Review
Hematology
Ines Ghariani, Nejia Braham, Agnes Veyradier, Leila Bekir
Summary: Acquired von Willebrand syndrome is a rare bleeding disorder that shares similarities with inherited von Willebrand disease. This study presents a retrospective case series of five male patients diagnosed with acquired von Willebrand syndrome between 2010 and 2020. They all exhibited recent mucocutaneous bleeding and had a biological phenotype consistent with type 2 von Willebrand disease. Underlying conditions such as lymphoproliferative, autoimmune, and cardiovascular diseases were identified. Treatment for the underlying disorder, including high-dose intravenous immunoglobulins, resulted in improvement of plasma von Willebrand factor levels in most cases.
THROMBOSIS RESEARCH
(2022)
Review
Immunology
Edward J. Filippone, Eric D. Newman, Li Li, Rakesh Gulati, John L. Farber
Summary: Monoclonal gammopathies are caused by neoplastic clones of the B-cell lineage, potentially leading to kidney disease. MGRS is a specific paraprotein that can cause kidney damage, but is not a malignancy requiring treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Endocrinology & Metabolism
Emmanuelle Kuhn, Alexandra A. Weinreich, Nienke R. Biermasz, Jens Otto L. Jorgensen, Philippe Chanson
Summary: During pregnancy, pituitary apoplexy can occur in pre-existing microprolactinomas, causing tumor enlargement and headache, which may be self-limiting but may require intervention by re-initation of dopamine agonists or surgery. This clinical event is rare but must be identified promptly and managed appropriately in pregnant patients with microprolactinomas.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Review
Immunology
Yuzhu Zhang, Yuchen Liu, Jing Liu, Tiande Liu, Hu Xiong, Wen Li, Xiaowei Fu, Fan Zhou, Shousheng Liao, Lu Fang, Bo Liang
Summary: Combination therapy of tislelizumab and S-1 effectively controls tumors in advanced GBC patients, especially those with high PD-L1 expression or high tumor mutation burden. However, treatment may cause immune-related pneumonia and drug resistance is a concern.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Konrad Szymanski, Cezary Kowalewski, Ewelina Pietrzyk, Katarzyna Wozniak
Summary: Epidermolysis bullosa acquisita (EBA) is a chronic autoimmune disease characterized by autoantibodies targeting type VII collagen. Standard therapy includes corticosteroids and dapsone, but biologics such as infliximab, rituximab, and IVIG have shown promise in severe cases. This article presents four EBA cases treated with biologics, resulting in significant improvement and disease cessation for 1-3 years, with no observed side effects during treatment or follow-up. These cases suggest that biologics may be a valuable addition to EBA therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Elena Sophia Fratini, Maddalena Migliavacca, Federica Barzaghi, Claudia Fossati, Stefania Giannelli, Ilaria Monti, Miriam Casiraghi, Francesca Ferrua, Salvatore Recupero, Giulia Consiglieri, Valeria Calbi, Francesca Tucci, Vera Gallo, Maria Ester Bernardo, Sabina Cenciarelli, Monica Palmoni, Margherita Moni, Luca Galimberti, Marzia Duse, Lucia Leonardi, Elena Sieni, Elena Soncini, Fulvio Porta, Lucia Dora Notarangelo, Raffaella De Santis, Saverio Ladogana, Alessandro Aiuti, Maria Pia Cicalese
Summary: This article reports two cases of ADA-SCID patients who developed HIS. The first patient developed HIS during enzyme replacement therapy and achieved remission with corticosteroids and immunoglobulin therapy. The second patient developed HIS 2 years after hematopoietic stem cell gene therapy and responded to immunosuppressive therapy. These cases highlight the importance of early identification and varying degrees of immunosuppressive treatment in ADA-SCID patients, with allogeneic HSCT required only in refractory cases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Endocrinology & Metabolism
Asif Surani, Ty B. Carroll, Bradley R. Javorsky, Hershel Raff, James W. Findling
Summary: Alcohol-induced hypercortisolism (AIH) is often misdiagnosed as neoplastic hypercortisolism (Cushing syndrome), leading to difficulties in accurate diagnosis. A chart review of eight patients showed that AIH shares similar clinical features with neoplastic hypercortisolism, but there are certain characteristics that can help differentiate the two conditions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Oncology
Yongsheng Tang, Xianyu Chen, Xu Lu, Zenan Yuan, Yang Yang, Chunhui Qiu, Hua Li
Summary: This study found that a combination of serological, radiological, and immunohistochemical examinations can aid in the diagnosis of primary hepatic neuroendocrine tumors (PHNETs). Additionally, it was determined that transarterial embolization (TAE) combined with drug therapy could be an effective method for controlling PHNET progression. Regular postoperative follow-ups are important for monitoring the prognosis and tumor progression status of patients with PHNET.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Tao Zhang, Si-fan Yin, Wen-bo Feng, Run-lin Feng, Chang-xing Ke
Summary: This study reports three rare cases of degenerated schwannoma in the adrenal glands. These cases were asymptomatic and incidentally discovered during physical examinations. The prognosis is favorable.
