Article
Nutrition & Dietetics
Grace Austin, Jessica J. A. Ferguson, Rohith N. Thota, Harjinder Singh, Tracy Burrows, Manohar L. Garg
Summary: The study showed that LCn-3PUFA with or without MCSFA, but not MCSFA alone, are effective in reducing postprandial triglycerides in healthy individuals.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Alfonso M. Duran, W. Lawrence Beeson, Anthony Firek, Zaida Cordero-MacIntyre, Marino De Leon
Summary: This study aims to identify the cellular pathways stimulated by dietary omega-3 polyunsaturated fatty acid (PUFA) supplementation in patients with type 2 diabetes mellitus (T2DM) affected by painful diabetic neuropathy (pDN). The results show that supplementation leads to a shift towards an anti-inflammatory state and improved membrane fluidity, which may be responsible for the reduction in adverse symptoms associated with neuroinflammatory diseases and painful neuropathy.
Article
Chemistry, Applied
Jose A. Perez, Almudena Castro, Carla Rolo, Alexandr Torres, Roberto Dorta-Guerra, Nieves G. Acosta, Covadonga Rodriguez
Summary: Western societies have unhealthy high dietary omega-6/omega-3 fatty acid ratios, with seafood being the main source of omega-3 long chain polyunsaturated fatty acids. However, aquafeed formulations based on marine ingredients have serious environmental impacts. This study found that chicken can accumulate arachidonic acid despite its low dietary supply, and chicken hepatocytes are capable of metabolizing C18 precursors to produce LC-PUFA.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2021)
Article
Obstetrics & Gynecology
J. Stanhiser, A. M. Z. Jukic, D. R. McConnaughey, A. Z. Steiner
Summary: The study found that self-reported use of omega-3 fatty acid supplements was associated with an increased probability of conceiving.
HUMAN REPRODUCTION
(2022)
Review
Nutrition & Dietetics
Alice Cartoni Mancinelli, Simona Mattioli, Cornelia Twining, Alessandro Dal Bosco, Ann M. Donoghue, Komala Arsi, Elisa Angelucci, Diletta Chiattelli, Cesare Castellini
Summary: This study provides an overview of the main strategies for enriching and preserving n-3 LC-PUFA in poultry products, which include dietary supplementation and improving rearing conditions. Additionally, factors such as genotype, rearing system, transport, and cooking processes can impact the content of this fatty acid in poultry products.
Article
Geriatrics & Gerontology
R. Erhardt, B. R. Cardoso, B. J. Meyer, S. Brownell, S. O'Connell, S. Mirzaee, R. L. Duckham, H. Macpherson
Summary: This study examined the relationship between circulating omega-3 LCPUFA levels and dietary intake of DHA and EPA with cognition and physical function in community-dwelling older adults at risk of dementia. Results showed that higher dietary intake of DHA and EPA were associated with better cognitive function, while higher dietary EPA intake was linked to better attention and mobility. No associations were found between erythrocyte omega-3 LCPUFA levels and cognitive or functional performance measures in this cohort.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Nutrition & Dietetics
Lara T. Meital, Karl Schulze, Rebecca Magee, Jill O'Donnell, Pankaj Jha, Chaim Y. Meital, Rebecca Donkin, Tom G. Bailey, Christopher D. Askew, Fraser D. Russell
Summary: Abdominal aortic aneurysm (AAA) is a vascular disease involving permanent focal dilation of the abdominal aorta that can lead to catastrophic rupture. Supplementation with long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs) may decrease aortic stiffness in patients with AAA, but the clinical implications are yet to be fully elucidated.
Article
Geriatrics & Gerontology
Roxana Coras, Brian Pedersen, Rekha Narasimhan, Anahy Brandy, Lourdes Mateo, Agueda Prior-Espanol, Arthur Kavanaugh, Aaron M. Armando, Mohit Jain, Oswald Quehenberger, Melania Martinez-Morillo, Monica Guma
Summary: The study revealed that arthritis symptoms in older adults were related to disturbances in serum oxylipins, suggesting that certain oxylipins may be key effectors in arthritis in this population.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Review
Nutrition & Dietetics
Maria Elena Capra, Brigida Stanyevic, Antonella Giudice, Delia Monopoli, Nicola Mattia Decarolis, Susanna Esposito, Giacomo Biasucci
Summary: Long-chain polyunsaturated fatty acids (LCPUFAs) have been extensively studied in adults for their positive effects on heart health, especially in secondary prevention after a cardiac event. LCPUFAs can be safely consumed either through food or as supplements without adverse effects. Their effects on global health have also been recognized in pediatric patients, but their cardiovascular effects in childhood are still not well-studied. Nutritional and lifestyle interventions, including the consumption of specific nutrients such as LCPUFAs, can play a role in cardiovascular risk prevention in developmental age, particularly in conditions like weight excess and dyslipidemia.
