Article
Medicine, General & Internal
Ji Eun Park, Jin A. Seo, Jung Guen Cha, Jae Kwang Lim, Jongmin Park, Yong Hoon Lee, Sun Ha Choi, Hyewon Seo, Seung Soo Yoo, Shin Yup Lee, Seung Ick Cha, Jae Yong Park, Chang Ho Kim, Jaehee Lee
Summary: This study aimed to evaluate the association between systemic blood pressure and the unknown etiology of hemoptysis. The study found that patients with unidentified causes of hemoptysis had a higher proportion of severe hypertension. Age, smoking history, and initial systolic blood pressure were significantly associated with hemoptysis of unidentified causes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Ali T. Kahraman, Tomas Froding, Dimitrios Toumpanakis, Natasa Sladoje, Tobias Sjoblom
Summary: An automated algorithm was developed to accurately detect, segment, and measure mediastinal structures in routine CTPA examinations. The system showed good accuracy in multiple tasks and the automatic measurements correlated well with those of radiologists.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Amber McCormick, Amita Krishnan, David Badesch, Raymond L. Benza, Todd M. Bull, Teresa De Marco, Jeremy Feldman, Anna R. Hemnes, Russel Hirsch, Evelyn Horn, Jaime Kennedy, Stephen C. Mathai, Wesley McConnell, Steven C. Pugliese, Jeffrey S. Sager, Oksana A. Shlobin, Marc A. Simon, Matthew R. Lammi
Summary: This study investigated the pulmonary artery compliance and resistance-compliance time in pulmonary arterial hypertension (PAH) patients, and compared the differences between different PAH subgroups. The results showed that there was no difference in pulmonary artery compliance among PAH subgroups, and it was not an independent predictor of transplant-free survival in PAH. However, resistance-compliance time differed among PH subgroups, challenging the constancy of resistance-compliance time.
Article
Cardiac & Cardiovascular Systems
Mehmet Sami Islamoglu, Mehmet Dokur, Emrah Ozdemir, Omer Faruk Unal
Summary: Pulmonary embolism, a common cardiovascular syndrome, presents with typical electrocardiographic findings and tomographic features that are crucial for early diagnosis and treatment. The S1Q3 and T negativity in electrocardiography are key features to distinguish pulmonary embolism from acute ST elevation myocardial infarction.
BMC CARDIOVASCULAR DISORDERS
(2021)
Review
Critical Care Medicine
Dennis McGonagle, Charlie Bridgewood, James F. M. Meaney
Summary: Emergent 21st century betacoronaviruses, including SARS-CoV-2, lead to clinicopathological manifestations with unusual features, such as early-onset chest pain, pulmonary infarction, and extensive thrombosis. The study suggests a novel vascular pathology in COVID-19, disrupting the normal oxygenation of parenchyma and leading to systemic clot embolization and alveolar-capillary barrier disruption. The proposed model provides insights into severe COVID-19 pathology and implications for immunomodulatory therapies.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Carmine Capone, Adele Valentini, Silvia Lina Spinillo, Catherine Klersy, Anna Celentano, Maurizio Pin, Cristian Monterosso, Roberto Dore, Emilio Maria Bassi, Michela Zacchino, Giuseppe Rodolico, Angelo Guido Corsico, Lorenzo Preda, Stefano Ghio, Andrea Maria D'Armini
Summary: This study aimed to describe the radiological features of chronic thromboembolic pulmonary disease (CTEPD) and compared them with chronic thromboembolic pulmonary hypertension (CTEPH) patients. The results showed significant differences in vascular obstruction, hypoperfusion, mosaic attenuation, and signs of pulmonary hypertension between the two groups, suggesting that the absence of peripheral microvascular disease may be the reason for the absence of pulmonary hypertension in CTEPD patients.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gudula J. A. M. Boon, Yvonne M. Ende-Verhaar, Ludo F. M. Beenen, Johan Coolen, Marion Delcroix, Marek Golebiowski, Menno Huisman, Albert T. A. Mairuhu, Lilian J. Meijboom, Saskia Middeldorp, Piotr Pruszczyk, Cornelis J. van Rooden, Anton Vonk Noordegraaf, Lucia J. M. Kroft, Frederikus A. Klok
Summary: The study found that the presence of three or more predefined radiological predictors in patients with acute PE was highly specific for predicting future CTEPH diagnosis, comparable to overall expert judgment, with the latter showing higher sensitivity. Dedicated CTPA reading for signs of CTEPH may help in early detection of CTEPH after PE, although not detecting all cases in the cohort.
