Article
Medicine, Research & Experimental
Zhanjun Chen, Leyang Xiang, Longhai Li, Huohui Ou, Yinghao Fang, Yuyan Xu, Qin Liu, Zhigang Hu, Yu Huang, Xianghong Li, Dinghua Yang
Summary: The study revealed that linc00261 suppressed EMT and stem-like traits in HCC cells by inhibiting TGF-beta1/SMAD3 signaling.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Ha Young Jang, Soo-Jin Kim, Kyu-Sang Park, Jeong Hun Kim
Summary: Degenerative changes of RPE triggered by TGF-beta 2 and oxidative stress play a critical role in AMD progression. The expression of antiaging protein alpha-klotho declines with age, increasing the risk of age-related diseases. Alpha-klotho protects against TGF-beta 2-induced RPE degeneration and EMT both in vitro and in vivo. It inhibits TGF-beta 2 signaling, EMT, oxidative stress, and senescence-associated signaling.
CELL DEATH & DISEASE
(2023)
Article
Immunology
Danxue Qin, Peiqiang Liu, Huiqin Zhou, Jing Jin, Wanyang Gong, Kunyu Liu, Siyuan Chen, Jingyu Huang, Wenjun Fan, Zezhang Tao, Yu Xu
Summary: Chronic rhinosinusitis with nasal polyps (CRSwNP) is caused by prolonged inflammation of the paranasal sinus mucosa. In this study, TIM-4 was found to be increased in the sinonasal mucosa of CRSwNP patients, especially in macrophages. TIM-4 was positively correlated with clinical scores and inhibition of TIM-4 reduced polyp formation and EMT.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jisu Jeong, Jiyeon Kim
Summary: EMT plays a crucial role in the development of lung cancer, and targeting EMT could inhibit cancer cell invasion and metastasis. This study found that combination treatment with erlotinib and cilengitide showed enhanced inhibitory effects on EMT in lung cancer cells, suggesting that cilengitide could improve the efficacy of anticancer drugs and contribute to improved treatment strategies for inhibiting EMT-based cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Jisu Jeong, Jiyeon Kim
Summary: The combination treatment of gefitinib and cilengitide effectively inhibits TGF-β 1-induced EMT and invasion of NSCLC cells, which may enhance the efficacy of anticancer drugs in combination chemotherapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Yang-Zhi Hu, Zhi-Li Hu, Tian-You Liao, Yuan Li, Yun-Long Pan
Summary: This study aimed to investigate the effects of lncRNA SND1-IT1, miR-124, and COL4A1 gene on TGF-beta 1-induced EMT in gastric cancer (GC). Through the analysis of tissue samples and experiments on HGC-27 cells, the results demonstrated that TGF-beta 1 can regulate cancer cell migration, invasion, and stimulate EMT through the SND1-IT1/miR-124/COL4A1 axis in GC.
CELL DEATH DISCOVERY
(2022)
Article
Integrative & Complementary Medicine
Guangtao Zhang, Zhaoyan Li, Jiahuan Dong, Weili Zhou, Zhanxia Zhang, Zujun Que, Xiaohong Zhu, Yan Xu, Nida Cao, Aiguang Zhao
Summary: Acacetin inhibits proliferation, invasion, and migration of human gastric cancer cells by regulating EMT-related proteins. It reverses morphological changes induced by TGF-beta 1 and restricts invasion and migration by regulating EMT. Acacetin also suppresses PI3K/Akt signaling and delays metastasis in vivo.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Biochemistry & Molecular Biology
Tianxiao Sun, Haihua Li, Yan Zhang, Guixin Xiong, Yuerun Liang, Fang Lu, Rong Zheng, Qi Zou, Jiejie Hao
Summary: In this study, it was found that DGM could inhibit TGF-beta 1-induced EMT in A549 cells and bleomycin-induced pulmonary fibrosis in rats. Furthermore, DGM treatment improved lung function, reduced lung inflammation and fibrosis, and decreased collagen deposition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Noemi Monti, Simona Dinicola, Alessandro Querqui, Gianmarco Fabrizi, Valeria Fedeli, Luisa Gesualdi, Angela Catizone, Vittorio Unfer, Mariano Bizzarri
Summary: Epithelial-Mesenchymal Transition (EMT) causes the transformation of epithelial cells into a mesenchymal-like phenotype, leading to loss of cell-to-cell contact and increased motility/invasive capabilities. This process is important in inflammation and cancer progression, driven by factors such as TGF-beta 1. However, myo-inositol can reverse the EMT process induced by TGF-beta 1 and restore the epithelial phenotype.
Article
Biochemistry & Molecular Biology
Fengbao Luo, Renfang Xu, Guanglai Song, Dong Xue, Xiaozhou He, Ying Xia
Summary: The study demonstrates that DOR activation efficiently blocks the fibrosis process induced by TGF-beta 1 in renal proximal tubule cells, by inhibiting multiple signaling pathways.
Article
Immunology
Hongjuan He, Lihua Cao, Zheng Wang, Zhenzhen Wang, Jinxin Miao, Xiu-Min Li, Mingsan Miao
Summary: Sin suppresses epithelial-mesenchymal transition (EMT) by inhibiting IL-4 and downregulating TGF-beta 1 and Smad3 expression, thereby alleviating airway remodeling and inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Aparna Cherukunnath, Ravichandra S. Davargaon, Rahail Ashraf, Urja Kamdar, Amit K. Srivastava, Prem P. Tripathi, Nabanita Chatterjee, Sanjay Kumar
Summary: KLF8 is overexpressed in ovarian cancer and promotes cancer progression. TGF-beta 1 activates KLF8 expression through the Smad2 pathway and regulates epithelial-mesenchymal transition (EMT), contributing to OC progression.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Hongrui Guo, Zhijie Jian, Huan Liu, Hengmin Cui, Huidan Deng, Jing Fang, Zhicai Zuo, Xun Wang, Ling Zhao, Yi Geng, Ping Ouyang, Huaqiao Tang
Summary: Copper is an essential trace element for living organisms, but over-exposure can lead to adverse health effects. Research found that copper sulfate treatment induced pulmonary fibrosis in mice, activating multiple signaling pathways and causing epithelial-mesenchymal transition. This study reveals the mechanism of copper-induced pulmonary toxicity through EMT induced by TGF-beta 1/Smad and MAPKs pathways.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Oncology
Chunli Tan, Wenbo Sun, Zhi Xu, Shuyi Zhu, Weizi Hu, Xiumei Wang, Yanyan Zhang, Guangqin Zhang, Zibin Wang, Yong Xu, Jinhai Tang
Summary: The study demonstrated that sEV-mediated TGF-beta 1 intercellular transfer contributes to adriamycin resistance in breast cancer by enhancing cell survival and migration through increased Smad2 phosphorylation. The findings were validated using a zebrafish xenograft tumor model.
MOLECULAR ONCOLOGY
(2021)
Article
Oncology
Qiuju Liang, Zhijie Xu, Yuanhong Liu, Bi Peng, Yuan Cai, Wei Liu, Yuanliang Yan
Summary: NR2F1 regulates platinum sensitivity and immune response in ovarian cancer by modulating TGF-beta 1-mediated EMT.
