Article
Oncology
A. S. Tjalsma, A. Wagner, W. N. M. Dinjens, P. C. Ewing-Graham, L. S. M. Alcala, M. E. R. de Groot, K. E. Hamoen, A. C. van Hof, W. Hofhuis, L. N. Hofman, K. J. Hoogduin, J. Kaijser, A. C. F. Makkus, S. J. J. Mol, G. M. Plaisier, K. Schelfhout, H. P. M. Smedts, R. A. Smit, P. J. Timmers, P. M. L. H. Vencken, B. Visschers, A. A. M. van der Wurff, H. C. van Doorn
Summary: In the Netherlands, a nationwide guideline introduced in 2016 recommended routine Lynch syndrome screening for women under 70 with endometrial cancer, evaluating the implementation of this guideline showed a high coverage of LSS (90%), but there is room for improvement in referral for genetic counselling. Gynaecologists need to be more aware of the benefits and drawbacks of knowing mutational status and require training in discussing this with their patients.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Thiago Pereira Diniz, Jacqueline Nunes Menezes, Bruna Tirapelli Goncalves, Carlos Chaves Faloppa, Henrique Mantoan, Lillian Yuri Kumagai, Levon Badiglian-Filho, Graziele Bovolim, Andrea Paiva Gadelha Guimaraes, Louise De Brot, Glauco Baiocchi
Summary: This study evaluated the relationship between mismatch repair (MMR) status and the risk of lymph node metastasis in endometrial cancer. MMR deficiency was found to be correlated with higher grade and lymphovascular space invasion, and it was an independent risk factor for lymph node metastasis. Furthermore, MMR status may help in selecting patients who can avoid systematic lymphadenectomy.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Medicine, General & Internal
Abdul K. Siraj, Sandeep Kumar Parvathareddy, Padmanaban Annaiyappanaidu, Nabil Siraj, Maha Al-Rasheed, Ismail A. Al-Badawi, Fouad Al-Dayel, Khawla S. Al-Kuraya
Summary: PD-L1 expression was strongly associated with non-endometrioid EC and was an independent prognostic marker of lymph node metastasis.
Review
Oncology
Amelia Favier, Justine Varinot, Catherine Uzan, Alex Duval, Isabelle Brocheriou, Geoffroy Canlorbe
Summary: This review summarizes the current knowledge on the role of immunohistochemistry markers in identifying mismatch repair-deficient tumors in endometrial cancer. The identification of MMRd tumors is critical for therapeutic management, clinical decision making, and prognosis. Despite challenges to its role, IHC remains the most common, robust, and cost-effective method for diagnosing MMRd tumors in EC and is a valuable tool for exploring novel biotherapies and treatment modalities.
Article
Oncology
Janna Siemanowski, Birgid Schoemig-Markiefka, Theresa Buhl, Anja Haak, Udo Siebolts, Wolfgang Dietmaier, Norbert Arens, Nina Pauly, Beyhan Ataseven, Reinhard Buettner, Sabine Merkelbach-Bruse
Summary: This study focused on challenges in microsatellite instability testing in endometrial cancer and compared four different PCR-based approaches to improve MSI testing in future screenings. By directly comparing the systems, the study was able to highlight the advantages and limitations of each.