FRONTIERS IN ONCOLOGY
(2023)
Review
Endocrinology & Metabolism
F. Robin, S. Cadiou, J-D Albert, G. Bart, G. Coiffier, P. Guggenbuhl
Summary: Methotrexate (MTX)-related osteopathy, characterized by pain, osteoporosis, and atypical fractures, is a rare condition that has been reported in patients treated with low doses of MTX for inflammatory diseases. Pathophysiological studies suggest a possible dose-dependent residual effect of MTX on osteo-forming bone cells.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Oncology
Wen-Bin Xu, Nai-Kun Sun, Di-Xin Cai, Ding-Qiang Chen, Yuan Niu, Fang Jia, Guang-Xun Lin, Gang Rui
Summary: This article reports a rare case of dorsal complete ossified meningioma in a 68-year-old woman and reviews this subject. After complete surgical resection, despite complications such as cerebrospinal fluid leakage and fever, the patient ultimately recovered well.
FRONTIERS IN ONCOLOGY
(2023)
Review
Cell Biology
Changwen Zhai, Huan Wang, Shimin Li, Dehui Wang
Summary: This study evaluated the clinicopathological and molecular characteristics of five cases of Low-grade Papillary Schneiderian Carcinoma (LGPSC) in the sinonasal tract, confirming it as a new aggressive carcinoma with metastatic potential. Further research is needed to fully understand its behavior and characteristics.
Review
Medicine, General & Internal
Nianting Tong, Liangyu Wang, Nan Wang, Zhanyu Zhou
Summary: BDUMP is a rare intraocular syndrome associated with underlying malignancies. In this case, treatment for the primary malignancy resulted in the absorption of subretinal fluid and significant reduction in ciliary body and choroid thickness.
FRONTIERS IN MEDICINE
(2021)
Review
Immunology
Konrad Szymanski, Alicja Adaszewska, Beata Jakubowska, Cezary Kowalewski, Ewelina Pietrzyk, Katarzyna Wozniak
Summary: Pemphigoid nodularis is a rare form of pemphigoid characterized by the combination of prurigo nodularis and bullous pemphigoid. In this study, we analyzed the clinical and immunological features of five female patients with long-lasting nodular pemphigoid and evaluated the efficacy of different therapies. Our findings suggest that most patients fulfilled the clinical and immunological criteria of nodular bullous pemphigoid, with some presenting initially with blistering and erythematous lesions before developing nodules. Treatment with clobetasol propionate and antidepressants showed the best control of the disease. Pemphigoid nodularis mainly affects elderly women, and the use of antidepressants can be considered as an important complementary therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Jiexia Guan, Chang Zhao, Hengming Li, Wenjing Zhang, Weizhen Lin, Luying Tang, Jianning Chen
Summary: Adenomatoid tumors are rare benign neoplasms of mesothelial origin, typically found in the male and female genital tracts. Two new cases were reported in male patients aged 30 and 31, with no distant metastasis observed.
FRONTIERS IN ENDOCRINOLOGY
(2021)
