Article
Engineering, Environmental
Jiayou Zhang, Yiming Mo
Summary: Photoredox catalysis has gained significant attention for synthesizing fine chemicals and active pharmaceutical ingredients. However, heat management in photochemical reactors is hindered by the photon and heat generation from light sources. In this study, a strategy to decouple photon and heat using light guide plate (LGP) technology was proposed, leading to the design of a continuous light-diffusing photochemical reactor (LDPR). The LDPR effectively manages heat by distributing the photons emitted by the light source uniformly on the LGP, isolating heat generation from the reaction zone.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Cristian Cavedon, Sebastian Gisbertz, Susanne Reischauer, Sarah Vogl, Eric Sperlich, John H. Burke, Rachel F. Wallick, Stefanie Schrottke, Wei-Hsin Hsu, Lucia Anghileri, Yannik Pfeifer, Noah Richter, Christian Teutloff, Henrike Mueller-Werkmeister, Dario Cambie, Peter H. Seeberger, Josh Vura-Weis, Renske M. van der Veen, Arne Thomas, Bartholomaus Pieber
Summary: We demonstrate visible-light-mediated carbon-heteroatom cross-coupling reactions using a photoactive Ni(II) precatalyst. The activation of this precatalyst involves an initial intraligand charge transfer event triggered by visible light irradiation. Additionally, a porous, recyclable organic polymer for heterogeneous nickel catalysis of cross-coupling reactions is obtained through ligand polymerization.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Hua-Hua Wang, Hui Shao, Guanglong Huang, Jianqiang Fan, Wai-Pong To, Li Dang, Yungen Liu, Chi-Ming Che
Summary: In this study, chiral iron porphyrin complexes were found to catalyze the asymmetric intramolecular C(sp(3))-H amination of aryl and arylsulfonyl azides, providing chiral indolines and benzofused cyclic sulfonamides, respectively. The reactions exhibited high enantioselectivity (up to 93% ee) and high yields (up to 99%) under mild conditions with 410 nm light.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Tsz Chun Lee, Yi Tong, Wai Chung Fu
Summary: Fluorination reactions are crucial in constructing organofluorine motifs in pharmaceuticals and agrochemicals, but they pose challenges due to their hazardous nature, high exothermicity, and limited selectivity and scalability. This review explores recent advancements in continuous flow techniques that address the limitations and challenges of fluorination reactions, including gas-liquid reactions, packed-bed reactors, in-line purifications, reaction telescoping, large-scale reactions, as well as flow photoredox- and electrocatalysis.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Chemistry, Applied
Gabriele Menges-Flanagan, Eva Deitmann, Lars Goessl, Christian Hofmann, Patrick Loeb
Summary: The continuous synthesis and consumption of organozinc reagents in catalyzed and noncatalyzed coupling reactions were investigated, with a focus on quality control and process optimization.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2021)
Article
Chemistry, Multidisciplinary
Tahani A. C. A. Bayrakdar, Camille Lescot
Summary: A simple Rh-based catalyst has been developed for the carbene transfer reaction of methyl diazoacetate (MDA) and various substrates under heterogeneous flow conditions. Two different methods for heterogenizing the catalyst in a column reactor have been successfully applied. The catalyst exhibited high activity and selectivity for functionalizing different X-H (X=O, S, Si, CH2) bonds and for cyclopropenation under mild continuous flow conditions. Catalyst recycling experiments showed that up to 5 catalytic cycles could be achieved for the carbene O-H insertion reaction, and a sequential transformation of different substrates with up to 10 consecutive runs per reactor was achieved without any loss in catalytic activity, allowing the production of compound families.