Article
Biochemistry & Molecular Biology
Marta Mendiola, Victoria Heredia-Soto, Ignacio Ruz-Caracuel, Amparo Baillo, Jorge Luis Ramon-Patino, Francisco Javier Escudero, Maria Miguel, Alberto Pelaez-Garcia, Alicia Hernandez, Jaime Feliu, David Hardisson, Andres Redondo
Summary: This study aimed to establish and compare different approaches for assessing the MMR status in endometrial carcinomas. A total of 126 early-stage EC samples were analyzed using immunohistochemistry, PCR-based MSI, methylation-specific multiplex ligation-dependent probe amplification, and targeted next-generation sequencing. The study found that approximately 53.2% of the samples were MMR deficient, while 46.8% were MMR proficient. Additionally, 44.3% of the samples showed genetic or epigenetic alterations, with MLH1 promoter methylation being the most common event.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Doris Mangiaracina Benbrook, James Randolph Sanders Hocker, Katherine Marie Moxley, Jay S. Hanas
Summary: This study analyzed serum samples from endometrial cancer patients and benign gynecology surgical patients using electron spray ionization mass spectrometry (ES-MS), and evaluated the differences in serum proteins through leave one out cross validation (LOOCV). The study found that serum proteins could distinguish between different groups and predict positive lymph node metastases. Pathways related to metastases include loss of PTEN activation, calcium signaling activation, and estrogen receptor-induced transcription. These findings provide new insights for treatment decisions in endometrial cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Soyoun Rachel Kim, Alicia Tone, Raymond H. Kim, Matthew Cesari, Blaise A. Clarke, Lua Eiriksson, Tae Hart, Melyssa Aronson, Spring Holter, Alice Lytwyn, Katherine Lajkosz, Leslie Oldfield, Steven Gallinger, Marcus Q. Bernardini, Amit M. Oza, Bojana Djordjevic, Jordan Lerner-Ellis, Emily Van de Laar, Danielle Vicus, Trevor Pugh, Aaron Pollett, Sarah E. Ferguson
Summary: The study compared the clinical characteristics, survival, and recurrence patterns between MMRd and MMRi EEC. The results showed that MMRd tumors have more aggressive features, lower recurrence-free survival, and are more likely to recur in retroperitoneal lymph nodes. MLH1 methylated tumors had the worst prognostic features and survival outcomes.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Hannah C. Karpel, Maria Smith, Allison Brodsky, Bhavana Pothuri
Summary: This study aimed to increase the rate of genetic counseling referrals and testing for Lynch Syndrome in endometrial cancer patients through the implementation of a specific protocol. The results showed a significant increase in the frequency of genetic counseling referrals after the protocol initiation. However, there was no statistically significant difference in the rate of genetic testing. This study highlights the importance of Lynch Syndrome screening in clinical practice.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Zhiling Wang, Shuo Zhang, Yifei Ma, Wenhui Li, Jiguang Tian, Ting Liu
Summary: This study identified that LVSI is the most predictive factor for LNM in patients with EC. The developed nomogram based on valuable parameters showed good discrimination accuracy for predicting the risk of LNM.
Article
Health Care Sciences & Services
Hiroshi Yoshida, Waku Takigawa, Mayumi Kobayashi-Kato, Tadaaki Nishikawa, Kouya Shiraishi, Mitsuya Ishikawa
Summary: This study aimed to compare the concordance and interchangeability of the Dako/Agilent and Ventana/Roche mismatch repair (MMR) immunohistochemistry (IHC) assays commonly used in pathology. It also examined the frequency and characteristics of the dot-like artifact observed in MLH1 M1 clone staining in endometrial cancer. The study found a high concordance between the MMR-IHC assays and emphasized the importance of considering the dot-like artifact in MLH1 M1 clone staining when diagnosing endometrial cancer with MMR deficiency.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Medicine, General & Internal
Wan Kam Chiu, Shuk Tak Kwok, Yaokai Wang, Hiu Mei Luk, Aaron Hei Yin Chan, Ka Yu Tse
Summary: Lymph node status plays an important role in predicting prognosis and guiding treatment in endometrial cancer. Sentinel lymph node biopsy has emerged as an acceptable alternative to full lymphadenectomy, with high detection rate and reduced surgical morbidity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Christine S. Walsh, Kari E. Hacker, Angeles Alvarez Secord, Deborah F. DeLair, Carolyn McCourt, Renata Urban
Summary: The Cancer Genome Atlas publication identified four molecular subtypes of endometrial cancer with different prognoses. The Proactive Molecular Classifier for Endometrial Cancer facilitates the classification of endometrial cancers into similar subtypes more conveniently and inexpensively. In addition to these subtypes, other molecular biomarkers may impact clinical behavior and response to targeted therapies. The understanding of molecular classification is essential for clinicians treating endometrial cancer to guide appropriate testing and treatment decisions.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Jessie Y. Li, Henry S. Park, Gloria S. Huang, Melissa R. Young, Elena Ratner, Alessandro Santin, Shari Damast
