Article
Immunology
Pierre M. Bataille, Cecile-Audrey Durel, Dominique Chauveau, Arnaud Panes, Eric Simon Thervet, Benjamin Terrier
Summary: A study conducted in France revealed that despite advances in therapeutic management, the mortality rates of GPA and MPA patients remain high and stable, highlighting the need for further improvement in management.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Rheumatology
Maxime Samson, Herve Devilliers, Sara Thietart, Pierre Charles, Christian Pagnoux, Pascal Cohen, Alexandre Karras, Luc Mouthon, Benjamin Terrier, Xavier Puechal, Loic Guillevin
Summary: The study aimed to develop a score for assessing the likelihood of relapse in granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). Long-term follow-up data from patients with GPA and MPA included in five randomized controlled trials were pooled. Variables associated with relapse were identified and used to build a score, which was validated in an independent cohort.
Article
Respiratory System
Thomas Villeneuve, Gregoire Prevot, Gregory Pugnet, Gavin Plat, Valentin Heluain, Stanislas Faguer, Nicolas Guibert
Summary: Bronchoscopy performed at diagnosis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) provides valuable information. Endobronchial lesions are more common in granulomatosis with polyangiitis (GPA) and should be biopsied. Bronchoalveolar lavage (BAL) can confirm diffuse alveolar haemorrhage (DAH) or diagnose superadded infection.
Article
Radiology, Nuclear Medicine & Medical Imaging
Masaya Kawaguchi, Hiroki Kato, Tomoaki Nagasawa, Yo Kaneko, Koichiro Taguchi, Takahide Ikeda, Hiroyuki Morita, Tatsuhiko Miyazaki, Masayuki Matsuo
Summary: In this study, it was observed that intramuscular hyperintensity and fascial hyperintensity are common findings in MPA, with fascial regions being predominantly affected. Additionally, compared to PM/DM, fascial hyperintensity and diffuse subcutaneous fat hyperintensity were more frequently encountered in MPA patients.
Article
Rheumatology
T. G. Lee, T. Yoon, E. Ko, J. Y. Pyo, S. S. Ahn, J. J. Song, Y-B Park, S-W. Lee
Summary: This study investigated the potential of sTyro-3 and sAxl concentrations in reflecting the current activity and renal involvement in MPA and GPA patients. The results showed significant correlations between sTyro-3 and sAxl concentrations and BVAS scores, as well as renal manifestations. These findings suggest that sTyro-3 and sAxl concentrations can serve as indicators of disease activity and renal involvement in MPA and GPA patients.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
Hiroyuki Ide, Toshimasa Shimizu, Yuta Koike, Kuniko Abe, Kazuto Shigematsu, Shinya Nishihata, Kanako Kojima, Kunihiro Ichinose, Atsushi Kawakami
Summary: This case report presents a patient who developed eosinophilic granulomatosis with polyangiitis (EGPA) during the clinical course of microscopic polyangiitis (MPA), suggesting that EGPA can be induced by eosinophilic inflammation in other subgroups of antineutrophil cytoplasmic autoantibody-associated vasculitis (AAV).
Review
Ophthalmology
Lin Mei, Luoziyi Wang, Hong Yan
Summary: Granulomatosis with polyangiitis (GPA) is a systemic inflammatory disease characterized by necrotizing vasculitis. Ocular involvement is common in GPA and can cause various manifestations such as orbital mass and keratitis. Diagnosis is based on comprehensive analysis of systemic manifestations, imaging examinations, laboratory tests, and histological biopsy. Immunosuppressive therapy has greatly improved the prognosis of GPA, and the emergence of biological therapy offers a promising treatment strategy.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Review
Rheumatology
Julia A. Ford, Yaseen Aleatany, Ora Gewurz-Singer
Summary: This review summarizes the recent advances in the management of eosinophilic granulomatosis with polyangiitis (EGPA), with a focus on the use of biologic therapies. The anti-interleukin (IL)-5 agent mepolizumab has shown efficacy in inducing and maintaining remission, particularly in patients with asthma and allergic manifestations. Rituximab is recommended for remission induction in severe disease, especially in ANCA-positive patients with vasculitic manifestations. However, the evidence for the use of traditional DMARDs and other biologic agents is limited. Advances in biologics have expanded the treatment options for EGPA.