Article
Chemistry, Multidisciplinary
Yuki Saito, Shu Kobayashi
Summary: The article discusses the application of chiral heterogeneous Sc catalysts in continuous-flow reactions, achieving efficient synthesis of compounds through noncovalent interactions and the crucial role of heteropoly acid.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Engineering, Environmental
Yu-Jing Hu, Jie Chen, Yu-Qing Wang, Ning Zhu, Zheng Fang, Jian-He Xu, Kai Guo
Summary: This article mainly summarizes the applications of biocatalysts in multi-step continuous flow reactions, covering both chemo-enzymatic and multi-enzymatic systems, with a particular focus on the main challenges and strategies involved.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Applied
Mohanraj Kandasamy, Haruro Ishitani, Shu Kobayashi
Summary: A continuous-flow procedure for the synthesis of beta-ketoesters using a Sn-MCM-41 catalyst has been developed. This methodology showed good to excellent yields with a variety of aldehydes and diazoesters. The prepared beta-ketoesters were also successfully transformed into coumarin derivatives and 5-pyrazolone through sequential reactions.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Yu Zhang, Huizhong Liu, Qingshan Shi, Xiaoyang Chen, Xiaobao Xie
Summary: The combination of photocatalysis and biocatalysis has greatly advanced the development of novel synthetic strategies due to functional diversity and stereoselectivity. In this study, a one-pot cascade process combining photo-oxidative fluoridation and bio-reduction was described, which achieved enantiocomplementary vicinal fluoro alcohols with up to 87% isolated yield and 99% ee.
Article
Chemistry, Multidisciplinary
Alessandra Sivo, Vincenzo Ruta, Vittoria Granata, Oleksandr Savateev, Mark A. Bajada, Gianvito Vile
Summary: Efficient catalytic methods for trifluoromethylation of (hetero)arenes play a crucial role in the production of organic and pharmaceutical compounds. Current protocols often rely on toxic reagents and expensive or difficult-to-handle catalysts. Carbon nitride, a non-toxic photocatalyst prepared from inexpensive precursors, offers a promising alternative. However, the relationship between physicochemical properties of carbon nitride and its catalytic performance remains poorly understood.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Review
Chemistry, Multidisciplinary
Qian-Yu Li, Yuhang He, Yu-Mei Lin, Lei Gong
Summary: Photo-induced methylation is a valuable method for introducing methyl groups into organic molecules, especially in pharmaceutical chemistry. This article provides a comprehensive review of photochemical strategies for direct and selective methylation of different types of C-H bonds. These advancements are expected to drive progress in organic synthesis, photocatalysis, and pharmaceutical development.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Organic
Koichiro Masuda, Sandip G. Agalave, Wenlong Chen, Shun-ya Onozawa, Shigeru Shimada, Kazuhiko Sato, Shu Kobayashi
Summary: Under continuous-flow conditions, the researchers investigated the Diels-Alder reactions of unactivated dienes with various dienophiles. H-beta zeolite was identified as a suitable catalyst for this transformation, achieving a high productivity of 1.88 kg/dm(3).day and showing excellent catalyst durability for over 72 hours of continuous operation. The catalyst could be easily recycled up to four times by simple calcination without any loss in activity.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Stefan Simic, Migle Jakstaite, Wilhelm T. . S. Huck, Christoph K. Winkler, Wolfgang Kroutil
Summary: The challenges of light-dependent biocatalytic transformations of lipophilic substrates in aqueous media are addressed through continuous flow reactions. The immobilization of the catalyst on a carrier or using a homogeneous system is determined by the photostability of the catalyst. Homogeneous conditions in the CvFAP-catalyzed photodecarboxylation of palmitic acid achieved a high space-time yield, demonstrating the advantage of continuous flow for photobiocatalytic processes.
Article
Chemistry, Multidisciplinary
Yuki Saito, Shu Kobayashi
Summary: The application of heterogeneous catalysts in continuous-flow enantioselective hydroacylation reactions was studied. Catalysts were prepared by mixing supports and rhodium complexes, and showed excellent activity and enantioselectivity. Under optimized conditions, the catalysts exhibited high turnover numbers and could be applied to various substrates. Furthermore, sequential-flow reactions with other heterogeneous catalysts were demonstrated for the synthesis of biologically active molecules and functional materials.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
M. A. Tiburcio, A. R. Rocha, R. A. Romano, N. M. Inada, V. S. Bagnato, R. M. Carlos, H. H. Buzza
Summary: The study investigated the photosensitizing efficiency of RupPDIp against S. brasiliensis and C. albicans. Results showed that RupPDIp eliminated both fungi at <= 5.0 mu M, with green light showing the best results.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Article
Optics
Alessandra R. Lima, Lucas D. Dias, Matheus Garbuio, Natalia M. Inada, Vanderlei S. Bagnato
Summary: This article reviews the past 51 years of the application of photodynamic inactivation (PDI) in the control of pests and vector-borne diseases, discussing its mechanism of action, key parameters, and limitations.
