Article
Cardiac & Cardiovascular Systems
Paolo Meani, Roberto Lorusso, Mariusz Kowalewski, Giuseppe Isgro, Anna Cazzaniga, Angela Satriano, Alice Ascari, Mattia Bernardinetti, Mauro Cotza, Giuseppe Marchese, Erika Ciotti, Hassan Kandil, Umberto Di Dedda, Tommaso Aloisio, Alessandro Varrica, Alessandro Giamberti, Marco Ranucci
Summary: The LV unloading strategy is associated with increased in-hospital survival in pediatric patients with congenital heart disease treated with V-A ECLS.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pediatrics
Jerome Rambaud, Lars M. Broman, Sylvie Chevret, Federico Visconti, Pierre-Louis Leger, Yigit Guner, Laura Butragueno-Laiseca, Jean-eudes Piloquet, Matteo Di Nardo
Summary: The aim of this study was to describe the mechanical ventilation (MV) settings during extracorporeal membrane oxygenation (ECMO) for pediatric acute respiratory distress syndrome (P-ARDS) in six European centers. The study found that the use of high PEEP levels during ECMO was associated with higher mortality rates, as well as a DP above 15 cmH(2)O and a native lung FiO(2) above 60% on D14 of ECMO.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
En-Pei Lee, Oi-Wa Chan, Jainn-Jim Lin, Shao-Hsuan Hsia, Han-Ping Wu
Summary: In the pediatric intensive care unit, cardiac arrest is a rare but serious event that often leads to poor outcomes. A retrospective analysis of 223 patients who experienced in-PICU cardiac arrest was conducted, and it was found that the use of vasoactive-inotropic drugs, previous poor neurological status, underlying hemato-oncologic disease, and longer CPR duration were all risk factors associated with poor outcomes.
FRONTIERS IN PEDIATRICS
(2022)
Article
Clinical Neurology
Daniel J. Clark, Caitlin Bond, Alexander Andrews, Daniel J. Mueller, Angela Sarkisian, Robert O. Opoka, Richard Idro, Paul Bangirana, Andy Witten, Nicholas J. Sausen, Gretchen L. Birbeck, Chandy C. John, Douglas G. Postels
Summary: In this study of 149 children with cerebral malaria, the association between coma depth, clinical seizure numbers, EEG features and mortality, neurologic deficits, and cognitive outcomes was evaluated. The results showed that higher coma scores, higher background voltage, and normal reactivity on EEG were associated with lower mortality. The number of seizures and specific EEG features were associated with better cognitive outcomes.
Article
Biochemistry & Molecular Biology
Evan Xu, Yan Xie, Ziyad Al-Aly
Summary: Individuals with COVID-19 have an increased risk of developing a range of neurologic disorders at 12 months, even if they were not hospitalized during the acute phase of the infection.
Article
Clinical Neurology
Huda M. Alharbi, Elana F. Pinchefsky, My-An Tran, Carlos Ivan Salazar Cerda, Jessy Parokaran Varghese, Daphne Kamino, Elysa Widjaja, Eva Mamak, Linh Ly, Paeivi Nevalainen, Cecil D. Hahn, Emily W. Y. Tam
Summary: This study examined the relationship between electrographic seizure burden and neurologic outcomes in neonatal encephalopathy. The results showed that higher seizure burden during this period was associated with worse cognitive and language scores at 18 months.
Article
Clinical Neurology
Shahar Shelly, Christopher J. Klein, P. James B. Dyck, Pritikanta Paul, Michelle L. Mauermann, Sarah E. Berini, Benjamin Howe, James P. Fryer, Eati Basal, Hammami M. Bakri, Ruple S. Laughlin, Andrew McKeon, Sean J. Pittock, John Mills, Divyanshu Dubey
Summary: The study revealed that patients positive for NF155-IgG4 had distinct clinical and electrodiagnostic features compared to other NF155 antibody isotypes or IgG subclasses, showing unique characteristics. NF155-IgG4-positive patients responded well to immunotherapy and had favorable long-term clinical outcomes.
