Review
Immunology
Nishelle D'souza, Milena Weber, Eszter Sarzsinszky, Susanne Vrtala, Mirela Curin, Mirjam Schaar, Victoria Garib, Margarete Focke-Tejkl, Yanqiu Li, Richard Jones, Hao Chen, Rudolf Valenta, Baoqing Sun
Summary: Approximately 30% of the global population suffers from IgE-mediated allergy, with China having the largest population and over 400 million allergic patients. Allergy prevention and treatment strategies include allergen avoidance, vaccination, and tolerance induction, requiring a detailed understanding of relevant allergen molecules affecting specific populations.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Food Science & Technology
Ziye Zhang, Xiu-Min Li, Hao Wang, Hong Lin, Hang Xiao, Zhenxing Li
Summary: This paper provides an overview of seafood allergens, IgE-binding epitopes, and allergen immunotherapy for seafood allergies, highlighting the importance of identifying and characterizing allergens for allergy diagnosis and treatment.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Allergy
Debra de Silva, Pablo Rodriguez del Rio, Nicolette W. de Jong, Ekaterina Khaleva, Chris Singh, Anna Nowak-Wegrzyn, Antonella Muraro, Philippe Begin, Giovanni Pajno, Alessandro Fiocchi, Angel Sanchez, Carla Jones, Caroline Nilsson, Carsten Bindslev-Jensen, Gary Wong, Hugh Sampson, Kirsten Beyer, Mary-Jane Marchisotto, Montserrat Fernandez Rivas, Rosan Meyer, Susanne Lau, Ulugbek Nurmatov, Graham Roberts
Summary: Oral immunotherapy improves tolerance in patients with peanut, cow's milk, and hen's egg allergy during therapy and is likely safe. The effects of other allergies and administration routes are inconclusive and require further research.
Article
Immunology
Yasmeen S. El Ansari, Cynthia Kanagaratham, Oliver T. Burton, Jenna V. Santos, Brianna-Marie A. Hollister, Owen L. Lewis, Harald Renz, Hans C. Oettgen
Summary: Mast cells and basophils play important roles in IgE-mediated hypersensitivity reactions. IgG and IgA antibodies can regulate the activation of these cells by activating or inhibiting receptors. This study found that IgA antibodies can bind to mast cells and basophils, and inhibit their activation to maintain immune homeostasis at mucosal sites.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Stephen R. Durham, Mohamed H. Shamji
Summary: Allergen immunotherapy is a therapeutic vaccination for established IgE-mediated hypersensitivity. It involves repeated injection of allergen extracts, leading to allergen-specific tolerance. Sublingual administration has emerged as an effective alternative. The mechanisms of immunotherapy-induced tolerance involve reduction of allergen-specific T(H)2 cells, induction of regulatory T and B cells, and production of blocking antibodies. Novel strategies are being explored to achieve safer and more effective long-term tolerance.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Allergy
Leo Laoubi, Morgane Lacoffrette, Severine Valsesia, Vanina Lenief, Aurelie Guironnet-Paquet, Amandine Mosnier, Gwendoline Dubois, Anna Cartier, Laurine Monti, Jacqueline Marvel, Eric Espinosa, Bernard Malissen, Sandrine Henri, Lucie Mondoulet, Hugh A. Sampson, Audrey Nosbaum, Jean-Francois Nicolas, Vincent Dioszeghy, Marc Vocanson
Summary: This study investigates the phenotype and functional characteristics of skin dendritic cells (skDCs) during epicutaneous immunotherapy (EPIT), finding that skDCs gradually change their phenotype and functional properties during EPIT, which is crucial for achieving desensitization.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Immunology
Chiara Tontini, Silvia Bulfone-Paus
Summary: Allergy is a type-I hypersensitivity reaction that can lead to life-threatening systemic symptoms. Novel therapeutic options targeting mast cells activation, such as monoclonal antibodies and allergen-specific immunotherapy, are promising for severe allergies treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Juan L. Paris, Lalitkumar K. Vora, Maria Jose Torres, Cristobalina Mayorga, Ryan F. Donnelly
Summary: The incidence of allergies has been increasing recently. Allergen-specific immunotherapy (AIT) is the only approach that can induce long-term immune tolerance towards allergens. However, its clinical success is limited by efficacy and safety concerns related to the administration route. Microneedles have been proposed to improve therapeutic delivery into the skin, but the stratum corneum poses a challenge. This review discusses recent developments in the use of microneedles for AIT and suggests future research directions.
