期刊
MONATSHEFTE FUR CHEMIE
卷 147, 期 3, 页码 599-604出版社
SPRINGER WIEN
DOI: 10.1007/s00706-016-1684-z
关键词
Ellipticine; Celiptium; Nocadazole; Antiproliferative activity
资金
- Department of Science & Technology, India [SB/FT/CS-141/2013]
A series of ten novel benzimidazole fused ellipticine derivatives have been synthesized and these compounds were evaluated for their antiproliferative activity against four human cancer cell lines (Zr-75-1, MCF-7, HeLa, and A-549). It is observed that all the synthesized compounds showed significant antiproliferative activity with GI(50) values ranging from <0.1 to 34.6 mu M, while the positive control, etoposide demonstrated the GI(50) in the range of 0.2-3.08 mu M, respectively. Some of the compounds were distinctly more potent than etoposide, with GI(50) concentrations in the submicromolar level on certain cell lines. [GRAPHICS] .
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