Article
Engineering, Chemical
Chunying Li, Fang Nie, Changyin Feng, Mengfei Tian, Meiting Yu, Chunjian Zhao, Yujie Fu
Summary: A dual-template molecularly imprinted polymer with good magnetic properties and specific recognition of echinacoside and acteoside was prepared by surface imprinting. The polymer showed desirable adsorption capacity and satisfactory reuse for echinacoside and acteoside.
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2022)
Article
Biotechnology & Applied Microbiology
Lei Hou, Guanghui Li, Qingliang Chen, JinJin Zhao, Jiaowen Pan, Ruxia Lin, Xiujin Zhu, Pengfei Wang, Xingjun Wang
Summary: This study conducted full-length transcriptome sequencing and gene expression profiling of C. tubulosa, revealing key genes involved in PhGs biosynthesis and proposing a potential model for PhGs biosynthesis in C. tubulosa.
Article
Biochemistry & Molecular Biology
Yuhao Ding, Yuan Zhang, Zhonghao Wang, Fanle Zeng, Qianzhen Zhen, Huizi Zhao, Jun Li, Taotao Ma, Cheng Huang
Summary: This study aimed to evaluate the effect of echinacoside (ECH) on ALD. The results showed that ECH alleviated ethanol-induced liver injuries by increasing the activity of Nrf2, reducing oxidative stress and cell apoptosis, indicating the potential of ECH for ALD treatment.
Article
Chemistry, Medicinal
Wei-Lin Xiong, Yu Sun, Tian-Cheng Ma, Xiao-Ying Zhang, Jin-Yu Wang, Yi-Yang Du, Bo Wu, Ting-Xu Yan, Ying Jia
Summary: A pair of differential epimers with opposite C-7 configurations and their unique glycoside structures were isolated and identified from the succulent stem of Cistanche tubulosa. The inhibitory effects of these compounds on lipopolysaccharide-induced nitric oxide production in mouse microglial cells were tested.
Article
Medicine, Research & Experimental
Shilei Zhang, Fukai Gong, Jiali Liu, Tao Liu, Jianhua Yang, Junping Hu
Summary: This study found that ACT can promote mitophagy by inhibiting PHD2, thereby improving CRF and demonstrating potential clinical applications.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Shilei Zhang, Fukai Gong, Jiali Liu, Tao Liu, Jianhua Yang, Junping Hu
Summary: ACT improves muscle fatigue by promoting mitophagy through suppression of PHD2, showing promising clinical application prospects.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Physical
Helin Xu, Xueqin Li, Yanyan Hao, Xiaobin Zhao, Yun Cheng, Jinli Zhang
Summary: In this study, efficient separation of acteoside from crude extracts of Cistanche tubulosa was achieved using an ionic liquid-based aqueous two-phase system. The combination of [C4mim]BF4 and (NH4)2SO4 showed excellent extraction performance for acteoside, providing valuable insights for future applications.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Multidisciplinary
Fang Nie, Changyin Feng, Naveed Ahmad, Mengfei Tian, Qinglong Liu, Weihao Wang, Ziqi Lin, Chunying Li, Chunjian Zhao
Summary: In this study, a novel ternary natural deep eutectic solvent (NADES) was obtained through adjustment and optimization. The optimal extraction conditions were determined, and NADES ultrasound-assisted extraction showed higher yields and shorter extraction times compared to traditional methods. This study highlights the potential of NADES as a sustainable alternative for extracting natural active substances.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
Article
Food Science & Technology
Dominique Turck, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch-Ernst, John Kearney, Alexandre Maciuk, Inge Mangelsdorf, Harry J. McArdle, Androniki Naska, Carmen Pelaez, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Rosangela Marchelli, Monika Neuhauser-Berthold, Morten Poulsen, Miguel Prieto Maradona, Josef Rudolf Schlatter, Henk van Loveren, Wolfgang Gelbmann, Helle Katrine Knutsen
Summary: The text summarizes the evaluation of water extract of Cistanche tubulosa stems as a novel food by the European Food Safety Authority, mentioning the use of the extract as a prescription drug in China and safety concerns raised from human studies.
