitaker, Sharon Pitteri, Dean A. Troyer, Ning Wang, David J. Elliott, Richard R. Drake, Jennifer Munkley
Summary: Aberrant glycosylation, specifically the increase in α2,6 sialylation of N-glycans driven by ST6GAL1, plays a crucial role in prostate cancer progression. ST6GAL1 is upregulated in prostate cancer tissue and its levels are significantly increased in the blood of men with prostate cancer. Targeting α2,6 sialylated N-glycans through the inhibition of ST6GAL1 presents an opportunity for the development of new prostate cancer therapeutics.
JOURNAL OF PATHOLOGY
(2023)
Review
Oncology
Jennifer Munkley
Summary: All cells are covered in a layer of sugar molecules known as glycans, and changes to this sugar coat are common in cancer. Sialic acid glycans, which are often highly expressed in cancer cells, play important roles in tumor growth, metastasis, immune evasion, and drug resistance. Strategies to target sialic acid have huge potential for cancer research.
Review
Neurosciences
Kangkang Yang, Zhaofei Yang, Xiaofeng Chen, Wenzhe Li
Summary: Sialylation plays a role in the occurrence and development of Alzheimer's disease, but its relationship with AD is still not well understood. Understanding the impact of sialylation on AD can provide valuable insights for diagnosis and treatment.
BRAIN RESEARCH BULLETIN
(2021)
Review
Oncology
Jianmei Huang, Jianming Huang, Guonan Zhang
Summary: Sialylation plays a crucial role in tumor transformation, growth, metastasis, and immune evasion. Targeting tumor-derived sialoglycans is a promising approach for cancer treatments, as it can limit the dissemination of tumor cells, reveal immunogenic tumor antigens, and boost anti-cancer immunity.
Article
Chemistry, Analytical
Zhixiong Li, Duong T. Bui, Yanxiang Shao, Elena N. Kitova, Stephanie White, Danny Vesprini, Stanley K. Liu, Lara K. Mahal, Hon S. Leong, John S. Klassen
Summary: The PSA test is commonly used for prostate cancer screening but it may result in misdiagnosis. Increased levels of α2-3-linked N-acetylneuraminic acid in the N-glycan sialylation of PSA have been identified as a potential biomarker for clinically significant prostate cancer. A native mass spectrometry approach was developed to quantify α2-3-linked N-acetylneuraminic acid levels in PSA extracted from blood serum, which can discriminate between clinically significant prostate cancer and low-grade prostate cancer.
ANALYTICAL CHEMISTRY
(2023)
Article
Oncology
Siyaporn Putthisen, Atit Silsirivanit, Orasa Panawan, Akiko Niibori-Nambu, Yuki Nishiyama-Ikeda, Prasertsri Ma-In, Sukanya Luang, Kunimasa Ohta, Kanha Muisuk, Sopit Wongkham, Norie Araki
Summary: A new type of glioma stem cell has been discovered, which expresses a unique sialic acid-modified glycan. This glycan is highly expressed in glioma stem cells and its inhibition can induce apoptosis of the stem cells, making it a potential marker and therapeutic target for glioma treatment.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Leandre M. Glendenning, Julie Y. Zhou, Emily N. Kukan, Chao Gao, Richard D. Cummings, Smita Joshi, Sidney W. Whiteheart, Brian A. Cobb
Summary: The IgG antibody class plays a crucial role in the humoral immune response, offering protection against both pathogens and autoimmunity. The function of IgG is influenced by the IgG subclass and the glycan composition at N297 within the Fc domain. However, little is known about the regulation of IgG glycan composition.
