Article
Cardiac & Cardiovascular Systems
Francesco Gentile, Vincenzo Castiglione, Raffaele De Caterinao
Summary: CAAs are a group of congenital conditions characterized by abnormal origin or course of the 3 main epicardial coronary arteries. While they have been identified as a common underlying condition in young athletes, their recognition among adults has increased with the widespread use of invasive and noninvasive coronary imaging. The clinical correlates and therapeutic choices for CAAs remain poorly understood, with studies suggesting that multimodality imaging may play a key role in management.
Article
Cardiac & Cardiovascular Systems
Jenifer M. Brown, Wunan Zhou, Brittany Weber, Sanjay Divakaran, Leanne Barrett, Courtney F. Bibbo, Jon Hainer, Viviany R. Taqueti, Sharmila Dorbala, Ron Blankstein, Marcelo F. Di Carli
Summary: Insufficient myocardial perfusion to match global metabolic demand may be a risk marker for heart failure.
EUROPEAN HEART JOURNAL
(2022)
Article
Multidisciplinary Sciences
Olga V. Gruzdeva, Ekaterina V. Belik, Yulia A. Dyleva, Daria A. Borodkina, Maxim Yu. Sinitsky, Danil Yu. Naumov, Evgeniya E. Bychkova, Elena V. Fanaskova, Elena I. Palicheva, Anastasia A. Kuzmina, Viktoriya N. Karetnikova, Olga L. Barbarash
Summary: The study found that in patients with CAD, there were changes in the expression and secretion of adipocytokines in the heart fat depot, with the most significant alterations observed in severe and extremely severe CA lesions. Epicardial adipocytes showed minimal adiponectin gene expression and maximal gene expression of leptin and IL-6 compared to subcutaneous and perivascular adipocytes.
Article
Health Care Sciences & Services
Yana Polonskaya, Elena Kashtanova, Ivan S. Murashov, Evgenia Striukova, Alexey Kurguzov, Ekaterina M. Stakhneva, Viktoria S. Shramko, Nikolay A. Maslatsov, Aleksandr M. Chernyavsky, Yulia Ragino
Summary: The study investigated the relationship between matrix metalloproteinases and coronary artery calcification. Results showed the involvement of some MMPs, particularly MMP-9, in the calcification process. MMP-1, MMP-7, and MMP-12 were associated with CHD and may serve as potential biomarkers for further research.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jangho Park, Sangwoo Park, Yong-Giun Kim, Soe Hee Ann, Hyun Woo Park, Jon Suh, Jae-Hyung Roh, Young-Rak Cho, Seungbong Han, Gyung-Min Park
Summary: An analysis of National Health Insurance data in Korea showed that pre-existing depression does not have a significant impact on mortality in patients with established coronary artery disease undergoing PCI. However, younger patients with angina and depression may have a higher risk of all-cause mortality.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Yulan Ma, Lulu Zhu, Zhijun Ma, Zhongshan Gao, Yumiao Wei, Youlu Shen, Lin Li, Xingli Liu, Ming Ren
Summary: The study revealed that Tibetan Highlanders suffering from coronary artery disease have higher gut microbiota diversity, which is associated with their unique dietary characteristics.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Vanessa Nader, Anthony Matta, Ryeonshi Kang, Antoine Deney, Rania Azar, Charlotte Rouzaud-Laborde, Oxana Kunduzova, Romain Itier, Pauline Fournier, Michel Galinier, Didier Carrie, Jerome Roncalli
Summary: This study evaluates the effect of revascularization strategy on all-cause mortality in patients with ischaemic heart failure. The findings show that coronary revascularization does not modify short-term survival outcomes in HF patients compared with optimal medical therapy alone.
