Article
Biochemistry & Molecular Biology
Yu Han, Yuan Zhou
Summary: In this study, cell-type-specific miRNAs were identified using multiple correspondence analysis and Gini coefficients, resulting in collections of chromatin activity-specific miRNAs in 91 cell types and expression-specific miRNAs in 124 cell types. It was found that cell-type-specific miRNAs are closely associated with disease miRNAs, providing important clues for research on cancer prognosis and other aspects. Additionally, the online tool mirCellType was constructed for dissecting the cell type composition of complex samples with miRNA expression profiles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Environmental
Dongdong Xiao, Mengbo Yang, Ming Zhang, Liduo Rong, Yamei Wang, Huan Cheng, Xiaofeng Sui, Soren Paludan Sheikh, Mujun Lu
Summary: The tri-layer hydrogel scaffold, consisting of bladder acellular matrix graft-alginate di-aldehydegelatin hydrogel-silk mesh (BAMG-HS), shows excellent mechanical and biodegradable properties, promoting angiogenesis and bladder morphological regeneration, as well as facilitating functional restoration without fibrosis or inflammation. Human ASCs-EVs activate the bladder CXCR4/SDF-1 alpha pathway, enhancing proliferation, invasiveness, and tube-like structure formation of HUVEC, ultimately increasing VEGF secretion through ERK1/2 phosphorylation.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Endocrinology & Metabolism
Roberta Sanguineti, Alessandra Puddu, Massimo Nicolo, Carlo Enrico Traverso, Renzo Cordera, Giorgio L. Viviani, Davide Maggi
Summary: This study found that high glucose significantly decreased miR-126 levels, leading to an increase in VEGF-A expression in RPE cells. However, overexpression of miR-126 under high glucose conditions can counteract the increase in VEGF-A secretion.
JOURNAL OF DIABETES RESEARCH
(2021)
Article
Medicine, Research & Experimental
Febina Ravindran, Anisha Mhatre, Jinsha Koroth, Suchitra Narayan, Bibha Choudhary
Summary: The study aims to understand the epigenetic role of curcumin in inducing cytotoxicity in two molecularly distinct ovarian cancer cell lines. The results show that curcumin activates different miRNA-mRNA regulatory networks to induce multiple modes of cellular cytotoxicity, showcasing its potential as a promising drug candidate for ovarian cancer treatment.
Article
Cardiac & Cardiovascular Systems
Prabhat Ranjan, Rajesh Kumari, Sumanta Kumar Goswami, Jing Li, Harish Pal, Zainab Suleiman, Zhongjian Cheng, Prasanna Krishnamurthy, Raj Kishore, Suresh Kumar Verma
Summary: This study highlights the crucial role of miR-200a-3p enriched in activated fibroblast-derived exosomes in regulating endothelial cell biology and function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cell Biology
Yongqing Wang, John Sun, Bashar Kahaleh
Summary: The impaired angiogenesis in scleroderma (SSc) is closely linked to the down-regulation of miR-126 and its host gene EGFL7, which results in diminished response to VEGF. Epigenetic regulation of miR-126 expression can help normalize angiogenic capacity in SSc-MVECs. These findings suggest the critical role of miR-126 in angiogenesis and its potential as a therapeutic target in SSc.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Xinhai Lin, Haodong Wang, Tiantian Wu, Yaqin Zhu, Long Jiang
Summary: These findings suggest that exosomal miR-126 derived from SCAPs under hypoxia can enhance HUVEC angiogenesis by suppressing SPRED1 and activating the ERK signaling pathway.
