Article
Chemistry, Multidisciplinary
Fidel Mendez Canellas, Vivek Verma, Jacek Kujawski, Robert Geertman, Lidia Tajber, Luis Padrela
Summary: The effects of processing conditions on the polymorphism of indomethacin were studied, and it was found that consistent formation of the pure alpha polymorphic form was only achieved when poloxamer 407 was used as an additive. The GAS method combined with poloxamer 407 as a molecular additive allowed for full control over the polymorphic form of indomethacin, regardless of the processing conditions employed.
Article
Chemistry, Physical
Paula de Freitas Rosa Remiro, Paulo de Tarso Vieira Rosa, Angela Maria Moraes
Summary: This study aimed to promote the micronization of imiquimod using the SAS process, finding that increasing pressure tends to increase particle size, concentration leads to an increase in size, and temperature results in a reduction in size. The combination of process variables affects particle size and yield, enhancing data reproducibility.
JOURNAL OF SUPERCRITICAL FLUIDS
(2022)
Article
Chemistry, Physical
Patrick Hariyanto, Aye Aye Myint, Jaehoon Kim
Summary: The supercritical antisolvent process was utilized to produce fine ecamsule powder with micronized particles. By evaluating different process parameters, such as temperature, pressure, solution flow rate, and solute concentration, high yield of micronsized ecamsule particles was achieved with improved chemical properties.
JOURNAL OF SUPERCRITICAL FLUIDS
(2021)
Article
Food Science & Technology
Somaris E. Quintana, David Villanueva-Bermejo, Diana Martin, Guillermo Reglero, Monica R. Garcia-Risco, Tiziana Fornari
Summary: This study presents a novel method called BIOSAS for formulating homogeneous dispersions of bioactive substances in an oily matrix. The method utilizes carbon dioxide supercritical antisolvent (SAS) technique to produce small drops of solution containing the bioactive substances. It allows for particle size control and can be used to formulate lipid-based nutraceuticals or food supplements, contributing to reducing the oxidation and thermal degradation of bioactive substances and lipid matrix.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2022)
Article
Pharmacology & Pharmacy
Tingxuan Yan, Haili Wang, Xingfang Song, Tingyuan Yan, Yuwen Ding, Kang Luo, Juan Zhen, Gui He, Libin Nian, Shuangshou Wang, Zhixiang Wang
Summary: Flavonoids have positive pharmacological properties, but their low solubility and dissolution rate limit their use. Microparticles and nanoparticles of apigenin were prepared using antisolvent precipitation technologies, resulting in enhanced dissolution rate and bioactivity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Physical
Paola Franco, Iolanda De Marco
Summary: The study used Supercritical Antisolvent coprecipitation to prepare controlled-release systems of antihistamines, showing significantly prolonged release of the active ingredients and achieving last generation formulations with bimodal releases.
JOURNAL OF SUPERCRITICAL FLUIDS
(2021)
Review
Polymer Science
Karol Tutek, Anna Masek, Anna Kosmalska, Stefan Cichosz
Summary: This article reviews the use of fluids under supercritical conditions in processes related to the modern and innovative polymer industry. The focus is on extraction, micronization, particle formation, and encapsulation, emphasizing the importance of ecological and efficient processes. Advanced technological solutions using less toxic fluids under supercritical conditions are becoming more prevalent in the chemical industry, creating new opportunities for materials with specialized applications.
Article
Engineering, Chemical
Michael Tuerk
Summary: The application of supercritical fluids in particle formation processes has advantages over classical size reduction technologies and can overcome some limitations of traditional methods. The focus of this article is on the rapid expansion of supercritical solution for micronization of organic compounds.
JOURNAL OF AEROSOL SCIENCE
(2022)
Review
Optics
Andrey Romanov, Maxim A. Yurkin
Summary: The field of light-scattering characterization of single particles has grown rapidly in the past 30 years due to advancements in measurement and simulation capabilities. Various methods have been developed to characterize particles with high geometric resolution, but development has been fragmented and specific to experimental setups. Existing methods are categorized into model-driven, model-free, and data-driven methods, with a focus on algorithms and experimental aspects.
LASER & PHOTONICS REVIEWS
(2021)
Article
Chemistry, Applied
Xiaonan Zhang, Yan Huang, Hongwei Zhu, Zhiwei Liu, Lubin Zhang, Zhiru Li, Yaqian Niu, Huajiang Zhang
Summary: A new antisolvent recrystallization technique was used to create genistein particles. The response surface approach was used to optimize the experimental parameters and find the ideal conditions. The antisolvent recrystallization method showed better dissolution rate and antioxidant activity compared to the traditional method, and it also reduced particle size and energy consumption.