EUROPEAN RADIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Luca Valerio, Anna C. Mavromanoli, Stefano Barco, Christina Abele, Dorothea Becker, Leonhard Bruch, Ralf Ewert, Martin Faehling, David Fistera, Felix Gerhardt, Hossein-Ardeschir Ghofrani, Aleksandar Grgic, Ekkehard Gruenig, Michael Halank, Matthias Held, Lukas Hobohm, Marius M. Hoeper, Frederikus A. Klok, Mareike Lankeit, Hanno H. Leuchte, Nadine Martin, Eckhard Mayer, F. Joachim Meyer, Claus Neurohr, Christian Opitz, Kai-Helge Schmidt, Hans-Jurgen Seyfarth, Rolf Wachter, Heinrike Wilkens, Philipp S. Wild, Stavros Konstantinides, Stephan Rosenkranz
Summary: This study systematically assessed the late outcomes of acute pulmonary embolism (PE) and investigated the clinical implications of post-PE impairment (PPEI). The results showed that the cumulative incidence of chronic thromboembolic pulmonary hypertension (CTEPH) was 2.3%, while the incidence of PPEI diagnosed by standardized criteria was 16.0%. The presence of PPEI increased the risk of re-hospitalization and death, as well as worsened quality of life.
EUROPEAN HEART JOURNAL
(2022)
Article
Respiratory System
Tiantian Deng, Ke Xu, Beishou Wu, Fei Sheng, Xu Li, Zhuxian Zhu, Ziqiang Zhang
Summary: This study aimed to investigate the clinical features and potential risk factors for early diagnosis of pulmonary embolism (PE) in bronchiectasis (BE) patients. Data of patients were collected, and the results showed that long-term bed rest, chronic lung disease, autoimmune disease, peripheral artery disease (PAD), tuberculosis history, dyspnea, blood homocysteine, CD4/CD8 ratio, or SIQIIITIII syndrome were closely correlated with the incidence of PE in the bronchiectasis patients. Multivariate logistic regression analysis showed that CD4/CD8 ratio and autoimmune disease are independent risk factors for BE/PE patients. The presence of hemoptysis in BE patients was not significantly different from BE/PE patients.
BMC PULMONARY MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Chunyan Rong, Xuhan Liu, Baoguo Wang, Weihua Zhang
Summary: Venous thromboembolism (VTE) associated with minimal change disease (MCD) in adults is rare. Treatment of MCD with corticosteroids may be associated with a higher risk of developing blood clots. This type of case should be given attention and further research on the mechanism of VTE in MCD is warranted.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Olga Dzikowska-Diduch, Katarzyna Kurnicka, Barbara Lichodziejewska, Olga Zdonczyk, Dominika Dabrowska, Marek Roik, Szymon Pacho, Maksymilian Bielecki, Piotr Pruszczyk
Summary: This study suggests that a Doppler index, TRPG/AcT, improves the assessment of symptomatic pulmonary embolism (PE) survivors. TRPG/AcT > 0.6 indicates a high probability of chronic thromboembolic pulmonary hypertension (CTEPH) or chronic thromboembolic pulmonary disease (CTED), while TRPG/AcT < 0.6 allows for the safe exclusion of CTEPH + CTED in patients with a low echocardiographic probability of pulmonary hypertension (PH).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Stefano Barco, Anna C. Mavromanoli, Karl-Friedrich Kreitner, Alexander C. Bunck, Roman J. Gertz, Sebastian Ley, Luca Valerio, Frederikus A. Klok, Felix Gerhardt, Stephan Rosenkranz, Stavros Konstantinides
Summary: This study found that 15% of patients with acute pulmonary embolism (PE) showed signs of chronic PE or chronic thromboembolic pulmonary hypertension (CTEPH) on CT pulmonary angiography (CTPA). Specific radiologic parameters, such as intravascular webs, arterial narrowing or retraction, dilated bronchial arteries, and right ventricular hypertrophy, could help identify preexisting CTEPH. Early diagnosis of CTEPH can be facilitated by targeted follow-up strategies and risk-adapted CTEPH screening based on these parameters.