Article
Biochemistry & Molecular Biology
Panagiotis Theofilis, Georgia Vogiatzi, Evangelos Oikonomou, Maria Gazouli, Gerasimos Siasos, Hector Katifelis, Despoina Perrea, Manolis Vavuranakis, Dimitrios C. Iliopoulos, Costas Tsioufis, Dimitris Tousoulis
Summary: The study revealed that delivery of microRNA-126 improved vascular perfusion in the ischemic hind limb of mice with upregulation of VEGF. Additionally, a significant negative correlation between microRNA-126 and VEGF tissue expression levels was observed in the entire study population.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Chemistry, Analytical
Yu-Yang Wei, Shao-Hua Wu, Qi-Meng Wang, Jian-Jun Sun
Summary: A novel split-type and signal-on photoelectrochemical (PEC) biosensor was developed for sensitive detection of microRNA-155. The biosensor utilized double-strand specific nuclease (DSN)-assisted recycling amplification and photodeposited Ag enhanced BiVO4 photoanode. The method showed good stability and ease of operation.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Pharmacology & Pharmacy
Stephanie He, Davindra Singh, Hossein Yusefi, Brandon Helfield
Summary: This study investigates the feasibility of delivering the angiogenesis-promoting miR-126 using ultrasound-stimulated microbubbles. The results show that by stimulating miR-126-decorated microbubbles, the intracellular levels of miR-126 can be increased while decreasing the expression of its target genes. This delivery method has the potential to stimulate therapeutic angiogenesis while minimizing endothelial damage.
Article
Multidisciplinary Sciences
Renchao Chen, Yiqiong Liu, Mohamed N. Djekidel, Wenqiang Chen, Aritra Bhattacherjee, Zhiyuan Chen, Ed Scolnick, Yi Zhang
Summary: In this study, a Setd1a haploinsufficiency mouse model was generated to investigate the effect of this SCZ-associated epigenetic factor on gene expression in brain regions relevant to SCZ. The results showed that Setd1a heterozygosity leads to highly variable transcriptional adaptations in different cell types in the prefrontal cortex and striatum, and the Foxp2(+) neurons exhibit the most prominent gene expression changes. Additionally, Setd1a(+/-) mice display behavioral features similar to SCZ patients, suggesting a potential role of Setd1a in SCZ pathogenesis.
Article
Hematology
Fang-Hao Guo, Ya-Na Guan, Jun-Jun Guo, Lu-Jun Zhang, Jing-Jing Qiu, Yong Ji, Alex F. Chen, Qing Jing
Summary: This study reveals that endothelial cells (ECs) exhibit heterogeneity as early as the embryonic stage, and the deficiency of miR-126 disrupts the differentiation and diversification of embryonic ECs. This suggests that miR-126 plays an essential role in maintaining EC heterogeneity.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Cell Biology
Antonella Bordin, Maila Chirivi, Francesca Pagano, Marika Milan, Marco Iuliano, Eleonora Scaccia, Orazio Fortunato, Giorgio Mangino, Xhulio Dhori, Elisabetta De Marinis, Alessandra D'Amico, Selenia Miglietta, Vittorio Picchio, Roberto Rizzi, Giovanna Romeo, Fabio Pulcinelli, Isotta Chimenti, Giacomo Frati, Elena De Falco
Summary: Platelet lysate (PL) contains a subset of small vesicles with angiogenic effects, enriched with miR-126. These extracellular vesicles (EVs) play a key role in promoting angiogenic tubular structures in endothelial cells, representing a potential target for developing a product solely made of EVs for biological manipulation.
CELL PROLIFERATION
(2022)
Review
Endocrinology & Metabolism
Yixiao Ma, Hua Liu, Yong Wang, Junjie Xuan, Xing Gao, Huixian Ding, Chunlian Ma, Yanfang Chen, Yi Yang
Summary: This article reviews the roles of miR-126 and its downstream proteins as exercise mechanisms and proposes that miR-126 can be used as an exercise indicator for cardiovascular prescriptions and as a preventive or therapeutic target for cardiovascular complications in T2DM.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Biology
Sweta Parab, Rachael E. Quick, Ryota L. Matsuoka
Summary: The study reveals that specific combinations of vascular endothelial growth factors are essential for driving fenestrated vessel formation in the zebrafish myelencephalic choroid plexus. The results also suggest that vEC-autonomous Vegfc and meningeal fibroblast-derived Vegfab and Vegfd are critical for CP vascularization. This study provides insights into the molecular cues and cell types critical for directing fenestrated CP vascularization.