Summary: The study investigated the impact of mismatch repair (MMR) status on the prognosis of EEC patients treated with vaginal brachytherapy (VBT). It was found that patients with deficient MMR (dMMR) had poorer recurrence-free survival (RFS) compared to proficient MMR (pMMR) patients, regardless of their high-intermediate-risk (HIR) or low-intermediate-risk (LIR) classification.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Obstetrics & Gynecology
Ju-Hyun Kim, Byung-Su Kwon, Hyojin Kim, Dong Hoon Suh, Kidong Kim, Yong Beom Kim, Jae Hong No
Summary: This study evaluated the clinicopathologic characteristics of DNA mismatch repair protein (MMRP) deficiency in endometrial cancer and found that MMRP-deficient patients had a better overall survival. Further research is needed to confirm its prognostic implication.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2022)
Article
Medicine, General & Internal
Eun-Jung Yang, Ji-Hyeon Lee, A-Jin Lee, Nae-Ry Kim, Yong-Taek Ouh, Mi-Kyung Kim, Seung-Hyuk Shim, Sun-Joo Lee, Tae-Jin Kim, Kyeong-A So
Summary: This study investigated the prevalence and oncologic outcomes of gynecologic cancer patients with multiple primary malignant tumors (MPMT). The results showed that the prevalence of MPMT in patients was 8.6% and the average diagnostic period between primary and secondary cancer was 60 months. The most common coexisting cancer in the MPMT group was endometrial-ovarian cancer, while breast cancer was the most common non-gynecologic cancer in the coexisting cancer group. The incidence of synchronous cancer was significantly higher in the MPMT group compared to the coexisting cancer group, and early-stage ovarian cancer was more highly diagnosed in the MPMT group.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Nae Ry Kim, Zee Hae Baek, A. Jin Lee, Eun Jung Yang, Yung-Taek Ouh, Mi Kyung Kim, Seung-Hyuk Shim, Sun Joo Lee, Tae Jin Kim, Kyeong A. So
Summary: The study found that although there were no significant differences in residual disease and CIN recurrence between the GI-negative and GI-positive groups, GI-positive patients were more likely to receive additional surgical treatments. Careful consideration should be given to repeat surgery based on GI positivity to avoid overtreatment and surgical complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Nae Ry Kim, Kyeong A. So, Tae Jin Kim, Kyungtaek Lim, Ki Heon Lee, Mi-Kyung Kim
Summary: The objective of this study was to determine the clinical significance of systematic lymph node dissection (LND) and better define its extent in intermediate-to high-risk early stage endometrial cancer (EC). The rates of lymph node metastasis (LNM) were assessed according to risk groups and anatomic sites. LNM served as an independent risk factor for recurrence, and nodal assessment should be performed up to the infra-renal level in high-risk EC.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Letter
Medical Laboratory Technology
Gun-Hyuk Lee, Hanah Kim, Mina Hur, Kyeong A. So, Dong Woo Shin, Yun Ji Hong, Kyoung Un Park
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Pathology
Dong Woo Shin, Gun-Hyuk Lee, Hanah Kim, Kyeong A. So, Yun Ji Hong, Mina Hur, Kyoung Un Park
Summary: This study identified three DNT individuals by analyzing the family members of a DNT proband, and found that DNT is serologically indistinguishable from D+. Recommendations for prophylaxis and genotyping were proposed for DNT individuals and partial D family members.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Medicine, General & Internal
Bo Ra Kim, Mi-Kyung Kim, Yun Hwan Kim
Summary: This study aimed to investigate the impact of LEEP on sexual dysfunction in Korean women. The results showed that the prevalence of female sexual dysfunction before and after LEEP was 62.5% and 66.7%, respectively. However, the changes in total FSFI and FSDS scores after LEEP were not significant. The subdomains of sexual function and sexual distress were also not significantly altered by LEEP.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Oncology
Ha Kyun Chang, Seung-Hyuk Shim, Maria Lee, Won Moo Lee, Kyung Jin Eoh, Heon Jong Yoo, Mi Kyung Kim, Min Kyu Kim, Kwang-Beom Lee, Kyeong A. So, Young Tae Kim, Dae Woo Lee, Doo-Yoon Hyun, Jong-Min Lee
Summary: The sociomedical environment is changing, leading to a shift in the traditional authoritative physician-patient relationship. To meet legal requirements, improve patient understanding, and protect medical staff, the Korean Society of Gynecologic Oncology decided to standardize surgical consent forms.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2022)