Article
Radiology, Nuclear Medicine & Medical Imaging
Roman Johannes Gertz, Felix Gerhardt, Michael Pienn, Simon Lennartz, Jan Robert Kroeger, Liliana Caldeira, Lenhard Pennig, Thomas Henning Schoemig, Nils Grosse Hokamp, David Maintz, Stephan Rosenkranz, Alexander Christian Bunck
Summary: This study aimed to differentiate between acute pulmonary embolism (PE) and chronic thromboembolic pulmonary hypertension (CTEPH) using dual-layer dual-energy computed tomography (dlDECT)-derived pulmonary perfusion maps. The study found that patients with acute PE had higher iodine uptake in normal perfused lung areas compared to those with CTEPH. Additionally, after normalizing iodine density in perfusion defects, patients with acute PE had reduced average perfusion compared to both CTEPH patients and controls. dlDECT enables quantification and characterization of pulmonary perfusion patterns in acute PE and CTEPH and can enhance differentiation between the two diseases when combined with morphological CT parameters.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Kun Li, Mingzhe Cui, Kewei Zhang, Kai Liang, Heng Liu, Shuiting Zhai
Summary: This retrospective study evaluated the therapeutic effects of the AngioJet system in treating severe acute pulmonary embolism, demonstrating its safety and effectiveness when combined with local thrombolysis for HR-PE and IHR-PE. Significant improvements in clinical, haemodynamic, and angiographic parameters were observed post-procedure. Further studies are needed to compare efficacy with existing treatments.
Article
Cardiac & Cardiovascular Systems
Szymon Darocha, Marek Roik, Grzegorz Kopec, Aleksander Araszkiewicz, Michal Furdal, Maciej Lewandowski, Wojciech Jachec, Marek Grabka, Marta Banaszkiewicz, Arkadiusz Pietrasik, Radoslaw Pietura, Jakub Stepniewski, Marcin Waligora, Wojciech Magon, Kamil Jonas, Andrzej Labyk, Michal Potepa, Aleksandra Fudryna, Stanislaw Jankiewicz, Sylwia Slawek-Szmyt, Tatiana Mularek-Kubzdela, Maciej Lesiak, Ewa Mroczek, Joanna Orlowska, Malgorzata Peregud-Pogorzelska, Andrzej Tomasik, Katarzyna Mizia-Stec, Roman Przybylski, Piotr Podolec, Dariusz Zielinski, Andrzej Biederman, Adam Torbicki, Piotr Pruszczyk, Marcin Kurzyna
Summary: This study evaluated the safety and efficacy of balloon pulmonary angioplasty (BPA) for chronic thromboembolic pulmonary hypertension (CTEPH) using a multicentre registry in Poland. The results showed significant improvement in hemodynamic, functional, and biochemical parameters after BPA treatment, with low complication rates and comparable overall survival to other registries.
Article
Respiratory System
Timothy J. W. Dawes, Colm McCabe, Konstantinos Dimopoulos, Iain Stewart, Simon Bax, Carl Harries, Chinthaka B. Samaranayake, Aleksander Kempny, Philip L. Molyneaux, Samuel Seitler, Thomas Semple, Wei Li, Peter M. George, Vasileios Kouranos, Felix Chua, Elisabetta A. Renzoni, Maria Kokosi, Gisli Jenkins, Athol U. Wells, Stephen J. Wort, Laura C. Price
Summary: This study investigated the potential benefit of phosphodiesterase 5 inhibitors (PDE5i) in improving survival for patients with interstitial lung disease-associated pulmonary hypertension (ILD-PH). The results showed that patients treated with PDE5i had longer survival compared to untreated patients, with a particularly significant difference when right ventricular function was normal at presentation. These findings suggest that PDE5i treatment in ILD-PH should be further studied through a prospective randomized trial.
