Controlling donor and newborn neuron migration and maturation in the eye through microenvironment engineering

Monocyte-derived SDF1 supports optic nerve regeneration and alters retinal ganglion cells’ response to Pten deletion

(2022) Lili Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping the immune environment in clear cell renal carcinoma by single-cell genomics

(2021) Nicholas Borcherding et al.   Communications Biology

Transplantation of miPSC/mESC-derived Retinal Ganglion Cells into healthy and glaucomatous retinas

(2021) Julia Oswald et al.   Molecular Therapy-Methods & Clinical Development

Efficient stimulation of retinal regeneration from Müller glia in adult mice using combinations of proneural bHLH transcription factors

(2021) Levi Todd et al.   Cell Reports

CRISPR Generated SIX6 and POU4F2 Reporters Allow Identification of Brain and Optic Transcriptional Differences in Human PSC-Derived Organoids

(2021) Karl J. Wahlin et al.   Frontiers in Cell and Developmental Biology

Interaction between SDF1 and CXCR4 Promotes Photoreceptor Differentiation via Upregulation of NFκB Pathway Signaling Activity in Pax6 Gene-Transfected Photoreceptor Precursors

(2020) Jun Shimizu et al.   OPHTHALMIC RESEARCH

Single-Cell Transcriptomic Comparison of Human Fetal Retina, hPSC-Derived Retinal Organoids, and Long-Term Retinal Cultures

(2020) Akshayalakshmi Sridhar et al.   Cell Reports

Convolutional Neural Networks Can Predict Retinal Differentiation in Retinal Organoids

(2020) Evgenii Kegeles et al.   Frontiers in Cellular Neuroscience

Semi-Automated Approach for Retinal Tissue Differentiation

(2020) Evgenii Kegeles et al.   Translational Vision Science & Technology

Role of the Internal Limiting Membrane in Structural Engraftment and Topographic Spacing of Transplanted Human Stem Cell-Derived Retinal Ganglion Cells

(2020) Kevin Y. Zhang et al.   Stem Cell Reports

Neuronal migration in the CNS during development and disease: insights from in vivo and in vitro models

(2019) Isabel Yasmin Buchsbaum et al.   DEVELOPMENT

Optimizing the Conditions and Use of Synthetic Matrix for Three-Dimensional In Vitro Retinal Differentiation from Mouse Pluripotent Cells

(2019) Tatiana Perepelkina et al.   TISSUE ENGINEERING PART C-METHODS

Neuroprotection in Glaucoma: Towards Clinical Trials and Precision Medicine

(2019) Tasneem Z. Khatib et al.   CURRENT EYE RESEARCH

Awakening the regenerative potential of the mammalian retina

(2019) James F. Martin et al.   DEVELOPMENT

Retinogenesis of the Human Fetal Retina: An Apical Polarity Perspective

(2019) Peter M.J. Quinn et al.   Genes

Single-Cell Profiles of Retinal Ganglion Cells Differing in Resilience to Injury Reveal Neuroprotective Genes

(2019) Nicholas M. Tran et al.   NEURON

Neuronal Migration and Lamination in the Vertebrate Retina

(2018) Rana Amini et al.   Frontiers in Neuroscience

The Activation and Signaling Mechanisms of GPR56/ADGRG1 in Melanoma Cell

(2018) Kuan-Yeh Huang et al.   Frontiers in Oncology

Temporal expression of CD184(CXCR4) and CD171(L1CAM) identifies distinct early developmental stages of human retinal ganglion cells in embryonic stem cell derived retina

(2017) J.G. Aparicio et al.   EXPERIMENTAL EYE RESEARCH

Reaching the brain: Advances in optic nerve regeneration

(2017) Larry I. Benowitz et al.   EXPERIMENTAL NEUROLOGY

Enhanced Stem Cell Differentiation and Immunopurification of Genome Engineered Human Retinal Ganglion Cells

(2017) Valentin M. Sluch et al.   Stem Cells Translational Medicine

Neuroprotective Mechanisms Mediated by CDK5 Inhibition

(2016) Gohar Mushtaq et al.   CURRENT PHARMACEUTICAL DESIGN

The expanding clinical phenotype of Bosch-Boonstra-Schaaf optic atrophy syndrome: 20 new cases and possible genotype–phenotype correlations

(2016) Chun-An Chen et al.   GENETICS IN MEDICINE

Radial migration: Retinal neurons hold on for the ride

(2016) Jeremy N. Kay   JOURNAL OF CELL BIOLOGY

Independent modes of ganglion cell translocation ensure correct lamination of the zebrafish retina

(2016) Jaroslav Icha et al.   JOURNAL OF CELL BIOLOGY

Transplanted neurons integrate into adult retinas and respond to light

(2016) Praseeda Venugopalan et al.   Nature Communications

Arp2/3 complex inhibition radically alters lamellipodial actin architecture, suspended cell shape, and the cell spreading process

(2015) John H. Henson et al.   MOLECULAR BIOLOGY OF THE CELL

Spatial reconstruction of single-cell gene expression data

(2015) Rahul Satija et al.   NATURE BIOTECHNOLOGY

Retinal Damage Induced by Internal Limiting Membrane Removal

(2015) Rachel Gelman et al.   Journal of Ophthalmology

Cellular dynamics of neuronal migration in the hippocampus

(2015) Kanehiro Hayashi et al.   Frontiers in Neuroscience

Cas Adaptor Proteins Organize the Retinal Ganglion Cell Layer Downstream of Integrin Signaling

(2014) Martin M. Riccomagno et al.   NEURON

Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040

(2014) Yih-Chung Tham et al.   OPHTHALMOLOGY

Functional architecture of the retina: Development and disease

(2014) Mrinalini Hoon et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Integrative Mechanisms of Oriented Neuronal Migration in the Developing Brain

(2013) Irina Evsyukova et al.   Annual Review of Cell and Developmental Biology

Survival and Integration of Developing and Progenitor-Derived Retinal Ganglion Cells following Transplantation

(2013) Jonathan Hertz et al.   CELL TRANSPLANTATION

Small Molecules CK-666 and CK-869 Inhibit Actin-Related Protein 2/3 Complex by Blocking an Activating Conformational Change

(2013) Byron Hetrick et al.   CHEMISTRY & BIOLOGY

CXCL12/SDF-1 facilitates optic nerve regeneration

(2013) Annemarie Heskamp et al.   NEUROBIOLOGY OF DISEASE

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

Mouse embryonic stem cell culture for generation of three-dimensional retinal and cortical tissues

(2011) Mototsugu Eiraku et al.   Nature Protocols

Stromal Cell-Derived Factor-1 Is Essential for Photoreceptor Cell Protection in Retinal Detachment

(2010) Hiroki Otsuka et al.   AMERICAN JOURNAL OF PATHOLOGY

Adult SVZ Lineage Cells Home to and Leave the Vascular Niche via Differential Responses to SDF1/CXCR4 Signaling

(2010) Erzsebet Kokovay et al.   Cell Stem Cell

Delayed Treatment with Systemic (S)-Roscovitine Provides Neuroprotection and Inhibits In Vivo CDK5 Activity Increase in Animal Stroke Models

(2010) Bénédicte Menn et al.   PLoS One

SDF1/CXCR4 signalling regulates two distinct processes of precerebellar neuronal migration and its depletion leads to abnormal pontine nuclei formation

(2009) Y. Zhu et al.   DEVELOPMENT

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE

Retinal Ganglion Cells Downregulate Gene Expression and Lose Their Axons within the Optic Nerve Head in a Mouse Glaucoma Model

(2008) I. Soto et al.   JOURNAL OF NEUROSCIENCE