Review
Pharmacology & Pharmacy
Sai Kiran S. S. Pindiprolu, Jitender Madhan, Dadi A. Srinivasarao, Nagasen Dasari, Chirravuri. S. Phani Kumar, Chantibabu Katta, Vaskuri G. S. Sainaga Jyothi
Summary: Triple Negative Breast Cancer (TNBC) is a challenging and aggressive form of breast cancer, but nanocarrier-based therapies show promise in delivering therapeutic agents specifically to cancer cells. Targeting sialylation, a process linked to the survival of Breast Cancer Stem Cells (BCSCs) and the occurrence of Epithelial-Mesenchymal Transition (EMT), can be a potential approach for TNBC treatment. However, current therapeutic strategies for inhibiting sialylation have limitations, which can be overcome by nanocarrier-based approaches.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Priti Gupta, Tibor Saghy, Jauquline Nordqvist, Jonas Nilsson, Hans Carlsten, Karin Horkeby, Petra Henning, Cecilia Engdahl
Summary: This study aims to determine if estrogen levels can regulate IgG glycosylation in postmenopausal healthy situations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemical Research Methods
Fanny Boyaval, Rene van Zeijl, Hans Dalebout, Stephanie Holst, Gabi van Pelt, Arantza Farina-Sarasqueta, Wilma Mesker, Rob Tollenaar, Hans Morreau, Manfred Wuhrer, Bram Heijs
Summary: In patients with stage II colorectal cancer, malignant cells exhibit alterations in glycosylation characteristics, and these features spread into the surrounding stroma at the invasive front of the tumor, being more pronounced in patients with a poorer prognosis within the sample group.
MOLECULAR & CELLULAR PROTEOMICS
(2021)
Article
Microbiology
Onasis Vicente-Fermin, Edgar Zenteno, Ivan Ramos-Martinez, Clara Espitia, Jose Ivan Sanchez-Betancourt, Leonor Huerta
Summary: This study explored the effects of dexamethasone on the expression of sialic acid residues in A549, Vero, and MDCK cells. The results showed that dexamethasone completely inhibited the expression of Sia Alpha 2,3 in A549 cells and decreased its expression in Vero and MDCK cells. In contrast, dexamethasone increased the expression of Sia Alpha 2,6 in these three cell lines. These findings suggest that dexamethasone may alter the tropism of avian and human/pig influenza viruses and other infectious agents to animal and human epithelial cells. It also provides an important tool for studying the mechanism of sialylation of cell membrane molecules.
Review
Chemistry, Multidisciplinary
Amol M. Vibhute, Naoko Komura, Hide-Nori Tanaka, Akihiro Imamura, Hiromune Ando
Summary: Sialic acid is an important component of cell surface glycans, but its structure complexity and unique features make it challenging to isolate large quantities of pure sialoglycans from natural sources, leading to a focus on chemical synthesis methods. Despite the difficulties in alpha-glycosylation of sialic acid, various types of sialyl donors/acceptors have been developed for the synthesis.
Review
Immunology
Ravi Vattepu, Sunny Lyn Sneed, Robert M. Anthony
Summary: Antibodies play a critical role in linking the adaptive immune response to the innate immune system. Human antibodies are categorized into different classes and undergo post-translational modification by sugars. The structure of glycans on antibodies, especially sialic acid, significantly influences their functions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Karolina I. Smolag, Marcus Fager Ferrari, Eva Zetterberg, Eva Leinoe, Torben Ek, Anna M. Blom, Maria Rossing, Myriam Martin
Summary: This study reported a case of a 17-year-old boy suffering from severe macrothrombocytopenia caused by compound heterozygous variants in GNE. The decreased sialylation of platelets due to these variants led to reduced FH binding, moderate complement activation, and increased hemolysis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Obstetrics & Gynecology
Wei-Ting Chao, Guan-Yeu Chen, Chia-Hao Liu, Chia-Pei Chang, Peng-Hui Wang, Huann-Cheng Horng
Summary: This study evaluated the efficacy and surgical outcomes of the adjustable midurethral sling I-stop-mini in women with intrinsic sphincter deficiency (ISD)-type stress urinary incontinence compared to the Obtryx transobturator midurethral sling system. The results showed no significant differences in objective success between the two devices at 1-month, 6-month, and 12-month follow-ups. The I-stop-mini group had a significantly shorter operative time, while the adverse event rates were similar.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)