Review
Cardiac & Cardiovascular Systems
Konstantinos Dimopoulos, Andrew Constantine, Paul Clift, Robin Condliffe, Shahin Moledina, Katrijn Jansen, Ryo Inuzuka, Gruschen R. Veldtman, Clifford L. Cua, Edgar Lik Wui Tay, Alexander R. Opotowsky, George Giannakoulas, Rafael Alonso-Gonzalez, Rachael Cordina, George Capone, Judith Namuyonga, Charmaine H. Scott, Michele D'Alto, Francisco J. Gamero, Brian Chicoine, Hong Gu, Alisa Limsuwan, Tosin Majekodunmi, Werner Budts, Gerry Coghlan, Craig S. Broberg
Summary: Congenital heart disease is the most common cardiovascular condition in individuals with Down syndrome, affecting up to 50% of patients. Other factors that contribute to cardiovascular outcomes include pulmonary hypertension, pulmonary, endocrine, and metabolic diseases, and risk factors for atherosclerotic disease. Disparities in cardiovascular care for individuals with Down syndrome, which vary across different locations and healthcare systems, are often overlooked. This review provides a comprehensive summary of the diagnosis, prevalence, and management of cardiovascular disease in patients with Down syndrome, as well as addressing disparities in care based on resource availability.
Article
Cardiac & Cardiovascular Systems
Anna C. Mavromanoli, Stefano Barco, Walter Ageno, Helene Bouvaist, Marianne Brodmann, Claudio Cuccia, Francis Couturaud, Claudia Dellas, Konstantinos Dimopoulos, Daniel Duerschmied, Klaus Empen, Pompilio Faggiano, Emile Ferrari, Nazzareno Galie, Marcello Galvani, Alexandre Ghuysen, George Giannakoulas, Menno Huisman, David Jimenez, Matija Kozak, Irene M. Lang, Nicolas Meneveau, Thomas Muenzel, Massimiliano Palazzini, Antoniu Octavian Petris, Giancarlo Piovaccari, Aldo Salvi, Sebastian Schellong, Kai-Helge Schmidt, Franck Verschuren, Irene Schmidtmann, Gerrit Toenges, Frederikus A. Klok, Stavros Konstantinides
Summary: This study analyzed the changes in RV function in patients with intermediate-risk PE who were switched early to oral anticoagulation. The results showed that the majority of patients had normalized RV function within 6 days and maintained normal RV function throughout the first 6 months. However, almost one in four patients continued to have evidence of RV dysfunction over the long term.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Andrew Constantine, Konstantinos Dimopoulos, Ee Ling Heng, Aleksander Kempny
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Letter
Respiratory System
Chinthaka B. Samaranayake, Aleksander Kempny, Robert Naeije, Michael Gatzoulis, Laura C. Price, Konstantinos Dimopoulos, Lan Zhao, Stephen J. Wort, Colm McCabe
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Kaushiga Krishnathasan, Konstantinos Dimopoulos, Neill Duncan, Piera Ricci, Alexander Kempny, Isma Rafiq, Michael A. Gatzoulis, Ee Ling Heng, Sarah Blakey, Claudia Montanaro, Sonya Babu-Narayan, Darrel P. Francis, Wei Li, Andrew Constantine
Summary: Renal dysfunction in adults with congenital heart disease (CHD) and heart failure is associated with disease progression, increased diuretic doses, and longer hospital stays. Chronic kidney disease (CKD) is common and triples the risk of death, transplantation, or ventricular assist device. Intensified monitoring, optimization of medical therapy, and collaborative management with renal physicians are necessary in these patients.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Respiratory System
Kaushiga Krishnathasan, Andrew Constantine, Isma Rafiq, Ana Barrradas Pires, Hannah Douglas, Laura C. Price, Konstantinos Dimopoulos
Summary: Pregnancy is generally contraindicated in PAH due to high maternal mortality. Specialist care and counseling are essential for women with PAH wishing to become pregnant, in order to minimize risk and improve outcomes.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Piera Ricci, Konstantinos Dimopoulos, Melissa Bouchard, Cheryl Chong Zhiya, Virginia Castro Meira, Danielle Pool, Michelle Lambell, Isma Rafiq, Aleksander Kempny, Ee Ling Heng, Michael A. Gatzoulis, Loredana Haidu, Andrew Constantine