Article
Nutrition & Dietetics
Kathleen A. Lee-Sarwar, Kasper Fischer-Rasmussen, Klaus Bonnelykke, Hans Bisgaard, Bo Chawes, Rachel S. Kelly, Jessica Lasky-Su, Robert S. Zeiger, George T. O'Connor, Leonard B. Bacharier, Vincent J. Carey, Nancy Laranjo, Augusto A. Litonjua, Scott T. Weiss
Summary: The association between omega-3 fatty acids (n-3) and allergic diseases varies due to genetic variation. This study aimed to identify and validate genetic variants that modify the relationship between n-3 and childhood asthma or atopy. Results showed that certain SNPs in the DPP10 region interacted with n-3 levels in plasma or diet and were associated with atopy in early childhood and at age 6.
Article
Obstetrics & Gynecology
Laura Goodfellow, Angharad Care, Jane Harrold, Andrew Sharp, Jelena Ivandic, Borna Poljak, Devender Roberts, Ana Alfirevic, Bertram Muller-Myhsok, Robert Gibson, Maria Makrides, Zarko Alfirevic
Summary: The majority of participants in the study had low levels of long-chain omega-3, within the range that may benefit from supplementation, but these levels showed no association with the risk of recurrent early spontaneous preterm birth. Omega-3 levels may be of lesser importance in recurrent early preterm birth.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Review
Biochemistry & Molecular Biology
Roberta Cardim Lessa, Fabio de Abreu Alves, Erika Fortunati, Jun Lu
Summary: Oral mucositis (OM) is a painful condition caused by cancer treatments, impacting patients' quality of life and recovery. Current management strategies are insufficient, necessitating a search for new approaches. Utilizing ω-3 fatty acids to manage OM may be an effective strategy based on preliminary evidence.
Article
Agricultural Engineering
Anil Kumar Patel, Ajeet Singh Chauhan, Prashant Kumar, Philippe Michaud, Vijai Kumar Gupta, Jo-Shu Chang, Chiu-Wen Chen, Cheng-Di Dong, Reeta Rani Singhania
Summary: This article provides an update on the production of essential fatty acids from potential microbes and explores novel strategies to promote the accumulation of omega-3 and omega-6 through engineering and omics approaches.
BIORESOURCE TECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Xuefei Li, Zhengjie Lu, Yongjian Qi, Biao Chen, Bin Li
Summary: This study used the Mendelian randomization approach to explore the potential causal relationships between polyunsaturated fatty acids (PUFAs) and osteoarthritis (OA), and found that higher levels of omega-6 fatty acids may reduce the risk of knee OA and hip OA. These results highlight the importance of maintaining optimal levels of PUFAs, especially omega-6 fatty acids, in individuals with a genetic predisposition to OA.
Letter
Nutrition & Dietetics
Harry B. Rice, Gerard Bannenberg
Summary: In summary, this letter offers additional perspective on four statements that do not fully represent the totality of available scientific evidence. It urges authors to consider the totality of scientific evidence in their future publications.
Review
Biochemistry & Molecular Biology
Xin Zhang, Tian Yuan, Xuhui Chen, Xuebo Liu, Jun Hu, Zhigang Liu
Summary: The prevalence of Alzheimer's disease is increasing due to aging population, and ApoE4 allele is identified as the primary genetic risk factor. However, emerging research suggests that dietary factors, such as DHA, can modify the risk of AD. The interplay between DHA and ApoE genotype within the brain needs further investigation. Early DHA supplementation may benefit cognitively normal older adults carrying the ApoE4 gene, while its effectiveness for AD patients is limited.
PROGRESS IN LIPID RESEARCH
(2024)
Review
Biochemistry & Molecular Biology
Chen Wu, Haiqin Chen, Yongchao Mei, Bo Yang, Jianxin Zhao, Catherine Stanton, Wei Chen
Summary: This review summarizes the recent advances in microbial conjugated linoleic acid (CLA) production, including the mechanisms of linoleic acid conversion to CLA, factors influencing CLA production and isomer composition, and strategies for enhancing CLA content and nutritional value in fermented products using microorganisms. The review aims to serve as a reference for microbial CLA production and expand the understanding of the potential probiotic role of microbial CLA producers.
PROGRESS IN LIPID RESEARCH
(2024)