DRUG DISCOVERY TODAY
(2023)
Article
Immunology
I-Hui Lin, Ming-Chin Tsai, Jun-Peng Chen, Lin-Shien Fu
Summary: The study found that for two thirds of atopic children, a specific allergen could be identified during follow-up tests. Specific allergens could be identified through MAST tests and further assist in treatment options.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Biochemistry & Molecular Biology
Kavita Reginald, Fook Tim Chew
Summary: This review evaluates the current modes of allergen-specific immunotherapy for cockroach allergens in terms of clinical outcomes and explores future trends in research and development for a more targeted approach to cockroach immunotherapy with better efficacy and fewer adverse effects.
MOLECULAR IMMUNOLOGY
(2023)
Review
Allergy
Mohamed H. Shamji, Rudolf Valenta, Theodore Jardetzky, Valerie Verhasselt, Stephen R. Durham, Peter A. Wurtzen, R. J. Joost van Neerven
Summary: IgE-mediated allergy is a common hypersensitivity disease impacting over 30% of the population. Allergen-specific IgE triggers release of inflammatory mediators, while inducing IgG and IgA antibodies can compete with IgE for allergen binding to prevent allergic responses. Anti-IgE treatment can also prevent IgE from binding to receptors on mast cells and basophils to inhibit allergic reactions.
Article
Allergy
Amy M. Scurlock, A. Wesley Burks, Scott H. Sicherer, Donald Y. M. Leung, Edwin H. Kim, Alice K. Henning, Peter Dawson, Robert W. Lindblad, M. Cecilia Berin, Christine B. Cho, Wendy F. Davidson, Marshall Plaut, Hugh A. Sampson, Robert A. Wood, Stacie M. Jones
Summary: In this study, extended treatment with VP250 was well tolerated, and desensitization observed at week 52 persisted between weeks 52 and 130. Treatment success was predominantly observed in younger participants.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Jeffrey J. Landers, Katarzyna W. Janczak, Akhilesh Kumar Shakya, Vladimir Zarnitsyn, Samirkumar R. Patel, James R. Baker, Harvinder Singh Gill, Jessica J. O'Konek
Summary: This study compared the efficacy of peanut-coated microneedles with peanut epicutaneous immunotherapy (EPIT) in a peanut allergy mouse model. The findings suggest that peanut-coated microneedles are safe and enhance desensitization to peanut.
Article
Allergy
Jennifer Dantzer, Joan Dunlop, Kevin J. Psoter, Corinne Keet, Robert Wood
Summary: Baked milk oral immunotherapy (BMOIT) has shown safety and efficacy in treating children with baked milk allergy. After 12 months of treatment, the majority of participants in the BMOIT group were able to tolerate higher doses of baked milk protein compared to the placebo group. Dose-related adverse reactions were common but mild. BMOIT increased cow's milk-sIgG4 levels and decreased casein IgE levels.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Claudia Petrarca, Davide Viola
Summary: This study conducted a post hoc analysis to investigate the effect of endogenous vitamin D on the immunological mechanism underlying effective mite allergoid immunotherapy (AIT). The results showed that AIT is able to reshape the immune response against allergens and that vitamin D plays a role in this process. Patients with lower endogenous vitamin D levels had worse symptoms and higher medication use, while those concurrently taking VD3 as a supplement showed the best treatment outcomes. This suggests that vitamin D levels affect allergy severity and the effectiveness of allergen immunotherapy.
