Article
Public, Environmental & Occupational Health
Keyu Guo, Jiaqi Li, Liyin Zhang, Jianan Ye, Li Fan, Zhiyi Ding, Qin Zhou, Xia Li, Lin Yang, Zhiguang Zhou
Summary: This study compared the efficacy of continuous subcutaneous insulin infusion (CSII) therapy with multiple daily injection (MDI) therapy in Chinese patients with type 1 diabetes mellitus (T1DM). The results showed that CSII therapy was associated with lower HbA1c levels and better glycemic outcomes. However, it did not improve the risk of hypoglycemia.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Monique M. Hedderson, Sylvia E. Badon, Noel Pimentel, Fei Xu, Anne Regenstein, Assiamira Ferrara, Romain Neugebauer
Summary: This study compared the perinatal and neonatal outcomes of using glyburide and insulin to treat GDM in a clinical setting, and found no significant differences between the two in terms of outcomes.
Review
Endocrinology & Metabolism
Carlos A. Diaz-Balzac, David Pillinger, Steven D. Wittlin
Summary: Continuous subcutaneous insulin infusions (CSIIs) and continuous glucose monitors (CGMs) have revolutionized the management of diabetes mellitus (DM). They provide an integrated system to maintain tight glycemic control and reduce episodes of hypoglycemia, while improving the quality of life for individuals with DM. Ongoing efforts to develop an artificial pancreas (AP) have created effective tools for managing DM, but cost and accessibility remain obstacles to wider application.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
David Salcedo-Tacuma, Leonardo Bonilla, Maria Cristina Geney Montes, Jorge Ernesto Nino Gonzalez, Sandra Milena Sanchez Gutierrez, Miguel Chirivi, G. Andres Contreras
Summary: In this study, RNA-seq was used to analyze the transcriptomic profile of adipose tissues in patients with gestational diabetes. The results revealed differences based on anatomical location and provided whole-transcriptome data for further exploration of unique gene expression patterns in gestational diabetes patients.
Article
Nanoscience & Nanotechnology
Yiqun Liu, Qi Yu, Xiaojin Luo, Li Yang, Yue Cui
Summary: The study demonstrated the continuous monitoring of diabetes using an integrated microneedle biosensing device, which showed accurate sensing performance by inserting into the dermis layer of mouse skin and yielded detection results highly correlated with those from a commercial blood glucose meter.
MICROSYSTEMS & NANOENGINEERING
(2021)
Article
Public, Environmental & Occupational Health
Ellen O. Carlsen, Quaker Harmon, Maria C. Magnus, Helle M. Meltzer, Iris Erlund, Lars C. Stene, Siri E. Haberg, Allen J. Wilcox
Summary: This study found that among women without a history of diabetes, higher HbA1c levels at 18 weeks of pregnancy were associated with important perinatal outcomes, including birth weight, large-for-gestational age, preterm delivery, and preeclampsia.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Endocrinology & Metabolism
Zifan Wang, Tamarra M. James-Todd, Elvira Isganaitis, Julianne O'Connell, Sarit Helman, Jennifer A. Wyckoff, Shanti Serdy, Elizabeth Halprin, Karen O'Brien, Munish Gupta, Florence M. Brown
Summary: The study suggests that the use of insulin pump or CGM during pregnancy in women with type 1 diabetes can improve glycemic control, but pump use may be associated with higher birth weight measures.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Carlos Palma, H. David McIntyre, Carlos Salomon
Summary: Research on extracellular vesicles (EVs) has provided insights into physiological and pathophysiological conditions, particularly during pregnancy. Gestational diabetes mellitus (GDM) is a common and influential complication that affects the miRNAs and proteins within EVs, leading to metabolic changes.
Article
Endocrinology & Metabolism
Mark Warren, Bruce Bode, Jang I. Cho, Rong Liu, Janet Tobian, Thomas Hardy, Farai Chigutsa, Moshe Phillip, Barry Horowitz, Debra Ignaut
Summary: The study found that in patients with type 1 diabetes using CSII, URLi was more effective in improving postprandial glucose control and reducing time spent in hypoglycemia compared to lispro.
DIABETES OBESITY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Yu Song, Xiaodan Zhai, Yu Bai, Cong Liu, Le Zhang
Summary: Gestational diabetes mellitus is a common endocrine disease during pregnancy that can lead to adverse pregnancy outcomes. Continuous glucose monitoring (CGM) can effectively monitor blood glucose changes and improve gestational outcomes by reducing fluctuations and serious hypoglycemia or hyperglycemia events. Time in range (TIR) is an important indicator of blood glucose level, and patients with higher TIR during pregnancy have better outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Emma S. Scott, Andrzej S. Januszewski, Luke M. Carroll, Gregory R. Fulcher, Mugdha V. Joglekar, Anandwardhan A. Hardikar, Timothy W. Jones, Elizabeth A. Davis, Alicia J. Jenkins
Summary: Early use of continuous subcutaneous insulin infusion (CSII) versus multiple daily injections (MDI) may help reduce glycemic variability and have an impact on the expression of certain miRNAs related to diabetes vascular complications.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Valentina Vitale, Lise C. Berg, Bettina Birch Larsen, Andrea Hannesdottir, Preben Dybdahl Thomsen, Sigrid Hyldahl Laursen, Denis Verwilghen, Gaby van Galen
Summary: This study investigates the feasibility of using a continuous glucose monitoring system in critically ill adult horses and foals, finding that the system can accurately monitor glucose levels. However, there are challenges such as lag time in interstitial glucose levels and fluctuations that do not always correspond to blood glucose levels that need to be addressed for wider usability of the system.
