Article
Genetics & Heredity
Gilnei Bruno da Silva, Daiane Manica, Alana Patricia da Silva, Greicy Cristine Kosvoski, Marceli Hanauer, Charles Elias Assmann, Julia Leao Batista Simoes, Micheli Mainardi Pillat, Jessica Dotto de Lara, Filomena Marafon, Amanda Gollo Bertollo, Maiqueli E. D. Mingoti, Jullye Gavioli, Gislaine Zilli Reus, Gabriela Goncalves de Oliveira, Zuleide Maria Ignacio, Margarete Dulce Bagatini
Summary: This study investigated the changes in purinergic signaling and immune response in COVID-19 patients. The results showed altered purinergic signaling in both moderate and severe cases, including increased ATP hydrolysis in platelets and PBMCs, as well as significantly elevated ADP and AMP hydrolysis. The study also observed increased expression of CD39 and CD73 in total leukocytes, along with higher extracellular ATP levels in both groups. Additionally, moderate and severe cases exhibited elevated levels of IL-2, IL-6, IL-10, and IL-17. These findings provide valuable insights into the changes in purinergic signaling and immune response in COVID-19, highlighting the therapeutic potential of the purinergic system as a target for the treatment of SARS-CoV-2 disease.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Medicine, Research & Experimental
T. B-D Mcewan, R. A. Sophocleous, P. Cuthbertson, K. J. Mansfield, M. L. Sanderson-Smith, R. Sluyter
Summary: The study revealed that scratched cells release adenosine 5'-triphosphate (ATP) which activates P2Y(2) receptors to facilitate wound closure in HaCaT keratinocytes. Inhibition of ATP release and P2Y(2) receptor activation impaired wound healing, highlighting the importance of autocrine purinergic signaling in this process.
Article
Cell Biology
Elizabeth H. Zhong, Carola Ledderose, Paola De Andrade Mello, Keiichi Enjyoji, Justin Mark Lunderberg, Wolfgang Junger, Simon C. Robson
Summary: This study demonstrates the synergistic effects of ectoenzymes such as CD39 and CD73 in reducing inflammatory responses, suggesting that these bifunctional enzymes could serve as therapeutic agents in inflammatory diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Review
Fisheries
Shuo Li, Tongtong Zhang, Yu Feng, Jinsheng Sun
Summary: Extracellular nucleotides, such as ATP and ADP, released during inflammation or infection, play a crucial role in regulating immune responses in fish by activating specific purinergic receptors on immune cells.
Article
Endocrinology & Metabolism
Bynvant Sandhu, Maria C. Perez-Matos, Stephanie Tran, Garima Singhal, Ismail Syed, Linda Feldbruegge, Shuji Mitsuhashi, Julie Pelletier, Jinhe Huang, Yusuf Yalcin, Eva Csizmadia, Shilpa Tiwari-Heckler, Keiichi Enjyoji, Jean Sevigny, Eleftheria Maratos-Flier, Simon C. Robson, Z. Gordon Jiang
Summary: This study investigated the impact of NTPDase3 deficiency on diet-induced obesity and metabolism in mice. The results showed that global NTPDase3 deletion led to resistance to obesity and glucose intolerance, with metabolic changes in adipocytes playing a key role rather than NTPDase3 expression in pancreatic beta-cells.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Oncology
Jasmeet Kaur, Sanchit Dora
Summary: Cancer is a complex disease with diverse characteristics, and there is a need to discover new therapeutic targets to improve treatment outcomes.
FRONTIERS IN ONCOLOGY
(2023)
Review
Pharmacology & Pharmacy
Nicholas Dale
Summary: This review emphasizes the importance of real-time measurements of extracellular ATP and adenosine concentrations, provides additional mechanistic insights, and outlines current techniques available for spatially localized measurements. The examples of CO2 and nutrient sensing highlight the impact of direct real-time measurements, demonstrating the role of purinergic signaling in breathing control, weight regulation, and sleep-wake state. Additionally, the complex mechanisms of activity-dependent adenosine release in different brain regions are discussed, underscoring the potential of whole blood purine measurements in clinical practice.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Valentina Carotti, Juan P. Rigalli, Jenny van Asbeck-van der Wijst, Joost G. J. Hoenderop
Summary: Purinergic signalling is a process mediated by purinergic receptors, where extracellular nucleotides and nucleosides bind to the receptors, resulting in changes in cell physiology. This signalling is involved in important physiological processes and pathophysiological situations such as cancer and inflammation. Extracellular vesicles (EVs) play a crucial role in modulating purinergic signalling and can affect target cells and tissues located at distant locations. The regulation of extracellular ATP levels and adenosine by EVs has significant impact on processes like inflammation, immune response, and cancer pathogenesis.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Dominic L. Sykes, Mengru Zhang, Alyn H. Morice
Summary: Chronic cough has been a significant burden for patients, with no approved pharmacological therapies available. However, recent research on the pathophysiological mechanisms of chronic cough has provided new hope, including the potential use of P2X3 receptor antagonists and other emerging peripheral acting pharmacological agents.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Beatriz Gil, Jonathon Smith, Yong Tang, Peter Illes, Tobias Engel
Summary: Epilepsy is a common chronic disease with difficult treatment, and P2X7R antagonists may serve as a novel therapeutic strategy for epilepsy and its associated comorbidities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Jennifer Patritti-Cram, Robert. A. Coover, Michael P. Jankowski, Nancy Ratner
Summary: Purinergic receptor activation plays a crucial role in peripheral nerve development and disease, regulating SC proliferation and differentiation, as well as the development of nerve tumors and neuropathies.
Article
Neurosciences
Javier Gonzalez Sanabria, Maximiliano Hurtado Paso, Tamara Frontera, Adriana Losavio
Summary: ATP and adenosine modulate neurotransmitter release at the mouse neuromuscular junction by activating different types of receptors. Depending on the frequency and pattern of stimulation, endogenous purines can fine-tune neurosecretion in response to repetitive stimulation of the phrenic nerve.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Neurosciences
Silvia Prades, Gregory Heard, Jonathan E. Gale, Tobias Engel, Robin Kopp, Annette Nicke, Katie E. Smith, Daniel J. Jagger
Summary: The P2X(7) receptors are primarily expressed by peripheral glial cells rather than afferent neurons in the auditory nerve. This finding contributes to a better understanding of the effects of ATP-dependent mechanisms on hearing loss and sensory neuropathies.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
R. O. Leite, P. O. de Souza, C. B. Haas, F. da Silveira, K. R. Mohr, A. P. S. Bertoni, M. S. Soares, J. H. Azambuja, M. Dal Pra, L. L. P. da Cruz, N. E. Gelsleichter, K. Begnini, G. Hasko, M. R. Wink, R. M. Spanevello, E. Braganhol
Summary: Sepsis is a life-threatening organ dysfunction caused by a dysregulated inflammatory response to infection. Purinergic signaling, mediated by purines such as ATP and adenosine, plays a crucial role in the immune and inflammatory responses during sepsis. Sepsis disrupts the balance of ATP and adenosine levels, leading to dysregulation of immune responses. The measurement of serum levels and activities of purinergic pathway markers may serve as potential biomarkers for sepsis diagnosis and treatment.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Tassya Cataldi Cardoso, Marianna Araujo Rocha, Matheus M. L. Monteiro, Vinicius Santos Alves, Luiz Eduardo Baggio Savio, Claudia Lucia Martins Silva
Summary: The signaling of endothelial P2Y(2) receptor contributes to the adhesion of metastatic prostate cancer cells, suggesting a potential mechanism to reduce prostate cancer metastasis through the blockade of downstream signaling.