Article
Critical Care Medicine
Alicia M. Alcamo, Scott L. Weiss, Julie C. Fitzgerald, Matthew P. Kirschen, Laura L. Loftis, Swee Fong Tang, Neal J. Thomas, Vinay M. Nadkarni, Sholeen T. Nett
Summary: The presence of neurologic dysfunction during pediatric sepsis is associated with worse outcomes. However, the impact of early versus late onset of neurologic dysfunction on outcome remains unknown and further research is needed.
PEDIATRIC CRITICAL CARE MEDICINE
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sven Bambach, Mark Smith, P. Pearse Morris, Norbert G. Campeau, Mai-Lan Ho
Summary: Arterial spin labeling (ASL) is a noncontrast MRI technique used for quantitative evaluation of brain perfusion. This article discusses advanced applications of ASL across the lifespan, presenting case examples from children and adults with various pathologies. The article highlights the subtleties and pitfalls of ASL interpretation.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Medicine, General & Internal
Mircea R. Mihu, Marc O. Maybauer, Kaitlyn Cain, Laura V. Swant, Michael D. Harper, Robert S. Schoaps, Joseph M. Brewer, Ammar Sharif, Clayne Benson, Ahmed M. El Banayosy, Aly El Banayosy
Summary: This study shows that non-cardiothoracic surgeons can successfully perform remote ECMO cannulations and retrievals with low complication rates.
FRONTIERS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Luis Paixao, Haoqi Sun, Jacob Hogan, Katie Hartnack, Mike Westmeijer, Anudeepthi Neelagiri, David W. Zhou, Lauren M. McClain, Eyal Y. Kimchi, Patrick L. Purdon, Oluwaseun Akeju, M. Brandon Westover
Summary: Delirium burden throughout hospitalization independently predicts long-term neurologic outcomes and death up to 2.5 years post-critical illness, and is more predictive than delirium burden in the ICU alone or number of delirium days.
Review
Respiratory System
Romain Chopard, Peter Nielsen, Fabio Ius, Serghei Cebotari, Fiona Ecarnot, Hugo Pilichowski, Matthieu Schmidt, Benedict Kjaergaard, Iago Sousa-Casasnovas, Mehrdad Ghoreishi, Rajeev L. Narayan, Su Nam Lee, Gregory Piazza, Nicolas Meneveau
Summary: The results of this systematic review and meta-analysis suggest that mechanical reperfusion, particularly surgical embolectomy, may yield favorable outcomes regardless of the timing of ECMO implantation, thrombolysis administration, or cardiac arrest presentation.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Clinical Neurology
Bin Jiang, Nancy K. Hills, Rob Forsyth, Lori C. Jordan, Mahmoud Slim, Steven G. Pavlakis, Neil Freidman, Nomazulu Dlamini, Osman Farooq, Ying Li, Guangming Zhu, Heather Fullerton, Max Wintermark, Warren D. Lo
Summary: In childhood arterial ischemic stroke patients, larger infarct volume and younger age at stroke onset are associated with poorer outcomes, but the strength of these relationships is weak. Specific infarct locations are significantly associated with poorer outcomes, but lose significance when adjusted for infarct volume.
Article
Medicine, General & Internal
Michel Le May, Christina Osborne, Juan Russo, Derek So, Aun Yeong Chong, Alexander Dick, Michael Froeschl, Christopher Glover, Benjamin Hibbert, Jean-Francois Marquis, Sophie De Roock, Marino Labinaz, Jordan Bernick, Shawn Marshall, Ronnen Maze, George Wells
Summary: This study compared the clinical outcomes of comatose survivors of out-of-hospital cardiac arrest with target temperatures of 31 degrees C and 34 degrees C, and found that there was no significant difference in all-cause mortality or poor neurologic outcome between the two groups.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Critical Care Medicine
Takafumi Obara, Tetsuya Yumoto, Tsuyoshi Nojima, Takashi Hongo, Kohei Tsukahara, Naomi Matsumoto, Takashi Yorifuji, Atsunori Nakao, Jonathan Elmer, Hiromichi Naito
Summary: This study aimed to investigate the association between prehospital physician presence and neurologic outcomes in pediatric patients with out-of-hospital cardiac arrest (OHCA). The data from the Japanese Association for Acute Medicine-OHCA Registry were analyzed in a retrospective cohort study. The results showed that among pediatric patients with OHCA, prehospital physician presence was associated with a nearly two-fold increase in the odds of 1-month favorable neurologic outcomes.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)