LASER PHYSICS LETTERS
(2022)
Article
Engineering, Biomedical
Diego Dantas Lopes dos Santos, Joao Felipe Besegato, Priscila Borges Gobbo de Melo, Joao Augusto Oshiro Junior, Marlus Chorilli, Dongmei Deng, Vanderlei Salvador Bagnato, Alessandra Nara de Souza Rastelli
Summary: The study demonstrates that curcumin-encapsulated Pluronic(R) F-127 in antimicrobial photodynamic therapy can effectively reduce the viability of dual-species biofilm of Streptococcus mutans and Candida albicans, suggesting a potential strategy for biofilm control in oral health.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Cesar Augusto Abreu-Pereira, Marlise Inez Klein, Carmelia Isabel Vitorino Lobo, Ana Luiza Gorayb Pereira, Claudia Carolina Jordao, Ana Claudia Pavarina
Summary: This study evaluated the effectiveness of DNase I combined with antimicrobial photodynamic therapy against biofilms formed by a fluconazole-resistant Candida albicans strain. The results showed that DNase treatment combined with aPDT could significantly reduce cell viability and the components of the biofilm.
Article
Chemistry, Physical
Irwin A. P. Linares, Leticia P. Martinelli, Milene N. O. Moritz, Heloisa S. Selistre-de-Araujo, Kleber T. de Oliveira, Janice Rodrigues Perussi
Summary: Photodynamic Therapy (PDT) is a promising treatment that uses photosensitizers to generate reactive oxygen species and induce cell death. This study evaluated the photoactivity of four chlorins in tumor and non-tumor cell lines, and found that certain chlorins exhibited high selectivity and phototoxicity in tumor cells, suggesting their potential for clinical cancer treatment.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Optics
Vinicius M. Pepino, Achiles F. da Mota, Ben-Hur Borges, Fernando L. Teixeira
Summary: A fully passive terahertz pulse amplification device based on the temporal Talbot effect on a highly dispersive silicon-based metamaterial Bragg fiber is proposed. Three different strategies are explored to maximize the passive gain, and different pulse shapes and gain factors are investigated. Numerical simulation results demonstrate the potential of these approaches for further developments in high gain passive amplification THz devices.
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS
(2022)
Article
Oncology
Matheus Garbuio, Lucas D. Dias, Larissa M. de Souza, Thaila Q. Correa, Natasha F. Mezzacappo, Kate C. Blanco, Kleber T. de Oliveira, Natalia M. Inada, Vanderlei S. Bagnato
Summary: This study aimed to synthesize and evaluate different formulations of plant-based larvicides for the photoinactivation of Aedes aegypti larvae. The formulation CCD 3 showed the best efficacy, with the shortest internalization time and longest elimination time, and exhibited rapid degradation under light. In a field trial, CCD 3 had a residual time of 14 days and did not lead to abnormal microbial growth. Furthermore, CCD 3 was found to be non-toxic in Zebrafish.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Materials Science, Paper & Wood
Deyvid S. Porto, Ana Cassales, Heloisa Ciol, Natalia M. Inada, Elisabete Frollini
Summary: This study demonstrates the use of microcrystalline cellulose as a polyol in the synthesis of polyurethane films. The films exhibit transparency, high crystallinity, and moderate hydrophobicity. Biocompatibility tests show non-cytotoxicity, indicating potential applications in coatings, packaging, and dressings.