Article
Cardiac & Cardiovascular Systems
Jun Gu, Zhao-fang Yin, Zuo-jun Xu, Yu-qi Fan, Chang-qian Wang, Jun-feng Zhang
Summary: This study showed that after PCI, the predominant subtype of HF is HFpEF, and higher BNP levels, lower eGFR levels, and atrial fibrillation are independent risk factors for new-onset HF. Being male and being prescribed with ACEI/ARB medications are negative predictors for new-onset HF. Additionally, long-term ACEI/ARB therapy is associated with reduced risks of developing all three subtypes of HF (HFrEF, HFmrEF, and HFpEF), compared to beta-blocker use.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Physiology
Ferdinando Iellamo, Marco Alfonso Perrone, Giuseppe Caminiti, Maurizio Volterrani, Jacopo M. Legramante
Summary: The study found that in coronary artery patients, the recovery phase after exercise is characterized by post-exercise hypotension (PEH), which is mainly mediated by generalized peripheral vasodilation and appears to influence blood pressure behavior throughout daily life. Additionally, the cardiac component of the arterial baroreflex seems to indirectly contribute to the blood pressure reduction occurring after exercise.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Health Care Sciences & Services
Wojciech Jan Skorupski, Marta Kaluzna-Oleksy, Maciej Lesiak, Aleksander Araszkiewicz, Wlodzimierz Skorupski, Stefan Grajek, Przemyslaw Mitkowski, Malgorzata Pyda, Marek Grygier
Summary: The study evaluates the outcomes of left main percutaneous coronary interventions in patients who are not suitable for coronary artery bypass graft surgery. The results show that these patients have higher complexity of disease and lower ejection fraction, but the procedure is successful with low complication rates. However, long-term all-cause mortality rate is slightly higher in these patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Nathalia Gonzalez-Jaramillo, Matthias Wilhelm, Ana Maria Arango-Rivas, Valentina Gonzalez-Jaramillo, Cristina Mesa-Vieira, Beatrice Minder, Oscar H. Franco, Arjola Bano
Summary: This study found that maintaining or adopting an active lifestyle can reduce all-cause mortality risk in patients with CHD, especially for those who remained active. The results also suggest that the benefits of past activity in reducing CVD mortality risk may be lost if appropriate physical activity is not maintained.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Clara Saldarriaga, Dan Atar, Amanda Stebbins, Basil S. Lewis, Imran Zainal Abidin, Robert O. Blaustein, Javed Butler, Justin A. Ezekowitz, Adrian F. Hernandez, Carolyn S. P. Lam, Christopher M. O'Connor, Burkert Pieske, Piotr Ponikowski, Lothar Roessig, Adriaan A. Voors, Kevin J. Anstrom, Paul W. Armstrong
Summary: Coronary artery disease (CAD) is associated with higher cardiovascular events and heart failure hospitalizations in patients with Heart Failure with Reduced Ejection Fraction (HFrEF) and worsening HF. However, the treatment effect of vericiguat remains effective regardless of the presence of CAD. Patients with CAD are more likely to have other comorbidities compared to those without CAD.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Biology
Jingjing Yan, Jing Tian, Hong Yang, Gangfei Han, Yanling Liu, Hangzhi He, Qinghua Han, Yanbo Zhang
Summary: This study designed a machine learning-based risk-prediction system as an accurate, non-invasive, and cost-effective alternative method for diagnosing coronary stenosis. Through the construction of multiple models and external validation, the XGBoost model was found to have the best overall classification performance. A risk-assessment and management system was established for patient-specific intervention guidance.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Medicine, General & Internal
Lourdes Vicent, Jesus Alvarez-Garcia, Rafael Vazquez-Garcia, Jose R. Gonzalez-Juanatey, Miguel Rivera, Javier Segovia, Domingo Pascual-Figal, Ramon Bover, Fernando Worner, Francisco Fernandez-Aviles, Albert Ariza-Sole, Manuel Martinez-Selles
Summary: The aim of this study was to determine the prognostic impact of coronary artery disease (CAD) on heart failure with reduced ejection fraction (HFrEF) mortality and readmissions. A total of 583 patients with left ventricular ejection fraction <40% were included in the study, among which 266 had CAD and 137 had idiopathic dilated cardiomyopathy (DCM). The study found that one-year mortality and readmissions were similar between patients with CAD and idiopathic DCM, but patients with idiopathic DCM were more likely to receive a heart transplant.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Jose Alexandre Barbosa Almeida, Rencio Bento Florencio, Darllane Azevedo Lemos, Jessica Costa Leite, Karolinne Souza Monteiro, Lucien Peroni Gualdi
Summary: This study aims to assess the measurement properties, methodological quality, and content of outcome measures of cardiac self-efficacy instruments for individuals with coronary artery disease (CAD).