Summary: Less than one-third of adolescents with congenital heart disease (CHD) successfully transition to adult care and miss out on education about their condition. We assessed the efficacy of our transition clinic and identified factors associated with successful transition.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Elena Surkova, Andrew Constantine, Zhuoyuan Xu, Teresa Segura de la Cal, Daniela Bispo, Cathy West, Roxy Senior, Konstantinos Dimopoulos, Wei Li
Summary: This study aimed to evaluate the additional prognostic significance of echocardiographic parameters in patients with a systemic right ventricle (SRV). The results showed that echocardiographic parameters can predict mortality and transplantation rates in these patients, and the assessment of subpulmonary left ventricular (LV) size and function is closely related to prognosis. Accurate echocardiographic evaluation of SRV and subpulmonary LV is therefore crucial for risk stratification and patient management.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Ana Barradas-Pires, Pablo Meras, Andrew Constantine, Giulia Costola, Teresa Segura de la Cal, Isma Rafiq, Aleksander Kempny, Wei Li, Sonya V. Babu-Narayan, J. Andreas Hoschtitzky, Michael A. Gatzoulis, Antonio Martinez Rubio, Konstantinos Dimopoulos
Summary: This study investigates the indications and outcomes of aortic valve replacement (AVR) in young adults with severe aortic regurgitation, as well as the relationship between presurgical echocardiographic parameters and postoperative left ventricular size and function. The results show that a higher presurgical left ventricular end-systolic diameter is associated with a lack of left ventricular normalization after AVR. Pre- and postoperative left ventricular dimensions and postoperative left ventricular ejection fraction predict clinical events during follow-up.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Sian Chivers, Aoife Cleary, Rachel Knowles, Sonya Babu-Narayan, John M. Simpson, Heba Nashat, Konstantinos Dimopoulos, Michael A. Gatzoulis, Dirk Wilson, Milos Prica, James Anthony, Paul F. Clift, Victoria Jowett, Petra Jenkins, Bernadette Khodaghalian, Caroline B. Jones, Antonia Hardiman, Catherine Head, Owen Miller, Natali A. Y. Chung, Umar Mahmood, Frances A. Bu'Lock, Tristan K. W. Ramcharan, Ashish Chikermane, Jennifer Shortland, Andrew Tometzki, David S. Crossland, Zdenka Reinhardt, Clive Lewis, Leila Rittey, Dominic Hares, Olga Panagiotopoulou, Benjamin Smith, Muhammad L. Najih, Tara Bharucha, Piers E. F. Daubeney
Summary: This study examines the impact of COVID-19 on patients with congenital heart disease (CHD) and identifies risk factors for adverse outcomes. The study finds that children with CHD have a lower risk of death and hospitalization due to COVID-19, but younger children have higher hospital admission rates. In adults, the likelihood of death increases with age and pulmonary arterial hypertension, while the likelihood of hospitalization increases with age, comorbidities, and genetic disease.
Meeting Abstract
Cardiac & Cardiovascular Systems
Zhuoyuan Xu, Andrew Constantine, Konstantinos Dimopoulos, Hong Gu
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Respiratory System
C. Samaranayake, A. Kempny, L. C. Price, J. Pinguel, E. Morris, E. Moriarty, M. Gummadi, K. Dimopoulos, S. J. Wort, L. Zhao, C. Mccabe
EUROPEAN RESPIRATORY JOURNAL
(2022)
Meeting Abstract
Respiratory System
C. Samaranayake, R. Mcniven, A. Kempny, L. C. Price, C. Harries, M. Gatzoulis, K. Dimopoulos, S. J. Wort, C. Mccabe
EUROPEAN RESPIRATORY JOURNAL
(2022)