Article
Food Science & Technology
Maoxing Li, Xiuyu Tian, Xiaolin Li, Ting Mao, Tianlong Liu
Summary: The harsh climate conditions of the plateau can decrease people's athletic ability and lead to exercise fatigue. Research shows that the gardenia yellow pigment and Cistanche phenylethanoid glycosides mixture has significant anti-fatigue effects under hypoxia, possibly through various mechanisms.
Article
Chemistry, Medicinal
Xiping Xu, Yaru Yan, Wenqian Huang, Ting Mo, Xiaohui Wang, Juan Wang, Jun Li, Shepo Shi, Xiao Liu, Pengfei Tu
Summary: A new UGT, CtUGT1, was cloned from Cistanche tubulosa, which could catalyze the glucosylation of coumarins umbelliferone 1, esculetine 2, and hymecromone 3 in considerable yield. Although CtUGT1 was not involved in the biosynthesis of bioactive glycosides in C. tubulosa, it could be used in the enzymatic preparation of bioactive coumarin glycosides. The crucial catalysis basis for CtUGT1's activity was identified as H19 through homology modeling and molecular docking analyses, which played an irreplaceable role in the glucosylation of hydroxyl coumarins at the C7OH position.
Article
Plant Sciences
Kuiniu Zhu, Zhaoqing Meng, Yushan Tian, Rui Gu, Zhongkun Xu, Hui Fang, Wenjun Liu, Wenzhe Huang, Gang Ding, Wei Xiao
Summary: The study aimed to investigate the effects of total glycosides of Cistatnche tubulosa (TGCT) on hypoglycemic and hypolipidemic in diet/streptozotocin (STZ)-induced diabetic rats, and identified the major constituents of TGCT. Results showed that TGCT significantly improved glucose and lipid metabolism, potentially through its activities in inhibiting oxidative stress and inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Li Fan, Ying Peng, Jingwen Wang, Ping Ma, Lijuan Zhao, Xiaobo Li
Summary: The study found that total glycosides (TG) from Cistanche tubulosa are primarily responsible for its antidepressant activity, potentially through the bidirectional interaction of phytochemicals and gut microbiota, highlighting the advantage of Cistanche tubulosa in depression treatment.
Article
Chemistry, Multidisciplinary
Chunying Li, Changyin Feng, Mengfei Tian, Xianming Meng, Chunjian Zhao
Summary: An aqueous extraction system containing an ionic liquid surfactant has been developed for the extraction of echinacoside and acteoside from Cistanche deserticola. This method offers a shorter extraction time and higher yield compared to traditional methods, and the surfactant can be recycled and reused. It could also be applied to the extraction of phenylethanol glycosides from other plants.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2022)
Article
Medicine, Research & Experimental
Lingyun Xiao, Jie Yao, Yuyang Miao, Baoru Ou, Jie Wang, Yongqi Huang, Boping Zhou, Lanlan Ge, Jun Tian, Xiaobin Zeng
Summary: The phenylethanoid glycoside Tub B derived from Cistanche tubulosa showed significant anti-inflammatory effects by targeting ERK1/2 and Mob1, making it a potential drug candidate for the treatment of inflammatory diseases, particularly COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Shu-Ping You, Jun Zhao, Long Ma, Mukaram Tudimat, Shi-Lei Zhang, Tao Liu
DARU-JOURNAL OF PHARMACEUTICAL SCIENCES
(2015)
Article
Biochemistry & Molecular Biology
Jun Zhao, Shilei Zhang, Shuping You, Tao Liu, Fang Xu, Tengfei Ji, Zhengyi Gu
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Pharmacology & Pharmacy
Hong-Li Zhang, Ling-Hao Dai, Yi-Hang Wu, Xiao-Ping Yu, Yong-Yong Zhang, Rong-Fa Guan, Tao Liu, Jun Zhao
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2014)
Article
Integrative & Complementary Medicine
Jun Zhao, Tao Liu, Long Ma, Ming Yan, Zhengyi Gu, Yi Huang, Fang Xu, Yu Zhao
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2011)
Article
Biochemistry & Molecular Biology
Tao Liu, Jun Zhao, Haibo Li, Long Ma
Article
Plant Sciences
Jun Zhao, Tao Liu, Long Ma, Ming Yan, Yu Zhao, Zhengyi Gu, Yi Huang