Review
Biochemistry & Molecular Biology
Na Wang, Jing-Yi Li, Bo Zeng, Gui-Lan Chen
Summary: Sphingosine-1-phosphate (S1P) is a crucial sphingolipid molecule that regulates cardiovascular functions through binding and activating multiple G protein-coupled receptors in different cell types. It affects cell proliferation, migration, differentiation, and apoptosis through various downstream signaling pathways. Abnormal S1P levels are associated with cardiovascular disorders, and further research is needed to explore the potential therapeutic use of S1P in these diseases.
Review
Cell Biology
Kana Masuda-Kuroki, Shahrzad Alimohammadi, Anna Di Nardo
Summary: Psoriasis is a chronic skin condition that lacks a complete cure. Recent studies have identified sphingolipid metabolites as significant contributors to psoriasis, particularly ceramide and sphingosine-1-phosphate (S1P). The modulation of S1P and its receptor has shown potential in improving psoriasis inflammation.
Article
Biochemistry & Molecular Biology
Federica Pierucci, Antony Chirco, Elisabetta Meacci
Summary: Irisin is a hormone-like myokine that is produced in skeletal muscle in response to exercise. Sphingosine-1-phosphate (S1P), a bioactive lipid, plays a crucial role in the formation and release of irisin. It also has autocrine and paracrine effects on myoblast proliferation and differentiation. These findings suggest that the S1P/S1PR axis could be a potential therapeutic target for muscle dysfunctions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biology
Kana Masuda-Kuroki, Anna Di Nardo
Summary: Sphingosine 1-phosphate (S1P) and its receptors play important roles in the skin barrier interface, affecting cell differentiation, proliferation, immune responses, and mast cell immune response. They are also associated with various skin diseases.
Article
Obstetrics & Gynecology
Caterina Bernacchioni, Pasquapina Ciarmela, Valentina Vannuzzi, Stefania Greco, Silvia Vannuccini, Francesca Malentacchi, Pamela Pellegrino, Tommaso Capezzuoli, Flavia Sorbi, Francesca Cencetti, Paola Bruni, Chiara Donati, Felice Petraglia
Summary: The study revealed that S1P signaling is dysregulated in uterine fibroids and involved in activin A-induced fibrosis, presenting new perspectives for the treatment of uterine fibroids.
FERTILITY AND STERILITY
(2021)
Article
Cell Biology
Alhaji H. Janneh, Mohamed Faisal Kassir, F. Cansu Atilgan, Han Gyul Lee, Megan Sheridan, Natalia Oleinik, Zdzislaw Szulc, Christina Voelkel-Johnson, Hung Nguyen, Hong Li, Yuri K. Peterson, Elisabetta Marangoni, Ozge Saatci, Ozgur Sahin, Michael Lilly, Carl Atkinson, Stephen Tomlinson, Shikhar Mehrotra, Besim Ogretmen
Summary: This study reveals how oncogenic sphingosine 1-phosphate (S1P) metabolism activates C3 complement and induces NLRP3/inflammasome activation, enhancing cell migration/metastasis. Furthermore, activation of the S1PR1/C3/PPIL1/NLRP3 signaling axis is associated with metastatic melanoma, and targeting this axis can prevent lung colonization/metastasis.
Review
Biochemistry & Molecular Biology
Catherine Olesch, Bernhard Bruene, Andreas Weigert
Summary: The sphingolipid sphingosine-1-phosphate (S1P) plays a crucial role in tumor development by promoting proliferation, survival, and migration of cancer cells. It also regulates tumor angiogenesis and modulates the tumor microenvironment. However, its effects on tumor-associated immune system are complex and can range from suppressing autoimmune reactions to promoting pro-tumor activation of immune cells. This review provides an overview of the current literature on the role of S1P in tumor-associated immunity and discusses strategies for targeting S1P in anti-tumor therapy without causing immune paralysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ling-Wei Hii, Felicia Fei-Lei Chung, Chun-Wai Mai, Pei Yuen Ng, Chee-Onn Leong
Summary: SPHK1 is a conserved lipid enzyme that catalyzes the formation of S1P, and has been implicated in oncogenic functions, particularly in breast cancer. Recent evidence suggests a role for SPHK1 in regulating CSCs, indicating the therapeutic potential of targeting SPHK1 in refractory cancers enriched with CSCs.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Joanna A. Motyl, Joanna B. Strosznajder, Agnieszka Wencel, Robert P. Strosznajder
Summary: Molecular studies suggest that Parkinson's disease is a protein conformational disease involving the spread of alpha-synuclein pathology along the neuraxis. Pathogenic forms of alpha-synuclein induce oxidative stress, neuroinflammation, and protein alterations in neighboring cells, leading to increased toxicity and neurodegeneration. Maintaining homeostasis between bioactive sphingolipids is crucial in cell defense against oxidative stress, with a focus on sphingosine kinases and sphingosine-1-phosphate signaling as potential pharmacological targets for neurological diseases like PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Urology & Nephrology