Article
Chemistry, Multidisciplinary
Guo-Yue Qiao, Qin-Qin Xu, Aiqin Wang, Ju-Tao Liu, Dan Zhou, Zhenya Duan, Jian-Zhong Yin
Summary: In this study, a facile method to control the size and dispersion of CuO nanoparticles in SBA-15 using supercritical antisolvent method was described. By reducing the concentration of the cupric nitrate precursor, the size of CuO NPs was decreased and the Cu loading was controlled under a given depressurized rate. The nucleation rate and growth of cupric nitrate were regulated by adjusting the supercritical carbon dioxide depressurized rate.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Diego Valor, Antonio Montes, Maria Calderon-Dominguez, Inass Aghziel, Ismael Sanchez-Gomar, Martin Alcala, Ma Carmen Duran-Ruiz, Clara Pereyra
Summary: Submicron particles were produced from an ethanolic extract of Myrtus communnis leaves using supercritical carbon dioxide technology. The particles had small sizes, quasi-spherical shape, and high antioxidant activity. It was also observed that increasing pressure and temperature resulted in smaller particle sizes.
Article
Engineering, Chemical
Binbin Pei, Kunpeng Zhao, Zhengyuan Luo, Liang Zhao, Bofeng Bai
Summary: The heterogeneous structures of particles are generated due to significant temperature changes during the injection of cold particles into a supercritical water fluidized bed, which hinders the reaction of coal particles. By utilizing the entrainment mechanism of large-scale vortical structures, particle dispersion can be promoted. The study reveals that increasing the density ratio inhibits vortical structures and leads to particle clustering in vortex core regions, while increasing the velocity ratio enhances vortex stretching and particle entrainment.
Article
Crystallography
Salal Hasan Khudaida, Wei-Kai Wang, Wei-Yi Wu, Chie-Shaan Su
Summary: This study aimed to improve the solid-state properties and dissolution behavior of allopurinol using a supercritical antisolvent (SAS) process with CO2 as an antisolvent. The results showed that the micronization process effectively controlled and improved the solid-state properties and dissolution rate of allopurinol.
Review
Instruments & Instrumentation
Rahul Kumar, Amit K. K. Thakur, Gergely Kali, Kancharlapalli Chinaraga Pitchaiah, Raj Kumar Arya, Anurag Kulabhi
Summary: In this review, the utilization of supercritical carbon dioxide (SC CO2) as an antisolvent in particle engineering approaches is critically discussed. Different SC CO2-based antisolvent processes, including GAS, SAS, and SEDS, are described. The effects of process parameters on particle size, distribution, and morphology are discussed, as well as the applications of SAS process in improving dissolution rate, solubility, and bioavailability in different formulation approaches.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Applied
Paola Franco, Wanda Navarra, Olga Sacco, Iolanda De Marco, Antonietta Mancuso, Vincenzo Vaiano, Vincenzo Venditto
Summary: This study employed the supercritical antisolvent precipitation route to prepare Gd-doped ZnO photocatalysts for the degradation of atrazine under visible light. The addition of Gd successfully introduced Gd3+ ions into the ZnO lattice, leading to a decrease in band gap energy and the formation of oxygen vacancies. The photocatalytic activity of the doped photocatalyst with 0.7 mol% Gd loading was found to be the highest under visible light irradiation.
Article
Chemistry, Applied
Emanuela Drago, Paola Franco, Roberta Campardelli, Iolanda De Marco, Patrizia Perego
Summary: The search for advanced packaging solutions in recent years has focused on systems capable of extending the food shelf-life, with active packaging being one of the most interesting strategies. This paper proposes the combined use of electrospinning and supercritical fluids impregnation for producing active packaging, which allows for controlled release of antioxidant and antimicrobial agents. Through characterizations and study of release kinetics, it is found that these methods permit calibration of migration kinetics to obtain active food packaging with controlled release according to the final application. Comparing the two processes, it is observed that supercritical fluid impregnation results in controlled release of the active principle, while electrospinning process shows fast release kinetics.
FOOD HYDROCOLLOIDS
(2022)
Article
Chemistry, Physical
Sara Liparoti, Paola Franco, Roberto Pantani, Iolanda De Marco
Summary: This study focused on producing topical anti-cellulite devices using a supercritical one-step process that involved polymer foaming and impregnation of caffeine into PLA/PBAT/CaCO3 films to create a biocompatible and biodegradable patch. The results showed that porosities were formed in the polymeric support when in contact with supercritical CO2, and caffeine was found in needle-like forms on the polymer surface. The impregnation kinetics revealed an increase in caffeine loadings with contact time, resulting in extended release time of up to 2 days.