Article
Endocrinology & Metabolism
Fanny Goyette, Bi Lan Wo, Marie-Helene Iglesias, Evelyne Rey, Ariane Godbout
Summary: The glycemic thresholds used to diagnose GDM are still a topic of debate. This study compared maternal and neonatal outcomes in women with mild hyperglycemia who were treated or left untreated. The results showed that treating women with mild hyperglycemia decreased the risk of adverse outcomes.
DIABETES & METABOLISM
(2023)
Article
Engineering, Chemical
Paolo Trucillo
Summary: This paper is a description of a diabetic patient's experience with the treatment of diabetes using a multi-injection insulin system and an automated insulin administration system. The author compares the advantages and disadvantages of both systems and highlights the importance of educating patients to approach illness treatment in a scientific manner.
Article
Endocrinology & Metabolism
Huiying Wang, Yunting Zhou, Yuming Wang, Tingting Cai, Yun Hu, Ting Jing, Bo Ding, Xiaofei Su, Huiqin Li, Jianhua Ma
Summary: This study examined the glycaemic variability and safety of basal and premixed insulin in patients with type 2 diabetes. The results showed that compared to basal insulin, patients using premixed insulin had higher glycaemic variability, smaller time in range, and increased risk of hypoglycaemia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Mai Sato, Eiji Kondoh, Tomohide Iwao, Shusuke Hiragi, Kazuya Okamoto, Hiroshi Tamura, Haruta Mogami, Yoshitsugu Chigusa, Tomohiro Kuroda, Masaki Mandai, Ikuo Konishi, Genta Kato
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2019)
Article
Multidisciplinary Sciences
Fumitomo Nishimura, Haruta Mogami, Kaori Moriuchi, Yoshitsugu Chigusa, Masaki Mandai, Eiji Kondoh
Review
Pediatrics
Shingo Io, Eiji Kondoh, Yoshiki Iemura, Sachiko Minamiguchi, Yoshitsugu Chigusa, Haruta Mogami, Masaki Mandai
Summary: Umbilical vein varix is associated with a high incidence of fetal anomalies and perinatal complications. There are two types of umbilical vein varix: fetal intra-abdominal and extra-abdominal. This case report discusses a severe fetal anemia with extra-abdominal umbilical vein varix, which was successfully managed with intrauterine transfusion. Extra-abdominal umbilical vein varix has a reported antenatal diagnosis rate of 79% and can present with fetal hydrops and anemia, highlighting the importance of careful umbilical cord screening during ultrasound examination for fetal anemia.
CONGENITAL ANOMALIES
(2021)
Article
Obstetrics & Gynecology
Yoshitsugu Chigusa, Haruta Mogami, Sachiko Minamiguchi, Aki Kido, Ayami Ishida, Yasuhisa Kurata, Eriko Yasuda, Kaoru Kawasaki, Akihito Horie, Ken Yamaguchi, Masaki Mandai, Eiji Kondoh
Summary: The pathogenic mechanism of chronic abruption-oligohydramnios sequence (CAOS) remains unknown, with no objective standards for diagnosis on imaging or using pathological evidence. This study aimed to clarify the true pathology of CAOS through integration of clinical, magnetic resonance imaging (MRI) and histopathological findings. A retrospective review of clinical data, MRI findings and placental pathology of 18 patients with CAOS between 2010 and 2020 showed preterm birth in 94% of cases, with median gestational age at delivery of 25 weeks. Three neonates (17%) died within two years, and 10 neonates (56%) developed chronic lung disease. MRI revealed intrauterine hematoma and hemorrhagic amniotic fluid, while histopathological findings showed shedding and necrosis of the amniotic epithelium as a characteristic feature in 94% of cases. Diagnosis of diffuse chorionic hemosiderosis (DCH) was confirmed in all cases. The true pathology of CAOS is believed to be premature rupture of membranes rather than chronic abruption, caused by repeated intrauterine hemorrhage and subchorionic hematoma leading to necrosis and weakening of the amnion.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Mai Sato, Asako Inohaya, Eriko Yasuda, Haruta Mogami, Yoshitsugu Chigusa, Kaoru Kawasaki, Yosuke Kawamura, Yusuke Ueda, Hiroshi Takai, Masaki Mandai, Eiji Kondoh
Summary: A three-dimensional placental organ bud was successfully generated from human iPSCs and transplanted into the murine uterus, showing a 22% engraftment success rate. These iPSC-derived placental organ buds could serve as a new model for studying placental function and pathology in research.
