Review
Oncology
Chu Xiao, Tao Fan, He Tian, Yujia Zheng, Zheng Zhou, Shuofeng Li, Chunxiang Li, Jie He
Summary: Histone H3 lysine 36 trimethylation (H3K36me3) plays a crucial role in genome regulation, especially in cancer pathogenesis. Disruption of the histone methylation regulatory network and mutations in H3K36me3 codes may have a powerful impact on cancer initiation and development. Understanding the role of H3K36me3 in cancer can lead to targeted therapeutic strategies for cancer treatment.
CLINICAL EPIGENETICS
(2021)
Article
Oncology
Eleni Fitsiou, Abel Soto-Gamez, Marco Demaria
Summary: Therapy-induced cellular senescence is a stable growth arrest state caused by common cancer treatments such as chemotherapy and radiation. Its consequences in an oncogenic context can vary, acting as both a tumor suppressive mechanism and a tumor promoting factor due to differential expression and secretion of specific cytokines and factors.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Medicine, Research & Experimental
Ye Lin, Hong Cai
Summary: The incidence of cancer is increasing globally, and novel cancer diagnostic and prognostic biomarkers are important for developing treatment strategies. SHCBP1 is a protein that plays various roles in cancer biology and is abnormally expressed in tumors. Its expression level is related to clinicopathological characteristics and it is a promising biomarker for diagnosis and prognosis. This article reviews the expression, functions, mechanisms, and clinical significance of SHCBP1 in human tumors, providing a theoretical basis for cancer research.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Hongbo Wang, Qinghai Meng, Jinjun Qian, Muxi Li, Chunyan Gu, Ye Yang
Summary: This review provides an overview of different types of RNAs in cancer diagnostics and treatment, discussing their unique characteristics and potential applications. It highlights the increasing use of mRNAs, lncRNAs, circRNAs, and miRNAs as diagnostic markers or therapeutic targets in various cancers. The review also explores the mechanisms by which these RNAs regulate and participate in cancer development, as well as their potential in cancer prediction and treatment.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Oncology
Daisuke Takakura, Shoko Ohashi, Noritoshi Kobayashi, Motohiko Tokuhisa, Yasushi Ichikawa, Nana Kawasaki
Summary: Aberrant glycosylation, a prominent feature of cancer, can be targeted to improve cancer biomarkers and assess metastasis risks. Researchers developed a targeted O-glycoproteomics method using serum specimens and identified 44 O-glycoforms associated with advanced colorectal cancer. These glycoforms could serve as promising markers for the detection of advanced CRC.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Xiaoqi Yang, Tao Ye, Haoran Liu, Peng Lv, Chen Duan, Xiaoliang Wu, Kehua Jiang, Hongyan Lu, Ding Xia, Ejun Peng, Zhiqiang Chen, Kun Tang, Zhangqun Ye
Summary: circRNAs play crucial regulatory roles in BCa by modulating various biological behaviors through miRNA sponging mechanisms. The expression levels of circRNAs are significantly associated with clinicopathologic characteristics and can be used to predict patient survival parameters. Due to their abundance, conservation, stability, specificity, and detectability, circRNAs are considered potential diagnostic and prognostic biomarkers for BCa.
Review
Medicine, General & Internal
Giuseppe Privitera, Daniela Pugliese, Gian Ludovico Rapaccini, Antonio Gasbarrini, Alessandro Armuzzi, Luisa Guidi
Summary: Inflammatory bowel diseases are chronic conditions that affect the gastrointestinal tract, with a significant clinical heterogeneity. Despite an expanding pipeline of therapies, there is currently no ideal marker to predict patient response, but multiparametric models show promise in this regard.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Iwan Iwanov, Arianna Rossi, Monica Montesi, Irini Doytchinova, Armen Sargsyan, Georgi Momekov, Silvia Panseri, Emilia Naydenova
Summary: A series of lysine-based oligopeptides with expected Abl inhibitory activity were designed, synthesized, purified, and biologically tested in vitro in various cancer cell lines, showing promising antitumor effects.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Oncology
Guida Fang, Dalai Xu, Tao Zhang, Gang Wang, Lei Qiu, Xuzhu Gao, Yongchang Miao