JOURNAL OF SUPERCRITICAL FLUIDS
(2022)
Article
Chemistry, Multidisciplinary
Iolanda De Marco
Summary: This study conducted a life cycle assessment of the environmental impacts of producing PVP/PDS powders by supercritical antisolvent precipitation. The analysis identified the stabilizing of operating conditions, injection step, and washing step as the most impactful processes on the environment. An improved scenario was proposed to reduce the global impact by 85.8%.
JOURNAL OF CO2 UTILIZATION
(2022)
Article
Geochemistry & Geophysics
Katja Gotze, Roland Haseneder, Andreas Siegfried Braeuer
Summary: Extended studies have been conducted using Europe's first underground hybrid membrane pilot plant (TRL6) to selectively extract the critical raw materials indium and germanium from real bioleaching solutions. By introducing acidic-basic cleaning steps, it was found that the retention behavior could be kept at a constant level.
Article
Engineering, Chemical
Imke Preibisch, Martin P. Dirauf, Timo Lehmann, Pavel Gurikov, Andreas S. Braeuer, Irina Smirnova
Summary: CO2 induced gelation of aqueous biopolymer systems leads to stable and homogeneous hydrogels, which have a wide range of potential applications. The understanding of process parameters and their impact on the overall process and gel properties is crucial for industrial application. This study investigates the role of viscosity in CO2 dissolution and reveals the influence of gelation and gel network formation on CO2 dissolution kinetics.
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2022)
Article
Environmental Sciences
Katja Schaldach, Volker Herdegen, Andreas Siegfried Braeuer, Do Nang Vinh, Nguyen Van Toan, Le Van Tam
Summary: Due to global population growth, agriculture needs to increase productivity, which leads to an increase in agricultural by-products that can pose environmental risks. However, these by-products can also be used to produce valuable materials and products that improve crop yield and soil management.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Analytical
Felix Spiske, Martin Peter Dirauf, Andreas Siegfried Braeuer
Summary: The experimental study demonstrated that confining liquid water in aerogel-lined capillaries significantly increased the Raman signal with better stability compared to silver-lined capillaries. The aerogel-lined capillaries showed superior performance when exposed to mixtures of water, sugar, ethanol and acetic acid.
Article
Energy & Fuels
Michael H. H. Fechter, Jessica Koschack, Andreas S. Braeuer
Summary: Vapor-liquid equilibria of the binary systems 1-octanol/nitrogen and 1-octanol/oxygen were investigated at engine-relevant conditions. The experiment utilized T-junction and micmcapillary to measure the equilibrium compositions of the two phases, and compared the results with computational models. The study showed good agreement between the experimental data and the models.
Article
Chemistry, Physical
M. P. Dirauf, P. C. Wagner, A. S. Braeuer
Summary: In this study, composition profiles inside biopolymer gels during solvent exchange and supercritical drying were measured using one-dimensional Raman spectroscopy. The effective diffusion coefficients for solvent exchange and drying processes were obtained by fitting modelled profiles to experimental ones. The results showed that the tortuosities of gels varied under different experimental conditions.
JOURNAL OF SUPERCRITICAL FLUIDS
(2022)
Review
Polymer Science
Iolanda De Marco
Summary: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly administered orally in modified-release formulations, achieved through coprecipitation with a biodegradable polymeric carrier. This review analyzes coprecipitation studies of widely prescribed NSAIDs (ibuprofen, ketoprofen, and diclofenac sodium), categorizing the techniques and polymers used based on the desired release type. Specific therapeutic objectives can be achieved by controlling the dissolution rate, timing, and site of drug release based on the pathology being treated.
Review
Chemistry, Analytical
Vincenzo Vaiano, Iolanda De Marco
Summary: Azo dyes, commonly used in textile, leather, and paper industries, pose environmental and health risks due to their toxic nature. Various treatment methods, including photocatalysis and supercritical water oxidation, have been explored to remove azo dyes from wastewater. This review critically analyzes studies on the degradation of azo dyes using structured photocatalysts and supercritical water oxidation, highlighting important factors such as reactor configuration, photocatalytic efficiency, and removal of COD and TOC.
