Article
Dermatology
Esteban Fernandez Faith, Sonal D. Shah, Mitchell Braun, Elena Pope, Irene Lara-Corrales, Patricia M. Witman, Katya Harfmann, Flora Bradley, Rohali Keesari, Kenneth Jackson, Alexandra Hallagan, Ilona J. Frieden
Summary: This retrospective study found that the incidence of ulceration in infantile hemangiomas has decreased compared to previous reports. However, it remains a relatively common complication. Clinical factors associated with ulceration include partial segmental morphology, location in the diaper area, and size greater than 5 cm. Additionally, Black patients were found to have a higher risk of ulceration, potentially due to barriers to care.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Dermatology
Justin D. Arnold, Sunjung Yoon, Nidhi Shah, Morgan Byrne, Lukas Kieswetter, Cathryn Sibbald, Irene Lara-Corrales, Neha Kinariwalla, Maria C. Garzon, Mitchell Braun, Sonal D. Shah, Ilona J. Frieden, Nicole Travis, Carmen Liy Wong, Alan N. Snyder, Lara Wine Lee, Erin K. Collier, Marcia Hogeling, Esteban Fernandez Faith, Nicole DeVaul, Anna Yasmine Kirkorian
Summary: This study provides a better understanding of the high-risk features of anogenital hemangiomas and demonstrates that segmental or partial segmental hemangiomas develop within specific anatomical territories.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Dermatology
Ana I. Rodriguez Bandera, Deshan F. Sebaratnam, Orli Wargon, Li-Chuen F. Wong
Summary: Infantile hemangioma (IH) is the most common pediatric vascular tumor, with poorly understood pathogenesis thought to involve aberrant response of pluripotent stem cells. IH typically appears in the first few weeks of life and follows a characteristic trajectory of proliferation and involution, with clinical appearance depending on depth and distribution.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Review
Pediatrics
Elana P. Kleinman, Francine Blei, Denise Adams, Shoshana Greenberger
Summary: This is the first reported case of successful treatment of intestinal infantile hemangioma with sirolimus. The study suggests that there may be a correlation between intestinal infantile hemangioma and PHACE syndrome, which deserves further investigation.
PEDIATRIC RESEARCH
(2023)
Article
Acoustics
Maria McNab, Carolina Garcia, Denise Tabak, Ligia Aranibar, Ariel Castro, Ximena Wortsman
Summary: Color Doppler ultrasound can detect subclinical anatomic features of IHs that may impact their involution and response to treatment. Some characteristics may serve as markers for predicting and managing IHs in prolonged proliferative stages.
JOURNAL OF ULTRASOUND IN MEDICINE
(2021)
Article
Dermatology
Yi Ji, Siyuan Chen, Kaiying Yang, Bo Xiang, Xian Jiang, Xuewen Xu, Lizhi Li, Tong Qiu, Jiangyuan Zhou, Shiyi Dai, Xuepeng Zhang, Guoyan Lu, Feiteng Kong, Gang Yang, Qingxia Qiu
Summary: Screening for IHH is recommended in patients younger than 9 months who present with 5 or more cutaneous IHs.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Orthopedics
Salim Abboud, Aashish Bhatt, Irina Pateva, Shahrazad Saab, Meera Hameed, John Healey, Patrick Getty
Summary: This article reports a novel multidisciplinary, joint-sparing treatment approach for an epithelioid hemangioma of bone arising in the acetabulum. The treatment involved transarterial bland particle and ethanol embolization, followed by surgical resection. The results showed no evidence of recurrence and continued ossification of the lesion.
