Article
Biochemistry & Molecular Biology
Mahanama Geegana Gamage Awanthi, Manatsu Umosa, Yoshiaki Yuguchi, Hirosuke Oku, Kanefumi Kitahara, Michihiro Ito, Atsuko Tanaka, Teruko Konishi
Summary: This study investigated the structure and interlinking of alginate in the cell wall of brown algae. Through fractionation and analysis, it was found that alginate exhibited structural differences in different fractions, and the interlinking with cellulose may be related to the reinforcement of the cell wall.
CARBOHYDRATE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Bo-Rui Chen, Kung-Ting Hsu, Wei-Hsuan Hsu, Bao-Hong Lee, Tsung-Lin Li, Yi-Lin Chan, Chang-Jer Wu
Summary: Fucoidan from Cladosiphon okamuranus (COP) has shown significant immunomodulatory effects in improving atopic dermatitis (AD) both in vitro and in vivo, by reducing allergic reactions and modulating the immune system in animals. COP's therapeutic effects are comparable to corticosteroids without the associated side effects, making it a promising healthy food supplement for AD treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Immunology
Bo-Rui Chen, Kung-Ting Hsu, Tsung-Lin Li, Yi-Lin Chan, Chang-Jer Wu
Summary: The study demonstrates that fucoidan derived from Cladosiphon okamuranus inhibits nitric oxide production, reduces immunocyte proliferation, decreases epidermal hyperplasia and eosinophilic infiltration, regulates systemic immunity, promotes skin repair, and alleviates itching symptoms. Additionally, it up-regulates TGF-beta 1 level and down-regulates AD-associated cytokines, effectively improving atopic dermatitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Makoto Tomori, Takeaki Nagamine, Tomofumi Miyamoto, Masahiko Iha
Summary: The study demonstrated that fucoidan derived from Okinawa mozuku enhances natural killer (NK) cell activity significantly and is safe for consumption in healthy adults, with no observed adverse effects.
Article
Biotechnology & Applied Microbiology
Yoichi Sato, Eri Inomata, Hikari Nagoe, Michihiro Ito, Teruko Konishi, Hiroyuki Fujimura, Atsuko Tanaka, Gregory N. Nishihara
Summary: The uptake kinetics of NO3-, NH4+, and PO3- (4) were studied for Cladosiphon okamuranus, a cultivated brown alga in the Ryukyu Islands, Japan. The uptake rates of NH4+ and PO3- (4) increased with substrate concentration, while the NO3- uptake rates initially increased but then decreased. The Vmax/Ks ratio differed among samples, indicating different adaptation to low nutrient concentrations. The differences in nutrient uptake kinetics suggest an adaptive property for efficient absorption of NH4+ in low nitrate conditions.
JOURNAL OF APPLIED PHYCOLOGY
(2023)
Article
Fisheries
Yusuke Sudo, Saneyuki Yamada, Yoshimi Higa, Masahiro Notoya, Norishige Yotsukura
Summary: This study aims to determine inherent morphological differences of Cladosiphon okamuranus strains at different aquaculture sites and select suitable forms for aquaculture production and processing. Three candidate strains with excellent morphological characteristics (ON, SY, and KT) were selected from six local strains collected from Okinawa Islands and transplanted to four aquaculture sites for evaluation. Results show that the SY strain had significantly larger thallus length and higher density of primary lateral branches compared to the ON strain in each area. Principal component analysis further distinguished the characteristics of the SY and ON strains. The KT strain exhibited intermediate length between the ON and SY strains, and the biomass yield of the SY and KT strains was higher than that of the ON strain.