CURRENT OPINION IN RHEUMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Taejun Yoon, Jang Woo Ha, Jung Yoon Pyo, Jason Jungsik Song, Yong- Beom Park, Sung Soo Ahn, Sang-Won Lee
Summary: sTREM-1 may serve as an indicator of disease activity in MPA and GPA. This study found that sTREM-1 was associated with disease activity, clinical scores, and inflammatory markers, and higher sTREM-1 levels were associated with more severe disease activity.
Article
Medicine, Research & Experimental
Hyeok Chan Kwon, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
Summary: This study found that the FIB-5 index could predict the occurrence of ESRD in patients with MPA and GPA without substantial liver diseases, but could not predict all-cause mortality.
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Immunology
Rongli Li, Yingying Chen, Shangzhu Zhang, Linyi Peng, Jiaxin Zhou, Yunyun Fei, Wen Zhang, Yan Zhao, Xiaofeng Zeng
Summary: This study aimed to investigate the clinical characteristics, potential risk factors, and long-term outcomes in EGPA patients with gastrointestinal (GI) involvement. The results showed that EGPA patients with GI involvement had higher levels of hs-CRP, higher grades of BVAS and FFS scores compared to those without GI involvement. During the follow-up period, EGPA patients with GI involvement had lower cumulative survival rate, lower long-term remission rate, and higher cumulative relapse rate.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Naman Jain, Debaditya Roy, Satyanarayana Mysore, Manjunath M. Negigowdru, Vijay K. R. Rao
Summary: Granulomatosis with polyangiitis (GPA) is a rare autoimmune disease with prostatic involvement being even rarer. We present a case of a 26-year-old male with GPA who had pulmonary manifestations and prostatic lesions. The patient showed improvement after treatment with oral steroids and rituximab, and remained relapse-free on azathioprine maintenance therapy.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Tsu-Yi Hsieh, Ming-Han Chen, Chen-Ching Wu, Wei-Jhe Hong, Cheng-Hsun Lu, Chun-Chi Lu, Ling-Ying Lu, Song-Chou Hsieh, Chang-Youh Tsai, Chien-Sheng Wu, Taiwan Vasculitis Study Grp
Summary: This study investigated the clinical outcomes of granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) patients in Taiwan receiving rituximab induction and reinduction therapy. The results showed that MPA patients had higher rates of kidney involvement and initial creatinine levels compared to GPA patients. Within 24 weeks after the first course of rituximab, there was a significantly higher mortality rate in MPA patients, while the majority of patients receiving rituximab for kidney involvement survived without the need for renal replacement therapy.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Jan Henrik Schirmer, Beatriz Sanchez-Alamo, Bernhard Hellmich, David Jayne, Sara Monti, Raashid Ahmed Luqmani, Gunnar Tomasson
Summary: This systematic literature review provides evidence on the treatment of antineutrophil cytoplasm antibody-associated vasculitis (AAV) and suggests that cyclophosphamide and rituximab have similar efficacy for remission induction, but rituximab is more effective in relapsing disease. Faster tapering glucocorticoid protocols result in similar remission rates but lower rates of serious infections. Avacopan shows potential for rapid tapering and replacing glucocorticoids. Use of rituximab for maintenance of remission is associated with lower relapse rates compared with azathioprine. Prolonged maintenance treatment reduces relapse rates for both azathioprine and rituximab.
Article
Neurosciences
Emine R. Koc, Gizem Gullu, Altug Guner, Sahsene Tolunay, Rifat Ozpar, Huseyin E. Dalkilic
Summary: This report presents a case of pituitary dysfunction related to granulomatosis with polyangiitis, which is rare and usually associated with involvement of other organs.