Article
Biochemistry & Molecular Biology
Stefania Mottola, Gianluca Viscusi, Giovanna Iannone, Raffaella Belvedere, Antonello Petrella, Iolanda De Marco, Giuliana Gorrasi
Summary: In this study, fibrous membranes of thermoplastic polyurethane (TPU) were fabricated through electrospinning process and charged with two pharmacological agents, mesoglycan (MSG) and lactoferrin (LF), using supercritical CO2 impregnation. The results showed the formation of a micrometric structure with a homogeneous distribution of MSG and LF. The release of MSG reached a plateau after about 28 hours, while LF release leveled off after 15 hours. The in vitro compatibility of the electrospun membranes was evaluated on human keratinocytes and fibroblasts, demonstrating their potential application in wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Thermodynamics
Michael H. H. Fechter, Andreas S. Braeuer
Summary: Vapor-liquid equilibria (VLE) of binary systems consisting of nitrogen and n-alkanes have been measured using a microcapillary setup coupled with in situ Raman spectroscopy. The experimental data were compared with literature data and calculated data obtained from different models, including the predictive Peng-Robinson equation of state (PPR78) and the perturbed-chain statistical associating fluid theory (PC-SAFT). The models were able to describe the data well, with slightly higher deviations observed in the saturated vapor phase compared to the saturated liquid phase.
JOURNAL OF CHEMICAL AND ENGINEERING DATA
(2023)
Review
Engineering, Chemical
Iolanda De Marco
Summary: Transdermal delivery is a non-invasive route for drug administration through the skin surface. It is commonly used in pain therapy, where transdermal patches containing opioids are used. This review analyzes the production and use of transdermal patches containing fentanyl and buprenorphine. The analysis suggests that the selection of drug type and amount should be based on the patient's age, application area, and patch replacement frequency.
Article
Engineering, Environmental
Xinping Zhang, Yuxin Guo, Xiaoyang Liu, Shun-Yu Wu, Ya-Xuan Zhu, Shao-Zhe Wang, Qiu-Yi Duan, Ke-Fei Xu, Zi-Heng Li, Xiao-Yu Zhu, Guang-Yu Pan, Fu-Gen Wu
Summary: This study develops a nanotrigger HCFT for simultaneous photodynamic therapy and light-triggered ferroptosis therapy. The nanotrigger can relieve tumor hypoxia, induce enhanced photodynamic reaction, and facilitate the continuation of Fenton reaction, ultimately leading to lethal ferroptosis in tumor cells.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Olumide Bolarinwa Ayodele, Toyin Daniel Shittu, Olayinka S. Togunwa, Dan Yu, Zhen-Yu Tian
Summary: This study focused on the semihydrogenation of acetylene in an ethylene-rich stream using two alloyed Pt catalysts PtCu and PtCo. The PtCu catalyst showed higher activity and ethylene yield compared to PtCo due to its higher unoccupied Pt d-orbital density. This indicates that alloying Pt with Cu is more promising for industrial relevant SHA catalyst.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Guowei Chen, Wen-Cheng Chen, Yaozu Su, Ruicheng Wang, Jia-Ming Jin, Hui Liang, Bingxue Tan, Dehua Hu, Shaomin Ji, Hao-Li Zhang, Yanping Huo, Yuguang Ma
Summary: This study proposes an intramolecular dual-locking design for organic luminescent materials, achieving high luminescence efficiency and performance for deep-blue organic light-emitting diodes. The material also exhibits unique mechanochromic luminescence behavior and strong fatigue resistance.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Joren van Stee, Gregory Hermans, Jinu Joseph John, Koen Binnemans, Tom Van Gerven
Summary: This work presents a continuous solvent extraction method for the separation of cobalt and nickel in a millifluidic system using Cyphos IL 101 (C101) as the extractant. The optimal conditions for extraction performance and solvent properties were determined by investigating the effects of channel length, flow rate, and temperature. The performance of a developed manifold structure was compared to a single-channel system, and excellent separation results were achieved. The continuous separation process using the manifold structure resulted in high purity cobalt and nickel products.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Yan Xu, Jingai Jiang, Xinyi Lv, Hui Li, Dongliang Yang, Wenjun Wang, Yanling Hu, Longcai Liu, Xiaochen Dong, Yu Cai
Summary: A programmed gas release nanoparticle was developed to address the challenges in treating diabetic infected wounds. It effectively removes drug-resistant pathogens and remodels the wound microenvironment using NO and H2S. The nanoparticle can eliminate bacteria and promote wound healing through antibacterial and anti-inflammatory effects.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Tong Xia, Zhilin Xi, Lianquan Suo, Chen Wang
Summary: This study investigated a highly efficient coal dust suppressant with low initial viscosity and high adhesion-solidification properties. The results demonstrated that the dust suppressant formed a network of multiple hydrogen bonding cross-linking and achieved effective adhesion and solidification of coal dust through various chemical reactions.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Jinzhi Cai, Zhenshan Li