Yelena Drexler, Judith Molina, Alla Mitrofanova, Alessia Fornoni, Sandra Merscher
Summary: Recent studies have shown that sphingolipids and sphingolipid metabolites play important roles in the pathogenesis and progression of kidney diseases by influencing the intracellular sphingolipid composition of renal cells and the integrity of the glomerular filtration barrier. The sphingolipid metabolite S1P plays a crucial role in renal cells, and aberrant S1P signaling contributes to the pathogenesis and progression of kidney diseases.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rachel S. Resop, Bradley Salvatore, Shawn J. Kim, Brent R. Gordon, Bianca Blom, Dimitrios N. Vatakis, Christel H. Uittenbogaart
Summary: HIV-1 infection leads to upregulation of S1P receptor 1 (S1PR1) in the human thymus, potentially increasing the number and speed of thymocyte egress. This may have implications for immune function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Ezzat Hashemi, Ezra Yoseph, Hsing-Chuan Tsai, Monica Moreno, Li-Hao Yeh, Shalin B. Mehta, Mari Kono, Richard Proia, May H. Han
Summary: Multiple sclerosis (MS) is an inflammatory-demyelinating disease of the central nervous system (CNS) mediated by aberrant auto-reactive immune responses. The study reveals the important role of sphingosine-1-phosphate (S1P) signaling, specifically S1P(1) signaling, in remyelination process. The findings suggest that targeting S1P(1) signaling pathway may be a potential therapeutic strategy for MS.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Medicine, Research & Experimental
Maria Concepcion Izquierdo, Niroshan Shanmugarajah, Samuel X. Lee, Michael J. Kraakman, Marit Westerterp, Takumi Kitamoto, Michael Harris, Joshua R. Cook, Galina A. Gusarova, Kendra Zhong, Elijah Marbuary, Insug O-Sullivan, Nikolaus Rasmus, Stefania Camastra, Terry G. Unterman, Ele Ferrannini, Barry E. Hurwitz, Rebecca A. Haeusler
Summary: This study found that insulin resistance is associated with decreased HDL-associated S1P. Hepatic FoxO transcription factors are regulators of the ApoM/S1P pathway.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Biochemistry & Molecular Biology
Yuechun Zhao, Yuheng Zhang, Jiaqi Li, Ningxin Zhang, Qiubai Jin, Yuxia Qi, Ping Song
Summary: Sphingosine-1-phosphate (S1P) is a sphingolipid mediator that plays a role in various biological functions and has been found to be higher in patients with psoriasis compared to healthy individuals. The S1P-S1PR signaling system is involved in inhibiting keratinocyte proliferation, regulating lymphocyte migration, and promoting angiogenesis, which contributes to the development of psoriasis. S1P may serve as a potential target for future psoriasis treatment.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Medicine, Research & Experimental
Xuefeng Xu, Yi Han, Tianxin Zhu, Faxin Fan, Xin Wang, Yuqing Liu, Duosheng Luo
Summary: Osteoporosis is a common disease worldwide with significant economic burden. Understanding the role of SphK/S1P/S1PR signaling in regulating osteoblasts and osteoclasts is crucial for the treatment of osteoporosis. This review summarizes the effects of S1P on proliferation, differentiation, apoptosis, and functions, and focuses on S1P-based therapeutic approaches in bone metabolism.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Ariraman Subastri, Viswanathan Arun, Preeti Sharma, Ezhuthupurakkal Preedia Babu, Arumugam Suyavaran, Subramaniyam Nithyananthan, Ghedeir M. Alshammari, Balakrishnan Aristatile, Venkataraman Dharuman, Chinnasamy Thirunavukkarasu
CHEMICO-BIOLOGICAL INTERACTIONS
(2018)
Review
Biochemistry & Molecular Biology
Xin Zhang, Tian Yuan, Xuhui Chen, Xuebo Liu, Jun Hu, Zhigang Liu
Summary: The prevalence of Alzheimer's disease is increasing due to aging population, and ApoE4 allele is identified as the primary genetic risk factor. However, emerging research suggests that dietary factors, such as DHA, can modify the risk of AD. The interplay between DHA and ApoE genotype within the brain needs further investigation. Early DHA supplementation may benefit cognitively normal older adults carrying the ApoE4 gene, while its effectiveness for AD patients is limited.
PROGRESS IN LIPID RESEARCH
(2024)
Review
Biochemistry & Molecular Biology
Chen Wu, Haiqin Chen, Yongchao Mei, Bo Yang, Jianxin Zhao, Catherine Stanton, Wei Chen
Summary: This review summarizes the recent advances in microbial conjugated linoleic acid (CLA) production, including the mechanisms of linoleic acid conversion to CLA, factors influencing CLA production and isomer composition, and strategies for enhancing CLA content and nutritional value in fermented products using microorganisms. The review aims to serve as a reference for microbial CLA production and expand the understanding of the potential probiotic role of microbial CLA producers.
PROGRESS IN LIPID RESEARCH
(2024)