Letter
Respiratory System
Thomas Villeneuve, Gregoire Prevot, Aurelie Le Borgne, Magali Colombat, Samia Collot, Stephanie Ruiz, Thomas Lanot, Laurent Brouchet, Audrey Rabeau, Elise Noel-Savina, Alain Didier
EUROPEAN RESPIRATORY JOURNAL
(2020)
Letter
Respiratory System
Thomas Villeneuve, Nicolas Guibert, Samia Collot, Pierre Fajadet, Magali Colombat, Monique Courtade-Saidi, Thierry Levade, Alain Didier, Gregoire Prevot
EUROPEAN RESPIRATORY JOURNAL
(2021)
Letter
Respiratory System
Thomas Villeneuve, Sandrine Pontier, Gregoire Prevot, Nicolas Guibert, Christine Chevreau, Philippe Rochaix, Monique Courtade-Saidi
RESPIRATORY MEDICINE AND RESEARCH
(2023)
Letter
Respiratory System
Pascalin Roy, Valentin Heluain, Pierre Leyx, Thomas Villeneuve, Romain Verge, Laurent Brouchet, Nicolas Guibert
Article
Respiratory System
Thomas Villeneuve, Gregoire Prevot, Gregory Pugnet, Gavin Plat, Valentin Heluain, Stanislas Faguer, Nicolas Guibert
Summary: Bronchoscopy performed at diagnosis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) provides valuable information. Endobronchial lesions are more common in granulomatosis with polyangiitis (GPA) and should be biopsied. Bronchoalveolar lavage (BAL) can confirm diffuse alveolar haemorrhage (DAH) or diagnose superadded infection.
Letter
Respiratory System
Thomas Villeneuve, Gregoire Prevot, Samia Collot, Magali Colombat, Alain Didier
RESPIRATORY MEDICINE AND RESEARCH
(2022)
Article
Respiratory System
Thomas Villeneuve, Romane Fumat, Valentin Heluain, Pierre Pascal, Gavin Plat, Nicolas Guibert
Letter
Respiratory System
Thibault Viatge, Thomas Villeneuve, Dominique D'Aure, Julien Mazieres, Gavin Plat, Christophe Hermant, Nicolas Guibert
Article
Rheumatology
Walter P. Maksymowych, Nele Herregods, Nisha Varma, Arthur B. Meyers, Jennifer Stimec, Andrea S. Doria, Nikolay Tzaribachev, Tarimobo M. Otobo, Marion A. van Rossum, Joel Paschke, Stephanie Wichuk, Robert G. Lambert
Summary: This study aimed to investigate whether systematic calibration improves the scoring proficiency of JAMRIS-SIJ and whether contrast-enhancement enhances its performance. The results showed that calibrated readers achieved greater reliability in scoring specific inflammatory and structural lesions. Sensitivity and reliability for scoring inflammatory lesions were higher on fluid-sensitive sequences compared to contrast-enhanced sequences. Therefore, systematic calibration should be implemented before using JAMRIS-SIJ in clinical trials, and it is unlikely that contrast-enhanced MRI will improve the performance of this method.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
Article
Rheumatology
L. van Ouwerkerk, S. A. Bergstra, T. D. Maarseveen, T. W. J. Huizinga, R. Knevel, C. F. Allaart
Summary: This study evaluated whether the initial use of glucocorticoid (GC) bridging in RA patients leads to a higher probability of long-term GC and bDMARD use. The results showed that patients who initially started GC had a higher risk of later GC use, but the risk of bDMARD use was not significantly increased.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
Article
Rheumatology
ShuangHua Liu, YiMei Tan, WeiDong Huang, HongSheng Luo, BingCheng Pan, Shuan Wu
Summary: This study assessed the cardiovascular safety of zoledronic acid in the treatment of primary osteoporosis. The results showed that in women with primary osteoporosis, zoledronic acid may increase the risk of atrial fibrillation and arrhythmias, but the cardiovascular risk in men with osteoporosis is uncertain.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)