Article
Biochemistry & Molecular Biology
Renato Jose da Silva-Oliveira, Izabela Natalia Faria Gomes, Luciane Sussuchi da Silva, Andre van Helvoort Lengert, Ana Carolina Laus, Matias Eliseo Melendez, Carla Carolina Munari, Fernanda de Paula Cury, Giovanna Barbarini Longato, Rui Manuel Reis
Summary: This study evaluated the efficacy of pan-EGFR inhibitors in KRAS mutant NSCLC cell lines. The results showed that allitinib was more effective than afatinib in NSCLC cell lines. KRAS mutations increased aggressive behavior and affected cell function through upregulation of the focal adhesion-PI3K-Akt-mTOR signaling. Everolimus could restore sensitivity to EGFR inhibitors in KRAS mutant NSCLC cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Priyanka Vasanthakumari, Renan A. Romano, Ramon G. T. Rosa, Ana G. Salvio, Vladislav Yakovlev, Cristina Kurachi, Jason M. Hirshburg, Javier A. Jo
Summary: This study developed and validated a label-free image-guided strategy based on maFLIM dermoscopy for evaluating suspicious pigmented skin lesions. The results showed that time-resolved autofluorescence global features extracted from maFLIM images can be used to discriminate malignant from benign lesions.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Oncology
Felipe Pereira, Sarah Raquel de Annunzio, Thais de Assis Lopes, Kleber Thiago de Oliveira, Eduardo Maffud Cilli, Paula Aboud Barbugli, Carla Raquel Fontana
Summary: The study evaluated the antimicrobial effects of AMP P5 and aPDT mediated by bixin and chlorin-e6 on Cutibacterium acnes, with Ce6 proving to be a more efficient photosensitizer. The combination of P5 with Ce6-aPDT showed a synergistic effect in reducing microbial load on bacterial biofilm.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Chemistry, Organic
Gabriel Martinez, Nelson Ricardo Avila-Rovelo, Christian C. Carmona-Vargas, Imrane Id-boubrik, Amparo Ruiz-Carretero
Summary: DPP derivatives with thiophene capping rings are widely used as semiconductors in organic electronics, and their optoelectronic properties can be adjusted through different strategies. Incorporating hydrogen-bonding units into DPPs has been shown to improve the performance and morphology of organic solar cells. Modifying the thiophene capping units with hydrogen-bonding groups is a challenging synthetic task, but can yield exciting results.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Proceedings Paper
Dermatology
Priyanka Vasanthakumari, Renan A. Romano, Ramon G. T. Rosa, Ana G. Salvio, Vladislav Yakovlev, Cristina Kurachi, Javier A. Jo
Summary: The study utilizes a deep learning model and multispectral autofluorescence lifetime dermoscopy images for the diagnosis of melanoma, and evaluates the diagnostic performance by constructing probability maps and using Receiver Operator Characteristics (ROC). The results demonstrate that the method can effectively distinguish between benign and malignant lesions.
PHOTONICS IN DERMATOLOGY AND PLASTIC SURGERY 2022
(2022)
Proceedings Paper
Engineering, Biomedical
Vitor Hugo Panhoca, Marcelo Saito Nogueira, Vanderlei Salvador Bagnato
Summary: This study used low-level laser therapy (LLLT) to recover facial nerve palsies, including Bell's Palsy (BP) and trauma-induced paralysis. The results showed that LLLT can promote nerve regeneration, and the combination of laser therapy and vacuum therapy can accelerate facial expression recovery.
IMAGING, THERAPEUTICS, AND ADVANCED TECHNOLOGY IN HEAD AND NECK SURGERY AND OTOLARYNGOLOGY 2022
(2022)
Article
Engineering, Biomedical
Stephanie R. do Amaral, Camila F. Amantino, Sarah R. De Annunzio, Ariela V. de Paula, Carla R. Fontana, Fernando L. Primo
Summary: Photodynamic therapy (PDT) combined with nanoparticles has shown promising results in the treatment of cancer. In this study, nanoemulsions containing a photosensitizer were developed and characterized. The results showed that the nanomaterials had appropriate physical-chemical characteristics, stable properties, and high biocompatibility. In vitro experiments demonstrated the photodynamic activity of the formulation and its potential for cancer treatment.
LASERS IN MEDICAL SCIENCE
(2022)