SKELETAL RADIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Priscilla Kaulanjan-Checkmodine, Sandra Oucherif, Sorilla Prey, Etienne Gontier, Sabrina Lacomme, Maya Loot, Marijana Miljkovic-Licina, Muriel Cario, Christine Leaute-Labreze, Alain Taieb, Francois Moisan, Hamid Reza Rezvani
Summary: The study reveals that the catecholamine noradrenaline plays a role in the response of infantile hemangioma (IH) to propranolol treatment. IH tissues contain a higher amount of noradrenaline compared to involuted IHs or propranolol-treated IHs. The sensitivity of IH to propranolol depends on the crosstalk between endothelial cells, pericytes, and telocytes in the presence of a high local amount of noradrenaline.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Malgorzata Kowalska, Wojciech Debek, Ewa Matuszczak
Summary: Most infantile hemangiomas can be managed with observation, but about 10% may require immediate treatment due to complications. Treatment options include systemic and topical therapy, with other forms of treatment considered in cases of inadequate response or rebound growth.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Emilio J. Inarejos Clemente, Joana Diaz Leyva, S. Pinar Karakas, Ana Margarita Duarte, Thomas R. Mas Ricardo Restrepo
Summary: Infantile hemangioma (IH) is a common neoplasm in children that can mimic other types of vascular anomalies or non-vascular tumors. Clinical appearance, time of onset, and pattern of involution aid in diagnosis. Imaging modalities such as US and MRI are used when necessary. Photographic documentation is important for monitoring IH lesions and assisting radiologists in interpretation. Uniform terminology and awareness of other neoplasms that resemble IH are crucial to avoid misdiagnosis.
Article
Oncology
Juan Antonio Lenero-Bardallo, Begona Acha, Carmen Serrano, Jose Antonio Perez-Carrasco, Juan Ortiz-Alvarez, Jose Bernabeu-Wittel
Summary: Infantile hemangiomas are common vascular tumors in infants, and their diagnosis can be challenging. This study shows that thermographic imaging can be an accurate tool for monitoring hemangioma extensions and assessing treatment outcomes.
Article
Health Care Sciences & Services
Tong Qiu, Kaiying Yang, Shiyi Dai, Siyuan Chen, Yi Ji
Summary: This study included 153 patients with segmental IH and 1375 patients with nonsegmental IH. Segmental IHs mainly occur in the extremities, are often accompanied by ulceration, and are more commonly treated with oral medications.
THERAPEUTICS AND CLINICAL RISK MANAGEMENT
(2021)
Review
Oncology
Wei Xu, Haiguang Zhao
Summary: Infantile hemangiomas are common vascular tumors in children. Early identification, diagnosis, and referral to specialists are crucial for preventing complications and achieving better prognosis. Oral propranolol remains a well-accepted first-line treatment.
FRONTIERS IN ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Laura Macca, Domenica Altavilla, Luca Di Bartolomeo, Natasha Irrera, Francesco Borgia, Federica Li Pomi, Federico Vaccaro, Violetta Squadrito, Francesco Squadrito, Mario Vaccaro
Summary: Hemangiomas are the most common benign vascular tumors in infants, affecting about 5-10% of one-year-old children. Most hemangiomas regress spontaneously, but some require treatment to prevent complications. Steroids have been the first-line treatment for over 30 years, but beta-blockers are increasingly being used. In this review, we discussed different treatment options and also explored laser treatment and cases involving the central nervous system.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Dermatology
Anita Rotter, Xinaida T. Lima, Zilda N. P. Oliveira
Summary: In this study, it was found that levels of VEGF and MMP-9 in patients with IH did not differ significantly from healthy controls, and these markers were not increased in the proliferative stage of IH and did not correlate with tumor size.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2021)
Biographical-Item
Dermatology
Elena Pope
PEDIATRIC DERMATOLOGY
(2021)
Review
Dermatology
Carmen Liy-Wong, Elena Pope, Miriam Weinstein, Irene Lara-Corrales
Summary: Staphylococcal scalded skin syndrome (SSSS) mainly affects infants and children, presenting with erythema, exfoliation, and vesicles. Skin tenderness is a common symptom, and surgical debridement should be discouraged during treatment. Adding clindamycin as an anti-toxin agent did not affect the duration of hospitalization, suggesting the need for further investigation.
PEDIATRIC DERMATOLOGY
(2021)
Letter
Genetics & Heredity
David Croitoru, Justin D. Lu, Irene Lara-Corrales, Peter Kannu, Elena Pope
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2021)
Letter
Dermatology
M. L. Ramien, A. Bahubeshi, I. Lara-Corrales, E. Pope, M. L. Levy, A. J. Nopper, N. H. Shear, L. Eichenfield
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Otorhinolaryngology
Weining Yang, Nikolaus E. Wolter, Sharon L. Cushing, Elena Pope, Jennifer K. Wolter, Evan J. Propst
Summary: Children with subglottic hemangioma treated with propranolol or nadolol had similar response rates and side effect profiles.