SCIENTIFIC REPORTS
(2021)
Review
Obstetrics & Gynecology
Haruta Mogami
Summary: Preterm prelabor rupture of fetal membranes (pPROM) is a serious problem in obstetrics. However, in a mouse model, it was observed that the amnion can spontaneously heal with the assistance of fetal macrophages. Epithelial-mesenchymal transition appears to play a key role in the healing process of amnion.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Obstetrics & Gynecology
Megumi Aki, Miyu Katsumata, Koji Yamanoi, Akihiko Ueda, Baku Nakakita, Hirohiko Tani, Kaoru Kawasaki, Yoshitsugu Chigusa, Haruta Mogami, Masaki Mandai, Eiji Kondoh
Summary: This study found that in patients with SCH and persistent vaginal bleeding in early pregnancy, cases where bleeding occurred before hematoma formation were associated with a longer duration of SCH and higher risk of preterm delivery, as well as various complications.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Miki Ohtsuki, Yoshitsugu Chigusa, Haruta Mogami, Akihiko Ueda, Kaoru Kawasaki, Ken Yamaguchi, Masaki Mandai, Eiji Kondoh
Summary: Retrospective data analysis of pregnant women receiving Celecoxib for tocolysis for more than 48 hours showed that this treatment could be safe and tolerable in terms of fetal PSV-DA and amniotic fluid volume.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2022)
Article
Endocrinology & Metabolism
Yusuke Ueda, Haruta Mogami, Yosuke Kawamura, Masahito Takakura, Asako Inohaya, Eriko Yasuda, Yu Matsuzaka, Yoshitsugu Chigusa, Shinji Ito, Masaki Mandai, Eiji Kondoh
Summary: Cervical excision leads to decreased expression of MUC5B and MUC5AC in cervicovaginal fluid, which may affect cervical function in pregnant women. The study suggests that MUC5B and MUC5AC may serve as barriers against ascending pathogens during pregnancy. This finding has important implications for understanding the role of the cervix in maintaining pregnancy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Obstetrics & Gynecology
Takuma Ohsuga, Miho Egawa, Misato Kii, Yumie Ikeda, Akihiko Ueda, Yoshitsugu Chigusa, Haruta Mogami, Masaki Mandai
Summary: This pilot study suggests a possible association between non-anemic iron deficiency (NAID) in early pregnancy and perinatal depressive symptoms. Lower ferritin levels in early pregnancy may reduce resilience to perinatal depression.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yosuke Kawamura, Haruta Mogami, Eriko Yasuda, Masahito Takakura, Yu Matsuzaka, Yusuke Ueda, Asako Inohaya, Kaoru Kawasaki, Yoshitsugu Chigusa, Masaki Mandai, Eiji Kondoh
Summary: The research indicates that fetal macrophages play a crucial role in amnion repair by inducing epithelial-mesenchymal transition in amnion epithelial cells, facilitating the healing of amniotic sac ruptures.
Article
Reproductive Biology
Asako Inohaya, Yoshitsugu Chigusa, Masahito Takakura, Shingo Io, Min-A Kim, Yu Matsuzaka, Eriko Yasuda, Yusuke Ueda, Yosuke Kawamura, Shiro Takamatsu, Haruta Mogami, Yasuhiro Takashima, Masaki Mandai, Eiji Kondoh
Summary: This study found that shear stress promotes the differentiation of human placenta cells into villous trophoblasts, and increases cell fusion, hormone secretion, and microvilli formation.
BIOLOGY OF REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Shoko Nishikawa, Mana Taki, Haruko Okamoto, Yosuke Kawamura, Yoshitsugu Chigusa, Seiichi Tomotaki, Masaki Mandai, Haruta Mogami
Summary: This study aimed to examine respiratory function and risk factors for respiratory prognosis in infants with chronic abruption-oligohydramnios sequence (CAOS) within 3 years after birth and clarify the management of CAOS. The results showed that amniotic fluid volume could predict the use of inhaled nitric oxide (iNO) in neonates to improve oxygenation, but it did not affect the child's respiratory function after the newborn period. Almost all children born to women with CAOS can improve their respiratory function as they grow up.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Article
Medicine, Research & Experimental
Sayuri Takahashi, Akihito Horie, Sachi Yamamura, Akeo Kawamura, Ayaka Yamaguchi, Masumi Sunada, Hirohiko Tani, Haruta Mogami, Junzo Hamanishi, Eiji Kondoh, Masaki Mandai
Summary: The study revealed that breast cancer patients tended to take longer to initiate oncofertility treatment compared to hematologic cancer patients. Among pregnant patients undergoing oncofertility care, the majority opted for non-assisted reproductive technology to achieve pregnancy.