Summary: A density functional theory-based rate equation was developed to predict the gas-solid reaction kinetics of CaO carbonation with CO2 in calcium looping. The negative activation energy of CaO carbonation close to equilibrium was accurately predicted through experimental validation.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Jianxiong Chen, Fuhao Ren, Ningning Yin, Jie Mao
Summary: This study presents an economically efficient and easily implementable surface modification approach to enhance the high-temperature electrical insulation and energy storage performance of polymer dielectrics. The self-assembly of high-insulation-performance boron nitride nanosheets (BNNS) on the film surface through electrostatic interactions effectively impedes charge injection from electrodes while promoting charge dissipation and heat transfer.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Zijian Li, Zhaohui Yang, Shao Wang, Hongxia Luo, Zhimin Xue, Zhenghui Liu, Tiancheng Mu
Summary: This study reports a strategy for upgrading polyester plastics into value-added chemicals using electrocatalytic methods. By inducing the targeted transfer of *OH species, polyethylene terephthalate was successfully upgraded into potassium diformate with high purity. This work not only develops an excellent electrocatalyst, but also provides guidance for the design of medium entropy metal oxides.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Navneet Singh Shekhawat, Surendra Kumar Patra, Ashok Kumar Patra, Bamaprasad Bag
Summary: This study primarily focuses on developing a sulphur dyeing process at room temperature using bacterial Lysate, which is environmentally friendly, energy and cost effective, and sustainable. The process shows promising improvements in dye uptake and fastness properties.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Dengjia Shen, Hongyang Ma, Madani Khan, Benjamin S. Hsiao
Summary: This study developed cationic PVC nanofibrous membranes with high filtration and adsorption capability for the removal of bacteria and hexavalent chromium ions from wastewater. The membranes demonstrated remarkable performance in terms of filtration efficiency and maximum adsorption capacity. Additionally, modified nanofibrous membranes were produced using recycled materials and showed excellent retention rates in dynamic adsorption processes.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Xiaoyan Wang, Zhikun Wang, Ben Jia, Chunling Li, Shuangqing Sun, Songqing Hu
Summary: Inspired by photosystem II, self-supported Fe-doped NiCoP nanowire arrays modified with carboxylate were constructed to boost industrial-level overall water splitting by employing the concerted proton-coupled electron transfer mechanism. The introduction of Fe and carboxyl ligand led to improved catalytic activity for HER and OER, and NCFCP@NF exhibited long-term durability for overall water splitting.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Pengyao Yu, Ge Yang, Yongming Chai, Lubomira Tosheva, Chunzheng Wang, Heqing Jiang, Chenguang Liu, Hailing Guo
Summary: Thin LTA zeolite membranes were prepared through secondary growth of nano LTA seeds in a highly reactive gel, resulting in membranes with superior permeability and selectivity in gas separation applications.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Baiqin Zhou, Huiping Li, Ziyu Wang, Hui Huang, Yujun Wang, Ruichun Yang, Ranran Huo, Xiaoyan Xu, Ting Zhou, Xiaochen Dong
Summary: The use of machine learning to predict the performance of specific adsorbents in phosphate adsorption shows great promise in saving time and revealing underlying mechanisms. However, the small size of the dataset and insufficient detailed information limits the model training process and the accuracy of results. To address this, the study employs a fuzzing strategy that replaces detailed numeric information with descriptive text messages on the physiochemical properties of adsorbents. This strategy allows the recovery of discarded samples with limited information, leading to accurate prediction of adsorption amount, capacity, and kinetics. The study also finds that phosphate uptake by adsorbents is generally through physisorption, with some involvement of chemisorption. The framework established in this study provides a practical approach for quickly predicting phosphate adsorption performance in urgent scenarios, using easily accessible information.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Paula Alejandra Lamprea Pineda, Joren Bruneel, Kristof Demeestere, Lisa Deraedt, Tex Goetschalckx, Herman Van Langenhove, Christophe Walgraeve
Summary: This study evaluates the use of four esterified fatty acids and three vegetable oils as absorption liquids for hydrophobic VOCs. The experimental results show that isopropyl myristate is the most efficient liquid for absorbing the target VOCs.
CHEMICAL ENGINEERING JOURNAL
(2024)