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2021)
Editorial Material
Dermatology
Elena Pope
PEDIATRIC DERMATOLOGY
(2021)
Article
Dermatology
Nimrita Sangha, A. Nikolas MacLellan, Elena Pope
Summary: This study examined the psychosocial impact of EB on patients and explored ways to improve their quality of life. Four themes were identified: school interaction, daily life, family interactions, and societal interactions. The findings emphasized the importance of EB awareness and resources to support patients and caregivers for improving quality of life.
PEDIATRIC DERMATOLOGY
(2021)
Editorial Material
Dermatology
A. W. Lucky, E. Pope
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Mohammed Albaghdadi, Maria Dossi, Preeti Grewal, Jill Hamilton, Elena Pope, Irene Lara-Corrales
Summary: Data on skin manifestations associated with pediatric obesity are limited. A prospective study was conducted to evaluate the association between pediatric obesity and skin dermatoses as well as dermatologic quality of life. The findings suggest that ongoing monitoring of skin problems is recommended for children with obesity.
PEDIATRIC DERMATOLOGY
(2022)
Article
Genetics & Heredity
Amy S. Paller, Elena Pope, Dan Rudin, Anna Malyala, Deborah Ramsdell, Ramsey Johnson, Hal Landy, Dedee F. Murrell
Summary: This study aimed to evaluate the suitability of DEB assessments as clinical trial endpoints. The results showed the dynamic nature of wounds over a 4-week period of observation and suggested the need for a comprehensive assessment of DEB severity and impact using a combination of clinician-assessed outcomes and patient-/caregiver-reported outcomes.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Dermatology
Adrienn N. N. Bourkas, Elena Pope, Roberto Mendoza-Londono, Binita M. M. Kamath, Irene Lara-Corrales
Summary: Congenital ichthyosis is a rare genetic skin disease characterized by abnormal epidermal differentiation. The neonatal period is crucial for these patients due to the risk of serious complications and mortality, primarily caused by impaired skin barrier function. Early recognition plays a significant role in changing the clinical course of the disease. This case study highlights the interdisciplinary approach in promptly assessing, confirming a genetic diagnosis, and managing potential complications in a neonate with ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis syndrome (ILVASC).
PEDIATRIC DERMATOLOGY
(2023)
Review
Dermatology
Elena Pope, Irene Lara-Corrales, Wingfield Rehmus, Michele Ramien, Shanna Spring, Catherine Mccuaig, Loretta Fiorillo, Cathryn Sibbald, James Bergman
Summary: The need for pediatric dermatology services in Canada is rising, but the current supply of healthcare providers and training programs are insufficient. Proposed solutions include increasing double board certification, creating a protected pediatric stream within existing dermatology residency programs, and establishing accredited fellowships in pediatric dermatology.
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2023)
Article
Dermatology
Luis Fernando Sanchez-Espino, Cathryn Sibbald, Jennifer Stimec, Ronald M. Laxer, Elena Pope
Summary: This study provides insightful clinical, radiologic, and diagnostic data for the evaluation, management, and treatment of pediatric patients with segmental stiff skin syndrome (SSS).
PEDIATRIC DERMATOLOGY
(2023)
Article
Dermatology
Margaret E. Scollan, Laura E. Levin, Anne W. Lucky, Kristen P. Hook, Kathleen Peoples, Anna L. Bruckner, James A. Feinstein, Elena Pope, Catherine C. McCuaig, Julie Powell, Lawrence F. Eichenfield, Moise L. Levy, Lucia Diaz, Sharon A. Glick, Amy S. Paller, John C. Browning, Kimberly D. Morel
Summary: The most common bacteria isolated from wound cultures in patients recorded in the Epidermolysis Bullosa Clinical Characterization and Outcomes Database (EBCCOD) are Staphylococcus aureus and Pseudomonas aeruginosa. To explore the significance of Pseudomonas aeruginosa in patients with epidermolysis bullosa, we analyzed patients with positive wound cultures for this bacterium in the EBCCOD. Our descriptive analysis and suggestions for future longitudinal studies may have important implications in wound care management for these patients.
PEDIATRIC DERMATOLOGY
(2023)