AQUACULTURE RESEARCH
(2022)
Article
Immunology
Hailin Huang, Fangze Guo, Xuyang Deng, Mingzhe Yan, Danyang Wang, Zhanyi Sun, Changqing Yuan, Qihui Zhou
Summary: Fucoidan has immunomodulatory effects on macrophages, neutrophils, and natural killer cells. It also promotes T cell proliferation and affects osteogenesis. This research provides new insights into the interplay between fucoidan, T cells, and osteoblasts.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anton B. Rasin, Natalia M. Shevchenko, Artem S. Silchenko, Mikhail Kusaykin, Galina N. Likhatskaya, Tatyana N. Zvyagintseva, Svetlana P. Ermakova
Summary: This study investigated the structure of two fucoidans from Fucus evanescens algae using NMR spectroscopy and examined the effects of fucoidan/chitosan mass ratio on the properties of nanoparticles. Molecular docking and thermodynamic analysis revealed significant conformational changes of the molecules during binding, potentially enhancing binding effectiveness.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Yuanping Hao, Weiping Zheng, Zhanyi Sun, Demeng Zhang, Kunyan Sui, Peili Shen, Peifeng Li, Qihui Zhou
Summary: Marine polysaccharide-based hydrogels have attracted attention for biomedical applications due to their excellent properties. These hydrogels, composed of chitosan, alginate, or fucoidan, can be easily prepared with tunable microporous architecture, swelling, and biodegradable properties. They exhibit high mechanical strength and excellent cytocompatibility, blood compatibility, and histocompatibility, making them promising bioscaffolds in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Yanli Zhu, Lubin Liu, Zhanyi Sun, Yanjing Ji, Danyang Wang, Li Mei, Peili Shen, Zhixin Li, Shang Tang, Hui Zhang, Qihui Zhou, Jing Deng
Summary: Fucoidan, a marine-origin prebiotic, has been shown to affect the responses of Lactobacillus rhamnosus, with high-temperature autoclave treatment causing depolymerization of fucoidan. The proliferation, morphology, and metabolism of probiotics are dependent on fucoidan concentrations, with an increased concentration leading to reduced formation of probiotic biofilm and variable antibacterial ability. These findings provide new insights into probiotic modulation and the potential application of fucoidan in inhibiting bacterial infections.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Akanksha Dubey, Jayanthi Sivaraman
Summary: Inflammation is a preliminary immune response to harmful stimuli, and lipoxygenases are involved in inflammatory reactions. Fucoidan, a sulphated polysaccharide, is being studied for its potential in treating inflammatory diseases. This study investigated the inhibitory effects of fucoidan on lipoxygenase and found that it has anti-inflammatory potentials.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biotechnology & Applied Microbiology
D. L. Bellan, I. H. Bini, F. C. Santi, G. R. Rossi, S. M. P. Biscaia, A. I. Maximo, M. B. Reis, F. F. Simas, C. C. Oliveira, S. M. B. Winnischofer, D. M. Leme, R. Chammas, H. A. O. Rocha, E. S. Trindade
Summary: Despite advances in targeted and immunotherapy, effective treatment for metastatic melanoma remains challenging with limited success and severe adverse effects. This study explored the potential of a sulfated fucoidan called Fucan A, obtained from brown seaweed, as an antimelanoma drug. Fucan A showed selective antiproliferative effects on melanoma cells, reduced colony formation and invasive capacity, and modulated invasion-related genes. It also reduced in vivo tumor volume and pulmonary metastasis colonization with minimal adverse effects. These findings suggest that Fucan A has potential as a promising antimelanoma drug candidate.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2023)
Article
Chemistry, Physical
Hong Zhang, Liyang Jiang, Mengdan Tong, Yi Lu, Xiao-Kun Ouyang, Junhong Ling
Summary: The composite nanosystem prepared with fucoidan and zein demonstrated good stability and high encapsulation efficiency for hydrophobic active substances encapsulation and delivery.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Biotechnology & Applied Microbiology
Zoe Kampff, Douwe van Sinderen, Jennifer Mahony
Summary: The Streptococcus genus consists of both commensal and pathogenic species, and their cell surfaces are covered with a complex range of cell wall polysaccharides that facilitate their interactions and environmental adaptation. This review provides a comprehensive overview of the genetic and compositional diversity of streptococcal cell wall polysaccharides, including rhamnose-glucose polysaccharides, exopolysaccharides, and teichoic acids. It also highlights the species-specific combinations of cell wall polysaccharides, particularly the presence of rhamnose-glucose polysaccharides in certain species and the presence of teichoic acids in other species.
BIOTECHNOLOGY ADVANCES
(2023)
Article
Multidisciplinary Sciences
Bo-Rui Chen, Wei-Ming Li, Tsung-Lin Li, Yi-Lin Chan, Chang-Jer Wu
Summary: The fucoidan from Sargassum hemiphyllum has been found to significantly reduce H. pylori infection without developing drug resistance. Fucoidan acts as a strong anti-inflammatory agent and inhibits the adhesion of H. pylori to host cells, thereby reducing the infection rate.
SCIENTIFIC REPORTS
(2022)