Summary: Colorectal cancer (CRC) is a major cause of cancer-related death worldwide, lacking effective biomarkers for diagnosis and prognosis as well as therapeutic targets, resulting in low patient survival rates. Circular RNA (circRNA), an endogenous non-coding RNA (ncRNA) with a closed-loop structure, plays a crucial role in physiological processes and pathological diseases. Recent studies suggest that circRNAs are involved in the diagnosis, prognosis, drug resistance, and development of tumors, particularly in CRC. Therefore, circRNA could potentially be a novel target for improving CRC diagnosis, prognosis, and treatment.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Zhi-Qiang Wang, Zhao-Cong Zhang, Yu-Yang Wu, Ya-Nan Pi, Sheng-Han Lou, Tian-Bo Liu, Ge Lou, Chang Yang
Summary: BET proteins, as epigenetic interpreters, play a role in cancer development, and BET inhibitors offer a novel form of epigenetic anticancer treatment. However, the effectiveness of BET inhibitors as monotherapy is limited, and their use in combination with other drugs, considering the variations in pharmacodynamic activity, deserves attention.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Medicine, General & Internal
AnnaLynn M. Williams, Jeanne S. Mandelblatt, Mingjuan Wang, Qian Dong, Gregory T. Armstrong, Nickhill Bhakta, Tara M. Brinkman, Matthew J. Ehrhardt, Daniel A. Mulrooney, Nikesha Gilmore, Leslie L. Robison, Yutaka Yasui, Brent J. Small, Deokumar Srivastava, Melissa M. Hudson, Kirsten K. Ness, Kevin R. Krull, Zhaoming Wang
Summary: This study found an association between deficit accumulation index (DAI) and epigenetic age acceleration (EAA) among survivors of childhood cancer, suggesting that deficit accumulation represents underlying biological aging. These findings are important for measuring aging and assessing the response to interventions targeting aging pathways.
Review
Immunology
Na Liu, Mengfang Liu, Shengqiao Fu, Jinglei Wang, Haowen Tang, Adamu Danbala Isah, Deyu Chen, Xu Wang
Summary: This article introduces the role of Ang2 in different cancers and pathological conditions, as well as the inhibitory effect of blocking Ang2 on cancer cell growth and metastasis. The mechanisms regulating Ang2 expression, the importance of Ang2 in cancer growth, metastasis, and prognosis, and the research and challenges of combining Ang2 inhibition with chemotherapy, immunotherapy, and radiotherapy to enhance treatment efficacy are also discussed.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Medicinal
Juntao Wang, Dan Lu, Ran Sun, Shuwen Lei, Shuhua Luo, Xin Dang, Yang Zhang, Chang Yuan, Yong Zhang, Jinhong Wu, Guangyu Yang, Lei Fu, Faqin Jiang
Summary: GM3 derivatives show promise as potential therapeutic agents for cancer, with N-12 demonstrating excellent inhibitory effects on cell migration, invasion, and tumor growth, possibly through immune response induction.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Jun Wei, Yimin Wang, Bo Xie, Jiachi Ma, Yaguo Wang
Summary: The study investigated the role of HER2/cortactin co-overexpression in advanced gastric cancer, showing their association with patient survival and acting as independent prognostic factors. The results suggest that HER2/cortactin co-overexpression could serve as an important predictive biomarker for gastric cancer patients and may lead to improved survival prognosis with dual-targeted therapy in the future.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Wei Han, Liang Chen
Summary: PRR11 plays a critical role in cellular processes such as proliferation, migration, and apoptosis in various solid tumors through multiple signaling pathways and biological molecules. It also shows potential as a prognostic indicator and target therapy application in certain cancers.
Review
Biochemistry & Molecular Biology
Xin Zhang, Tian Yuan, Xuhui Chen, Xuebo Liu, Jun Hu, Zhigang Liu
Summary: The prevalence of Alzheimer's disease is increasing due to aging population, and ApoE4 allele is identified as the primary genetic risk factor. However, emerging research suggests that dietary factors, such as DHA, can modify the risk of AD. The interplay between DHA and ApoE genotype within the brain needs further investigation. Early DHA supplementation may benefit cognitively normal older adults carrying the ApoE4 gene, while its effectiveness for AD patients is limited.
PROGRESS IN LIPID RESEARCH
(2024)
Review
Biochemistry & Molecular Biology
Chen Wu, Haiqin Chen, Yongchao Mei, Bo Yang, Jianxin Zhao, Catherine Stanton, Wei Chen
Summary: This review summarizes the recent advances in microbial conjugated linoleic acid (CLA) production, including the mechanisms of linoleic acid conversion to CLA, factors influencing CLA production and isomer composition, and strategies for enhancing CLA content and nutritional value in fermented products using microorganisms. The review aims to serve as a reference for microbial CLA production and expand the understanding of the potential probiotic role of microbial CLA producers.
PROGRESS IN LIPID RESEARCH
(2024)
